Abstract：
:Insulin secretion was studied in 12 non-insulin dependent diabetics during middle-term administration of the sulphonylurea gliclazide. Blood sugar, C-peptide and glucagon were also estimated during the intravenous glucose tolerance and arginine tests performed before and after therapy. After 3 months of gliclazide therapy (240 mg/day) in addition to a low carbohydrate diet, the intravenous glucose tolerance test showed a significant reduction in blood sugar levels and in the partial and total areas under the blood sugar curve, as well as an improvement in early insulin secretion, characterized by a significant increase in plasma C-peptide at 4, 10 and 20 minutes. Plasma glucagon levels were not affected by the sulphonylurea therapy. In the arginine test, blood sugar levels were lower at the end of the treatment period; plasma insulin, C-peptide and glucagon did not change significantly. In this study, plasma C-peptide has proved to be a better indicator of stimulated insulin secretion than plasma insulin levels. The scarcity of hypoglycaemic episodes during therapy with gliclazide may be related to the selective stimulation of early insulin secretion by this drug.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Brogard JM,Pinget M,Dorner Mdoi
10.1185/03007998409109560subject
Has Abstractpub_date
1984-01-01 00:00:00pages
56-63issue
1eissn
0300-7995issn
1473-4877journal_volume
9pub_type
杂志文章abstract：:Nine patients with persistently elevated diastolic blood pressure, exceeding 130 mmHg, received an oral dose of labetalol ranging from 200 mg to 400 mg. In all patients, this produced a significant and gradual decline in recumbent systolic and diastolic blood pressure, unaccompanied by symptoms or complications, with ...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章
doi：10.1185/03007997709110155
更新日期：1977-01-01 00:00:00
abstract：:In a single-blind study in general practice, 60 patients with anxiety neuroses were randomly allocated to receive either 0.5 mg haloperidol twice daily or 2 mg diazepam 3-times daily for 6 weeks. Eighteen patients (6 on haloperidol and 12 on diazepam) were excluded from the analysis of efficacy. On the Hamilton Rating...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/03007997909109010
更新日期：1979-01-01 00:00:00
abstract：BACKGROUND:Most patients with hypertension require more than one drug to attain recommended blood pressure (BP) targets. Initiating therapy with two agents is recommended for patients at high risk of a cardiovascular event or with a BP > 20/10 mmHg above goal. Combination therapy is effective when comprised of agents w...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007990802597456
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Adequate vitamin D and calcium nutrition play a critical role in the maintenance of musculoskeletal health and are considered the first step in osteoporosis treatment. ROUNDTABLE DISCUSSION:In February 2008 Merck Sharp & Dohme sponsored a 2-day, evidence-based expert panel on the benefits of vitamin D for t...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/030079908x301857
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVE:Research indicates that insomnia may contribute significantly to healthcare costs; however, information on the effects of treatments on costs has not been thoroughly published. This study presents predictive models that forecast, from the perspective of commercial managed care, the effects of insomnia medicat...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079907X199619
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVE:A novel preoperative procedure From Home To Operation (FHTO) seeks to combat increasing operation and infection rates. This is the first prospective randomized controlled trial (RCT) comparing the cost-effectiveness and cost-utility of FHTO and conventional ward procedures for standardized Laparoscopic Cholec...
journal_title：Current medical research and opinion
pub_type： 杂志文章,随机对照试验
doi：10.1185/030079907x233223
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVE:To investigate the associations between obesity and any significant improvements in glycemic control, blood pressure, and lipid targets in Chinese patients with concomitant type 2 diabetes mellitus (T2DM) and hypertension. METHODS AND RESULTS:A total of 3041 dyslipidemia patients with an average age of 65.7 ...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007995.2015.1058770
更新日期：2015-01-01 00:00:00
abstract：:Objective: Global Phase III trials of suvorexant showed no obvious differences in the safety and efficacy profile of suvorexant between elderly and non-elderly patients. However, the clinical profile of suvorexant in elderly patients with comorbidities in a real-world setting was not evaluated. To further understand t...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2019.1700361
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:Although beta-blocker therapy has been shown to improve survival in patients with chronic heart failure, this class of drugs tends to be underutilized in diabetic patients due to concerns about adverse metabolic effects, especially on glycemic control. No randomized clinical trial has specifically evaluated ...
