Application of signal transduction inhibition as a therapeutic strategy for central nervous system tumors.

abstract：:In order to describe the status of long-term survivors of brain stem glioma, neuropsychological and behavioral measures were obtained a median of 2.5 (range 1.5-5.6) years after diagnosis from 16 survivors of 51 consecutively diagnosed children with brain stem glioma between 1983 and 1991. Among 11 children with dorsa...

journal_title：Pediatric neurosurgery

authors： Mulhern RK,Heideman RL,Khatib ZA,Kovnar EH,Sanford RA,Kun LE

更新日期：1994-01-01 00:00:00

abstract：:We discuss the surgical approach used for and outcome in 11 infants (< or =3 years) who were treated at our institution for ependymomas arising in the cerebellar-pontine (C-P) angle. The median age of the group was 19 months (range: 6-26 months). Of these 11 patients, the initial surgery for 8 was performed at our cen...

journal_title：Pediatric neurosurgery

authors： Sanford RA,Kun LE,Heideman RL,Gajjar A

更新日期：1997-08-01 00:00:00

abstract：:Holoprosencephaly is a rare congenital malformation resulting from an impaired midline division of the prosencephalon into distinct cerebral hemispheres. Hydrocephalus is a frequent problem among the few survivors with alobar holoprosencephaly (aHPE), its most severe form. The literature about neurosurgical management...

journal_title：Pediatric neurosurgery

authors： Sarica C,Yucetas C,Ozen A,Ucler N,Konca C,Akar S

更新日期：2018-01-01 00:00:00

abstract：:A young patient with a large left hemisphere porencephalic cyst underwent neuroimaging investigation (functional magnetic resonance imaging (fMRI), EEG-fMRI, DTI tractography) during presurgical evaluation for intractable epilepsy. The functional workup showed that (a) the healthy hemisphere had undertaken language pr...

journal_title：Pediatric neurosurgery

authors： Kokkinos V,Garganis K,Kontogiannis K,Zountsas B

更新日期：2011-01-01 00:00:00

abstract：:Anaplastic gangliogliomas with an oligodendroglial component are exceedingly rare tumors of uncertain growth potential. We report a 17-year-old female with a massive ganglioglioma containing anaplastic oligodendroglioma apparently arising from the thalamus. Two weeks after partial resection, she was started on a regim...

journal_title：Pediatric neurosurgery

authors： Johnson MD,Jennings MT,Toms ST

更新日期：2001-06-01 00:00:00

abstract：:Cervical spine injuries occur infrequently in children but are associated with significant disability and mortality. A retrospective analysis was performed of 84 consecutive pediatric spine injuries treated at our institute from January 2002 to December 2011. The mean age was 14.7 years. There were 18 patients (21%) i...

journal_title：Pediatric neurosurgery

authors： Babu RA,Arivazhagan A,Devi BI,Bhat DI,Sampath S,Chandramouli BA

更新日期：2016-01-01 00:00:00

abstract：:Optimal treatment for hydrocephalus related to Dandy-Walker syndrome (DWS) remains elusive. Patients with DWS-related hydrocephalus often require combinations of shunting systems to effectively drain both the supratentorial ventricles and posterior fossa cyst. We describe an endoscopic technique, whereby a frontally p...

journal_title：Pediatric neurosurgery

authors： Sikorski CW,Curry DJ

更新日期：2005-09-01 00:00:00

abstract：:The incidence of pneumocephalus after supratentorial craniotomy has been reported to be as high as 100%. However, transformation of postoperative pneumocephalus into tension pneumocephalus (symptomatic intracranial air) is a rather rare phenomenon. Tension pneumocephalus after posterior fossa surgery is reported mainl...

journal_title：Pediatric neurosurgery

authors： Biyani N,Silbiger A,Ben-Ari J,Constantini S

更新日期：2007-01-01 00:00:00

abstract：:The object of the study are 126 children with internal hydrocephalus treated within the period 1978-1990. The children were preoperatively divided into six groups according to the etiology of the hydrocephalus. Disorders of the visual functions accompanying elevated intracranial pressure (setting sun 51, syndrome of t...

journal_title：Pediatric neurosurgery

authors： Tzekov C,Cherninkova S,Gudeva T

更新日期：1991-01-01 00:00:00

abstract：:Congenital dwarfisms can be associated with a variety of vascular anomalies. Here, we describe 2 patients with congenital dwarfisms who presented with moyamoya syndrome and underwent indirect intracranial revascularization. The pathogenesis of moyamoya syndrome in this population is not well understood, but it is a ma...

