Patient acceptance as a factor in the effectiveness of treatment: an open assessment of potassium clorazepate ('Tranxene') and lorazepam in anxiety.

abstract：OBJECTIVE:In this study, we explored the analgesic and antihyperalgesic properties of a synthetic cannabinoid (nabilone) on experimental heat pain in men and women, as well as its effects on descending pain inhibitory systems. RESEARCH DESIGN AND METHODS:A double-blind, placebo controlled, crossover study of nabilone ...

journal_title：Current medical research and opinion

authors： Redmond WJ,Goffaux P,Potvin S,Marchand S

更新日期：2008-04-01 00:00:00

abstract：:Oxaprozin (4,5-diphenyl-2-oxazolepropionic acid) is a non-steroidal anti-inflammatory drug (NSAID) which is effective in models of inflammation, pain and pyrexia. It is effective and well tolerated in the clinical management of adult rheumatoid arthritis (RA), osteoarthritis (OA), ankylosing spondylitis, soft tissue d...

journal_title：Current medical research and opinion

authors： Kean WF

更新日期：2004-08-01 00:00:00

abstract：:In a double-blind study of 102 patients with a mean age of 79 years, zopiclone was compared to flunitrazepam. The patients rated their sleep in a diary. There was no statistically significant difference between the relatively low dose of 5 mg zopiclone and 1 mg flunitrazepam for eleven out of the twelve variables meas...

journal_title：Current medical research and opinion

authors： Dehlin O,Rubin B,Rundgren A

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of percutaneous polidocanol injection (PPI) in treatment of predominantly cystic thyroid nodules. MATERIALS AND METHODS:This prospective study included 111 patients with 122 benign predominantly cystic thyroid nodules inducing pressure symptoms or cosmetic problems. The no...

journal_title：Current medical research and opinion

authors： Gong X,Zhou Q,Chen S,Wang F,Wu W,Chen X

更新日期：2017-08-01 00:00:00

abstract：:A randomized four-way crossover study was carried out in 12 healthy volunteers to investigate the pharmacokinetics of a new oral combination of frusemide (40 mg) and amiloride (5 mg), formulated as a single tablet. The experimental design of this bioequivalence study used commercially-available 40 mg frusemide tablets...

journal_title：Current medical research and opinion

authors： Brooks SG,Christie RB,Roche J,Fairhead AP,Muirhead D,Townsend HA,Shaw HL

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:To determine the efficacy and safety of lumiracoxib for knee osteoarthritis (OA). METHODS:This was a 13-week, multicentre, randomized, double-blind, double-dummy, placebo-controlled study. Males or females aged >/= 18 years with primary knee OA received lumiracoxib 100 mg od, lumiracoxib 100 mg od with a loa...

journal_title：Current medical research and opinion

authors： Lehmann R,Brzosko M,Kopsa P,Nischik R,Kreisse A,Thurston H,Litschig S,Sloan VS

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVES:Inflammatory bowel disease (IBD) is a chronic condition commonly requiring lifelong care. Both IBD and IBD-related treatments can cause significant morbidity, and it is often difficult to differentiate their relative etiologic contribution to adverse events (AEs). The objectives of this study were to assess ...

journal_title：Current medical research and opinion

authors： McAuliffe ME,Lanes S,Leach T,Parikh A,Faich G,Porter J,Holick C,Esposito D,Zhao Y,Fox I

更新日期：2015-01-01 00:00:00

abstract：:Objective To assess the efficacy of a mixed intervention, educational, and reminder calendar of the intake, as a strategy to improve therapeutic adherence with dabigatran in patients with non-valvular atrial fibrillation (NVAF). Methods This was a prospective, longitudinal, multi-center study, carried out in 110 speci...

journal_title：Current medical research and opinion

authors： Márquez-Contreras E,Martell-Claros N,Márquez-Rivero S,Hermida-Campa E,Gracia-Diez C,Sanchez-López E,Gil-Guillén V,Compliance and Inertia Working Group, Spanish Society of Hypertension (SEH-LELHA).

