Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins.

abstract：:High titered IgE, IgG, and IgM antibody responses to the major antigenic determinant of penicillin, the benzylpenicilloyl hapten, were elicited by the intraperitoneal injection of the hapten coupled to keyhole limpet hemocyanin mixed with the appropriate adjuvant. However, treatment of such mice with the benzylpenicil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chiorazzi N,Eshhar Z,Katz DH

更新日期：1976-06-01 00:00:00

abstract：:We examined the interaction of ethanol with the gamma-aminobutyric acid (GABA)ergic system in neurons of slices of the rat central amygdala nucleus (CeA), a brain region thought to be critical for the reinforcing effects of ethanol. Brief superfusion of 11-66 mM ethanol significantly increased GABA type A (GABA(A)) re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roberto M,Madamba SG,Moore SD,Tallent MK,Siggins GR

更新日期：2003-02-18 00:00:00

abstract：:An automatic protein design procedure is used to select amino acid sequences that optimize the folding free energy function for a given protein. The only information used in designing the sequences is a set of known backbone structures for each protein, a rotamer library, and a well established classical empirical for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaramillo A,Wernisch L,Héry S,Wodak SJ

更新日期：2002-10-15 00:00:00

abstract：:Oxygen free radicals are highly reactive species generated by many cellular oxidation-reduction processes. These radicals damage cellular constituents and have been causally implicated in the pathogenesis of many human diseases. We report here that oxygen free radicals generated by Fe2+ in aqueous solution are mutagen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loeb LA,James EA,Waltersdorph AM,Klebanoff SJ

更新日期：1988-06-01 00:00:00

abstract：:Karrikins are a class of seed germination stimulants identified in smoke from wildfires. Microarray analysis of imbibed Arabidopsis thaliana seeds was performed to identify transcriptional responses to KAR(1) before germination. A small set of genes that are regulated by KAR(1), even when germination is prevented by t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nelson DC,Flematti GR,Riseborough JA,Ghisalberti EL,Dixon KW,Smith SM

更新日期：2010-04-13 00:00:00

abstract：:The lactose permease of Escherichia coli catalyzes coupled translocation of galactosides and H(+) across the cell membrane. It is the best-characterized member of the Major Facilitator Superfamily, a related group of membrane proteins with 12 transmembrane domains that mediate transport of various substrates across ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sorgen PL,Hu Y,Guan L,Kaback HR,Girvin ME

更新日期：2002-10-29 00:00:00

abstract：:We reported previously that human cells after neoplastic transformation in culture had acquired an increased susceptibility to chromatid damage induced by x-irradiation during the G2 phase of the cell cycle. Evidence suggested that this results from deficient DNA repair during G2 phase. Cells derived from human tumors...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parshad R,Sanford KK,Jones GM

更新日期：1985-08-01 00:00:00

abstract：:In the recently halted HIV type 1 (HIV-1) vaccine STEP trial, individuals that were seropositive for adenovirus serotype 5 (Ad5) showed increased rates of HIV-1 infection on vaccination with an Ad5 vaccine. We propose that this was due to activation and expansion of Ad5-specific mucosal-homing memory CD4 T cells. To t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benlahrech A,Harris J,Meiser A,Papagatsias T,Hornig J,Hayes P,Lieber A,Athanasopoulos T,Bachy V,Csomor E,Daniels R,Fisher K,Gotch F,Seymour L,Logan K,Barbagallo R,Klavinskis L,Dickson G,Patterson S

更新日期：2009-11-24 00:00:00

abstract：:The heterodisaccharide lactose (1,4-O-beta-D-galactopyranosyl-D-glucose) induces cellulase formation in the ascomycete Hypocrea jecorina (= Trichoderma reesei). Lactose assimilation is slow, and the assimilation of its beta-D-galactose moiety depends mainly on the operation of a recently described reductive pathway an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fekete E,Seiboth B,Kubicek CP,Szentirmai A,Karaffa L

更新日期：2008-05-20 00:00:00

abstract：:Turbulence is an important determinant of phytoplankton physiology, often leading to cell stress and damage. Turbulence affects phytoplankton migration both by transporting cells and by triggering switches in migratory behavior, whereby vertically migrating cells can actively invert their direction of migration upon e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrara F,Sengupta A,Behrendt L,Vardi A,Stocker R

