Abstract：
:Study of antitumor and radiosensitizing properties of W. somnifera (Ashwagandha), a well known medicinal plant, have yielded encouraging results. The alcoholic extract of the dried roots of the plant as well as the active component withaferin A isolated from the extract showed significant antitumor and radiosensitizing effects in experimental tumors in vivo, without any noticeable systemic toxicity. Withaferin A gave a sensitizer enhancement ratio of 1.5 for in vitro cell killing of V79 Chinese hamster cells at a non toxic concentration of approximately 2 microM. The mechanism of action of this compound is not known. The studies so far indicate that W. somnifera could prove to be a good natural source of a potent and relatively safe radiosensitizer/chemotherapeutic agent. Further studies are needed to explore the clinical potential of this plant for cancer therapy.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Devi PUsubject
Has Abstractpub_date
1996-10-01 00:00:00pages
927-32issue
10eissn
0019-5189issn
0975-1009journal_volume
34pub_type
杂志文章,评审abstract：:Isoproturon, a nonhalogenated substituted phenylurea herbicide, was evaluated for its cumulative toxic effects on testicular histomorphology., steroid hormone biosynthesis-related enzymes, spermatogenesis and sperm cells in adult albino rats. The compound, suspended in refined groundnut oil, was administered (po) to r...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1997-02-01 00:00:00
abstract：:In the present study, anti-proliferative effects of dietary polyphenolic compounds have been observed and demonstrated the strong anticancer efficacy of curcumin (CMN), an active constituent of dietary spice (turmeric) using human leukemia cancer cell line. CMN inhibited the proliferation of K562 leukemic cells by ind...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
abstract：:Attempts were made to infect mice and immunosuppressed rabbits with Ehrlichia bovis. While evidence of infection could be noticed in rabbits, their identity as E. bovis needs confirmation. Mice appeared to be infected and showed clear inclusions in both blood monocytes and peritoneal macrophages. While symptoms of dis...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1995-06-01 00:00:00
abstract：:Polypeptides synthesized from polysome-bound and unbound fractions of polyA mRNA were studied by in-vivo cells labelling and cDNA-mRNA hybrid-arrest translation. The polypeptides synthesized from unbound(free) fraction appeared to be significantly reduced in the absence of cycloheximide in L6 myoblast. The cDNA excess...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：:Adult mice weighing 20 g, divided into 5 groups, were immunised with single and three cycle cryodestroyed ascites fibrosarcoma cells using different modes of immunisation with respect to dose and administration frequency. Survival against subsequent challenge with the same tumour cells and immune response given by leu...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
abstract：:Ruminal fungal isolates (Orpinomyces sp.; C-14, Piromyces sp.; C-15, Orpinomyces sp.; B-13 and Anaeromyces sp.; B-6), were evaluated under anoxic conditions for their effect on in vitro dry matter digestibility, neutral detergent fibre, acid detergent fibre and acid detergent lignin using rice and wheat straw as subst...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
abstract：:The present study evaluates effect of pharmacokinetic interaction between caffeine (300 mg) in three divided doses with sodium valproate (400 mg) and carbamazepine (200 mg) given as single doses, in normal human volunteers, using a open cross over design. Both the serum concentration of sodium valproate and pharmacoki...
journal_title：Indian journal of experimental biology
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:Chemical composition of inter and intracellular hyphae was elucidated in Pennisetum pedicellatum roots colonized by Gigaspora margarita by employing energy dispersive X-ray microanalysis. Maximum amount of phosphate was estimated in polyphosphate granules present in the roots. Amount of phosphate was low in fungal hyp...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2000-04-01 00:00:00
abstract：:Potentiality of C. tropicalis and D. polymorphus, to produce surface active compounds (bioemulsifiers/biosurfactants) during shake cultivation on hexadecane and oily waste was studied. Better emulsification activity, specific towards aromatic hydrocarbons, was observed with C. tropicalis culture broth. Emulsification ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：:Head and neck squamous cell carcinoma (HNSCC), a common malignancy that possibly involves a combination of exposure to the carcinogens and inherited genetic differences in the enzymes catalyzing their metabolism. Alcohol and tobacco consumption are the primary environmental risk factors, while polymorphism in various ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：2010-07-01 00:00:00
abstract：:The antifungal activity of saponins isolated as a byproduct from the defatted cake of M. butyracea oil seed is reported. The inhibitory concentrations against plant pathogenic fungi ranged from 500 to 2000 ppm. Maximum sensitivity to saponins was shown by Penicillium expansum. Cephalosporium acrimonium, Helminthospori...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
abstract：:Immobilization of cyanobacterium Spirulina platensis in sodium alginate (1.5 %) gave the best quality of bead and 15-16 beads were formed per mL of aqueous solution of alginate. The immobilized cells were used in a batch process for treatment of diluted sewage. After 8 days, 95 % of BOD5, 77 % of COD, 90 % of ammonia,...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2001-08-01 00:00:00
abstract：:The present study was undertaken to identify the receptor for dengue virus type 2 (DV) induced macrophage cytotoxin (CF2) on mouse peritoneal macrophages (MPhi). The binding of 125I-labelled CF2 to MPhi was saturable (15 nM), reversible, temperature, pH- and time-dependent. The saturation concentration was similar to ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：:A study to monitor marine pollution with reference to trace elements (Fe, Zn, Mn and Cu) on T. attenuata, commonly called as screw shell over a period of one year on the whole body and various organs, viz. digestive diverticula, foot, mantle and ovary was conducted from the sandy beach of Porto Novo Coast (Lat 11 degr...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1999-11-01 00:00:00
