[Pharmacological characterization of head and neck cancer in ex-vivo tests].

Abstract:

:Precise knowledge about the chance of success of a given pharmacologic therapy of head and neck squamous cell carcinoma (HNSCC) before starting therapy would be very desirable to guide the selection of the most suitable or the most efficient combination out of the ever-growing spectrum of available pharmaceuticals. This selection has hitherto been made at best on the basis of the availability of guideline-conformant and approved combinations according to results of published clinical studies and approved general effectiveness in HNSCC. However, the inhomogeneous biology of HNSCC depending on localization, varying metastatic behavior, TNM and UICC stage in the context of the patient's general condition and risk status according to lifestyle and occupational exposure make it impossible to accurately predict the success of pharmacological therapy regimens for the individual HNSCC based on today's clinical and pathohistological diagnostics. A solution may lie in the testing of biopsy specimens ex vivo before starting therapy. The present review describes recent advances in ex-vivo tests and discusses the requirements for their inclusion in the decision-making process.

journal_name

HNO

journal_title

HNO

authors

Wichmann G,Dietz A

doi

10.1007/s00106-011-2362-4

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

866-73

issue

9

eissn

0017-6192

issn

1433-0458

journal_volume

59

pub_type

杂志文章,评审

相关文献

HNO文献大全
  • [Implementation of the new quality assurance agreement for the fitting of hearing aids in daily practice. Part 1: New regulations pertaining to hearing aid fitting].

    abstract::Alongside evidence-based medicine, quality assurance has becoming increasingly important in daily medical practice during the last decade. The introduction of a specific quality assurance questionnaire in connection with hearing aid fitting represents the first large-scale assessment of certain elements of patient sat...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-014-2879-4

    authors: Löhler J,Akcicek B,Wollenberg B,Schönweiler R

    更新日期:2014-08-01 00:00:00

  • [Blocking secretion of exocrine glands in the head-neck area by administration of botulinum toxin A. Therapy of a rare disease picture].

    abstract:BACKGROUND:Hypersecretion disorders of the exocrine glands of the head and neck area are a therapeutic problem in the field of otorhinolaryngology. In the present study, we demonstrate the effectiveness of local injections of botulinum toxin A to block secretions of exocrine glands of the head and neck area. PATIENTS ...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s001060170028

    authors: Ellies M,Laskawi R,Rohrbach-Volland S,Rödel R,Beuche W

    更新日期:2001-10-01 00:00:00

  • [Magnetic resonance angiography of the head and neck area].

    abstract::Magnetic resonance angiography is a noninvasive method in vascular imaging using non-contrast-enhanced and contrast-enhanced techniques. The contrast media used in contrast-enhanced magnetic resonance angiography are different from the X-ray contrast media and do not affect the thyroid gland or renal function. In dete...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-003-0982-z

    authors: Aschenbach R,Esser D

    更新日期:2004-01-01 00:00:00

  • [Evoked otoacoustic emissions in adults. Criteria for evaluation in clinical use].

    abstract::The work here presents the first part of a prospective study regarding the clinical use of evoked otoacoustic emissions (EOAE) in adults. Sixty subjects with normal hearing and 160 patients suffering from cochlear hearing loss were tested. The results were used to develop and optimize analysis criteria for the emissio...

    journal_title:HNO

    pub_type: 杂志文章

    doi:

    authors: Uppenkamp S,Neumann J,Aurbach G,Kollmeier B

    更新日期:1992-11-01 00:00:00

  • [Autoimmune sialadenitis].

    abstract::Using the European-American classification criteria the diagnosis of autoimmune sialadenitis in Sjögren's syndrome can generally be easily established or excluded. In addition, sonography performed by the ENT physician is helpful in diagnosing and especially in follow-up screening for MALT lymphomas, which 5%-10% of p...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-009-2074-1

    authors: Guntinas-Lichius O,Vissink A,Ihrler S

    更新日期:2010-03-01 00:00:00

  • Superior canal dehiscence syndrome : Diagnosis with vestibular evoked myogenic potentials and fremitus nystagmus.

    abstract:BACKGROUND:Superior canal dehiscence syndrome (SCDS) is a relatively rare neurotological disorder that is characterized by a heterogeneous clinical picture. Recently, vestibular evoked myogenic potential (VEMP) measurement was established for the diagnosis of SCDS. In the present study, a case series of patients with S...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-017-0441-x

    authors: Gürkov R,Jerin C,Flatz W,Maxwell R

    更新日期:2018-01-01 00:00:00

  • [Unilateral maxillary sinusitis: a cavernous haemangioma with bone destruction].

