A comparative trial of large doses of ketoprofen and indomethacin in the treatment of rheumatoid arthritis.

abstract：AIM:To assess the efficacy of a strategy to improve vascular risk management in patients with type 2 diabetes mellitus (T2DM). METHODS:This was a pilot best practice implementation enhancement programme that enrolled 578 patients with T2DM. A baseline visit was followed by a concerted effort from previously trained ph...

journal_title：Current medical research and opinion

authors： Athyros VG,Hatzitolios A,Karagiannis A,Didangelos TP,Iliadis F,Dolgyras S,Vosnakidis T,Vasiliadis P,Malias I,Tziomalos K,Samouilidou M,Mikhailidis DP,INDEED Collaborative Group.

更新日期：2009-08-01 00:00:00

abstract：:A clinical trial was undertaken in 50 patients with osteoarthritis of the knee to assess the therapeutic value of glycosaminoglycan-peptide complex in treatment. The first year consisted of a randomized, double-blind, placebo-controlled, parallel-group trial (25 patients in each group), after which all patients receiv...

journal_title：Current medical research and opinion

authors： Katona G

更新日期：1987-01-01 00:00:00

abstract：:Evidence is needed to guide therapeutic decisions on patients who had ischaemic cerebral events. The recently published European/Australasian Stroke Prevention in Reversible Ischaemia Trial (ESPRIT), an open-label randomised controlled study, compared long-term treatment of patients randomised to aspirin 30-325 mg dai...

journal_title：Current medical research and opinion

authors： Einhäupl K

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Tumor necrosis factor (TNF)-α plays a critical role in psoriasis pathogenesis, and several anti-TNF agents have been developed as therapeutic drugs in this indication. SCOPE:To present the preclinical rationale and clinical data for onercept, a novel anti-TNF agent developed for the treatment of moderate-to...

journal_title：Current medical research and opinion

authors： Papp K

更新日期：2010-10-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia seen in clinical practice and has attracted much attention due to its association with a substantial mortality and morbidity, particularly from stroke, thromboembolism and heart failure. This Editorial Commentary provides a brief overview of the ...

journal_title：Current medical research and opinion

authors： Khoo CW,Lip GY

更新日期：2009-05-01 00:00:00

abstract：:Objective: We compare estimates of proportion of days covered (PDC) based on dispensation-only data versus linked prescription and dispensation information, and we analyse their differences in a real-world cohort of patients with osteoporosis.Methods: Prospective cohort study. We compared four alternative measures of ...

journal_title：Current medical research and opinion

authors： García-Sempere A,Hurtado I,Sanfélix-Genovés J,Rodríguez-Bernal C,Peiró S,Sanfélix-Gimeno G

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the long-term safety and effectiveness of tadalafil in patients with pulmonary arterial hypertension (PAH) in real-world clinical practice. METHODS:This prospective, multicenter, noninterventional, post-marketing surveillance included patients with PAH who were observed for up to 2 years after in...

journal_title：Current medical research and opinion

authors： Yamazaki H,Kobayashi N,Taketsuna M,Tajima K,Murakami M

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Most patients with hypertension require more than one drug to attain recommended blood pressure (BP) targets. Initiating therapy with two agents is recommended for patients at high risk of a cardiovascular event or with a BP > 20/10 mmHg above goal. Combination therapy is effective when comprised of agents w...

journal_title：Current medical research and opinion

authors： Ram CV

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:The relationship between patient characteristics and posaconazole exposures was evaluated in a population pharmacokinetic (PK) model using trial data from neutropenic patients administered oral posaconazole suspension as antifungal prophylaxis. METHODS:Data were analyzed using nonlinear mixed-effects modelin...

journal_title：Current medical research and opinion

authors： AbuTarif MA,Krishna G,Statkevich P

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Calcipotriol 50 µg/g and betamethasone 0.5 mg/g dipropionate (Cal/BD) aerosol foam formulation provides greater effectiveness and improved patient preference compared with traditional Cal/BD formulations for the topical treatment of plaque psoriasis. OBJECTIVE:To determine the cost-effectiveness of Cal/BD f...

journal_title：Current medical research and opinion

authors： Foley P,Garrett S,Ryttig L

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Lowering intraocular pressure (IOP) is currently the only therapeutic approach that preserves visual function in primary open-angle glaucoma. In making treatment decisions for first- and second-line therapy, the clinician needs to provide an appropriate balance of efficacy and tolerability. Prostaglandin ana...

