Epidermal growth factor rapidly impairs activation of p34cdc2 protein kinase in HeLa cells at the G2-M boundary.

abstract：:The presence of inflammatory cells and their products in the tumor microenvironment plays a crucial role in the pathogenesis of a tumor. Releasing the cytokines from a host in response to infection and inflammation can inhibit tumor growth and progression. However, tumor cells can also respond to the host cytokines wi...

journal_title：Journal of cellular physiology

authors： Shadpour P,Zamani M,Aghaalikhani N,Rashtchizadeh N

更新日期：2019-02-18 00:00:00

abstract：:The molecular weight of rat basic fibroblast growth factor is predicted to be 18 kDa when the amino acid sequence is read from the single AUG initiation codon found in the cDNA. DNA sequencing upstream of this AUG codon indicated, however, that there was an extended open reading frame. In vitro translation of the rat ...

journal_title：Journal of cellular physiology

authors： Powell PP,Klagsbrun M

更新日期：1991-08-01 00:00:00

abstract：:We can distinguish two classes of membrane transport changes in cultured cells: (a) growth-rate contingent changes are those which occur in coordination with the onset of density-dependent inhibition of growth; (b) transformation-specific changes are those which occur when cells become transformed, and which can be de...

journal_title：Journal of cellular physiology

authors： Weber MJ,Hale AH,Yau TM,Buckman T,Johnson M,Brady TM,LaRossa DD

更新日期：1976-12-01 00:00:00

abstract：:During human pregnancy, the trophoblast develops from differentiation of cytotrophoblast cells into an endocrine active syncytiotrophoblast. In culture, isolated mononuclear cytotrophoblasts aggregate and then fuse to form a syncytium, reproducing the in vivo process. In this study, we examined the effect of low oxyge...

journal_title：Journal of cellular physiology

authors： Alsat E,Wyplosz P,Malassiné A,Guibourdenche J,Porquet D,Nessmann C,Evain-Brion D

更新日期：1996-08-01 00:00:00

abstract：:Cancer stem cells (CSCs), also called Tumor Initiating Cells (TICs), can be defined as cancer cells that are present within solid tumors or hematological cancers, which have characteristics associated with normal stem cells, but which can give rise to all cell types found in a particular cancer sample. CSCs, therefore...

journal_title：Journal of cellular physiology

authors： Brinckerhoff CE

更新日期：2017-10-01 00:00:00

abstract：:Phosphodiesterase 5A (PDE5A) specifically degrades the ubiquitous second messenger cGMP and experimental and clinical data highlight its important role in cardiac diseases. To address PDE5A role in cardiac physiology, three splice variants of the PDE5A were cloned for the first time from mouse cDNA library (mPde5a1, m...

journal_title：Journal of cellular physiology

authors： Campolo F,Zevini A,Cardarelli S,Monaco L,Barbagallo F,Pellegrini M,Cornacchione M,Di Grazia A,De Arcangelis V,Gianfrilli D,Giorgi M,Lenzi A,Isidori AM,Naro F

更新日期：2018-01-01 00:00:00

abstract：:The in vitro culture of porcine bone marrow-derived mesenchymal stem cells (MSCs) was used for the investigation of adult stem cell biology. Isolated porcine MSCs possessed the ability to proliferate extensively in an antioxidants-rich medium containing 5% fetal bovine serum (FBS). Greater than 40 serial MSC passages ...

journal_title：Journal of cellular physiology

authors： Vacanti V,Kong E,Suzuki G,Sato K,Canty JM,Lee T

更新日期：2005-11-01 00:00:00

abstract：:Membrane vesicles derived principally from the plasma membrane and endoplasmic reticulum of mouse 3T3 cells transformed by Simian virus 40 take up alpha-aminoisobutyric acid (AIB) and phosphate (Pi). When NaCl is added simultaneously with AIB or Pi, uptake rises two- to three-times above the equilibrium to accumulate ...

journal_title：Journal of cellular physiology

authors： Nilsen-Hamilton M,Hamilton RT

更新日期：1976-12-01 00:00:00

abstract：:Lung cancer is a main cause of death all over the world with a high incidence rate. Metastasis into neighboring and distant tissues as well as resistance of cancer cells to chemotherapy demand novel strategies in lung cancer therapy. Curcumin is a naturally occurring nutraceutical compound derived from Curcuma longa (...

journal_title：Journal of cellular physiology

authors： Ashrafizadeh M,Najafi M,Makvandi P,Zarrabi A,Farkhondeh T,Samarghandian S

更新日期：2020-12-01 00:00:00

abstract：:Besides the nerve endings, the soma of trigeminal neurons also respond to membrane depolarizations with the release of neurotransmitters and neuromodulators in the extracellular space within the ganglion, a process potentially important for the cross-communication between neighboring sensory neurons. In this study, we...