    abstract::Haemangioma originating in the paranasal sinuses are a rare entity. In the case of unilateral sinusitis the differential diagnosis should include tumors. The following case of a 30-year-old female patient with a therapy-resistant sinusitis showed bone destruction and a maxillary shadow on computed tomography. The hist...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-010-2225-4

    authors: Louza JP,Gürkov R,Weiler C,Krause E

    更新日期:2011-07-01 00:00:00

  • [Tuberculous pre- and paravertebral abscess with spondylodiscitis].

    abstract::A rare case of an adult with a large retropharyngeal cold abscess arising from a lesion of the upper cervical spine and causing airway obstruction is presented. The incidence, clinical features, and early diagnosis of spondylitis by magnetic resonance tomography, and the management of a retropharyngeal abscess are dis...

    journal_title:HNO

    pub_type: 杂志文章

    doi:

    authors: Höhmann D,Höhmann M

    更新日期:1992-02-01 00:00:00

  • [Lemierre syndrome: thrombosis of the internal jugular vein after tonsillectomy].

    abstract:BACKGROUND:Thrombosis of the internal jugular vein is a rare and critical disease which can also be a complication of a benign oropharyngeal infection (Lemierre syndrome). PATIENT:A 62 year old patient underwent septomplasty, endonasal turbinectomy, paranasal sinus surgery and tonsillectomy. The postoperative course w...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-003-0846-6

    authors: Sagowski C,Koch U

    更新日期:2004-03-01 00:00:00

  • [The definition of "selectivity" in reduced speech discrimination as a sequela of peripheral perceptual damage].

    abstract::The term "selectivity" means the ability to correctly select speech in the presence of other kinds of noise. In the literature the term "selectivity" is used very differently with regard to the different levels of the hearing system. In actual practice a separation of this term is important for possible audiometric to...

    journal_title:HNO

    pub_type: 杂志文章

    doi:

    authors: Dieroff HG

    更新日期:1992-10-01 00:00:00

  • [Sudden unilateral deafness and geotropic positional nystagmus--a special form of acute cochleo-vestibular disorders?].

    abstract::Three patients with complete sudden unilateral hearing loss suffered from delayed vertigo and presented a strong geotropic positional nystagmus during the evolution of their disease. Significant direction-fixed spontaneous nystagmus was absent, although two of the three patients had markedly decreased caloric response...

    journal_title:HNO

    pub_type: 杂志文章

    doi:

    authors: Böhmer A

    更新日期:1990-02-01 00:00:00

  • [Swallowing and dysphagia in the elderly].

    abstract::Disturbances of the swallowing process can occur at any age and might lead to choking. However, the risk of dysphagia increases with advanced age. This is not only due to a higher incidence of diseases that cause dysphagia, but also to age-related changes in the mechanisms of swallowing. Aging affects all of the anato...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-014-2864-y

    authors: Jungheim M,Schwemmle C,Miller S,Kühn D,Ptok M

    更新日期:2014-09-01 00:00:00

  • [Social orientation of parents of children with cleft lip and palate].

    abstract:BACKGROUND:Cleft lip and palate are the most common malformation in the orofacial region. The type and dimension of the cleft determine the functional limitations of respiration, swallowing, speech, articulation and hearing. In addition, cosmetic and communicative restrictions influence the cognitive, social and educat...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-003-0843-9

    authors: Schuster M,Kummer P,Eysholdt U,Rosanowski F

    更新日期:2003-06-01 00:00:00

  • [Otosialorrhoea - a rare case of a spontaneous salivary fistula of the external auditory canal].

    abstract::Spontaneous salivary fistulas are rare. Extremely rare are spontaneous salivary fistulas of the external auditory canal. We report a case of otorrhoea caused by such a fistula in connection with defects of the cartilagenous and the osseous external auditory canal (Fissures of Santorini, foramen of Huschke) and its suc...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-001-0581-9

    authors: Chilla R

    更新日期:2002-10-01 00:00:00

  • [Therapy of hypopharyngeal cancer. Part II: Review of the literature for using chemotherapy within the scope of multimodality therapy].

    abstract::Supplemental to the previous publication on the results of surgery and/or radiotherapy, the application of various cytostatic drugs--neoadjuvant, sequential, simultaneous, alternating or adjuvant--in addition to surgery and/or radiotherapy in the treatment of hypopharynx carcinomas is subjected to critical analysis. E...