journal_title：Current medical research and opinion

authors： Aptel F,Denis P

更新日期：2011-10-01 00:00:00

abstract：:A double-blind, crossover trial was carried out in 40 in-patients with gastro-intestinal spasmodic syndromes to compare the effectiveness and tolerance of fenoverine and trimebutine. Patients were allocated at random to receive either 100 mg fenoverine or 150 mg trimebutine 3-times daily for 20 days and were then cros...

journal_title：Current medical research and opinion

authors： Camarri E

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Exenatide, an incretin mimetic for adjunctive treatment of type 2 diabetes (T2DM), reduced hemoglobin A(1c) (A1C) and weight in clinical trials. The objective of this study was to evaluate the effects of > or = 3 years exenatide therapy on glycemic control, body weight, cardiometabolic markers, and safety. ...

journal_title：Current medical research and opinion

authors： Klonoff DC,Buse JB,Nielsen LL,Guan X,Bowlus CL,Holcombe JH,Wintle ME,Maggs DG

更新日期：2008-01-01 00:00:00

abstract：:In a multi-centre study, the antidepressant efficacy and incidence of on-therapy events of trazodone (100 to 400 mg daily) and mianserin (30 to 120 mg daily) was compared using a double-blind pre-determined randomized parallel group design in depressed patients unresponsive to placebo after a 7-day screening period. O...

journal_title：Current medical research and opinion

authors： Bennie EH,Khan MC,Tyrer SP,Siddiqui U,Ankier SI

更新日期：1984-01-01 00:00:00

abstract：:Two new benzodiazepines, potassium clorazepate (15 mg. at night), and lorazepam (1 mg. t.d.s.) were compared in 50 patients presenting with anxiety in general practice. The response to treatment was assessed clinically and for patient acceptance. The single-dose regime of potassium clorazepate was significantly better...

journal_title：Current medical research and opinion

authors： Harris PG

更新日期：1974-01-01 00:00:00

abstract：:Two hundred and sixty male patients with gonorrhoea, allocated to 4 unequal groups, were treated with one single oral dose of: (a) 2 g epicillin plus 1 g probenecid, (b) 2 g epicillin alone, (c) 1 g epicillin, 1 g cephradine plus 1 g probenecid, and (d) 1 g epicillin and 1 g cephradine. The last 3 groups acted as cont...

journal_title：Current medical research and opinion

authors： Theodoridis A,Marcollou-Kindi O,Vagana A,Sivenas C,Capetanakis J

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:Poor quality has been reported for some generics and other copies of original products. We performed a pilot study to compare the disintegration/dissolution profiles of FOSAMAX (alendronate) 70 mg tablets with those of copies of FOSAMAX that were manufactured outside the United States. RESEARCH DESIGN AND ME...

journal_title：Current medical research and opinion

authors： Epstein S,Cryer B,Ragi S,Zanchetta JR,Walliser J,Chow J,Johnson MA,Leyes AE

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To compare clinical characteristics, statin treatment patterns and adherence among patients at different risk for coronary heart disease (CHD) as defined by National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III guidelines. METHODS:Patients ≥ 18 years old with ≥ 1 claim for dyslipidemi...

journal_title：Current medical research and opinion

authors： Kern DM,Balu S,Tunceli O,Anzalone D

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Fasting during the month of Ramadan is practiced by over 1.5 billion Muslims worldwide. It remains unclear, however, how this change in lifestyle affects heart failure, a condition that has reached epidemic dimensions. This study examined the effects of fasting in patients with acute heart failure (AHF) usin...

journal_title：Current medical research and opinion

authors： Salam AM,Sulaiman K,Alsheikh-Ali AA,Singh R,Asaad N,Al-Qahtani A,Salim I,AlHabib KF,Al-Zakwani I,Al-Jarallah M,AlMahmeed W,Bulbanat B,Ridha M,Bazargani N,Amin H,Al-Motarreb A,Al Faleh H,Albackr H,Panduranga P,Shehab

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:High-sensitivity C-reactive protein (hs-CRP) has been explored for use in predicting cardiovascular risk. The recent Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) study found that statin therapy reduced cardiovascular events in those with ...

journal_title：Current medical research and opinion

authors： Slejko JF,Page RL 2nd,Sullivan PW

更新日期：2010-10-01 00:00:00

abstract：:Cholinesterase inhibitors, which act by inhibiting the degradation of acetylcholine in the brain, form the mainstay of therapy for AD. Predominant adverse events are cholinergic in nature, the most frequent being gastrointestinal side effects. Here we present a case series of patients with dementia who were treated wi...