journal_title：Journal of cellular physiology

authors： Sforna L,Franciolini F,Catacuzzeno L

更新日期：2019-07-01 00:00:00

abstract：:Hydrocortisone and dexamethasone produced a time-dependent increase [125I]epidermal growth factor [( 125I]EGF) binding in primary cultures of isolated rat hepatocytes. Maximally effective doses of glucocorticoids resulted in a 70-100% increase in binding. The effect was similar when hepatocytes were maintained on coll...

journal_title：Journal of cellular physiology

authors： Lin Q,Blaisdell J,O'Keefe E,Earp HS

更新日期：1984-06-01 00:00:00

abstract：:Primary porcine bronchial epithelial cells (PBECs) are an ideal model to study the molecular and pathogenic mechanisms of various porcine respiratory pathogens. However, the short lifespan of primary PBECs greatly limit their application. Here, we isolated and cultured primary PBECs and established immortalized PBECs ...

journal_title：Journal of cellular physiology

authors： Xie X,Gan Y,Pang M,Shao G,Zhang L,Liu B,Xu Q,Wang H,Feng Y,Yu Y,Chen R,Wu M,Zhang Z,Hua L,Xiong Q,Liu M,Feng Z

更新日期：2018-12-01 00:00:00

abstract：:There are two known phosphorylation-mediated inactivation mechanisms for TRPC3 channels. Protein kinase G (PKG) inactivates TRPC3 by direct phosphorylation on Thr-11 and Ser-263 of the TRPC3 proteins, and protein kinase C (PKC) inactivates TRPC3 by phosphorylation on Ser-712. In the present study, we explored the rela...

journal_title：Journal of cellular physiology

authors： Kwan HY,Huang Y,Yao X

更新日期：2006-05-01 00:00:00

abstract：:Glucose and tumor necrosis factor-alpha (TNFalpha) concentrations are elevated in diabetes. Both of these factors correlate with diabetic vasculopathy and endothelial cell apoptosis, yet their combined effects have not been measured. We have previously shown that the angiogenic growth factor fibroblast growth factor-2...

journal_title：Journal of cellular physiology

authors： Clyne AM,Zhu H,Edelman ER

更新日期：2008-10-01 00:00:00

abstract：:A mutant (A204) of Chinese hamster ovary cells (CHO-K1), which is deficient in dihydroorotate (DHO) dehydrogenase (E.C. 1.3,3.1) activity, has been isolated by a replica plating procedure. The mutant does not show a requirement for exogenously added pyrimidines. Examination of intact cells shows that the mutant accumu...

journal_title：Journal of cellular physiology

authors： Stamato TD,Patterson D

更新日期：1979-03-01 00:00:00

abstract：:The biological roles of sphingosine 1-phosphate (S1P) and S1P receptors (S1PRs) have been broadly investigated. However, at present pathophysiological roles of S1P/S1PRs axis in liver fibrosis are not well defined. Here, we investigated the functions of S1P/S1PRs axis in human hepatic stellate cells (HSC) line, LX-2 c...

journal_title：Journal of cellular physiology

authors： Liu X,Yue S,Li C,Yang L,You H,Li L

更新日期：2011-09-01 00:00:00

abstract：:Lactoferrin, a single chain cationic glycoprotein, present in the secondary granules of neutrophils, acts as a negative feedback regulator of myelopoiesis. Specific receptors for lactoferrin were detected on the surface of different hematopoietic cell types. The influence of lactoferrin on cell growth in culture has b...

journal_title：Journal of cellular physiology

authors： Garré C,Bianchi-Scarrá G,Sirito M,Musso M,Ravazzolo R

更新日期：1992-12-01 00:00:00

abstract：:The effect of hypoxia on 3T3-L1 cell differentiation was examined in confluent cultures incubated with differentiation medium (DM) followed by incubation in growth medium (GM). Control cultures remained in GM throughout the incubation period. Eight days after the incubation, cells were assessed either for changes in m...

journal_title：Journal of cellular physiology

authors： Sahai A,Patel MS,Zavosh AS,Tannen RL

更新日期：1994-07-01 00:00:00

abstract：:The cholinergic system plays a crucial role in modulating in the central nervous system physiological responses such as neurogenesis, neuronal differentiation, synaptic plasticity, and neuroprotection. In a recent study, we showed that Oxotremorine-M, a non-selective muscarinic acetylcholine receptor agonist, is able ...

journal_title：Journal of cellular physiology

authors： Frinchi M,Scaduto P,Cappello F,Belluardo N,Mudò G

更新日期：2018-08-01 00:00:00

abstract：:Cancer cells acquire dysregulated gene expression to establish specific transcriptional dependencies and their underlying mechanisms that are ultimately responsible for this addictions have not been fully elucidated. Glucose-regulated protein 78 (GRP78) is a stress-inducible, multifunctional, prosurvival, endoplasmic ...