journal_title：Current medical research and opinion
pub_type： 杂志文章,meta分析
doi：10.1185/030079906X80459
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND:Inadequate removal of extracellular volume markedly increases blood pressure and contributes to high morbidity and mortality in hemodialysis patients. Advances in fluid management are needed to improve clinical outcomes. The aim of this quality improvement project was to examine the advantages of using a hem...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007995.2015.1047746
更新日期：2015-01-01 00:00:00
abstract：:A large, open, multi-centre study was carried out in general practice to evaluate the effectiveness and tolerance of a combination of 10 mg pindolol plus 5 mg clopamide, in single tablet form, in the treatment of patients with essential hypertension. Computer analysis of the records of 8989 patients who completed the ...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章
doi：10.1185/03007997909109449
更新日期：1979-01-01 00:00:00
abstract：OBJECTIVE:To compare the safety and efficacy of celecoxib versus diclofenac slow release (SR) plus omeprazole in elderly arthritis patients. RESEARCH DESIGN AND METHODS:Patients aged≥65 years, with osteoarthritis and/or rheumatoid arthritis, at high gastrointestinal (GI) risk who participated in the CONDOR trial (Cele...
journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1185/03007995.2012.717528
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:Healthcare organizations must evaluate the cost effectiveness of the alternative therapies that are available to treat anemia and improve quality of life (QoL) of patients with cancer, that is, erythropoietic protein therapy and blood transfusion. METHODS:Pharmacoeconomic studies that evaluated the cost of ...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/030079906X167282
更新日期：2007-02-01 00:00:00
abstract：BACKGROUND:Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and is associated with increased cardiovascular morbidity and mortality. Epicardial adipose tissue (EAT) serves as a biologically active organ with important endocrine and inflammatory function. Review An accumulating body of evidenc...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1080/03007995.2018.1462786
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVE:Healthcare providers managing older patients with type 2 diabetes mellitus (T2DM) face a complex milieu of medical conditions and comorbidities, which increase the risk of unintended treatment consequences. The objective of this study was to understand factors associated with hypoglycemia-related hospitalizat...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007995.2014.922944
更新日期：2014-09-01 00:00:00
abstract：GOALS OF THE WORK:This open compassionate-use prospective registration study evaluated the tolerability, ease of use and applied doses of transdermal (TTS) fentanyl in adult patients with cancer-related pain requiring strong opioid analgesia. Elderly patients were particularly focussed on. PATIENTS AND METHODS:Previou...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079902125001272
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:In controlled clinical trials, rabeprazole effectively improves symptoms and heals oesophageal erosions in patients with gastro-oesophageal reflux disease (GORD). AIM:To examine symptom relief during week 1 of rabeprazole therapy, in addition to GORD healing, in a clinical practice setting. METHODS:In this...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1185/030079905X41444
更新日期：2005-04-01 00:00:00
abstract：OBJECTIVE:Vildagliptin is a potent and selective dipeptidyl peptidase-IV (DPP-4) inhibitor that improves glycemic control in patients with type 2 diabetes by increasing alpha and beta-cell responsiveness to glucose. This study assessed the effect of multiple doses of vildagliptin 100 mg once daily on warfarin pharmacok...
journal_title：Current medical research and opinion
pub_type： 杂志文章,随机对照试验
doi：10.1185/030079907x188008
更新日期：2007-05-01 00:00:00
abstract：OBJECTIVE:Osteoporosis is a skeletal disorder characterized by diminished bone strength, which results in an increased risk of fracture. Currently, osteoporosis is a public health priority due to the large number of individuals affected and the detrimental effect on quality of life. Primary osteoporosis, the most commo...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007995.2013.838549
更新日期：2013-11-01 00:00:00
abstract：:A double-blind, multi-centre trial was carried out in 191 patients with acute musculoskeletal conditions to compare the efficacy of naproxen and indomethacin. Patients were randomly allocated to receive either 250 mg naproxen or 50 mg indomethacin twice daily. Treatment was for 7 or 14 days. The results, assessed by t...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/03007997609109332
更新日期：1976-01-01 00:00:00
abstract：OBJECTIVE:To review the evidence evaluating the efficacy of vardenafil in subgroups of hypertensive patients with erectile dysfunction (ED). METHODS:Meta-analysis of randomized, double-blinded, placebo-controlled, flexible-dose vardenafil clinical trials that were >or=12 weeks in duration evaluated men with a >or=6-mo...