journal_title：Pediatric neurosurgery

authors： Moftakhar P,Smith ER,Choulakian A,Scott RM,Danielpour M

更新日期：2010-01-01 00:00:00

abstract：:Spinal cord injuries are a well-known cause of neurological bladder and a well-known complication of high-velocity trauma. They can, however, be difficult to diagnose in young children, in whom the absence of initial neurological symptoms and normality of the radiological workup can be falsely reassuring. Management o...

journal_title：Pediatric neurosurgery

authors： Abbo O,Mouttalib S,L'Kaissi M,Sauvat F,Accadbled F,Harper L

更新日期：2013-01-01 00:00:00

abstract：:A 4-year-old child with AIDS developed encephalitis 2 months prior to death. Adenovirus was cultured from the cerebrospinal fluid. At autopsy, sections of the brain revealed complete sloughing of the intracranial ependyma, with marked gliosis and edema of the periventricular white matter. Cells with large, dark, smudg...

journal_title：Pediatric neurosurgery

authors： Anders KH,Park CS,Cornford ME,Vinters HV

更新日期：1990-01-01 00:00:00

abstract：:Although some complications have been reported when using endoscopic techniques, epidural hematoma (EDH) has rarely been caused. The authors report a case of EDH complicating a concomitant endoscopic biopsy procedure with ventricular shunt placement in a young, 14-year-old boy harboring a third ventricle tumor with a ...

journal_title：Pediatric neurosurgery

authors： Hamlat A,Heckly A,Doumbouya N,Seigneuret E,Brassier G

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Midline suboccipital craniotomy has been proposed as an alternative to conventional craniectomy for removal of posterior fossa tumors. METHOD:We describe a modified technique for midline suboccipital osteoplastic craniotomy based on the atlantooccipital membrane for a 17-year-old boy with superior vermian a...

journal_title：Pediatric neurosurgery

authors： Maiti T,Bhat DI,Devi BI,Shukla D

更新日期：2012-01-01 00:00:00

abstract：:Complications of chemotherapy in pediatric brain tumor patients tend to be acute and short-lived with some special exceptions such as permanent hearing impairment secondary to cisplatin, infertility and an increased risk of second primary neoplasms. Chemotherapy will be better tolerated and probably more effective in ...

journal_title：Pediatric neurosurgery

authors： Allen JC

更新日期：1991-01-01 00:00:00

abstract：AIMS:We report a special type of skull fracture in children - internal open brain injury (IOBI). We summarize its clinical characteristics and propose a treatment strategy based on our experience. METHODS:Eight patients between 2 and 5 years old were identified to have IOBI. Preoperative computed tomography (CT) scann...

journal_title：Pediatric neurosurgery

authors： Yang CH,Li Q,Li GP,You C

更新日期：2009-01-01 00:00:00

abstract：:To compare the functional development of the fourth ventricular outlet in the myeloschisis-Chiari malformation complex with that of a normal brain, the chronological development of the outlet in C57BL/6J non-neural-tube defect mouse embryos was examined as the first step. Then we compared the results with those of hom...

journal_title：Pediatric neurosurgery

authors： Wang KC,Higbee R,Knepper PA,McLone DG

更新日期：1997-10-01 00:00:00

abstract：:The occurrence and pattern of cervical spinal fusions have been assessed in 59 cases of Apert syndrome (acrocephalosyndactyly type 1). Radiological evidence of vertebral fusion either in progress or completed was observed in 37 (63%) of the cases. Fusion was limited to a single vertebral level in 18 cases and multiple...

journal_title：Pediatric neurosurgery

authors： Thompson DN,Slaney SF,Hall CM,Shaw D,Jones BM,Hayward RD

更新日期：1996-07-01 00:00:00

abstract：:Arachnoid cysts are collections of cerebrospinal fluid covered by arachnoidal cells and collagen. They may have a congenital or acquired origin. We present the case of a 7-year-old boy with a cerebellopontine angle arachnoid cyst harbouring a portion of neuroglia. Microscopically, the cyst wall consisted of a delicate...

journal_title：Pediatric neurosurgery

authors： Ariai S,Koerbel A,Bornemann A,Morgala M,Tatagiba M

更新日期：2005-07-01 00:00:00

abstract：:Encephaloceles arise from developmental defects in neural tube formation. These lesions contain brain and meninges which herniate through a defect in the skull. These may present as isolated malformations or rarely be associated with brain tumors. We hereby discuss a case of an unusual association of an occipital ence...

