Single oral dose of epicillin combined with probenecid in the treatment of gonorrhoea.

abstract：OBJECTIVE:To determine the efficacy and safety of lumiracoxib for knee osteoarthritis (OA). METHODS:This was a 13-week, multicentre, randomized, double-blind, double-dummy, placebo-controlled study. Males or females aged >/= 18 years with primary knee OA received lumiracoxib 100 mg od, lumiracoxib 100 mg od with a loa...

journal_title：Current medical research and opinion

authors： Lehmann R,Brzosko M,Kopsa P,Nischik R,Kreisse A,Thurston H,Litschig S,Sloan VS

更新日期：2005-04-01 00:00:00

abstract：:Seventy frail elderly patients attending a day hospital were studied to investigate the incidence of postural hypotension in control patients on no diuretic treatment (n = 30), patients on loop diuretics (frusemide) for mild cardiac failure (n = 20) and patients on thiazide diuretics for mild cardiac failure (n = 20)....

journal_title：Current medical research and opinion

authors： Heseltine D,Bramble MG

更新日期：1988-01-01 00:00:00

abstract：:A double-blind trial was carried out in 60 elderly patients with osteoarthritis of the knee or hip to compare the efficacy and tolerability of treatment with tiaprofenic acid and indomethacin. Patients received either 600 mg tiaprofenic acid or 100 mg indomethacin daily for 3 months. The results of assessments made ev...

journal_title：Current medical research and opinion

authors： Meurice J

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVES:GOAL (Gauging Osteoarthritis [OA] with Limbrel*), an open-label, post-marketing study was performed to determine the overall efficacy and gastrointestinal (GI) tolerability of flavocoxid, a novel, plant-based, anti-inflammatory medication, in a 'real world' clinical practice setting. To this end, the study e...

journal_title：Current medical research and opinion

authors： Pillai L,Burnett BP,Levy RM,GOAL Study Cooperative Group.

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:Recent survey data have reported the incidence rate of needlestick injuries (NIs) and NIs which draw blood sustained by nurses caring for patients with diabetes in an in-patient hospital setting. The purpose of this study was to deduce the potential short-term annual economic impact resulting from such NI, and ...

journal_title：Current medical research and opinion

authors： Lee WC,Nicklasson L,Cobden D,Chen E,Conway D,Pashos CL

更新日期：2005-12-01 00:00:00

abstract：:Migraine is a very common disorder, affecting about 11% of adult populations in Western countries. Prevalence is highest during the peak productive years--between the ages of 25 and 55. The prevalence is higher in females than males at all post-pubertal ages, but the sex ratio varies with age. In the United States, mi...

journal_title：Current medical research and opinion

authors： Lipton RB,Stewart WF,Scher AI

更新日期：2001-01-01 00:00:00

abstract：:A double-blind trial of methocarbamol versus placebo was carried out in 59 matched pairs of patients suffering from painful muscle spasm. Methocarbamol (1500 mg. q.d.s.) was found to be effective in approximately 60% of patients compared with 30% of patients receiving placebo (p less than 0.01). Side-effects were of a...

journal_title：Current medical research and opinion

authors： Valtonen EJ

更新日期：1975-01-01 00:00:00

abstract：OBJECTIVE:The use of embolic protection devices to decrease major adverse cardiac events (MACEs) in patients with saphenous vein graft lesions is considered class I therapy by the recent practice guidelines. However, the benefits of adjunctive protection devices to prevent distal embolization in patients with native co...

journal_title：Current medical research and opinion

authors： Jin B,Dong XH,Zhang C,Li Y,Shi HM

更新日期：2012-06-01 00:00:00

abstract：UNLABELLED:Abstract Background: The Schizophrenia Trial of Aripiprazole (STAR) showed superior efficacy for aripiprazole compared with atypical antipsychotic standard-of-care (SOC) for the community treatment of schizophrenia 1 based on the Investigator Assessment Questionnaire total score. OBJECTIVE:To determine the ...

journal_title：Current medical research and opinion

authors： King D,Knapp M,Thomas P,Razzouk D,Loze JY,Kan HJ,van Baardewijk M

更新日期：2011-02-01 00:00:00

abstract：:A randomized four-way crossover study was carried out in 12 healthy volunteers to investigate the pharmacokinetics of a new oral combination of frusemide (40 mg) and amiloride (5 mg), formulated as a single tablet. The experimental design of this bioequivalence study used commercially-available 40 mg frusemide tablets...

journal_title：Current medical research and opinion

authors： Brooks SG,Christie RB,Roche J,Fairhead AP,Muirhead D,Townsend HA,Shaw HL

更新日期：1984-01-01 00:00:00

abstract：:Objective: The aim of this study was to provide recommendations for improving the design of subsequent studies through analysis of the registered coronavirus disease 2019 (COVID-19) clinical trials.Methods: A retrospective analysis of 189 trial retrievals achieved on 20 February 2020.Results: A total of 189 trials are...

