Abstract:
:This study investigated the effects of neonatal unilateral adrenalectomy on the serotonin- (5-HT) and thyrotropin-releasing hormone-like immunoreactivities (TRH-LI) in the intermediolateral cell column (IML) of the rat spinal cord where the sympathetic preganglionic neurons innervating the adrenal medulla are located. The density of the innervation was measured by a computer-assisted image analysis. Two weeks after the lesion, only one rat (1/3) showed a 30% decrease of 5-HT-LI in the ipsilateral IML, although no modifications were observed for TRH-LI. At 1 month, we observed a variable decrease of 19% to 30% for either 5-HT- or TRH-LI in the ipsilateral IML. However, one animal (1/3) showed nonsignificant modifications. At 3 months, we showed a 17% mean loss of 5-HT-LI and TRH-LI in the ipsilateral IML. However, the decreases of 5-HT-LI and TRH-LI did not always appear similar. These results appear different from those obtained after neonatal removal of the superior cervical ganglion.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Poulat P,Marlier L,Rajaofetra N,Privat Adoi
10.1016/0361-9230(93)90091-osubject
Has Abstractpub_date
1993-01-01 00:00:00pages
617-22issue
5-6eissn
0361-9230issn
1873-2747pii
0361-9230(93)90091-Ojournal_volume
30pub_type
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