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Association of frailty with short-term outcomes, organ support and resource use in critically ill patients.

Abstract：

PURPOSE:Frail patients are known to experience poor outcomes. Nevertheless, we know less about how frailty manifests itself in patients' physiology during critical illness and how it affects resource use in intensive care units (ICU). We aimed to assess the association of frailty with short-term outcomes and organ support used by critically ill patients. METHODS:Retrospective analysis of prospective collected data from 93 ICUs in Brazil from 2014 to 2015. We assessed frailty using the modified frailty index (MFI). The primary outcome was in-hospital mortality. Secondary outcomes were discharge home without need for nursing care, ICU and hospital length of stay (LOS), and utilization of ICU organ support and transfusion. We used mixed logistic regression and competing risk models accounting for relevant confounders in outcome analyses. RESULTS:The analysis consisted of 129,680 eligible patients. There were 40,779 (31.4%) non-frail (MFI = 0), 64,407 (49.7%) pre-frail (MFI = 1-2) and 24,494 (18.9%) frail (MFI ≥ 3) patients. After adjusted analysis, frailty was associated with higher in-hospital mortality (OR 2.42, 95% CI 1.89-3.08), particularly in patients admitted with lower SOFA scores. Frail patients were less likely to be discharged home (OR 0.36, 95% CI 0.54-0.79) and had higher hospital and ICU LOS than non-frail patients. Use of all forms of organ support (mechanical ventilation, non-invasive ventilation, vasopressors, dialysis and transfusions) were more common in frail patients and increased as MFI increased. CONCLUSIONS:Frailty, as assessed by MFI, was associated with several patient-centered endpoints including not only survival, but also ICU LOS and organ support.

journal_name

Intensive Care Med

journal_title

Intensive care medicine

authors

Zampieri FG,Iwashyna TJ,Viglianti EM,Taniguchi LU,Viana WN,Costa R,Corrêa TD,Moreira CEN,Maia MO,Moralez GM,Lisboa T,Ferez MA,Freitas CEF,de Carvalho CB,Mazza BF,Lima MFA,Ramos GV,Silva AR,Bozza FA,Salluh JIF,Soar

doi

10.1007/s00134-018-5342-2

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

1512-1520

issue

eissn

0342-4642

issn

1432-1238

pii

10.1007/s00134-018-5342-2

journal_volume

pub_type

杂志文章,多中心研究

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Association of frailty with short-term outcomes, organ support and resource use in critically ill patients.