更新日期：2021-02-02 00:00:00

abstract：:We identified a viral IL-10 homolog encoded by an ORF (UL111a) within the human cytomegalovirus (CMV) genome, which we designated cmvIL-10. cmvIL-10 can bind to the human IL-10 receptor and can compete with human IL-10 for binding sites, despite the fact that these two proteins are only 27% identical. cmvIL-10 require...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kotenko SV,Saccani S,Izotova LS,Mirochnitchenko OV,Pestka S

更新日期：2000-02-15 00:00:00

abstract：:Complementary DNA clones encoding the entire rat 1,25-dihydroxyvitamin D3 receptor were isolated, and the total 423-amino acid sequence was deduced. The amino acid sequence of the rat receptor is similar but not identical to the reported human receptor sequence. The cysteine-rich DNA-binding domain is completely conse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burmester JK,Wiese RJ,Maeda N,DeLuca HF

更新日期：1988-12-01 00:00:00

abstract：:Recent studies have highlighted the importance of peripheral induction of Foxp3-expressing regulatory T cells (Tregs) in the dominant control of immunological tolerance. However, Foxp3(+) Treg differentiation from naïve CD4(+) T cells occurs only under selective conditions, whereas the classical T helper (Th) 1 and 2 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei J,Duramad O,Perng OA,Reiner SL,Liu YJ,Qin FX

更新日期：2007-11-13 00:00:00

abstract：:Agrobacterium tumefaciens can transfer part of its Ti plasmid, the T-DNA, to plant cells where it integrates into the nuclear genome via illegitimate recombination. Integration of the T-DNA results in small deletions of the plant target DNA, and may lead to truncation of the T-DNA borders and the production of filler ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bundock P,Hooykaas PJ

更新日期：1996-12-24 00:00:00

abstract：:A conformational isoform of the mammalian prion protein (PrP(Sc)) is the sole component of the infectious pathogen that causes the prion diseases. We have obtained X-ray fiber diffraction patterns from infectious prions that show cross-beta diffraction: meridional intensity at 4.8 A resolution, indicating the presence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wille H,Bian W,McDonald M,Kendall A,Colby DW,Bloch L,Ollesch J,Borovinskiy AL,Cohen FE,Prusiner SB,Stubbs G

更新日期：2009-10-06 00:00:00

abstract：:The influential role of Wnt5a in tumor progression underscores the requirement for developing molecules that can target Wnt5a-mediated cellular responses. In the aggressive skin cancer, melanoma, elevated Wnt5a expression promotes cell motility and drives metastasis. Two approaches can be used to counteract these effe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jenei V,Sherwood V,Howlin J,Linnskog R,Säfholm A,Axelsson L,Andersson T

更新日期：2009-11-17 00:00:00

abstract：:Computers are organized into hardware and software. Using a theoretical approach to identify patterns in gene expression in a variety of species, organs, and cell types, we found that biological systems similarly are comprised of a relatively unchanging hardware-like gene pattern. Orthogonal patterns of software-like ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kravchenko-Balasha N,Levitzki A,Goldstein A,Rotter V,Gross A,Remacle F,Levine RD

更新日期：2012-03-20 00:00:00

abstract：:The origin-binding protein (OBP) from herpes simplex virus 1 is a member of the SF2 helicase superfamily and is required for the initiation of DNA synthesis from a viral origin of DNA replication (oriS). The high-affinity binding sites for OBP in oriS, boxes I and II, are separated by an A+T-rich spacer. We used the g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gustafsson CM,Hammarsten O,Falkenberg M,Elias P

更新日期：1994-05-24 00:00:00

abstract：:Cyclodextrins are cyclic oligosaccharides widely used in the pharmaceutical industry to improve drug delivery and to increase the solubility of hydrophobic compounds. Anabaenolysins are lipopeptides produced by cyanobacteria with potent lytic activity in cholesterol-containing membranes. Here, we identified the 23- to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shishido TK,Jokela J,Kolehmainen CT,Fewer DP,Wahlsten M,Wang H,Rouhiainen L,Rizzi E,De Bellis G,Permi P,Sivonen K

更新日期：2015-11-03 00:00:00

abstract：:The cAMP-dependent protein kinase (PKA) has been shown to play an important role in long-term potentiation (LTP) in the hippocampus, but little is known about the function of PKA in long-term depression (LTD). We have combined pharmacologic and genetic approaches to demonstrate that PKA activity is required for both h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brandon EP,Zhuo M,Huang YY,Qi M,Gerhold KA,Burton KA,Kandel ER,McKnight GS,Idzerda RL