journal_title：Pediatric neurosurgery

authors： Rumana M,Khursheed N,Ramzan A

更新日期：2012-01-01 00:00:00

abstract：:Seventy pediatric patients with brain and spinal cord tumors had cytogenetic analysis of 99 samples of their tumors. Successful analysis was accomplished in 95%. Tumors included 43 gliomas, 9 medulloblastomas and a variety of other lesions. Forty-three patients had normal chromosomes; 28 of these had benign tumors and...

journal_title：Pediatric neurosurgery

authors： Chadduck WM,Boop FA,Sawyer JR

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVES:The treatment of symptomatic cranio-vertebral junction (CVJ) instability in children affected by CVJ abnormalities is a challenge. A series of severely symptomatic children has been reviewed to understand the controversial long-term effectiveness of the aggressive management of CVJ abnormalities, in terms of...

journal_title：Pediatric neurosurgery

authors： Giussani C,Roux FE,Guerra P,Pirillo D,Grimaldi M,Citerio G,Sganzerla EP

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to assess the head injury in children caused by an unusual projectile, a tear gas cartridge. The study is the only one on this subject which has been done in a teenage population. METHOD:This was a prospective study conducted over a period of 4 years in which all the patients aged ...

journal_title：Pediatric neurosurgery

authors： Wani AA,Zargar J,Ramzan AU,Malik NK,Qayoom A,Kirmani AR,Nizami FA,Wani MA

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Composite-type split spinal cord malformation (SCM) is very rare and results from 2 separate foci of ectoendodermal adhesions and endomesenchymal tracts leading to the development of SCM with an intervening normal cord in the same patient. Posterior spurs are even rarer. We report a unique case of composite ...

journal_title：Pediatric neurosurgery

authors： Ailawadhi P,Mahapatra AK

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Nondysraphic intramedullary lipomas of the spinal cord are rare lesions. They are most commonly seen in the second or third decade of life. Their occurrence in the pediatric age group is even rarer. CASE REPORT:The authors describe a 14-month-old child who presented with delayed motor milestones involving...

journal_title：Pediatric neurosurgery

authors： Kumar A,Chandra PS,Bisht A,Garg A,Mahapatra AK,Sharma MC

更新日期：2011-01-01 00:00:00

abstract：:Pineal region lesions consist of a wide variety of rare tumor types, including deep midline cysts, intrinsic pineal tumors, germ cell tumors and vascular lesions. Advances in microsurgical, endoscopic and stereotactic techniques have helped to lower morbidity and mortality in the care of patients harboring these lesio...

journal_title：Pediatric neurosurgery

authors： Knierim DS,Yamada S

更新日期：2003-06-01 00:00:00

abstract：:A case of an intracerebral juvenile xanthogranuloma (JXG) producing complex-partial seizures in a 13-year-old boy is presented. Although the child had no history of JXGs or a systemic histiocytic proliferative disorder, the histopathological and immunocytochemical studies of this lesion were identical to that of a cut...

journal_title：Pediatric neurosurgery

authors： Schultz KD Jr,Petronio J,Narad C,Hunter SB

更新日期：1997-06-01 00:00:00

abstract：:Today, hemispherectomy is a well-established procedure for the treatment of some sorts of catastrophic epilepsies. This, however, has not always been the case. The technique was developed to deal with brain tumors; however, the initial results were not remarkable. Moreover, when its morbidity became evident, it was al...

journal_title：Pediatric neurosurgery

authors： de Almeida AN,Marino R Jr

更新日期：2005-05-01 00:00:00

abstract：:Cystoperitoneal (CP) shunting is minimally invasive and achieves a high rate of resolution on neuroimaging. However, in the absence of definite symptoms, shunting should be reconsidered, because some patients can experience shunt dependency after CP shunting. In this study, the risk of shunt dependency in patients wit...

journal_title：Pediatric neurosurgery

authors： Kim SK,Cho BK,Chung YN,Kim HS,Wang KC

更新日期：2002-10-01 00:00:00

abstract：:The epidemiology of pediatric brain tumor was studied in a 10-year period from 1986 to 1995 in Yamaguchi prefecture. The total number of pediatric brain tumors was 83, and the incidence was 2.5/100, 000/year, which did not change during the period. The sign most frequently seen was intracranial hypertension, whereas f...

journal_title：Pediatric neurosurgery

authors： Nomura S,Nishizaki T,Yamashita K,Ito H

更新日期：1998-03-01 00:00:00