abstract：:Growth of C. tetragonoloba suffered with increase in concentration of Pb in soil. Plant biomass declined significantly at concentrations above 60 ppm of Pb. Roots showed more pronounced impact as compared to shoots. At highest applied concentration of lead (100 ppm), fresh weight of fruits decreased by 33% and dry wei...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2001-05-01 00:00:00
abstract：:Effect of cerebellar lesion and vestibular stimulation (VS) on the activity and alternation of ECL-cells along with changes in gastric volume and acid secretion was studied. The results suggest that cerebellar lesion caused increased gastric volume and acid secretion and tended to decrease ECL-cell density. On the oth...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1999-06-01 00:00:00
abstract：:Biogenesis of various endogenous opioid peptides, anatomical distribution and the characteristics of multiple receptors with which they interact provides an opportunity for understanding the role of opioid systems and mechanism of opioid tolerance. Cellular and anatomical distribution of opioid receptor and their func...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：2003-01-01 00:00:00
abstract：:The fish, tilapia (Oreochromis mossambicus) of 50-60 g body weight was experimentally exposed to effluent gradients of highly alkaline pH in a sewage-fed aquaculture farm for examining the pH stress-induced responses of mortality and the stress marker enzyme succinate dehydrogenase and the non-specific alkaline phosph...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2007-07-01 00:00:00
abstract：:Osteosarcoma (OSA) is the most common adolescence cancer among all primary bone tumors next only to multiplemyeloma. It has a substantially worse prognosis and ability to metastasize to lung. MMPs (matrix metalloproteinases) are among the major proteases that take part in regulation of ECM (extracellular matrix). MMPs...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
abstract：:Effect of chronic treatment with hydralazine (40 mg/kg/day) on isolated heart, anococcygeus muscle and myometrial preparations from rats has been studied. The treatment for 6 weeks caused a significant increase in isoprenaline induced positive inotropic response in rat heart. However, isoprenaline induced positive chr...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：:Light microscopic study of hippocampal sub-regions demonstrated significant number of degenerated nerve cell bodies in the CA3, CA4 and dentate gyrus(Dg) areas of sodium fluoride administered adult female mice. Ultrastructural studies revealed neurodegenrative characteristics like involution of cell membranes, swellin...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2002-05-01 00:00:00
abstract：:In an attempt to evaluate the effect and interaction of ethanol on endosulfan-induced hepatotoxicity in vivo to adult male rats, both, endosulfan (7.5 mg/kg body wt) and ethanol (1.5 g/kg body wt) were studied separately as well as in combination after a chronic oral exposure of 30 days. When fed separately, both the ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
abstract：:Nine halophilic archaea viz., Halobacterium salinarum, Halobacterium sp.1, Halobacterium sp.2, Halobaculum sp., Halococcus saccharolyticus, Halorubrum saccharovorum, Haloterrigena turkmenica, Halogeometricum sp. and Natrialba sp. isolated from marine salterns around Bhavnagar coast were screened for siderophore produc...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2006-04-01 00:00:00
abstract：:The mechanism of Agrobacterium mediated genetic transformation of plants is dependent upon certain genetic function of the chromosome of the bacterium as well as on Ti-plasmid borne vir loci and the border sequences of T-DNA. The organisationally variable forms of the naturally occurring border sequences amongst Ti-pl...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
abstract：:Administration of ethanol extract of stem bark from Z. rhoifolium (EEtOH-ZR) induced hypotension associated with a dual effect in heart rate in normotensive rats. This response was highlighted in spontaneously hypertensive rats (SHR). In rat superior mesenteric artery rings, the cumulative addition of EEtOH-ZR (0.1-75...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2013-08-01 00:00:00
abstract：:Creatinine in serum or urine is determined by Jaffe's reaction where creatinine produces quantitatively an orange color with picric acid in alkaline medium. After allowing an incubation time of 15 min at room temperature for color development the color is measured at 520 nm. Without taking into consideration the acidi...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:Various storage treatments on human blood samples have been described with respect to DNA yield, quality and fingerprinting. Blood samples were stored at room temperature, 4 degrees C, -20 degrees C and -70 degrees C for different duration varying from 1, 2, 4 and 8 weeks with or without anticoagulant/preservative (ED...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：:Intestinal uptake of lysine in rats progressively decreased with an increase in pH from 5.2 to 8.5, both in the presence and absence of Na+ ions. At pH 5.2 lysine uptake was 30-35% more than that at neutral pH. Na+ activated lysine uptake by 40-50% at pH 5.2 and it was increased to 110-120% at neutral pH. The observed...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
abstract：:Efficacy of vilva, a polyherbal formulation was evaluated in morphine induced constipated rats. Vilva juice, at a dose of 1.5 ml/100 g body wt was given orally for a period of 7 days. Morphine sulfate was injected to induce constipation on 8th day, 45 min before the experiments. Protein bound glycoconjungates were est...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-10-01 00:00:00
abstract：:Cathodal moving protein components were identified in agarose gel electrophoresis of the Veronal buffer extract of a non-motile strain of S. typhi (8393, Colindale). Rabbit antiserum was raised against these cationic proteins; it had both agglutinating and precipitating activity. A total of 80 salmonella strains belon...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
