Effects of neonatal adrenalectomy on 5-HT and TRH-like immunoreactivity in the rat spinal cord.

Abstract:

:This study investigated the effects of neonatal unilateral adrenalectomy on the serotonin- (5-HT) and thyrotropin-releasing hormone-like immunoreactivities (TRH-LI) in the intermediolateral cell column (IML) of the rat spinal cord where the sympathetic preganglionic neurons innervating the adrenal medulla are located. The density of the innervation was measured by a computer-assisted image analysis. Two weeks after the lesion, only one rat (1/3) showed a 30% decrease of 5-HT-LI in the ipsilateral IML, although no modifications were observed for TRH-LI. At 1 month, we observed a variable decrease of 19% to 30% for either 5-HT- or TRH-LI in the ipsilateral IML. However, one animal (1/3) showed nonsignificant modifications. At 3 months, we showed a 17% mean loss of 5-HT-LI and TRH-LI in the ipsilateral IML. However, the decreases of 5-HT-LI and TRH-LI did not always appear similar. These results appear different from those obtained after neonatal removal of the superior cervical ganglion.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Poulat P,Marlier L,Rajaofetra N,Privat A

doi

10.1016/0361-9230(93)90091-o

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

617-22

issue

5-6

eissn

0361-9230

issn

1873-2747

pii

0361-9230(93)90091-O

journal_volume

30

pub_type

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