Acute gastric outlet obstruction following the administration of prostaglandin: an additional case.

Abstract:

:We present a case of neonatal acute gastric outlet obstruction related to prostaglandin-induced gastric foveolar hyperplasia, which developed following infusion of prostaglandin E1 (PGE1) for treatment of hypoplastic left heart syndrome. Abdominal distension occurred after administration of PGE1 in a cumulative dose of 2914 microg/kg. Ultrasonography performed after a cumulative dose of 5074 microg/kg had been administered disclosed a lobulated thickening of the gastric mucosa with a brush-like appearance composed of alternately echogenic and hypoechoic, vertically oriented lines. These ultrasonographic findings corresponded to the histological abnormalities of gastric foveolar hyperplasia with impacted interfoveolar mucin products and dilated mucosal glands. The development of gastric outlet obstruction in our patient, a relatively rare manifestation of prostaglandin-induced foveolar hyperplasia, might have been related to the unusually high cumulative dose of PGE1.

journal_name

Pediatr Radiol

journal_title

Pediatric radiology

authors

Kobayashi N,Aida N,Nishimura G,Kashimura T,Ohta M,Kawataki M

doi

10.1007/s002470050064

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

57-9

issue

1

eissn

0301-0449

issn

1432-1998

journal_volume

27

pub_type

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