Abstract：
PURPOSE:Patients undergoing cardiac surgery often require transfusions of red blood cells, plasma and platelets. These components differ widely in both indications for use and composition. However, from a statistical point of view there is a significant colinearity between the components. This study explores the relation between the transfusion of different blood components and long-term mortality. METHODS:A retrospective single-centre study was performed including 5,261 coronary artery bypass grafting patients, excluding patients receiving more than eight units of red blood cells, those suffering early death (7 days) and emergency cases. Patients were followed up for a period of up to 7.5 years. A broad spectrum of potential risk factors was analysed using Cox proportional hazards survival regression. Non-significant risk factors were removed by step-wise elimination, and transfusion of red blood cells, plasma and platelets was forced to remain in the model. RESULTS:The transfusion of red blood cells was not associated with decreased long-term mortality (HR = 1.007, p = 0.775), whereas the transfusion of plasma was associated with decreased long-term survival (HR = 1.060, p < 0.001), and the transfusion of platelets was associated with increased long-term survival (HR = 0.817, p = 0.011). The risk associated with transfusion of plasma was mainly attributed to patients receiving large amounts of plasma. All hazard ratios are per unit of blood product transfused. CONCLUSIONS:No association was found between the transfusion of red blood cells and mortality during the study period. However, transfusion of plasma was associated with increased mortality while transfusion of platelets was associated with decreased mortality during the study period.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Bjursten H,Dardashti A,Ederoth P,Brondén B,Algotsson Ldoi
10.1007/s00134-012-2723-9subject
Has Abstractpub_date
2013-03-01 00:00:00pages
437-44issue
3eissn
0342-4642issn
1432-1238journal_volume
39pub_type
杂志文章abstract：OBJECTIVE:To report the occurrence of life-threatening hyperkalaemia following treatment with therapeutic thiopentone coma. SETTING:The neurosurgical intensive care units of Royal North Shore Hospital and Liverpool Hospital, Sydney, Australia. PATIENTS:Three patients treated with theraputic thiopentone coma. One pati...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-002-1399-y
更新日期：2002-09-01 00:00:00
abstract：PURPOSE:Although low doses of oxygen (FiO2 <0.50) are considered nontoxic, recent studies have shown that even lower doses increase pulmonary inflammatory mediators. We aimed to evaluate the acute effects of reducing FiO2 on pulmonary inflammation in mechanically ventilated patients without respiratory failure. METHOD...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-012-2801-z
更新日期：2013-04-01 00:00:00
abstract：OBJECTIVES:Critically ill patients often develop anaemia which can be related to a number of factors. However, the exact causes of anaemia in many patients remain unexplained. We hypothesized that the relationship between erythropoietin (EPO) and haematocrit may be altered in critically ill patients. DESIGN:Serum conc...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s001340050310
更新日期：1997-02-01 00:00:00
abstract：:Values obtained for cardiac output (CO) were compared using thermodilution (TD) with those obtained using bioimpedance (Bi) as measured using the Bomed NCCOM3 (Revision 6) in 28 consecutive patients in the first 24 h after coronary artery bypass surgery (CABS). In 46 paired measurements made in the first 12 h after CA...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01720674
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to evaluate and compare the accuracy of the percentage of infected cells (%IC) in bronchoalveolar lavage (BAL) for ventilator-associated pneumonia (VAP) diagnosis according to its onset from the initiation of mechanical ventilation. PATIENTS:One hundred and eight patients admitted ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-004-2323-4
更新日期：2004-08-01 00:00:00
abstract：:To examine the right ventricular response to acute respiratory failure, serial studies of biventricular performance were analysed in 34 such patients, specifically detailing the role of associated underlying disease. During the initial study, the 34 patients with acute respiratory failure had a higher right ventricula...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00256963
更新日期：1988-01-01 00:00:00
abstract：:This report identifies some of the risk factors underlying the acquisition of hospital infections in patients admitted to Intensive Care Units (ICUs). Infection rates vary in different institutes and in different types of ICUs. Patients are particularly prone to septicaemia and respiratory infections and the underlyin...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/BF01709700
