Abstract:
BACKGROUND:Until recently scurvy has been viewed in developed countries as a disease of the past. More recently there have been reports of case series of children with scurvy who have had a delayed diagnosis after an extensive diagnostic workup that included imaging. Most of these children have had underlying neurologic conditions such as autism. OBJECTIVE:To review the medical records of children diagnosed with vitamin C (ascorbic acid) deficiency based on serum ascorbic acid levels at a large pediatric health care system, to determine imaging findings and utility of imaging in management, and to identify at-risk pediatric populations. MATERIALS AND METHODS:We retrospectively identified cases of vitamin C deficiency in children tested for serum ascorbic acid levels during the last 5 years. We used the criteria of normal ascorbic acid >23 μmol/L and included children with ascorbic acid levels <23 μmol/L. We evaluated their clinical history, underlying medical condition, imaging studies obtained and imaging findings. RESULTS:We identified 32 children with vitamin C deficiency. All of these children had underlying medical conditions, most commonly iron overload from multiple transfusions related to sickle cell anemia or thalassemia (20), neurologic disorders (4) and bone marrow transplant/chemotherapy (3). No cases of scurvy from dietary deficiency in otherwise normal children were identified. All except two children had multiple imaging studies, primarily related to their underlying conditions. Three of these children had extensive imaging workups related to diffuse musculoskeletal pain. Imaging findings included ill-defined sclerotic and lucent metaphyseal bands (mainly at the knee) on radiography and MRI studies that showed diffuse increased T2-weighted signal in the bilateral lower-extremity long-bone metaphyses, periosteal reaction and adjacent soft-tissue edema. CONCLUSION:Vitamin C deficiency is not uncommon in large pediatric health care facilities, and it is frequently missed on clinical evaluation and diagnostic imaging. At-risk populations include those with iron overload, neurologic conditions and history of chemotherapy. Scurvy related to dietary deficiency in otherwise normal children was not encountered. When characteristic MRI findings are seen, particularly in children with a predisposing condition for vitamin C deficiency, scurvy should be considered and a serum ascorbic acid level checked to potentially confirm a diagnosis prior to further invasive tests.
journal_name
Pediatr Radioljournal_title
Pediatric radiologyauthors
Golriz F,Donnelly LF,Devaraj S,Krishnamurthy Rdoi
10.1007/s00247-016-3726-4subject
Has Abstractpub_date
2017-02-01 00:00:00pages
214-220issue
2eissn
0301-0449issn
1432-1998pii
10.1007/s00247-016-3726-4journal_volume
47pub_type
杂志文章abstract::Pediatric multiple sclerosis (MS) deserves special attention because of its impact on cognitive function and development. Although knowledge regarding pediatric MS has rapidly increased, understanding the peculiarities of this population remains crucial for disease management. There is limited expertise about the effi...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-019-04582-3
更新日期:2020-05-01 00:00:00
abstract::Parameters of linear measurement were compared with actual brain volume to assess the significance of linear measurements as indices of atrophy in 31 neurologically normal children and 22 neurologically abnormal children. Brain volume was established by means of an image-analyzing system using contiguous CT scans. The...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02013822
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Computed tomography (CT) is commonly used to evaluate suspected acute appendicitis. Although very effective, CT uses ionizing radiation, exposing patients to an increased risk of cancer. OBJECTIVE:This study assessed the potential for decreasing the field of view of the CT (and therefore the dose to the pat...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-016-3773-x
更新日期:2017-03-01 00:00:00
abstract::Venous drainage to the portal vein in pulmonary sequestration is rare. A 7-month-old girl was referred to our hospital following surgery for ventricular septal defect because of a left upper abdominal mass with a large feeding artery from the abdominal aorta and venous drainage to the portal vein. She had had frequent...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470000251
更新日期:2000-07-01 00:00:00
abstract::Machine learning algorithms can help to improve the accuracy and efficiency of cancer diagnosis, selection of personalized therapies and prediction of long-term outcomes. Artificial intelligence (AI) describes a subset of machine learning that can identify patterns in data and take actions to reach pre-set goals witho...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-019-04360-1
更新日期:2019-10-01 00:00:00
abstract::Endobronchial carcinoid is an extremely rare neoplasm in children. We report a case in which this entity was prospectively diagnosed by 3-D CT bronchography with volume rendering techniques. The ability to prospectively implicate an endobronchial neoplasm in a child may help to guide subsequent therapy and management....