    journal_title:HNO

    pub_type: 杂志文章,评审

    doi:

    authors: Steiner W

    更新日期:1994-02-01 00:00:00

  • [The infracochlear approach for diagnostic petrous apicotomy].

    abstract::Diagnostic and therapeutic approaches to the petrous apex involve sub-/transtemporal, retrosigmoidal, infratemporal and-lesser invasive-e. g. infracochlear, infralabyrinthine or under favourable anatomic conditions, transsphenoidal surgical pathways. For diagnostic purposes, minimally invasive approaches should be pre...

    journal_title:HNO

    pub_type: 杂志文章,评审

    doi:10.1007/s00106-019-0687-6

    authors: Plontke SK,Kösling S,Schilde S,Wittlinger J,Kisser U

    更新日期:2019-10-01 00:00:00

  • [Human papillomavirus and squamous cell cancer of the head and neck region : Prognostic, therapeutic and prophylactic implications].

    abstract::Human papilloma viruses (HPV) are responsible for approximately half of all oropharyngeal squamous cell carcinomas (OPSCC) and incidence rates of HPV-associated OPSCC continue to increase substantially. The defined viral carcinogenesis permits development of specific diagnostic, therapeutic, and prophylactic approache...

    journal_title:HNO

    pub_type: 杂志文章,评审

    doi:10.1007/s00106-016-0123-0

    authors: Reuschenbach M,Wagner S,Würdemann N,Sharma SJ,Prigge ES,Sauer M,Wittig A,Wittekindt C,von Knebel Doeberitz M,Klussmann JP

    更新日期:2016-07-01 00:00:00

  • [Chronic rhinosinusitis. Subjective assessment of benefit 1 year after functional endonasal sinus surgery].

    abstract:BACKGROUND:Against the background of constantly intensifying economic pressure in the healthcare sector, in the future confirmation of subjective and economic benefit of different forms of therapy will be the criterion applied by the health insurance companies to decide whether to reimburse the costs they involve. The ...

    journal_title:HNO

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00106-006-1529-x

    authors: Baumann I,Blumenstock G,Klingmann C,Praetorius M,Plinkert PK

    更新日期:2007-11-01 00:00:00

  • [A review of spontaneous cerebrospinal fluid rhinorrhoea (author's transl)].

    abstract::Thirty-two patients described in the literature between 1947 and 1977, together with a personal one, with spontaneous cerebrospinal fluid rhinorrhoea are presented. These 32 patients are assessed and the different aspects of their problems discussed. There is a striking female to male preponderance of 5:1. ...

    journal_title:HNO

    pub_type: 杂志文章

    doi:

    authors: Brüner M

    更新日期:1979-07-01 00:00:00

  • [Reconstruction of defects following pharyngolaryngectomy with free transplanted jejunum].

    abstract::We report 10 patients undergoing pharyngo-laryngectomy in whom the pharyngeal defect was reconstructed with a free jejunal graft. This method is technically demanding. The advantages are excellent healing due to the excellent blood supply of the edges of the graft, and the almost unlimited supply of jejunum. The use o...

    journal_title:HNO

    pub_type: 杂志文章

    doi:

    authors: Wicke W,Ehrenberger K,Grasl MC,Swoboda H,Piza H,Roka R

    更新日期:1986-06-01 00:00:00

  • [Giant Madelung's disease. Report of a case and review of the literature].

    abstract::Madelung's disease, also known as benign symmetrical lipomatosis, is a rare proliferative disorder of unknown etiology that was first mentioned by Brodie in 1846. Characterized by multiple symmetrical deposits of unencapsulated fat in the head and neck region, the disease is most common in middle-aged men with a histo...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-002-0629-5

    authors: Zeidler R,Lang S,Rasp G

    更新日期:2002-12-01 00:00:00

  • Recent developments in the diagnosis and treatment of obstructive sleep apnea : English version.

    abstract::Over the past few years, the diagnostic tools and therapeutic approaches for obstructive sleep apnea (OSA) have evolved further. Based on a review of the current literature and the personal experiences of the authors, the most relevant developments are summarized in this article and discussed with regard to their impa...

    journal_title:HNO

    pub_type: 杂志文章,评审

    doi:10.1007/s00106-016-0176-0

    authors: Stuck BA,Maurer JT

    更新日期:2017-01-01 00:00:00

  • [Tinnitus and psychological comorbidities].

