Blood lactate levels are better prognostic indicators than TNF and IL-6 levels in patients with septic shock.

abstract：OBJECTIVE:Hospital mortality of patients with septic multiorgan failure (MOF) is still around 95%. The present study investigates whether this high mortality could be significantly reduced by the addition of sequential hemofiltration (SH) with bicarbonate hemodialysis (HD) to the currently used life supportive measures...

journal_title：Intensive care medicine

authors： Gotloib L,Shostak A,Lev A,Fudin R,Jaichenko J

更新日期：1995-02-01 00:00:00

abstract：PURPOSE:Sepsis and its progression are known to have a major influence on the coagulation system. Current coagulation tests are of limited use when assessing coagulation in sepsis patients. This study aims to assess the potential for a new functional biomarker of clot microstructure, fractal dimension, to identify chan...

journal_title：Intensive care medicine

authors： Davies GR,Pillai S,Lawrence M,Mills GM,Aubrey R,D'Silva L,Battle C,Williams R,Brown R,Thomas D,Morris K,Evans PA

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:To study plasma concentrations of interleukin 6 (IL-6) and interleukin 8 (IL-8) in patients with splanchnic hypoxia, as documented by gastric intramucosal measurements (pH-i), during major abdominal surgery and the relationship between IL-6 and IL-8 concentrations and postoperative complications as well as cl...

journal_title：Intensive care medicine

authors： Donati A,Battisti D,Recchioni A,Paoletti P,Conti G,Caporelli S,Adrario E,Pelaia P,Pietropaoli P

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVES:To establish a preliminary list of critical incidents (CIs) associated with mechanical ventilation and to describe a CI reporting method. DESIGN:A list of CIs was established based on a consensus among ICU caregivers. The list was compared to CIs collected prospectively during a predefined study period. SE...

journal_title：Intensive care medicine

authors： Auriant I,Reignier J,Pibarot ML,Bachat S,Tenaillon A,Raphael JC

更新日期：2002-04-01 00:00:00

abstract：PURPOSE:Inflammatory markers may have a role in predicting severity of illness of intensive care unit (ICU) patients. The aim of this study is to determine whether low eosinophil count can predict 28-day mortality in medical ICU. METHODS:A prospective study over a 4-month period. To evaluate the prognosis information ...

journal_title：Intensive care medicine

authors： Abidi K,Belayachi J,Derras Y,Khayari ME,Dendane T,Madani N,Khoudri I,Zeggwagh AA,Abouqal R

更新日期：2011-07-01 00:00:00

abstract：UNLABELLED:Admission of cancer patients with serious medical complications to the ICU remains controversial primarily because of the high short-term mortality rates in these patients. However, the cancer patient population is heterogeneous regarding age, underlying conditions, and curability of their disease, suggestin...

journal_title：Intensive care medicine

authors： Azoulay E,Moreau D,Alberti C,Leleu G,Adrie C,Barboteu M,Cottu P,Levy V,Le Gall JR,Schlemmer B

更新日期：2000-12-01 00:00:00

abstract：:The spread of a multi-resistant glucose-acidifying Acinetobacter calcoaceticus strain in a community hospital was studied. After admission of a colonized patient to the hospital the strain was found in clinical specimens from ICU patients and subsequently from several of these patients after transfer to medical wards....

journal_title：Intensive care medicine

authors： Crombach WH,Dijkshoorn L,van Noort-Klaassen M,Niessen J,van Knippenberg-Gordebeke G

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:Assessment of the cost utility (CU) of acute renal replacement therapy (RRT) from a societal perspective during a 5-year follow-up. METHODS:This was a cross-sectional cohort study in a medical-surgical intensive care unit and an acute RRT unit of 410 consecutive patients treated with acute RRT in Helsinki Univ...

journal_title：Intensive care medicine

authors： Laukkanen A,Emaus L,Pettilä V,Kaukonen KM

更新日期：2013-03-01 00:00:00

abstract：:In a randomized clinical trial the prophylactic effects of locally administered antimicrobials on quantitative colonization and respiratory infections were studied in intubated patients with an expected period of mechanical ventilation of greater than 6 days. Nineteen patients received 50 mg of polymyxin B and 80 mg o...

journal_title：Intensive care medicine

authors： Unertl K,Ruckdeschel G,Selbmann HK,Jensen U,Forst H,Lenhart FP,Peter K

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:Mechanical ventilation with lower tidal volumes (≤6 ml/kg of predicted body weight, PBW) could benefit patients without acute respiratory distress syndrome (ARDS). However, tidal volume reduction could be associated with increased patient discomfort and sedation needs, and consequent longer duration of ventilat...