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-004-1293-6
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Various reports support the use of cervical spine (c-spine) CT over conventional radiography in screening of c-spine injury. Interest now exists in diagnostic radiation-induced morbidity. OBJECTIVE:To estimate excess relative risk for developing cancer from c-spine high-resolution CT radiation exposure. MA...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-007-0728-2
更新日期:2008-06-01 00:00:00
abstract::A case of Wilms' tumor metastatic to the liver with previously undescribed MR findings is presented. Although there is no evidence that there were hepatic metastases at presentation in this case, small lesions with this appearance would be difficult to detect with MRI. This could lead to incorrect staging of Wilms' tu...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02467310
更新日期:1989-01-01 00:00:00
abstract::We present the CT and MRI findings of an 8-day-old infant with an infected cephalhaematoma complicated by skull osteomyelitis, venous sinus thrombosis and left cerebellar haemorrhage. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-001-0647-6
更新日期:2002-05-01 00:00:00
abstract::Congenital solitary nonparasitic cysts of the liver (CSNCL) are extremely rare causes of abdominal masses in newborns and infants. We describe a cystic abdominal mass virtually all extrahepatic in a newborn that proved to be a CSNCL. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02013009
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Aortic dilatation and dissection are rare but important complications of Turner syndrome that increase the risk of sudden death in young patients. OBJECTIVE:To assess the value of aortic MRI in patients with Turner syndrome; in particular to demonstrate early aortic dilatation. MATERIALS AND METHODS:A tota...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-004-1359-5
更新日期:2005-03-01 00:00:00
abstract::We present a case of blow-out fracture of the superomedial orbital wall in a 6-year-old boy. The initial plain radiograph showed an intact orbital margin and opacification of the ethmoid sinus. A fine-cut CT scan of the facial bones revealed a complex fracture of the medial orbital wall extending into the orbital roof...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-009-1280-z
更新日期:2009-08-01 00:00:00
abstract::Magnetic resonance imaging (MRI) was compared with iodine-131-labeled monoclonal antibody scanning for ability to detect bone marrow metastases in the spine, pelvis, and femurs of children with disseminated neuroblastoma. The five patients in this study had received high-dose chemotherapy and radiation, either with (N...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02010638
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:The onset of Crohn disease (CD) can occur in childhood. Imaging, which often involves radiation, is frequent in CD both for disease diagnosis and follow-up. However, information regarding radiation dose for contemporary CT and fluoroscopy is not available for determining the cost/benefit ratio for imaging st...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-007-0702-z
更新日期:2008-03-01 00:00:00
abstract::Pulmonary capillary haemangiomatosis (PCH) is a rare disorder characterized by widespread capillary proliferation in the lung, infiltrating the interstitium and the alveolar walls. We present the HRCT features of PCH in a surviving ex-premature infant. To our knowledge, this is a unique case of the radiological featur...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-004-1374-6
更新日期:2005-06-01 00:00:00
abstract::Sonographic studies on 52 children with suspected peripheral vascular disease examined between January 1988 and December 1989 were retrospectively reviewed. A technique for examining the jugular, subclavian veins, and superior vena cava (SVC) was developed and is described. The technique for examining the extremities ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02011718
更新日期:1991-01-01 00:00:00
abstract::The safety and diagnostic efficacy of the new non-ionic, monomeric contrast medium iopentol (Imagopaque) were evaluated and compared with those of the ionic medium metrizoate (Isopaque), in urography in children in a randomized, double-blind, parallel study. The trial comprised 59 children aged from 3 months to 8 year...
