Abstract:
:Supplemental to the previous publication on the results of surgery and/or radiotherapy, the application of various cytostatic drugs--neoadjuvant, sequential, simultaneous, alternating or adjuvant--in addition to surgery and/or radiotherapy in the treatment of hypopharynx carcinomas is subjected to critical analysis. Exclusively for these carcinomas there are still no results of prospectively randomized studies, although this may reflect their relatively small incidence when compared with all head and neck tumors. Induction chemotherapy (before standard therapy) has been disappointing clinically, at least concerning hypopharynx carcinomas. To date, organ and function preservation with improved survival in these neoplasms has not been shown clearly, even for resectable tumors. Simultaneous radiochemotherapy is obviously superior to sequential chemotherapy and has demonstrated higher remission rates when compared to conventional radiotherapy, but the effectiveness of modified fractionizing patterns must be kept distinct from the effectiveness of simultaneous chemotherapy. Moreover, it must be defined whether the observed decline in the rate of distant metastases after adjuvant chemotherapy entails (statistically) significant higher survival rates. Only with the help of prospective randomized multicenter studies can the true benefits of chemotherapy be verified and specified in the treatment of hypopharynx carcinomas. The results of chemotherapy to date are critically reviewed and future concepts planned.
journal_name
HNOjournal_title
HNOauthors
Steiner Wsubject
Has Abstractpub_date
1994-02-01 00:00:00pages
84-8issue
2eissn
0017-6192issn
1433-0458journal_volume
42pub_type
杂志文章,评审相关文献
HNO文献大全abstract::During cochlear implant (CI) surgery, audiological-technical diagnostics is required which includes the proof of the implant function as well as the verification of its physiological coupling to the auditory nerve in order to undertake required interventions before the end of the surgery in case of need. The technical...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-014-2936-z
更新日期:2014-10-01 00:00:00
abstract::Dural arteriovenous fistulas (DAVF) are intracranial vascular malformations which can cause severe complications, such as intracranial bleeding and neurological deficits. We report the case of a patient presenting with pulsatile tinnitus caused by a DAVF. The DAVF was endovascularly treated including transarterial emb...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-011-2297-9
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:In this study, an objective version of the postlaryngectomy telephone test (PLTT) for measuring speech intelligibility based on automatic speech recognition is presented. METHODS:Thirty-one patients with tracheoesophageal substitute voice (25 men and six women, 63.4+/-8.7 years) were evaluated by 11 naïve li...
journal_title:HNO
pub_type: 临床试验,杂志文章
doi:10.1007/s00106-008-1698-x
更新日期:2009-01-01 00:00:00
abstract::Hemangiopericytomas are rare perivascular tumors. The nasal cavity and paranasal sinuses are most often involved in the head and neck region. A case of hemangiopericytoma in a 63 year old patient is presented. The initial symptom was recurrent bleeding from the nose. The patient had a history of radiotherapy for a pit...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-003-1030-8
更新日期:2004-12-01 00:00:00
abstract::Color-coded duplex sonography is being increasingly used in the head and neck as another method for diagnosis of such disorders as stenosis of arteries or veins or hemangiomas. A possible additional advantage of testing is the ability to differentiate benign from malignant tumors. Since the underlying cause of a suspi...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060050073
更新日期:1996-12-01 00:00:00
abstract::The diagnosis of autism or autistic traits always necessitates exclusion of a primary or secondary speech or hearing disorder. The following findings are based on experience gained from 12 children with the diagnosis of early infantile autism. If an acoustic or speaking disorder is caused by brain damage, it will incr...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1975-11-01 00:00:00
abstract::The horizontal vestibulo-ocular reflex was studied in normals and 35 patients with an acute or compensated unilateral peripheral vestibular deficit (PVD) in order to determine the efficacy of different response measures obtained from a rotating chair test in localizing the deficit side and defining its central compens...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:The Oldenburg children's rhyme test (OlKi) was designed and optimized for speech intelligibility measurements for primary school pupils in silence [8, 3]. In the optimization, the intelligibility of the particular test words was equalized. METHODS:The evaluation of the test with 147 primary school pupils wi...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-005-1304-4
更新日期:2006-03-01 00:00:00
abstract::We treated 64 patients with the diagnosis of laryngitis gastrica with Antra (Omeprazol) in doses of 10, 20, and 40 mg. To determine the success of the therapy, pH monitoring of the esophagus and hypopharynx, the voice status and measurement of vocal penetrating capacity were used. The results prove that a 20-mg dose o...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060050609
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:In 2003 Baiardini et al. presented the RHINASTHMA questionnaire, which measures the impairment of quality of life in patients with rhinitis and asthma and takes the "united airway disease" model into its account. The aim of our study was to create a valid version of this questionnaire adapted for use with Ge...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-006-1453-0
更新日期:2007-05-01 00:00:00
abstract::A short review of experiences in animal usage is made, and the first clinical experiences with the endolaryngeal application of the Neodymium: YAG laser MediLas in the treatment of benign vocal cord lesions are reported. The initial results are favourable, but final judgement of this microsurgical technique must be ba...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1979-09-01 00:00:00
abstract::Obstructive sleep apnea (OSA) is a common disease in children. It is defined by the onset of snoring, hypopneas or apneas with impaired sleep and daytime function. Obstruction of the upper airway during sleep is the underlying pathogenetic mechanism. It is caused either by an anatomic obstruction, increased airway col...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-010-2214-7
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:A case-control study was conducted to investigate occupational and other risk factors for squamous cell carcinoma of the oral cavity, the pharynx and the larynx. The study included 209 male cancer patients and 110 male control persons without known malignant disease, matched for age, alcohol co...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060100539
更新日期:2002-08-01 00:00:00
abstract::A metaanalysis on pharmacological and psychological treatment reports was conducted in order to evaluate the overall effectiveness of these treatment conditions in chronic tinnitus. A totality of 109 treatment studies published between 1976 and 3/1995 and meeting minimal inclusion criteria was located, but only 24 stu...
