Abstract：
OBJECTIVE:To determine CA-125 levels in cervical mucus (CM) during the menstrual cycle and their relationship to gonadal steroids and ovulation. DESIGN:Prospective study. SETTING:Two academic tertiary referral centers. PARTICIPANTS:Thirteen women with a normal fertility work-up. INTERVENTIONS:CA-125 and protein concentrations were measured in CM aspirated from the endocervical canal on alternate days in the early follicular and luteal phases and on a daily basis during the periovulatory period. Results were correlated with hormonal determinations, serum CA-125 levels, and ultrasound examination. RESULTS:Twenty ovulatory nonconceptional cycles were analyzed. Although the mean (+/- SD) concentration of CA-125 in CM (173,900 +/- 128,900 arbitrary U/mL) appeared relatively constant along the cycle, a large variation among the different samples was observed, ranging from 9,000 to 830,000 arbitrary U/mL. No clear trend could be detected as related to hormonal changes and ovulation. However, when the mucus CA-125 concentration was multiplied by the total volume of the correspondent sample, a clear periovulatory increase of total CA-125 levels was found. This was further supported by a similar trend showed by the calculated CA-125:protein concentration ratio. CONCLUSIONS:CA-125 is present in CM in high concentrations that vary widely along the cycle. Although no cyclical variation in CA-125 concentration could be determined, there was an apparent increase of total CA-125 levels parallel to the augmented mucus production during the periovulatory period. This further suggests a possible involvement of this glycoprotein in the secretory process of endocervical glands.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Martinez AR,Thomas CM,Segers MF,Schoemaker J,Eskes TKdoi
10.1016/s0015-0282(16)56694-1subject
Has Abstractpub_date
1994-05-01 00:00:00pages
843-9issue
5eissn
0015-0282issn
1556-5653pii
S0015-0282(16)56694-1journal_volume
61pub_type
杂志文章abstract：OBJECTIVE:To assess the molecular signatures underlying endometrial disorder using cDNA microarray. DESIGN:Gene expression-based oligonucleotide array of the normal endometrium. SETTING:University hospital. PATIENT(S):Humans. INTERVENTION(S):Endometrial tissues were obtained from 28 normal cycling women undergoing ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.01.130
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:To compare the diagnostic accuracy of two methods of assessment of tubal patency, viz, hysterosalpingography (HSG) and laparoscopic hydrotubation. DESIGN:One hundred four infertile women who were investigated with both HSG and laparoscopy in King Khalid University Hospital were selected for the study. Comple...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)57540-2
更新日期：1995-05-01 00:00:00
abstract：OBJECTIVE:To evaluate whether serum replacement with growth factor-free synthetic substances contributed to the effective establishment of embryonic stem (ES) cells. DESIGN:Randomized, prospective model study. SETTING:Gamete and stem cell biotechnology laboratory at Seoul National University in Korea. ANIMAL(S):F1 (...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.01.056
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVE:To compare the longer-term development outcomes in children born after freeze-only versus fresh embryo transfer (ET) in women with an ovulatory cycle. DESIGN:Long-term follow-up study (NCT04099784) of babies born alive after the first ET in a randomized controlled trial (RCT) comparing ongoing pregnancy and ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2020.04.041
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVE:To identify whether the cause, site of ductal obstruction, and characteristics of fluid aspirates are associated with the cryosurvival and fertility after thawing of sperm obtained during reconstruction of the excurrent ducts with microsurgical epididymal sperm aspiration, vasal sperm aspiration, or both. DE...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)00274-4
更新日期：1997-10-01 00:00:00
abstract：OBJECTIVE:To study concordance rates of cryptorchidism (undescended testis) in pairs of boys with varying family structure, to evaluate the risk contribution from the intrauterine environment and genetic factors. DESIGN:Population based study of 1,024,500 Danish boys born from January 1, 1973 to December 31, 2004. Cla...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.09.041
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the usefulness of narrow-band imaging (NBI) technology for improving the diagnostic reliability of hysteroscopy. DESIGN:Prospective controlled clinical study (Canadian Task Force classification II-2). SETTING:University hospital. PATIENT(S):Three hundred ninety-five outpatient women undergoing ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.12.083
更新日期：2010-11-01 00:00:00
abstract：:In this Views and Reviews section, the authors present the most updated information on menopausal hormone therapy (MHT) and an individualized treatment approach. Care of women through the menopausal transition and post-menopausally requires physicians to integrate multi-organ implications of MHT and understand the ful...
