Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region.

abstract：:Outer membrane protein (OMP) biogenesis is critical to bacterial physiology because the cellular envelope is vital to bacterial pathogenesis and antibiotic resistance. The process of OMP biogenesis has been studied in vivo, and each of its components has been studied in isolation in vitro. This work integrates paramet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Costello SM,Plummer AM,Fleming PJ,Fleming KG

更新日期：2016-08-16 00:00:00

abstract：:An automatic protein design procedure is used to select amino acid sequences that optimize the folding free energy function for a given protein. The only information used in designing the sequences is a set of known backbone structures for each protein, a rotamer library, and a well established classical empirical for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaramillo A,Wernisch L,Héry S,Wodak SJ

更新日期：2002-10-15 00:00:00

abstract：:The active form of vitamin D, 1alpha,25-dihydroxyvitamin D [1alpha,25(OH)2D], is synthesized from its precursor 25 hydroxyvitamin D [25(OH)D] via the catalytic action of the 25(OH)D-1alpha-hydroxylase [1alpha(OH)ase] enzyme. Many roles in cell growth and differentiation have been attributed to 1,25(OH)2D, including a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Panda DK,Miao D,Tremblay ML,Sirois J,Farookhi R,Hendy GN,Goltzman D

更新日期：2001-06-19 00:00:00

abstract：:Addition of Na+ to Na+-depleted Swiss 3T3 cells causes a rapid and dramatic increase in intracellular pH, as monitored by uptake of the weak acid 5,5-dimethyloxazolidine-2,4-dione. The effect of Na+ is concentration dependent (half-maximal effect at 38 mM); this cation can be replaced by Li+ but not by K+ or the choli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schuldiner S,Rozengurt E

更新日期：1982-12-01 00:00:00

abstract：:Overproduction or deficiency of many chaperones and other cellular components cure the yeast prions [PSI+] (formed by Sup35p) or [URE3] (based on Ure2p). However, at normal expression levels, Btn2p and Cur1p eliminate most newly arising [URE3] variants but do not cure [PSI+], even after overexpression. Deficiency or o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gorkovskiy A,Reidy M,Masison DC,Wickner RB

更新日期：2017-05-23 00:00:00

abstract：:I reject the Darwinian assumption that larvae and their adults evolved from a single common ancestor. Rather I posit that, in animals that metamorphose, the basic types of larvae originated as adults of different lineages, i.e., larvae were transferred when, through hybridization, their genomes were acquired by distan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williamson DI

更新日期：2009-11-24 00:00:00

abstract：:New geochemical data from the Malawi Rift (Chiwondo Beds, Karonga Basin) fill a major spatial gap in our knowledge of hominin adaptations on a continental scale. Oxygen (δ18O), carbon (δ13C), and clumped (Δ47) isotope data on paleosols, hominins, and selected fauna elucidate an unexpected diversity in the Pleistocene ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lüdecke T,Kullmer O,Wacker U,Sandrock O,Fiebig J,Schrenk F,Mulch A

更新日期：2018-12-26 00:00:00

abstract：:Recent evidence suggests that the microbial community in the human intestine may play an important role in the pathogenesis of obesity. We examined 184,094 sequences of microbial 16S rRNA genes from PCR amplicons by using the 454 pyrosequencing technology to compare the microbial community structures of 9 individuals,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang H,DiBaise JK,Zuccolo A,Kudrna D,Braidotti M,Yu Y,Parameswaran P,Crowell MD,Wing R,Rittmann BE,Krajmalnik-Brown R

更新日期：2009-02-17 00:00:00

abstract：:Monotremes have left a poor fossil record, and paleontology has been virtually mute during two decades of discussion about molecular clock estimates of the timing of divergence between the platypus and echidna clades. We describe evidence from high-resolution x-ray computed tomography indicating that Teinolophos, an E...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rowe T,Rich TH,Vickers-Rich P,Springer M,Woodburne MO

更新日期：2008-01-29 00:00:00

abstract：:The larger structures are, the lower their mechanical strength. Already discussed by Leonardo da Vinci and Edmé Mariotte several centuries ago, size effects on strength remain of crucial importance in modern engineering for the elaboration of safety regulations in structural design or the extrapolation of laboratory r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiss J,Girard L,Gimbert F,Amitrano D,Vandembroucq D