journal_title：Intensive care medicine

authors： Serpa Neto A,Simonis FD,Barbas CS,Biehl M,Determann RM,Elmer J,Friedman G,Gajic O,Goldstein JN,Horn J,Juffermans NP,Linko R,de Oliveira RP,Sundar S,Talmor D,Wolthuis EK,de Abreu MG,Pelosi P,Schultz MJ

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:Patients undergoing cardiac surgery often require transfusions of red blood cells, plasma and platelets. These components differ widely in both indications for use and composition. However, from a statistical point of view there is a significant colinearity between the components. This study explores the relati...

journal_title：Intensive care medicine

authors： Bjursten H,Dardashti A,Ederoth P,Brondén B,Algotsson L

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:To determine the prevalence and the prognostic significance of microalbuminuria in patients after aneurysmal subarachnoid hemorrhage (SAH). DESIGN:Prospective and observational clinical study. SETTING:Multidisciplinary intensive care unit. PATIENTS:Fifty-one consecutive patients who underwent aneurysm clip...

journal_title：Intensive care medicine

authors： Terao Y,Takada M,Tanabe T,Ando Y,Fukusaki M,Sumikawa K

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:To estimate the direct and indirect (contextual) effects of the factorized constituents of selective digestive decontamination and selective oropharyngeal decontamination (SDD/SOD), being topical antibiotic (TA) and protocolized antifungal prophylaxis (PAFP), on ICU-acquired candidemia. METHODS:A broad range o...

journal_title：Intensive care medicine

authors： Hurley JC

更新日期：2015-11-01 00:00:00

abstract：:Pneumonia caused by herpes simplex virus type 1 (HSV1) is rare and occurs in severely immunosuppressed patients. HSV1 can be detected in bronchoalveolar lavage (BAL) from patients presenting with respiratory failure, but its direct effect on disease is difficult to prove. We demonstrate the causative role of HSV1 in t...

journal_title：Intensive care medicine

authors： François-Dufresne A,Garbino J,Ricou B,Wunderli W

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:Postoperative pneumonia is a potentially devastating complication associated with high mortality in intensive care unit (ICU)-patients. One of the major predisposing factors is the perioperative occurrence of atelectatic formations in non-dependent lung areas. Perioperative ventilation/perfusion mismatch due ...

journal_title：Intensive care medicine

authors： Hutschala D,Kinstner C,Skhirtladze K,Mayer-Helm BX,Zeitlinger M,Wisser W,Müller M,Tschernko E

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVES:Previous studies on therapeutic interventions in sepsis have assumed stability of the measure of splanchnic blood flow throughout the study. We assessed the variability of splanchnic blood flow during stable global hemodynamics in eight patients with sepsis requiring treatment with dobutamine and/or norepine...

journal_title：Intensive care medicine

authors： Sakka SG,Reinhart K,Wegscheider K,Meier-Hellmann A

更新日期：2001-08-01 00:00:00

abstract：PURPOSE:Plasma immunoglobulin concentrations are acutely altered in critically ill patients with sepsis. However, the association between immunoglobulin levels on the day of sepsis diagnosis and subsequent mortality is inconsistent. METHODS:Systematic review of studies that report immunoglobulin measurements and morta...

journal_title：Intensive care medicine

authors： Shankar-Hari M,Culshaw N,Post B,Tamayo E,Andaluz-Ojeda D,Bermejo-Martín JF,Dietz S,Werdan K,Beale R,Spencer J,Singer M

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:The role of critical care pharmacists in the United States has recently been documented; however, little information exists about the role of international critical care pharmacists. The objective of this study was to describe the duties and activities of international pharmacists who practice in critical car...

journal_title：Intensive care medicine

authors： LeBlanc JM,Seoane-Vazquez EC,Arbo TC,Dasta JF

更新日期：2008-03-01 00:00:00

abstract：:In 16 patients with multiple injuries the effect of parenteral administration of a fat emulsion on the pulmonary vascular system has been studied. Using the Hewlett Packard 5600 A Intensive Care System, which allows vital parameters to be sampled at a rate of two values per min, pulmonary artery pressure (PAP) was mon...