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase 4 (DPP4) inhibitors are currently used as glucose-lowering agents in type 2 diabetes, due to their effects on insulin and glucagon secretion. These agents, which are effective in improving glucose control, could also have a beneficial...

journal_title：Current medical research and opinion

authors： Mannucci E,Dicembrini I

更新日期：2012-05-01 00:00:00

abstract：:The therapeutic efficacy of cimetidine given as 400 mg twice daily was compared to that of cimetidine given as 1.0 g daily in 4 divided doses (200 mg 3-times daily and 400 mg at night) in two groups of 25 patients (total 50 patients) with active duodenal ulceration. After 4 weeks, healing rates of 72% and 76%, respect...

journal_title：Current medical research and opinion

authors： Papadopoulos C,Kalantzis N,Rekoumis G,Kanaghinis T

更新日期：1985-01-01 00:00:00

abstract：:The potential advantages of eletriptan lie firstly in its lipophilicity reflected as an increased rate of absorption and Tmax compared to sumatriptan. This is manifested in a modest advantage over sumatriptan in terms of speed of onset, 2 h headache response and 2 h pain free. However, eletriptan has not yet been show...

journal_title：Current medical research and opinion

authors： Giffin N

更新日期：2001-01-01 00:00:00

abstract：:The effects of flurbiprofen on various coagulation and haemostasis parameters were studied in 19 patients adequately anticoagulated on a fixed dose of phenprocoumon. Laboratory controls were performed 5 times at weekly intervals. Flurbiprofen 50 mg 3-times daily was given for 2 weeks after an initial control period of...

journal_title：Current medical research and opinion

authors： Marbet GA,Duckert F,Walter M,Six P,Airenne H

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:In controlled clinical trials, rabeprazole effectively improves symptoms and heals oesophageal erosions in patients with gastro-oesophageal reflux disease (GORD). AIM:To examine symptom relief during week 1 of rabeprazole therapy, in addition to GORD healing, in a clinical practice setting. METHODS:In this...

journal_title：Current medical research and opinion

authors： Archimandritis AJ,Nikolopoulou V,Kouklakis G,Paraskevas E,Avgerinos A,Tsianos E,Triantafillidis JK,Hellenic Rabeprazole Study Group.

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:Chronic respiratory failure (CRF) is a syndrome defined by certain disturbances in arterial blood gases. Non-invasive mechanical ventilation (NIMV) is an increasingly used treatment modality in respiratory failure. The aim of this study was to investigate the long-term effects of NIMV on pulmonary function an...

journal_title：Current medical research and opinion

authors： Dogan OT,Turkyilmaz S,Berk S,Epozturk K,Akkurt I

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:To examine outcomes associated with colesevelam treatment among patients with hypercholesterolemia in real-world clinical practice. METHODS:This analysis was conducted as a retrospective, observational cohort study in an ambulatory-care medical network in Northern California. Patients with orders for colesev...

journal_title：Current medical research and opinion

authors： Romanelli RJ,Leahy A,Jukes T,Ye X,Qian C,Ishisaka DY

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Control of arterial hypertension in obese or overweight patients is complicated since obesity directly contributes to increased blood pressure, requiring new, highly effective antihypertensive drugs. This study evaluates the efficacy of azilsartan medoxomil in real clinical practice. METHODS:An internationa...

journal_title：Current medical research and opinion

authors： Chazova IE,Zhernakova YV

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:Natalizumab is a highly effective treatment for patients with relapsing-remitting multiple sclerosis (RRMS). Treatment with natalizumab has been associated with progressive multifocal leukoencephalopathy (PML), a rare yet serious disease of the brain. Published studies have quantified the PML risk by the pre...

journal_title：Current medical research and opinion

authors： Walker A,Watson C,Alexopoulos ST,Deniz B,Arnold R,Bates D

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Although risk factors for MI have been described in the general population, there is a lack of data on the assessment of risk factors associated with MI in venous thromboembolism (VTE) patients. OBJECTIVE:The purpose of this study was to identify risk factors associated with MI in VTE patients. PATIENTS AN...

journal_title：Current medical research and opinion

authors： Laliberté F,Nutescu EA,Lefebvre P,Rondeau-Leclaire J,Bookhart BK,LaMori JC,Damaraju CV,Schein J,Kaatz S

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:To compare the efficacy and safety of the concomitant administration of travoprost 0.004% once daily and brinzolamide 0.1% twice daily with those of a fixed combination of latanoprost 0.005%/timolol 0.5% once daily. RESEARCH, DESIGN AND METHODS:Forty-four patients with primary open-angle glaucoma or ocular hyp...

journal_title：Current medical research and opinion

authors： Martinez-de-la-Casa JM,Castillo A,Garcia-Feijoo J,Mendez-Hernandez C,Fernandez-Vidal A,Garcia-Sanchez J

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Mycophenolate mofetil (MMF) is widely and successfully used in immunosuppressive regimens for the prophylaxis of organ rejection following transplantation. Conventionally, it is administered at a fixed dose without serial measurements of plasma concentrations of mycophenolic acid (MPA), the active metabolite...

journal_title：Current medical research and opinion

authors： Kaplan B

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:Poor quality has been reported for some generics and other copies of original products. We performed a pilot study to compare the disintegration/dissolution profiles of FOSAMAX (alendronate) 70 mg tablets with those of copies of FOSAMAX that were manufactured outside the United States. RESEARCH DESIGN AND ME...