journal_title:HNO
pub_type: 杂志文章,meta分析
doi:10.1007/s001060050621
更新日期:2000-08-01 00:00:00
abstract::Precise knowledge about the chance of success of a given pharmacologic therapy of head and neck squamous cell carcinoma (HNSCC) before starting therapy would be very desirable to guide the selection of the most suitable or the most efficient combination out of the ever-growing spectrum of available pharmaceuticals. Th...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-011-2362-4
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:For the functional outcome after cochlear implant surgery, the electrode position is of essential importance. Therefore, radiological techniques to localize the electrode within the cochlea are becoming increasingly important. In our study, we used multi-slice computed tomography (CT) to find radiological cr...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-008-1810-2
更新日期:2009-06-01 00:00:00
abstract::The various stages of tumor growth are characterized by typical epithelial, vascular, and secondary connective tissue changes. Narrow Band Imaging (NBI) endoscopy is a minimally invasive imaging technique that presents vascular structures in particular at a higher contrast than white light endoscopy alone. In combinat...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-016-0284-x
更新日期:2017-01-01 00:00:00
abstract::Bone anchored hearing aids (BAHA) achieve optimal acoustic coupling by means of direct bone conduction via an osseointegrated percutaneous titanium implant. Currently this system has a record of over 30 years of clinical application and reliability. Patients with bilateral hearing loss with air-bone gaps will benefit ...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-009-1887-2
更新日期:2009-03-01 00:00:00
abstract:INTRODUCTION:The therapy of choice in nasoseptal defects is reconstruction with vital respiratory mucosa; in particular, three-layer repair using the bridge-flap technique according to Schultz-Coulon is the most promising. Cases exceeding operative limitations can be treated with silastic buttons. Our aim was to overco...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-009-2072-3
更新日期:2010-04-01 00:00:00
abstract::Three patients with CSF-rhinorrhea following frontobasal skull and brain injury were treated with lumbar CSF drainage. Rhinorrhea was successfully stopped in one patient few hours after onset of the drainage while a pneumatocephalus developed in each of the remaining patients during the first post-trauma week. We beli...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1980-04-01 00:00:00
abstract:BACKGROUND:We recently proposed test material for the purpose of testing phonological processing. While data regarding validity and reliability could already be established, normative data for preschool children are lacking. MATERIAL AND METHODS:A total of 203 preschool children aged 5.0-5.11 years participated in the...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-010-2235-2
更新日期:2011-03-01 00:00:00
abstract::The Freiburg speech intelligibility test according to DIN 45621 was introduced around 60 years ago. For decades, and still today, the Freiburg test has been a standard whose relevance extends far beyond pure audiometry. It is used primarily to determine the speech perception threshold (based on two-digit numbers) and ...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-016-0150-x
更新日期:2016-08-01 00:00:00
abstract::Comorbidity is the presence of one or more disorders in addition to the main disorder. Comorbidities negatively influence the development of the main disease. For patients with tinnitus a comorbidity is an additional component complicating the habituation of ear noise and patients with decompensated tinnitus often hav...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-009-2050-9
更新日期:2010-07-01 00:00:00
abstract::The importance of spiral-CT is clinically accepted for diagnosing spreading disease and for making a decision about the therapy strategy for head and neck tumors. Its importance for follow-up after radiotherapy was examined in 26 patients with irradiated laryngeal tumors. Using spiral-CT multiple signs of alterations ...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060050377
更新日期:1999-03-01 00:00:00
abstract::Interleukin 1 (IL-1) has several fundamental immunoregulatory, haematological, metabolic and physiological effects. It coordinates the different cellular interactions in wound healing and inflammation, but most importantly it stimulates the activation and differentiation of pre-B-cells and T-cells, the attraction of n...
journal_title:HNO
pub_type: 杂志文章,评审
doi:
更新日期:1991-08-01 00:00:00
abstract::Calcium phosphate ceramics have been proposed for obliteration of the mastoid cavity in middle ear surgery. To our knowledge no experimental data are available concerning the use of homologous fibrin glue associated with hydroxyapatite (HA) in animals. Obliteration of the epitympanic space and closure of defects in th...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:We examined whether training conceptualized as a complement to standard medical treatment (ST) for acute tinnitus to promote patients' capacity to distract attention from their tinnitus and to relax (distraction and relaxation training) has a positive effect on tinnitus-specific distress (tinnitus loudness, ...
journal_title:HNO
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00106-009-2019-8
更新日期:2010-05-01 00:00:00
abstract::A 21 year old male patient presented with dysphagia. Clinical examination as well as CT and MRT showed a tumor in the right parapharyngeal space. The tumor was resected completely using a transcervical approach. The pathological examination showed a neurofibroma. In this case report, preoperative diagnosis, therapy an...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-003-0871-5
更新日期:2004-05-01 00:00:00
abstract::The cricothyroid muscle is important to the singing voice, in the male in the chest and falsetto registers and in the female in the head register, assisting in production of the highest notes. In speech its contraction only occurs during high pitched speech. It serves as an additional tensor of the vocal cord. ...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1975-08-01 00:00:00
abstract:BACKGROUND:Balloon Eustachian Tuboplasty (BET) is a new minimally invasive treatment for chronic Eustachian tube dysfunction (ETD). Initially, perioperative prophylactic antibiotic therapy with ciprofloxacin 2 × 500 mg p.o. for 5 days was administered. This study aimed to characterize the bacterial flora in the ET, nos...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-015-0048-z
更新日期:2015-09-01 00:00:00