Herpes simplex encephalitis: MRI findings in two cases confirmed by polymerase chain reaction assay.

Abstract:

:Herpes simplex virus (HSV) type I causes a fulminant necrotising meningoencephalitis distinguished from other encephalitides by its focal and often haemorrhagic nature. Specific antiviral therapy with acyclovir can significantly improve the prognosis. We present MRI findings of two cases of herpes simplex encephalitis (HSE) confirmed by PCR analysis, focusing on the serial changes after acyclovir therapy: gyral swelling, high signal intensity on T2-weighted images in the subfrontal region, temporal lobe and insula in the initial stage, then regional extension with enhancement and haemorrhage despite appropriate acyclovir therapy, and finally encephalomalacia and brain atrophy.

journal_name

Pediatr Radiol

journal_title

Pediatric radiology

authors

Lee JW,Kim IO,Kim WS,Yeon KM,Lee HJ,Hwang YS

doi

10.1007/s002470100508

keywords:

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

619-23

issue

9

eissn

0301-0449

issn

1432-1998

journal_volume

31

pub_type

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