journal_title：Fertility and sterility
pub_type：
doi：10.1016/j.fertnstert.2014.02.026
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVE:To analyze the potential role of extraovarian factors such as endometrium in the reproductive outcome of obese patients. DESIGN:Retrospective study. SETTING:University-affiliated infertility clinic, between January 2001 and July 2005. PATIENT(S):Women undergoing a total of 2656 first ovum donation (OD) cyc...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.11.162
更新日期：2007-08-01 00:00:00
abstract：OBJECTIVE:To evaluate clinical outcomes of day 2 versus day 3 ET using a culture media with no glucose or phosphate. DESIGN:Retrospective clinical study. SETTING:Hospital-based fertility clinic. PATIENT(S):One hundred seventy-six IVF-ET patients undergoing controlled ovarian supraovulation. INTERVENTION(S):IVF and ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)00499-8
更新日期：1998-02-01 00:00:00
abstract：OBJECTIVE:To determine the incidence and type of mixoploidy in human blastocysts produced in vitro. DESIGN:A laboratory study of spare blastocysts from an IVF program. SETTING:University hospital laboratory. PATIENT(S):Thirty-nine couples undergoing IVF or intracytoplasmic sperm injection. INTERVENTION(S):A total o...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(02)04393-5
更新日期：2002-12-01 00:00:00
abstract：:Whereas the dose of hMG is significantly correlated with both BMI and BW, commencing the more obese patient on higher hMG doses is not justified in view of the cancellation of cycles from over-responsiveness in the more obese patients started on higher hMG dosage regimens. If the more obese patient is slow to respond,...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)55276-5
更新日期：1992-09-01 00:00:00
abstract：OBJECTIVE:To assess the value of the hypo-osmotic swelling test in predicting fertilization, pregnancy, implantation, miscarriage, and live birth rates in IVF-ET cycles. DESIGN:Prospective study. SETTING:Academic tertiary referral center for fertility treatment. PATIENTS:Three hundred twenty-six couples having IVF-E...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)58511-2
更新日期：1996-09-01 00:00:00
abstract：:To assess the risk of introducing microorganisms into the peritoneal cavity during intracervical or intrauterine insemination, we cultured the cervix and semen from 19 couples before insemination and the peritoneal fluid from the female partner after insemination. The peritoneal cultures taken before hydrotubation gre...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)49458-6
更新日期：1986-07-01 00:00:00
abstract：:Tumor necrosis factor-alpha stimulates the secretion of vascular endothelial growth factor by cultured human oviductal epithelial cells and stromal fibroblasts. Tumor necrosis factor-alpha-stimulated vascular endothelial growth factor secretion by these cells may control oviductal fluid secretion by regulating vascula...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.05.082
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of the anti-P Org 31710 on human blastocyst attachment to cultured endometrial epithelial cells. DESIGN:Experimental in vitro study. SETTING:University hospital. PATIENT(S):Eleven fertile endometrial donors. INTERVENTION(S):Timed endometrial biopsy for cell cultures. MAIN OUTCOM...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.08.040
更新日期：2005-04-01 00:00:00
abstract：:Rhesus monkeys immunized with the beta-subunit of ovine luteinizing hormone (oLHbeta) developed circulating antibodies which cross-reacted strongly with rhesus monkey chorionic gonadotropin. Normal ovulatory cycles continued, but the fertility of immunized monkeys as compared with that of controls was significantly re...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1979-02-01 00:00:00
abstract：OBJECTIVE:To assess correlation between blastocyst morphology and chromosomal status. DESIGN:Observational research study. SETTING:An IVF clinic and a specialist preimplanation genetic diagnosis (PGD) laboratory. PATIENT(S):Ninety-three couples undergoing IVF treatment in combination with chromosome screening of emb...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.04.003
更新日期：2011-02-01 00:00:00
abstract：:Based on American Society for Reproductive Medicine (ASRM) and Society for Assisted Reproductive Technology data available for 2010, ASRM's guidelines for the number of embryos to be transferred in in vitro fertilization cycles have been further refined in continuing efforts to reduce the number of higher-order multip...