journal_title：Journal of cellular physiology

authors： Gopal U,Pizzo SV

更新日期：2020-08-31 00:00:00

abstract：:The increasing rate of mortality and morbidity because of cardiac diseases has called for efficient therapeutic needs. With the advancement in cell-based therapies, stem cells are abundantly studied in this area. Nearly, all sources of stem cells are experimented to treat cardiac injuries. Tissue engineering has also ...

journal_title：Journal of cellular physiology

authors： Pooria A,Pourya A,Gheini A

更新日期：2019-02-27 00:00:00

abstract：:There is evidence that cadmium can initiate carcinogenesis. However, the underlying mechanisms remain unknown. There is also evidence that moderate centrosome amplification can initiate tumorigenesis. The present study investigated whether cadmium could trigger cell centrosome amplification, and examined the underlyin...

journal_title：Journal of cellular physiology

authors： Zhang RK,Wang P,Lu YC,Lang L,Wang L,Lee SC

更新日期：2019-08-01 00:00:00

abstract：:Smooth muscle responds to IP(3)-generating agonists by producing Ca(2+) waves. Here, the mechanism of wave progression has been investigated in voltage-clamped single smooth muscle cells using localized photolysis of caged IP(3) and the caged Ca(2+) buffer diazo-2. Waves, evoked by the IP(3)-generating agonist carbach...

journal_title：Journal of cellular physiology

authors： McCarron JG,Chalmers S,MacMillan D,Olson ML

更新日期：2010-08-01 00:00:00

abstract：:The level of poly A+ RNA in growing cultures of human diploid fibroblasts is 1.8-fold times greater than in resting cultures. The level of functional ribosomes in growing cultures is 2.8 times that in resting cultures. Since transit times are similar in both types of cells, it can be concluded that the rate of protein...

journal_title：Journal of cellular physiology

authors： Meedel TH,Levine EM

更新日期：1978-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are noncoding RNA molecules that regulate gene expression at the post-transcriptional level to cause translational repression or degradation of targets. The profiles of miRNAs across stages of lactation in small ruminant species such as dairy goats is unknown. A small RNA library was constructed usi...

journal_title：Journal of cellular physiology

authors： Wang H,Shi H,Luo J,Yi Y,Yao D,Zhang X,Ma G,Loor JJ

更新日期：2017-05-01 00:00:00

abstract：:The role of calmodulin (CaM) in modulating calcium (Ca) uptake by sarcoplasmic reticulum (SR) of vascular smooth muscle was studied in saponin skinned strips of rat caudal artery. Exogenous CaM concentrations ranging from 0.3-1.8 microM did not statistically change the steady state MgATP-dependent Ca content, the MgAT...

journal_title：Journal of cellular physiology

authors： Stout MA,Silver PJ

更新日期：1992-10-01 00:00:00

abstract：:Arachidonic acid when added simultaneously with the chemotactic peptide formyl-methionyl-leucyl-phenylalanine (f-Met-Leu-Phe) inhibits the ability of the latter to initiate several but not all of its effects on rabbit peritoneal neutrophils. Stimulated neutrophil aggregation, calcium uptake, and increases in the stead...

journal_title：Journal of cellular physiology

authors： Naccache PH,Molski TF,Volpi M,Mackin WM,Becker EL,Sha'afi RI

更新日期：1983-06-01 00:00:00

abstract：:The development and progression of hepatocellular carcinoma (HCC) have been associated with abnormal cellular metabolism. Gene Expression Profiling Interactive Analysis RNA sequencing data revealed caveolin-1 (CAV-1) and hexokinase 2 (HK2) messenger RNA (mRNA) were significantly upregulated in human HCC compared with ...

journal_title：Journal of cellular physiology

authors： Chai F,Li Y,Liu K,Li Q,Sun H

更新日期：2019-02-01 00:00:00

abstract：:Bladder cancer (BCa) is one of the most prevalent cancers of the urinary system worldwide. Accumulating evidence suggests that long noncoding RNAs (lncRNAs) perform a vital function in the pathogenesis and progression of BCa. In the current study, we identified a novel lncRNA OXCT1-AS1 and investigated its role and po...

journal_title：Journal of cellular physiology

authors： Chen JB,Zhu YW,Guo X,Yu C,Liu PH,Li C,Hu J,Li HH,Liu LF,Chen MF,Chen HQ,Xiong-Bing Z

更新日期：2019-08-01 00:00:00

abstract：:Recent studies have suggested that interferons (IFNs) have an antifibrotic effect in the liver independent of their antiviral effect although its detailed mechanism remains largely unknown. Some microRNAs have been reported to regulate pathophysiological activities of hepatic stellate cells (HSCs). We performed analys...

journal_title：Journal of cellular physiology

authors： Sekiya Y,Ogawa T,Iizuka M,Yoshizato K,Ikeda K,Kawada N

更新日期：2011-10-01 00:00:00