更新日期：2014-04-29 00:00:00

abstract：:Molecular analyses of Na,K-ATPase abundance and alpha-subunit isoform distribution were performed to determine whether pump expression varies at different points through the thickness of the circular layer of colonic smooth muscle. The mRNA and polypeptides of Na,K-ATPase alpha 1 and beta subunits were twice as abunda...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burke EP,Sanders KM,Horowitz B

更新日期：1991-03-15 00:00:00

abstract：:The derivation of germ-line competent avian primordial germ cells establishes a cell-based model system for the investigation of germ cell differentiation and the production of genetically modified animals. Current methods to modify primordial germ cells using DNA or retroviral vectors are inefficient and prone to epi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Macdonald J,Taylor L,Sherman A,Kawakami K,Takahashi Y,Sang HM,McGrew MJ

更新日期：2012-06-05 00:00:00

abstract：:In our earlier work we showed that either spermidine or spermine could support the growth of spe2Delta or spe3Delta polyamine-requiring mutants, but it was unclear whether the cells had a specific requirement for either of these amines. In the current work, we demonstrate that spermidine is specifically required for t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chattopadhyay MK,Tabor CW,Tabor H

更新日期：2003-11-25 00:00:00

abstract：:The region of human chromosome 22q11 is prone to rearrangements. The resulting chromosomal abnormalities are involved in Velo-cardio-facial and DiGeorge syndromes (VCFS and DGS) (deletions), "cat eye" syndrome (duplications), and certain types of tumors (translocations). As a prelude to the development of mouse models...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Puech A,Saint-Jore B,Funke B,Gilbert DJ,Sirotkin H,Copeland NG,Jenkins NA,Kucherlapati R,Morrow B,Skoultchi AI

更新日期：1997-12-23 00:00:00

abstract：:The positive transcription elongation factor b (P-TEFb) is involved in physiological and pathological events including inflammation, cancer, AIDS, and cardiac hypertrophy. The balance between its active and inactive form is tightly controlled to ensure cellular integrity. We report that the transcriptional repressor C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cherrier T,Le Douce V,Eilebrecht S,Riclet R,Marban C,Dequiedt F,Goumon Y,Paillart JC,Mericskay M,Parlakian A,Bausero P,Abbas W,Herbein G,Kurdistani SK,Grana X,Van Driessche B,Schwartz C,Candolfi E,Benecke AG,Van Lin

更新日期：2013-07-30 00:00:00

abstract：:Ecological character displacement describes a pattern where morphological differences between sympatric species are enhanced through interspecific competition. Although widely considered a pervasive force in evolutionary ecology, few clear-cut examples have been documented. Here we report a case of ecological characte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adams DC,Rohlf FJ

更新日期：2000-04-11 00:00:00

abstract：:An intermolecular intercalation of base pairs was found at the CA step in the I222 crystal structure of the RNA.DNA hybrid, r(CAAAGAAAAG).d(CTTTTCTTTG), which contains two-thirds of the polypurine tract sequence of HIV-1 with a substitution of cytosine for the initial adenine. This sequence crystallized in both P21212...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han GW,Kopka ML,Langs D,Sawaya MR,Dickerson RE

更新日期：2003-08-05 00:00:00

abstract：:Massively parallel signature sequencing (MPSS) generates millions of short sequence tags corresponding to transcripts from a single RNA preparation. Most MPSS tags can be unambiguously assigned to genes, thereby generating a comprehensive expression profile of the tissue of origin. From the comparison of MPSS data fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YT,Scanlan MJ,Venditti CA,Chua R,Theiler G,Stevenson BJ,Iseli C,Gure AO,Vasicek T,Strausberg RL,Jongeneel CV,Old LJ,Simpson AJ

更新日期：2005-05-31 00:00:00

abstract：:The subcellular localization of cathepsin B activity (EC 3.4.22.1) in three murine melanomas of increasing metastatic potential (Cloudman less than B16-F1 less than B16 amelanotic) was determined. Cathepsin B activity was localized in the heavy mitochondrial fraction of normal murine liver but in the light mitochondri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sloane BF,Rozhin J,Johnson K,Taylor H,Crissman JD,Honn KV

更新日期：1986-04-01 00:00:00

abstract：:Posttranscriptional regulation is an important step in the regulation of gene expression. In this article, we show an unexpected connection between two proteins that participate in different processes of posttranscriptional regulation that ensures the production of functional mRNA molecules. Specifically, we show that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agranat L,Raitskin O,Sperling J,Sperling R