journal_title：Current medical research and opinion

authors： Epstein S,Cryer B,Ragi S,Zanchetta JR,Walliser J,Chow J,Johnson MA,Leyes AE

更新日期：2003-01-01 00:00:00

abstract：:Objective: Determine healthcare resource utilization (HCRU) and costs associated with fatigue and stiffness among patients with rheumatoid arthritis (RA).Methods: A retrospective claims analysis compared RA patients with fatigue or stiffness to matched RA control patients with neither. Claims from a large US commercia...

journal_title：Current medical research and opinion

authors： Strand V,Shah R,Atzinger C,Zhou J,Clewell J,Ganguli A,Tundia N

更新日期：2020-01-01 00:00:00

abstract：:A 4-weeks' double-blind, crossover study in 30 patients with definite or classical rheumatoid arthritis is reported using 300 mg ketoprofen per day and 150 mg indomethacin per day. Both drugs had similar effects upon the patients' subjective improvement of pain. Objectively, the results also suggest that ketoprofen ma...

journal_title：Current medical research and opinion

authors： El-Ghobarey AF,Rennie JA,Hadidi T,Hamid HA,Mavrikakis M

更新日期：1976-01-01 00:00:00

abstract：OBJECTIVES:Health economic analysis from a healthcare and societal point of view was conducted to assess the cost-effectiveness of insulin degludec (IDeg) after switching from other basal insulins in people with type 1 diabetes. MATERIAL AND METHODS:This was a prospective, open-label, single arm, observational follow-...

journal_title：Current medical research and opinion

authors： Landstedt-Hallin L,Gundgaard J,Ericsson Å,Ellfors-Zetterlund S

更新日期：2017-04-01 00:00:00

abstract：:Insulin secretion was studied in 12 non-insulin dependent diabetics during middle-term administration of the sulphonylurea gliclazide. Blood sugar, C-peptide and glucagon were also estimated during the intravenous glucose tolerance and arginine tests performed before and after therapy. After 3 months of gliclazide the...

journal_title：Current medical research and opinion

authors： Brogard JM,Pinget M,Dorner M

更新日期：1984-01-01 00:00:00

abstract：: Background & aims: Vitamin D deficiency is widespread worldwide. In this study, we aimed to evaluate the effect of a nano encapsulated form of vitamin D used for fortifying low-fat dairy products (milk and yogurt) on anthropometric indices, glycemic status, and lipid profi...

journal_title：Current medical research and opinion

authors： Sharifan P,Ziaee A,Darroudi S,Rezaie M,Safarian M,Eslami S,Khadem-Rezaiyan M,Tayefi M,Mohammadi M,Ghazizadeh H,Khorasanchi Z,Bagherniya M,Sardar MA,Ferns G,Vatanparast H,Ghayour Mobarhan M

更新日期：2021-01-12 00:00:00

abstract：INTRODUCTION:Phenylketonuria (PKU) is a rare autosomal recessive disorder caused by a deficiency of phenylalanine hydroxylase (PAH). Its prevalence is estimated to be 1:10,000 in Europe. PKU is the commonest congenital inborn error of metabolism. The aim of our study was to investigate the characteristics of clinical p...

journal_title：Current medical research and opinion

authors： Burlina A,Leuzzi V,Spada M,Carbone MT,Paci S,Tummolo A

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:The management of iron-deficiency anaemia in patients with non-dialysis chronic kidney disease (ND-CKD) remains controversial, particularly regarding the use of oral versus intravenous iron supplementation. METHODS:A PubMed search from 1970 to February 2009 was conducted to identify relevant research articl...

journal_title：Current medical research and opinion

authors： Macdougall IC

更新日期：2010-02-01 00:00:00

abstract：:An open study was carried out in 41 children with mild to moderate psoriasis to assess the effectiveness and tolerance of treatment with a 0.1% dithranol plus 17% urea preparation applied twice daily. Thirty-four patients completed 6-weeks' treatment and 8 of them continued for a further 4 to 6 weeks. The results show...

journal_title：Current medical research and opinion

authors： Guerrier CJ,Porter DI

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Over the last two decades the development and analysis of a number of registries have enhanced the knowledge of the epidemiology, presentation, natural history, and pathophysiology of pulmonary arterial hypertension (PAH). The understanding of the effectiveness of available treatments has also been greatly i...

journal_title：Current medical research and opinion

authors： Poscia R,Ghio S,D'Alto M,Vitulo P,Mulè M,Albera C,Parisi F,Badagliacca R,Fedele F,Vizza CD

更新日期：2014-12-01 00:00:00