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVE:Spasms in patients with generalized tetanus can be suppressed by a spinal intrathecal infusion of baclofen. We report on four patients and review reported cases treated by this method elsewhere. DESIGN:Intrathecal baclofen infusion was started with a bolus dose (300-500 micrograms) and continued at a steady ...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s001340050429
更新日期：1997-08-01 00:00:00
abstract：OBJECTIVE:To analyze the actual cost of pediatric intensive care and its different components, particularly the differences between various patient groups, with special reference to the variable cost and the elements included in it. DESIGN:Prospective, observational study. SETTING:Multidisciplinary 12-bed pediatric i...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050320
更新日期：1997-02-01 00:00:00
abstract：PURPOSE:This study explored differences in end-of-life (EOL) decisions and respect for patient autonomy of religious members versus those only affiliated to that particular religion (affiliated is a member without strong religious feelings). METHODS:In 2005 structured questionnaires regarding EOL decisions were distri...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-012-2554-8
更新日期：2012-07-01 00:00:00
abstract：:The increase of the inflationary lung volume created by a respiratory maneuver is critical for preventing postoperative alveolar collapse. We measured this volume as achieved with IPPB or incentive spirometry (IS) in 20 postoperative surgical patients. Using IPPB, with gas flow and peak airway pressures carefully adju...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01641120
更新日期：1977-12-01 00:00:00
abstract：PURPOSE:Extracorporeal life support (ECLS) is used for patients with refractory heart failure with or without respiratory failure. This temporary support is provided by blood pumps which are connected to large vessels. Bleeding episodes are a typical complication in patients with ECLS. Recently, several studies illustr...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-011-2370-6
更新日期：2012-01-01 00:00:00
abstract：OBJECTIVE:To describe Enterococcus faecalis colonisation and endocarditis in 5 intensive care patients after treatment with selective decontamination (SDD). SETTING:Intensive care unit (ICU) in a general hospital. PATIENTS:The patients were admitted to the ICU because of adult respiratory distress syndrome, polytraum...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01701478
更新日期：1995-03-01 00:00:00
abstract：PURPOSE:Frail patients are known to experience poor outcomes. Nevertheless, we know less about how frailty manifests itself in patients' physiology during critical illness and how it affects resource use in intensive care units (ICU). We aimed to assess the association of frailty with short-term outcomes and organ supp...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s00134-018-5342-2
更新日期：2018-09-01 00:00:00
abstract：PURPOSE:We evaluated whether oscillatory compliance (C(X5)) measured by forced oscillation technique (FOT) at 5 Hz may be useful for positive end-expiratory pressure (PEEP) optimisation. METHODS:We studied seven pigs in which lung injury was induced by broncho-alveolar lavage. The animals were ventilated in volume con...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-011-2211-7
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVE:To assess the ability of the Clinical Risk Index for Babies (CRIB) to predict long-term neurodevelopmental impairment in very low birth weight (VLBW) infants. DESIGN:Single-center cohort study. SETTING:Tertiary neonatal care hospital and follow-up clinic. PATIENTS:Four hundred fifty-five VLBW infants conse...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340051157
更新日期：2000-03-01 00:00:00
abstract：PURPOSE:To study the incidence and clinical characteristics of delayed cerebral thrombosis in bacterial meningitis patients. METHODS:We assessed the incidence and clinical characteristics of delayed cerebral thrombosis in adults with cerebrospinal fluid (CSF) culture-proven community-acquired bacterial meningitis incl...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-012-2792-9
更新日期：2013-05-01 00:00:00
abstract：PURPOSE:To provide recommendations and standard operating procedures for intensive care unit and hospital preparations for an influenza pandemic or mass disaster with a specific focus on essential equipment, pharmaceuticals and supplies. METHODS:Based on a literature review and expert opinion, a Delphi process was use...