更新日期：1995-09-12 00:00:00

abstract：:DNA sequence complementary to Trypanosoma brucei mRNAs coding for the synthesis of the variant-specific antigens AnTat 1.1 and AnTat 1.8 have been cloned and characterized. These sequences have been used as probes to analyze the corresponding genes in the nuclear DNA. The two genes seem to be represented in several (t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pays E,Van Meirvenne N,Le Ray D,Steinert M

更新日期：1981-05-01 00:00:00

abstract：:The nod (no distributive disjunction) and the ncd (non-claret disjunctional) mutations are both female-specific, recessive meiotic mutations in Drosophila melanogaster. Mutations at either locus show high frequencies of nondisjunction at meiosis I and both have been shown to encode kinesin-like proteins. Unlike the nc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knowles BA,Hawley RS

更新日期：1991-08-15 00:00:00

abstract：:Musical training is known to modify cortical organization. Here, we show that such modifications extend to subcortical sensory structures and generalize to processing of speech. Musicians had earlier and larger brainstem responses than nonmusician controls to both speech and music stimuli presented in auditory and aud...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Musacchia G,Sams M,Skoe E,Kraus N

更新日期：2007-10-02 00:00:00

abstract：:The relation between changes in brain and plasma concentrations of neurosteroids and the function and structure of gamma-aminobutyric acid type A (GABAA) receptors in the brain during pregnancy and after delivery was investigated in rats. In contrast with plasma, where all steroids increased in parallel, the kinetics ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Concas A,Mostallino MC,Porcu P,Follesa P,Barbaccia ML,Trabucchi M,Purdy RH,Grisenti P,Biggio G

更新日期：1998-10-27 00:00:00

abstract：:The genes for platelet-derived growth factor (PDGF) A chain, B chain/c-sis, and the PDGF receptor are expressed in human malignant glioma cell lines. In the present investigation we have studied the expression of these genes in biopsy specimens from human glioblastomas. Hyperplasia of the vascular endothelium is a pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hermansson M,Nistér M,Betsholtz C,Heldin CH,Westermark B,Funa K

更新日期：1988-10-01 00:00:00

abstract：:The circadian rhythms of melatonin and body temperature are set to an earlier hour in women than in men, even when the women and men maintain nearly identical and consistent bedtimes and wake times. Moreover, women tend to wake up earlier than men and exhibit a greater preference for morning activities than men. Altho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duffy JF,Cain SW,Chang AM,Phillips AJ,Münch MY,Gronfier C,Wyatt JK,Dijk DJ,Wright KP Jr,Czeisler CA

更新日期：2011-09-13 00:00:00

abstract：:Synapsins are abundant synaptic-vesicle phosphoproteins that are known to regulate neurotransmitter release but whose precise function has been difficult to pinpoint. Here, we use knockout mice to analyze the role of synapsins 1 and 2 in the calyx of Held synapse, allowing precise measurements of neurotransmitter rele...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun J,Bronk P,Liu X,Han W,Südhof TC

更新日期：2006-02-21 00:00:00

abstract：:Presented analysis of human and fly life tables proves that with the specified accuracy their entire survival and mortality curves are uniquely determined by a single point (e.g., by the birth mortality q(0)), according to the law, which is universal for species as remote as humans and flies. Mortality at any age decr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Azbel' MY

更新日期：1999-12-21 00:00:00

abstract：:Infants' sensitivity to contingent reactivity as an indicator of intentional agency has been demonstrated by numerous referential gaze-following studies. Here we propose that variability of signal sequences in a turn-taking exchange provides an informative cue for infants to recognize interactions that may involve com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tauzin T,Gergely G

更新日期：2019-07-30 00:00:00

abstract：:Plastid development in seedlings of Arabidopsis thaliana is affected by the transfer of (1)O(2)-mediated retrograde signals from the plastid to the nucleus and changes in nuclear gene expression during late embryogenesis. The potential impact of these mechanisms on plastid differentiation is maintained throughout seed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim C,Lee KP,Baruah A,Nater M,Göbel C,Feussner I,Apel K

更新日期：2009-06-16 00:00:00