    abstract::Comorbidity is the presence of one or more disorders in addition to the main disorder. Comorbidities negatively influence the development of the main disease. For patients with tinnitus a comorbidity is an additional component complicating the habituation of ear noise and patients with decompensated tinnitus often hav...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-009-2050-9

    authors: Zirke N,Goebel G,Mazurek B

    更新日期:2010-07-01 00:00:00

  • [Glomus tumor of the nose].

    abstract::Between May 1995 and March 1996 we were able to diagnose and remove glomus tumors of the left nasal cavity from three female patients. Ages of the patients were 9, 36 and 74 years. All patients suffered from a frequent epistaxis and all were extremely sensitive to the slightest nasal touch. One patient reported breath...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s001060050369

    authors: Matschiner F,Bilkenroth U,Holzhausen HJ,Neumann K,Tausch-Treml R,Berghaus A

    更新日期:1999-02-01 00:00:00

  • [Menière's disease : evidence and controversies].

    abstract::Menière's disease is recognized as the idiopathic form of recurrent inner ear disease with the trias of hearing loss, tinnitus and vertigo with aural fullness and Menière's syndrome as the non-idiopathic form. Subentities with unknown pathogenesis are Lermoyez' s syndrome and Tumarkin crises. A common pathogenetic fac...

    journal_title:HNO

    pub_type: 杂志文章,评审

    doi:10.1007/s00106-009-1915-2

    authors: Westhofen M

    更新日期:2009-05-01 00:00:00

  • [Quality of life after treatment of head and neck tumors : longitudinal comparison after operation and adjuvant radio(chemo)therapy].

    abstract:BACKGROUND:Quality of life is extraordinary affected by malignant tumors of the head and neck region as functions of social interaction are disturbed. MATERIALS AND METHODS:The influence of surgical treatment and postoperative radio(chemo)therapy (RCT) on the quality of life was studied in patients with head and neck ...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-012-2628-5

    authors: Bücheler BM,Ehnes A,Kavsadze M,Langenberg S,Wilhelm-Buchstab T,Zipfel M,Keiner S,Gerstner AO

    更新日期:2012-12-01 00:00:00

  • [Vasoactive drugs and oxygen content in the perilymph (author's transl)].

    abstract::The effect of different vasodilating drugs on the perilymphatic oxygen content in the cat has been examined by means of the polarographic method. The drugs used such as Papaverin, Rheomacrodex, Ronicol, Praxilen and Lasix have had no significant effect on the oxygen concentration in the perilymph. Histamin, 7% Na2CO3 ...

    journal_title:HNO

    pub_type: 杂志文章

    doi:

    authors: Yagi N,Fisch U

    更新日期:1978-03-01 00:00:00

  • [3-D navigation in the petrous bone with submillimeter accuracy].

    abstract:BACKGROUND:In order to evaluate the possible submillimeter application accuracy in computer-aided navigation in the petrous bone, we performed a set of approximately 3,000 measurements on a specially prepared anatomic specimen using the Zeiss STN intraoperative navigation system. This allowed direct measurements of rel...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-003-0964-1

    authors: Kral F,Freysinger W

    更新日期:2004-08-01 00:00:00

  • [Drug and psychological therapies in chronic subjective tinnitus. Meta-analysis of therapeutic effectiveness].

    abstract::A metaanalysis on pharmacological and psychological treatment reports was conducted in order to evaluate the overall effectiveness of these treatment conditions in chronic tinnitus. A totality of 109 treatment studies published between 1976 and 3/1995 and meeting minimal inclusion criteria was located, but only 24 stu...

    journal_title:HNO

    pub_type: 杂志文章,meta分析

    doi:10.1007/s001060050621

    authors: Schilter B,Jäger B,Heermann R,Lamprecht F

    更新日期:2000-08-01 00:00:00

  • [Smoking and induction of the enzyme aryl hydrocarbon hydroxylase in patients with laryngeal carcinomas and precancerous conditions].

    abstract::The risk for a smoker of developing cancer of the larynx depends on the activity of the enzyme arylhydroxcarbonhydroxylase in his cells. The higher the genetically determined arylhydroxcarbonhydroxylase activity, the higher is the probability of developing the disease. ...

    journal_title:HNO

    pub_type: 杂志文章

    doi:

    authors: Trell E,Korsgaard R,Mattiasson I,Andreasson L,Björlin G,Kitzing P

    更新日期:1985-03-01 00:00:00