journal_title：Current medical research and opinion
pub_type： 杂志文章,meta分析
doi：10.1185/030079907X219616
更新日期：2007-10-01 00:00:00
abstract：:The efficacy of etodolac (600 mg/day) and placebo were compared in a 4-week double-blind, parallel-group study involving 104 patients with osteoarthritis of the knee and 106 with osteoarthritis of the hip. Most patients had improvement of their symptoms during the study, but significantly more improvement was seen in ...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/03007998909115933
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVE:Hyperuricaemia is associated with indapamide administration. In contrast, micronised fenofibrate can significantly decrease serum uric acid levels. However, there are no data on the effect of combination therapy of indapamide with micronised fenofibrate on uric acid metabolism. METHODS:We studied 20 non-diab...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079902125000273
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:In TRITON-TIMI 38, patients with acute coronary syndromes were treated with prasugrel or clopidogrel, with aspirin, for a median of 14.5 (maximum of 15) months. Based on this trial, the EU label for prasugrel recommends treatment for up to 12 months and excludes patients with prior stroke/transient ischemic ...
journal_title：Current medical research and opinion
pub_type： 杂志文章,随机对照试验
doi：10.1185/03007995.2014.944638
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVES:Chronic obstructive pulmonary disease (COPD) is becoming a leading cause of morbidity and mortality in China. In the IMPACT trial, fluticasone furoate[FF]/umeclidinium[UMEC]/vilanterol[VI] single-inhaler triple therapy demonstrated lower rates of moderate/severe exacerbations than dual therapy with FF/VI or ...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2020.1844646
更新日期：2021-01-01 00:00:00
abstract：:The influence of buflomedil on brain circulation was investigated in an open, preliminary trial in 12 patients with dementia caused by multi-cerebral infarcts. Patients were given 150 mg buflomedil 3-times daily for a period of 6 months. Assessments carried out before treatment included regional cerebral blood flow me...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007998709111107
更新日期：1987-01-01 00:00:00
abstract：:Elevated serum cholesterol level is a key risk factor for cardiovascular morbidity and mortality. Cerivastatin is a highly effective lipid-lowering agent currently licensed at doses of 0.1, 0.2, 0.3 and 0.4 mg. This was a multicentre, randomised, double-blind, parallel-group study comparing the efficacy and safety of ...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1185/03007999909114095
更新日期：1999-01-01 00:00:00
abstract：:Objectives Real-world patient outcomes data is scarce concerning the high disease burden of IBS-C. The aim of this study was to compare patient-reported symptom control, health-related quality of life (HRQoL), resource utilization, and treatment satisfaction of lubiprostone vs non-lubiprostone treatment for irritable ...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007995.2016.1150262
更新日期：2016-05-01 00:00:00
abstract：:A national survey of psychotherapeutic drug use was carried out in the U.S.A. in 1979. Data were obtained from a probability sample (n = 3161) of adults in the general population, using a clinically-oriented interview lasting an average of 90 minutes. The data provide estimates of the prevalence of using anxiolytic an...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007998409109542
更新日期：1984-01-01 00:00:00
abstract：OBJECTIVE:To investigate the efficacy of pantoprazole 20 mg once daily (o.d.) in relieving epigastric pain associated with ulcer-like functional dyspepsia. RESEARCH DESIGN AND METHODS:In this double-blind, placebo-controlled, multicentre study, patients experiencing ulcer-like functional dyspepsia, with epigastric pai...
journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1185/03007990802184545
更新日期：2008-07-01 00:00:00