journal_title:Pediatric radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02020165
更新日期:1994-01-01 00:00:00
abstract::The objective of this study was to compare the quality of conventional and helical computed tomography (CT) images in children unable to breath-hold. Sixteen patients (age range 1.1-7.5 years) underwent both conventional and helical chest CT on a General Electric HiSpeed Advantage scanner at a mean study interval of 3...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02021699
更新日期:1995-01-01 00:00:00
abstract::A peanut is a commonly inhaled foreign body during childhood. Some cases are difficult to diagnose especially in cases without a clear history of inhalation. We describe a 16-month-old boy presenting with stridor and fever. The chest x-ray suggested inhalation of a foreign body but there was no history of this. A high...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02019867
更新日期:1992-01-01 00:00:00
abstract::As the need for accurate diagnostic imaging often continues throughout a cancer survivor's life, imaging methods with the least toxicity must be used so as to provide needed information without contributing to long-term sequelae that might compound toxicities inherent with the primary disease and its treatment. In thi...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-011-2108-1
更新日期:2011-09-01 00:00:00
abstract::We describe the previously unreported finding of ossification within a rhabdomyosarcoma of the extremity in the absence of bone destruction. Rhabdomyosarcoma is a highly malignant tumor but could not be radiographically differentiated from benign or other malignant causes of soft-tissue masses containing calcium. Defi...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF00971789
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:A technique for reinsertion of an inadvertently removed tunneled central venous catheter is presented. A 6-year-old boy with short-gut syndrome caused by necrotizing enterocolitis accidentally removed his tunneled central venous catheter. MATERIALS AND METHODS:The existing subcutaneous catheter tract was re...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050724
更新日期:1999-12-01 00:00:00
abstract::We performed 25 percutaneous fine needle biopsies (PFNB) on pediatric patients during a 3-year period. Of 17 patients with proven malignancies, PFNB was true positive in 16 and false negative in one. In nine patients with benign or inflammatory disorders, there were three true positives and six false negatives. There ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02388363
更新日期:1985-01-01 00:00:00
abstract::Unilateral thalamic bleeding with associated intraventricular hemorrhage is reported in three full-term neonates. The first presented within 48 hours from birth with early onset streptococcal meningitis, persistent pulmonary hypertension, tonic seizures and a tense fontanelle. The second presented 6 days after birth w...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/BF02011312
更新日期:1992-01-01 00:00:00
abstract::Rapidly involuting congenital hemangioma (RICH) is a recently recognized entity in which the vascular tumor is fully developed at birth and undergoes rapid involution. Angiographic findings in two infants with congenital hemangioma are reported and compared with a more common postnatal infantile hemangioma and a conge...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-002-0726-3
更新日期:2003-01-01 00:00:00
abstract::Orbital sonography with color-flow Doppler imaging is a relatively new technology with significant application in the pediatric patient. This review stresses the primary indications for pediatric ophthalmic ultrasound and also discusses those instances where the use of ultrasound supplements other imaging studies. ...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/BF01372106
更新日期:1996-01-01 00:00:00
abstract::Abnormalities of the fetal urinary tract, most commonly hydronephrosis of differing causes, can be detected by ultrasound (US). Prenatal measurements of the kidney can help to predict the postnatal outcome of hydronephrosis. About 20% of abnormalities evident in utero are not present after birth. After delivery, vario...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s002470050434
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVES:Perinatal hypoxic ischaemic injury is a significant cause of neurodevelopmental impairment. The aim of this study was to evaluate localised proton magnetic resonance spectroscopy (1H-MRS) after birth asphyxia. MATERIALS AND METHODS:Thirty newborn infants suspected of having perinatal asphyxia (Apgar score <...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050572
更新日期:1999-03-01 00:00:00
abstract::Pseudoaneurysms (PAn) are uncommon in adults and even less common in children. They are most often encountered after iatrogenic arterial injury. Presentation may be substantially delayed after the iatrogenic event, and diagnosis can be difficult, especially when the PAn occurs in an unexpected location. Treatment of P...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-004-1320-7
更新日期:2005-04-01 00:00:00
abstract::The practice of contrast-enhanced ultrasound in children is in the setting of off-label use or research. The widespread practice of pediatric contrast-enhanced US is primarily in Europe. There is ongoing effort by the Society for Pediatric Radiology (SPR) and International Contrast Ultrasound Society (ICUS) to push fo...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-013-2746-6
更新日期:2013-09-01 00:00:00