journal_title：Intensive care medicine
pub_type： 指南,杂志文章
doi：10.1007/s00134-010-1763-2
更新日期：2010-04-01 00:00:00
abstract：:Two patients with severe hepatic and renal failure underwent emergency hepatic retransplantation (2nd and 6th day after transplantation). Continuous arteriovenous haemodialysis was begun before surgery and successfully performed, without any incident, during the retransplantation with a biospal (SCU/CAVH AN 69 S) devi...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01706360
更新日期：1990-01-01 00:00:00
abstract：PURPOSE:We examined whether influenza vaccination affects 1-year risk of myocardial infarction, stroke, heart failure, pneumonia, and death among intensive care unit (ICU) survivors aged ≥ 65 years. METHODS:Danish Intensive Care Database data on all elderly ( ≥ 65 years) patients hospitalized in Danish ICUs in the per...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-019-05648-4
更新日期：2019-07-01 00:00:00
abstract：INTRODUCTION:Microcirculatory abnormalities are frequently observed in patients with severe heart failure and correlate to worse outcomes. We tested the hypothesis that nitroglycerin dose-dependently improves perfusion in severe heart failure and that this could be monitored by measuring central-peripheral temperature ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-009-1591-4
更新日期：2009-11-01 00:00:00
abstract：PURPOSE:Little is known on the incidence of discomfort during the end-of-life of intensive care unit (ICU) patients and the impact of sedation on such discomfort. The aim of this study was to assess the incidence of discomfort events according to levels of sedation. METHODS:Post-hoc analysis of an observational prospe...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-020-05930-w
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVE:To determine the frequency and the eventual clinical characteristics of nosocomial sinusitis with anaerobic bacteria isolation in patients in the intensive care unit (ICU). DESIGN:Retrospective study. SETTING:A 12-bed medical ICU in a teaching hospital. PATIENTS:30 adult patients with documented nosocomial...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340051013
更新日期：1999-10-01 00:00:00
abstract：:The Editor-in-Chief has retracted this article [1] because a number of studies included in this review [2, 3, 4] (originally cited as references 98, 128, 129) have since been retracted. Consequently, this has rendered the content of the review unreliable. ...
journal_title：Intensive care medicine
pub_type： 杂志文章,撤回出版物
doi：10.1007/s00134-020-06068-5
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVE:To determine the value of procalcitonin (PCT) in the early diagnosis (and differentiation) of patients with SIRS, sepsis, severe sepsis, and septic shock in comparison to C-reactive protein (CRP), white blood cell and thrombocyte count, and APACHE-II score (AP-II). DESIGN:Prospective cohort study including a...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF02900728
更新日期：2000-03-01 00:00:00
abstract：:Extracorporeal life support (ECLS) can support gas exchange in patients with the acute respiratory distress syndrome (ARDS). During ECLS, venous blood is drained from a central vein via a cannula, pumped through a semipermeable membrane that permits diffusion of oxygen and carbon dioxide, and returned via a cannula to...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-020-06290-1
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVES:To compare the effects of norepinephrine and dobutamine to epinephrine on hemodynamics, lactate metabolism, and gastric tonometric variables in hyperdynamic dopamine-resistant septic shock. DESIGN:A prospective, intervention, randomized clinical trial. SETTING:Adult medical/surgical intensive care unit in ...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s001340050329
更新日期：1997-03-01 00:00:00
abstract：:Measurements of added inspiratory work (AIW) of breathing imposed by three different CPAP systems were performed in 10 patients. One system was a continuous flow system while the two others were demand flow systems separated from respirators (Ohmeda VD 101 and Draeger CPAP 800 devices). AIW was calculated from pressur...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00292929
更新日期：1986-01-01 00:00:00
abstract：PURPOSE:Plasma immunoglobulin concentrations are acutely altered in critically ill patients with sepsis. However, the association between immunoglobulin levels on the day of sepsis diagnosis and subsequent mortality is inconsistent. METHODS:Systematic review of studies that report immunoglobulin measurements and morta...
journal_title：Intensive care medicine
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00134-015-3845-7
更新日期：2015-08-01 00:00:00
abstract：:Male gender predisposes to severe sepsis and septic shock. This effect has been ascribed to higher levels of testosterone. The ESPNIC ARDS database was searched, to determine if there was evidence of a similar male preponderance in severe sepsis in prepubertal patients in spite of low levels of male sex hormones at th...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-003-1948-z
更新日期：2003-10-01 00:00:00
