[Suppression of endogenous LH increase in ovarian stimulation with the GnRH antagonist Cetrorelix].

Abstract:

:Surges of LH in serum, which result in luteinization, but occur prematurely with respect to the diameter of the leading follicle, frustrate attemps to induce multiple follicular maturation for in-vitro fertilisation in a number of women. We examined the possibility of blocking premature LH-surges by the administration of Cetrorelix, a potent antagonist of gonadotrophin releasing hormone. Twenty patients, who had repeatedly shown premature LH surges, were treated with human menopausal gonadotrophins from the 2nd day onwards. From the 7th day until the induction of ovulation by HCG, the GNRH-antagonist Cetrorelix was given daily. HCG was injected when the dominant follicle had reached the diameter of at least 18 mm and oestradiol levels were above 300 pg for each follicle and more than 15 mm. Oocyte collection was performed 36 hours later by transvaginal ultrasound puncture, followed by IVF and embryo transfer. The hormone profiles of these patients and the results of in-vitro fertilisation and embryo transfer are discussed. It could be demonstrated in this study, that combined treatment with gonadotrophins and the GNRH-antagonist seems to be a promising method for ovarian stimulation in patients, who frequently exhibit premature LH discharges and therefore fail to complete treatment.

authors

Diedrich K,Diedrich C,Santos E,Bauer O,Zoll C,al-Hasani S,Reissmann T,Krebs D,Klingmüller D

doi

10.1055/s-2007-1023589

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

237-40

issue

4

eissn

0016-5751

issn

1438-8804

journal_volume

54

pub_type

杂志文章
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  • Sonographic Assessment of the Umbilical Cord.

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  • [Perioperative infection prevention with cefotaxime].

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  • [Diagnosis of neonatal streptococcus group B infection in the obstetric department?].

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  • [Hemorrhagic shock caused by intraperitoneal hemorrhage after amniocentesis].

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  • [Immunohistochemical diagnosis of occult breast cancer].

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    更新日期:1978-02-01 00:00:00

  • [The IQ in gynaecology (author's transl)].

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  • [Systemic therapy in recurrent and primary advanced cervix cancer].

    abstract::Therapeutic results in advanced cervical cancer have not been showing any progress for more than 30 years. Only by means of systemic therapy does it seem possible, that further treatment results may be obtained similar to those in squamous cell carcinoma of the head and neck. Therefore, between 1985 and 1990 we tried ...

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  • [Doppler ultrasonography--perinatal data in cases with end-diastolic block and reverse flow].

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