journal_title：Current medical research and opinion

authors： Wang B,Lai J,Yan X,Jin F,Yao C

更新日期：2020-07-01 00:00:00

abstract：:A study was carried out in general practice to assess the clinical effectiveness and tolerability of the oral cephalosporin, cefuroxime axetil, in the treatment of 369 patients presenting with acute infections of the upper respiratory tract. The main diagnoses were tonsillitis, pharyngitis, sinusitis and otitis media....

journal_title：Current medical research and opinion

authors： Griffiths GK,VandenBurg MJ,Wight LJ,Gudgeon AC,Kelsey M

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:This retrospective study assessed the incidence and timing of adverse events (AEs) among patients prescribed varying dose levels of corticosteroids in the US. METHODS:Patients with selected autoimmune or inflammatory disease diagnoses between 2006 and 2015 were identified from a privately insured administrat...

journal_title：Current medical research and opinion

authors： Rice JB,White AG,Johnson M,Wagh A,Qin Y,Bartels-Peculis L,Ciepielewska G,Nelson WW

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:Migraine is a chronic, disabling neurological disease affecting >1 billion people worldwide. Migraine remains undertreated in Asia, including Taiwan. Galcanezumab is a humanized monoclonal antibody that selectively binds calcitonin gene-related peptide, a peptide firmly established in the pathophysiology of m...

journal_title：Current medical research and opinion

authors： Yang CP,Lee CF,Dell'Agnello G,Hundemer HP,Lipsius S,Wang SJ

更新日期：2020-10-01 00:00:00

abstract：:An open, multi-centre, non-comparative study was carried out in general practice to assess the efficacy and tolerance of piroxicam in 159 patients with osteoarthritis and 27 patients with rheumatoid arthritis. Initial dosage ranged from 10 to 40 mg piroxicam and all but a few patients continued treatment with 20 mg on...

journal_title：Current medical research and opinion

authors： Gow PJ

更新日期：1983-01-01 00:00:00

abstract：:Six patients suffering from rheumatoid arthritis with massive knee joint effusions were treated with single daily doses of 600 mg pirazolac, a novel non-steroidal anti-inflammatory drug, for 3 days. Before the first dose, 3 hours after the second and the third dose, specimens of plasma and synovial fluid were drawn si...

journal_title：Current medical research and opinion

authors： Kurowski M,Dunky A,Geddawi M

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:Non-adherence to pain medication is common in chronic pain patients and may result in unfavorable treatment outcomes. Interventions to improve adherence behavior often fail to significantly change medication use. In this report, we describe the application of a theoretical psychological model of behavior chan...

journal_title：Current medical research and opinion

authors： Timmerman L,Stronks DL,Huygen FJPM

更新日期：2017-07-01 00:00:00

abstract：:A double-blind, randomized study was carried out in 43 women, who had undergone spontaneous menopause at least 6 months earlier, to compare the effectiveness and tolerance of veralipride with that of a conjugated oestrogens preparation in the control of hot flushes. Twenty-one women received 100 mg veralipride per day...

journal_title：Current medical research and opinion

authors： Wesel S,Bourguignon RP,Bosuma WB

更新日期：1984-01-01 00:00:00

abstract：:Background: In routine clinical practice, the implantation of a drug-eluting stent (DES) versus a bare metal stent (BMS) for percutaneous coronary intervention (PCI) has been guided by criteria for appropriate use. The cost-effectiveness (CE) of adopting these guidelines, however, is not clear, and was investigated fr...

journal_title：Current medical research and opinion

authors： Ariyaratne TV,Ademi Z,Ofori-Asenso R,Huq MM,Duffy SJ,Yan BP,Ajani AE,Clark DJ,Billah B,Brennan AL,New G,Andrianopoulos N,Reid CM

更新日期：2020-03-01 00:00:00

abstract：: Background & aims: Vitamin D deficiency is widespread worldwide. In this study, we aimed to evaluate the effect of a nano encapsulated form of vitamin D used for fortifying low-fat dairy products (milk and yogurt) on anthropometric indices, glycemic status, and lipid profi...

journal_title：Current medical research and opinion

authors： Sharifan P,Ziaee A,Darroudi S,Rezaie M,Safarian M,Eslami S,Khadem-Rezaiyan M,Tayefi M,Mohammadi M,Ghazizadeh H,Khorasanchi Z,Bagherniya M,Sardar MA,Ferns G,Vatanparast H,Ghayour Mobarhan M

更新日期：2021-01-12 00:00:00

abstract：OBJECTIVE:To compare injection site pain of subcutaneous (sc) epoetin beta and darbepoetin alfa in adult patients with chronic kidney disease. RESEARCH DESIGN AND METHODS:This was a multi-centre, randomised, two-arm, single-blind, cross-over study. Patients were randomised to receive weekly sc darbepoetin alfa 30 mug ...

journal_title：Current medical research and opinion

authors： Roger SD,Suranyi MG,Walker RG,Disney A,Isbel NM,Kairaitis L,Pollock CA,Brown FG,Chow J,Truman MI,Ulyate KA,COMFORT study group.