更新日期：2008-04-01 00:00:00

abstract：:Feedback loops are ubiquitous features of biological networks and can produce significant phenotypic heterogeneity, including a bimodal distribution of gene expression across an isogenic cell population. In this work, a combination of experiments and computational modeling was used to explore the roles of multiple fee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Venturelli OS,El-Samad H,Murray RM

更新日期：2012-11-27 00:00:00

abstract：:hK7 or human stratum corneum chymotryptic enzyme belongs to the human tissue kallikrein (hKs) serine proteinase family and is strongly expressed in the upper layers of the epidermis. It participates in skin desquamation but is also implicated in diverse skin diseases and is a potential biomarker of ovarian cancer. We ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Debela M,Hess P,Magdolen V,Schechter NM,Steiner T,Huber R,Bode W,Goettig P

更新日期：2007-10-09 00:00:00

abstract：:Drosophila heteroneura and D. silvestris are sympatric species living on the island of Hawaii, while D. planitibia is allopatric on the nearby island of Maui. A pronounced ethological isolation is found between the sympatric species, and none between allopatric ones, except that D. planitibia females discriminate agai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahearn JN,Carson HL,Dobzhansky T,Kaneshiro KY

更新日期：1974-03-01 00:00:00

abstract：:Metal detoxification is essential for bacteria's survival in adverse environments and their pathogenesis in hosts. Understanding the underlying mechanisms is crucial for devising antibacterial treatments. In the Gram-negative bacterium Escherichia coli, membrane-bound sensor CusS and its response regulator CusR togeth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu B,Sengupta K,Genova LA,Santiago AG,Jung W,Krzemiński Ł,Chakraborty UK,Zhang W,Chen P

更新日期：2020-06-16 00:00:00

abstract：:p38 mitogen-activated protein kinase (MAPK) regulates cytokines in arthritis and is, in turn, regulated by MAPK kinase (MKK) 3 and MKK6. To modulate p38 function but potentially minimize toxicity, we evaluated the utility of targeting MKK3 by using MKK3(-/-) mice. These studies showed that TNF-alpha increased phosphor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inoue T,Boyle DL,Corr M,Hammaker D,Davis RJ,Flavell RA,Firestein GS

更新日期：2006-04-04 00:00:00

abstract：:Sleep is recognized as a physiological state associated with learning, with studies showing that knowledge acquisition improves with naps. Little work has examined sleep-dependent learning in people with developmental disorders, for whom sleep quality is often impaired. We examined the effect of natural, in-home naps ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spanò G,Gómez RL,Demara BI,Alt M,Cowen SL,Edgin JO

更新日期：2018-11-13 00:00:00

abstract：:The molecular weight of the major glycoprotein from the human erythrocyte membrane is 29,000, of which 55% is carbohydrate and 45% is protein. The binding of sodium dodecyl sulfate to this glycoprotein is anomalous when compared to water soluble proteins and leads to migration rates in sodium dodecyl sulfate-polyacryl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grefrath SP,Reynolds JA

更新日期：1974-10-01 00:00:00

abstract：:Whereas NF-kappaB has potent antiapoptotic function in most cell types, it was reported that in pancreatic beta cells it serves a proapoptotic function and may contribute to the pathogenesis of autoimmune type 1 diabetes. To investigate the role of beta cell NF-kappaB in autoimmune diabetes, we produced transgenic mic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim S,Millet I,Kim HS,Kim JY,Han MS,Lee MK,Kim KW,Sherwin RS,Karin M,Lee MS

更新日期：2007-02-06 00:00:00

abstract：:Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. Airway disease is the major source of morbidity and mortality. Successful implementation of gene- and cell-based therapies for CF airway disease requires knowledge of relations...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shah VS,Ernst S,Tang XX,Karp PH,Parker CP,Ostedgaard LS,Welsh MJ

更新日期：2016-05-10 00:00:00

abstract：:Mutant alleles at the dilute unconventional myosin heavy chain locus cause diluted coat color, opisthotonic seizures, and death. The dilute coat color phenotype is caused by irregular clumping of pigment in the hair, but amounts of melanin are unchanged from wild-type controls. The melanocyte phenotype has been descri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Provance DW Jr,Wei M,Ipe V,Mercer JA

更新日期：1996-12-10 00:00:00