journal_title：Fertility and sterility
pub_type： 杂志文章,实务指引
doi：10.1016/j.fertnstert.2012.09.038
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVE:To determine accumulated conception and live birth rates in ovum donation. DESIGN:Retrospective study from a computer database. Pregnancies with one gestational sac observed by ultrasound have been included as conceptional cycles and pregnancies that resulted in one live child were recorded for the analysis ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)81372-6
更新日期：1997-04-01 00:00:00
abstract：OBJECTIVE:To test the hypothesis that male reproductive tract leukocytes function in the elimination of abnormal spermatozoa from ejaculated semen. DESIGN:Semen specimens with > or = 2 x 10(6) nonspermatozoal cells/mL were examined for leukocytes and for mature sperm with ideal morphology. SETTING:Andrology laborator...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1995-07-01 00:00:00
abstract：OBJECTIVE:To determine if short-term weight change among women with unexplained infertility (UI) and polycystic ovary syndrome (PCOS) undergoing ovulation induction is associated with live birth. DESIGN:Secondary analysis of randomized trials. SETTING:Multicenter fertility trial sites. PATIENT(S):A total of 900 wome...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2020.06.002
更新日期：2020-11-01 00:00:00
abstract：:The present study was undertaken to investigate not only the effectiveness of bromoergocryptine therapy in 13 women with amenorrhea-galactorrhea and hyperprolactinemia without evidence of organic pathology, but also to assess the value of pretreatment evaluation in predicting the response to therapy. Sella turcica tom...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)42490-8
更新日期：1977-04-01 00:00:00
abstract：OBJECTIVE:To demonstrate the laparoscopic neuroanatomy of the autonomic nerves of the pelvis using the laparoscopic neuronavigation technique, as well as the technique for a nerve-sparing radical endometriosis surgery. DESIGN:Step-by-step explanation of the technique using videos and pictures (educational video) to de...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2015.07.1138
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:To determine whether the presence of a Y microdeletion confers any adverse effects on in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) outcome. DESIGN:Retrospective case-control study. SETTING:Academic infertility center. PATIENT(S):A total of 17 patients with Y microdeletions who atte...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2003.06.030
更新日期：2004-02-01 00:00:00
abstract：:Predictors of weight at resumption of menses were studied in 118 subjects with lifetime anorexia nervosa who recovered their ovarian function without hormonal therapies. About 64% of subjects had menses resumption during spring/summer season. The body mass index (BMI) at resumption of menses was significantly predicte...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.04.055
更新日期：2009-04-01 00:00:00
abstract：:The data from 83 consecutive in vitro fertilization-embryo transfer cycles were examined with emphasis on the presence of subfertile male parameters, including abnormal sperm density, motility, morphologic features, or an abnormal result in the sperm penetration assay (zona-free hamster ova penetration). There were 25...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)49338-6
更新日期：1986-05-01 00:00:00
abstract：OBJECTIVE:To confirm successful implantation of IVF, cryopreserved human embryos after assisted hatching with acidic Tyrode's solution. DESIGN:Case report. SETTING:In vitro fertilization-ET facility of a university-based practice. PATIENT:A 28-year-old female with nonoperable bilateral tubal occlusion and > 1 1/2 ye...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)57376-2
更新日期：1995-02-01 00:00:00
abstract：:Fifteen subfertile males with absent or atrophic right testes underwent ligation of left varicoceles. Sperm concentration rose significantly with correction of scrotal thermographic abnormality and nine wives (60%) became pregnant. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)55098-5
更新日期：1992-06-01 00:00:00
abstract：:The negative correlation between the thickness of the lamina propria and Johnsen's score count in individual seminiferous tubules was observed and the tubules with thin lamina propria indicated almost complete spermatogenesis. It is suggested that the thin lamina propria may be one of the good indicators of complete s...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.10.019
更新日期：2008-10-01 00:00:00