journal_title：Intensive care medicine

authors： van Deyk K,Hempel V,Münch F,Kopp M,Graf H,Epple E

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:Endotoxin administration to humans is a common means to study systemic inflammation. Worldwide, thousands of volunteers have received endotoxin, and adverse events are rarely reported. The aim of this report was to increase awareness of specific risks of the intravenous administration of endotoxin to human vo...

journal_title：Intensive care medicine

authors： van Eijk LT,Pickkers P,Smits P,Bouw MP,van der Hoeven JG

更新日期：2004-12-01 00:00:00

abstract：:In the first study 6 patients with raised intracranial pressure due to brain oedema following head injury were given dihydroergotamine because of low perfusion pressure. The intracranial pressure fell simultaneously with the increase in arterial pressure. The intracranial pressure fell from 24 +/- 2 mmHg by a maximum ...

journal_title：Intensive care medicine

authors： Grände PO

更新日期：1989-01-01 00:00:00

abstract：:The abundance of literature related to nutritional support reflects its recently recognised role in preventing metabolic complications and gut dysfunction during critical illness. However, some published studies lack relevance to critically ill patients, as a result of the selection of subjects and outcome variables, ...

journal_title：Intensive care medicine

authors： Preiser JC,Chioléro R,Wernerman J,ESICM(European Society of Intensive Care Medicine) Working Group on Nutrition and Metabolism.

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:To investigate the morphological changes in the liver in patients with organ failure and hyperbilirubinemia and to correlate them to the outcome. DESIGN:A case series prospective study. SETTING:Intensive care units of two general hospitals. PATIENTS:Twelve patients in organ failure with predominant hepatic...

journal_title：Intensive care medicine

authors： Douzinas EE,Vamvasakis E,Rigas K,Pitaridis M,Kittas C,Roussos C

更新日期：1996-06-01 00:00:00

abstract：: ...

journal_title：Intensive care medicine

authors： Monnet X,Saugel B

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:To examine whether urgent orotracheal intubation (OI) can induce bacteremia. To find predictive factors for post-intubation bacteremia. DESIGN:Prospective observational study. SETTING:Seventeen-bed medical intensive care unit in a university hospital. PATIENTS:Sixty-eight adult intensive care patients und...

journal_title：Intensive care medicine

authors： Rijnders BJ,Wilmer A,Van Eldere J,Van Wijngaerden E

更新日期：2001-02-01 00:00:00

abstract：:Of 28 consecutive patients over 64 years old, in whom endoscopy revealed gastro-duodenal ulcers with signs of recent hemorrhage (active bleeding, non-bleeding vessel or adherent clot), 14 were randomly assigned to receive endoscopic alcoholization of the lesions preceded by intragastric instillation of norepinephrine,...

journal_title：Intensive care medicine

authors： Acalovschi I,Pascu O,Drăghici A

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:To determine the oxygen affinity for optimal tissue oxygen delivery with a hemoglobin-hydroxyethyl starch conjugate (HRC 101). METHODS:Anesthetized rats were hemodiluted (180 ml kg(-1)) with low (P(50) approximately 70 mmHg) or high affinity (P(50) approximately 14 mmHg) HRC 101 at hemoglobin (Hb) concentratio...

journal_title：Intensive care medicine

authors： Hare GM,Liu E,Baker AJ,Mazer CD

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:To investigate whether serum procalcitonin (PCT) levels could be useful to differentiate between systemic infection and the activity of the underlying disease in autoimmune disease. METHODS:In 18 patients with systemic lupus erythematodes (SLE) and 35 patients with systemic antineutrophil cytoplasmic antibod...

journal_title：Intensive care medicine

authors： Brunkhorst R,Eberhardt OK,Haubitz M,Brunkhorst FM

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:In critically ill pediatric patients, fluid overload (FO) >10% has been identified as a threshold for possible interventions, including initiation of continuous renal replacement therapy (CRRT). However, multiple definitions have been reported, and there remains no consensus method for FO calculation. The goal ...

journal_title：Intensive care medicine

authors： Lombel RM,Kommareddi M,Mottes T,Selewski DT,Han YY,Gipson DS,Collins KL,Heung M

更新日期：2012-04-01 00:00:00

abstract：:Membranous laryngotracheobronchitis is a very serious infection which affects the larynx, trachea and bronchi, requiring aggressive therapeutic measures. It has been recently rediscovered as a cause of disease in children. However, it is a very unusual complication of measles. Two infants with measles and membranous l...

journal_title：Intensive care medicine

authors： Labay MV,Ramos R,Hervas JA,Reynes J,Gomez B

更新日期：1985-01-01 00:00:00