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the relative efficacy and safety of extended-release tramadol HCl 75 mg/acetaminophen 650 mg (TA-ER) and immediate-release tramadol HCl 37.5 mg/acetaminophen 325 mg (TA-IR) for the treatment of moderate to severe acute pain following total knee replacement. METHODS:This phase III, double-blind, p...

journal_title：Current medical research and opinion

authors： Park YB,Ha CW,Cho SD,Lee MC,Lee JH,Seo SS,Kang SB,Kyung HS,Choi CH,Chang N,Rhim HY,Bin SI

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Significant race and ethnic disparities exist in diabetes-related health care. Using a nationally representative database, we sought to determine if use of thiazolidinediones (TZDs) differs by race and ethnicity. As a secondary objective, we sought to determine if race and ethnicity is associated with use of ...

journal_title：Current medical research and opinion

authors： Aquilante CL,Zhang W,McCollum M

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Fasting during the month of Ramadan is practiced by over 1.5 billion Muslims worldwide. It remains unclear, however, how this change in lifestyle affects heart failure, a condition that has reached epidemic dimensions. This study examined the effects of fasting in patients with acute heart failure (AHF) usin...

journal_title：Current medical research and opinion

authors： Salam AM,Sulaiman K,Alsheikh-Ali AA,Singh R,Asaad N,Al-Qahtani A,Salim I,AlHabib KF,Al-Zakwani I,Al-Jarallah M,AlMahmeed W,Bulbanat B,Ridha M,Bazargani N,Amin H,Al-Motarreb A,Al Faleh H,Albackr H,Panduranga P,Shehab

更新日期：2018-02-01 00:00:00

abstract：:Nine patients with persistently elevated diastolic blood pressure, exceeding 130 mmHg, received an oral dose of labetalol ranging from 200 mg to 400 mg. In all patients, this produced a significant and gradual decline in recumbent systolic and diastolic blood pressure, unaccompanied by symptoms or complications, with ...

journal_title：Current medical research and opinion

authors： Ghose RR,Sampson A

更新日期：1977-01-01 00:00:00

abstract：OBJECTIVE:The Exenatide BID Observational Study (ExOS) was designed to evaluate the clinical effectiveness of exenatide BID use in patients with type 2 diabetes (T2D) in a real-world clinical practice setting in the United States. METHODS:Patients were enrolled from 74 practice sites from 9/2007 through 1/2009 and fol...

journal_title：Current medical research and opinion

authors： Bergenstal RM,Garrison LP Jr,Miller LA,Hou L,Blickensderfer A,Zagar A,Stanley S,Bhargava A,Wade R,Herman WH

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:To describe a post hoc analysis comparing the effect of a hyaluronic acid (HA)-trehalose solution to an established eyedrop solution containing HA alone using Ocular Surface Disease Index (OSDI) score <19 as a threshold for moderate to severe dry eye disease (DED). METHODS:A phase III, randomized, controlled...

journal_title：Current medical research and opinion

authors： Doan S,Bremond-Gignac D,Chiambaretta F

更新日期：2018-08-01 00:00:00

abstract：:Objective: To evaluate the risk of chronic kidney disease (CKD), cardiovascular disease (CVD), and osteoporotic fractures in human immunodeficiency virus (HIV) patients utilizing data within the Veteran's Affairs (VA) Administration system.Methods: A retrospective cohort study utilizing VA system claims (January 2000-...

journal_title：Current medical research and opinion

authors： Sutton SS,Magagnoli J,Cummings TH,Hardin JW,Edun B,Beaubrun A

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Decision aids (DAs) are increasingly used to operationalize shared decision-making (SDM) but their development is not often described. Decisions about oral anticoagulants (OACs) for atrial fibrillation (AF) involve a trade-off between lowering stroke risk and increasing OAC-associated bleeding risk, and consi...

journal_title：Current medical research and opinion

authors： Kaiser K,Cheng WY,Jensen S,Clayman ML,Thappa A,Schwiep F,Chawla A,Goldberger JJ,Col N,Schein J

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:To analyze the effect of brexpiprazole on metabolic parameters and body weight in adults with schizophrenia, including clinically relevant sub-groups of patients, based on data from two pivotal phase 3 studies (NCT01393613; NCT01396421) and a long-term extension study (NCT01397786). METHODS:The short-term st...

journal_title：Current medical research and opinion

authors： Newcomer JW,Eriksson H,Zhang P,Weiller E,Weiss C

更新日期：2018-12-01 00:00:00