journal_title：Current medical research and opinion

authors： Venkatesh K,Bullock R,Akbaş A

更新日期：2007-01-01 00:00:00

abstract：:An open, multi-centre study was carried out in 804 patients complaining of sleep disorders to assess the effectiveness and acceptance of temazepam as a hypnotic. Patients received between 10 mg and 30 mg (mean 16.4 mg) temazepam each night for a week. Subjective assessments using a self-administered questionnaire were...

journal_title：Current medical research and opinion

authors： Harry TV,Johnson PA

更新日期：1978-01-01 00:00:00

abstract：:An open study was carried out in 41 children with mild to moderate psoriasis to assess the effectiveness and tolerance of treatment with a 0.1% dithranol plus 17% urea preparation applied twice daily. Thirty-four patients completed 6-weeks' treatment and 8 of them continued for a further 4 to 6 weeks. The results show...

journal_title：Current medical research and opinion

authors： Guerrier CJ,Porter DI

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:In patch-based transdermal drug delivery, adhesiveness is critical for safe and effective treatment, especially in Parkinson's disease (PD) where excessive sweating is common. This study compared the adhesiveness of two transdermal patch formulations of rotigotine (improved room temperature-stable [PR2.3.1/Tr...

journal_title：Current medical research and opinion

authors： Elshoff JP,Bauer L,Goldammer N,Oortgiesen M,Pesch H,Timmermann L

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:The RED LEVEL study (REnal Disease: LErcanidipine Valuable Effect on urine protein Losses) directly compares, in an explorative fashion, the effects of lercanidipine + enalapril and amlodipine + enalapril combinations on renal parameters in hypertensive subjects. RESEARCH DESIGN AND METHODS:This was a 1 year...

journal_title：Current medical research and opinion

authors： Robles NR,Calvo C,Sobrino J,Espinel E,Esteban R,Mateos L,Macias JF

更新日期：2016-10-01 00:00:00

abstract：:Forty patients with definite or classical rheumatoid arthritis were entered for 3 months in a double-blind trial, 20 patients each on 200 mg flurbiprofen or 4.0 g enteric-coated aspirin daily. Statistically significant improvements (Page Test, p less than 0.05) on flurbiprofen were reported during the course of the st...

journal_title：Current medical research and opinion

authors： Dequeker J,Mardjuardi A

更新日期：1981-01-01 00:00:00

abstract：INTRODUCTION:Detection of β-thalassemia trait or carriers (β-TT) depends significantly on an increase in Hemoglobin A2 (HbA2) levels, which is found at low levels (<3%) in normal healthy individuals and elevated levels (≥3.5%) in β-TT individuals. The study was designed to evaluate the reliability of the diagnostic par...

journal_title：Current medical research and opinion

authors： Al-Amodi AM,Ghanem NZ,Aldakeel SA,Ibrahim Al Asoom L,Rafique Ahmed N,Almandil NB,Naserullah ZA,Al-Jarrash S,Shakil Akhtar M,AbdulAzeez S,Al-Ali AK,Borgio JF

更新日期：2018-05-01 00:00:00

abstract：:A double-blind trial was carried out in 76 patients with active rheumatoid arthritis to compare the analgesic and anti-inflammatory activity of 3 g. alclofenac with 4.8 g. aspirin daily over a 6-week period. All patients selected showed reversible inflammatory swelling of the finger joints. Of the 60 patients successf...

journal_title：Current medical research and opinion

authors： Bedi SS

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:The validity of opinions expressed in questionnaire surveys diminishes with lower response rates. Recent research suggests that general practitioners (GPs) are more likely to respond to questionnaire surveys if they are motivated to do so because the subject of the survey is perceived as relevant to the prac...

journal_title：Current medical research and opinion

authors： Jiwa M,Coker AE,Bagley J,Freeman J,Coleman M

更新日期：2004-03-01 00:00:00

abstract：:Hypertension is another predictor of erectile dysfunction (ED). This is further evidence supporting a link between the pathogenesis of atherosclerotic disease and ED. In one study (TOMHS) involving hypertensive patients, the incidence of ED was 14.4%. The drugs used to treat hypertension may cause ED. However, there i...

journal_title：Current medical research and opinion

authors： Mikhailidis DP,Khan MA,Milionis HJ,Morgan RJ

更新日期：2000-01-01 00:00:00