Abstract:
:Administration of nifedipine to mice over a period of six months caused a significant (p < 0.05) decrease in neutrophilic functions viz superoxide generation, coupled to NADPH oxidase activity as well as NADPH production by HMP shunt. Properties like chemotaxis and phagocytosis showed a similar decrease. From this study, it is seen that nifedipine causes neutrophil functional abrogation which is therefore an apparent concern for the prolonged usage of the drug. However, relevance of the mouse model to clinical situation needs further investigation.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Kaul N,Andrabi KI,Ganguly NK,Wahi PLdoi
10.1007/BF00925987subject
Has Abstractpub_date
1993-03-10 00:00:00pages
81-5issue
1eissn
0300-8177issn
1573-4919journal_volume
120pub_type
杂志文章abstract::Cervical cancer remains the second leading cause of gynecologic cancer-related mortality among women worldwide. STING (stimulator of interferon genes) was reported to be involved in the immune surveillance of tumors. However, the specific role of STING in cervical cancer remains unclear. In this study, we found that t...
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