Cell surface GRP78 signaling: An emerging role as a transcriptional modulator in cancer.


:Cancer cells acquire dysregulated gene expression to establish specific transcriptional dependencies and their underlying mechanisms that are ultimately responsible for this addictions have not been fully elucidated. Glucose-regulated protein 78 (GRP78) is a stress-inducible, multifunctional, prosurvival, endoplasmic reticulum chaperone in the heat shock protein 70 family. Expression of cell surface GRP78 (CS-GRP78) is associated with increased malignant behavior and resistance to chemotherapy and radiotherapy by endowing various cancer cells with increased proliferative ability, altered metabolism, improved survival, and augmented invasive and metastatic potential. Emerging evidence has highlighted an unusual role of CS-GRP78 in regulating transcription factors (TFs) by mediating various signaling pathways involved in malignant transformation, metabolic reprogramming, and tumor progression. During the last decade, we targeted CS-GRP78 with C38 monoclonal antibody (C38 Mab) in numerous studies, which have highlighted the epigenetic interplay between CS-GRP78 and various TFs including c-MYC, Yes-associated protein/transcriptional coactivator with PDZ-binding motif, c-Fos, and histone acetylation to potentiate subsequent modulation of tumorigenesis, invasion, and metastasis. Here, we summarize the current state of knowledge about the role of CS-GRP78 in cancer development and progression, including epigenetic regulation and sheds light on CS-GRP78 as vulnerable target for cancer therapy. Overall, this review focuses on the mechanisms of TFs that are behind the transcriptional dysregulation in cancer and lays the groundwork for rational therapeutic use of C38 Mab based on CS-GRP78 biology.


J Cell Physiol


Gopal U,Pizzo SV




Has Abstract


2020-08-31 00:00:00






  • Transient receptor potential vanilloid 4 channel deletion regulates pathological but not developmental retinal angiogenesis.

    abstract::Transient receptor potential vanilloid 4 (TRPV4) channels are mechanosensitive ion channels that regulate systemic endothelial cell (EC) functions such as vasodilation, permeability, and angiogenesis. TRPV4 is expressed in retinal ganglion cells, Müller glia, pigment epithelium, microvascular ECs, and modulates cell v...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Cappelli HC,Guarino BD,Kanugula AK,Adapala RK,Perera V,Smith MA,Paruchuri S,Thodeti CK

    更新日期:2020-10-20 00:00:00

  • Lipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion.

    abstract::The profiles of actions of lipoxin A4 (LXA4) and lipoxin B4 (LXB4), two lipoxygenase-derived eicosanoids, were examined with human neutrophils. At nanomolar concentrations, LXA4 and LXB4 each stimulated the release of [1-14C]arachidonic acid from esterified sources in neutrophils. Lipoxin-induced release of [1-14C]ara...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Nigam S,Fiore S,Luscinskas FW,Serhan CN

    更新日期:1990-06-01 00:00:00

  • Oxonol dyes as monitors of membrane potential: the effect of viruses and toxins on the plasma membrane potential of animal cells in monolayer culture and in suspension.

    abstract::Optical indicators of the cationic, cyanine and anionic oxonol classes were used to evaluate the plasma membrane potential of animal cells in suspension and in monolayer culture. The optical signals were calibrated by using diffusion potentials either of K+ (in the presence of valinomycin) or of H+ (in the presence of...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Bashford CL,Alder GM,Gray MA,Micklem KJ,Taylor CC,Turek PJ,Pasternak CA

    更新日期:1985-06-01 00:00:00

  • SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity.

    abstract::The tumor suppressor p53-related p73 shares significant amino-acid sequence identity with p53. Like p53, p73 recognizes canonical p53 DNA-binding sites and activates p53-responsive target genes and induces apoptosis. Moreover, SIRT1 binds to p53 while repressing the expression of their target genes. Here, we report th...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Dai JM,Wang ZY,Sun DC,Lin RX,Wang SQ

    更新日期:2007-01-01 00:00:00

  • Calcium sources used by post-natal human myoblasts during initial differentiation.

    abstract::Increases in cytoplasmic Ca(2+) are crucial for inducing the initial steps of myoblast differentiation that ultimately lead to fusion; yet the mechanisms that produce this elevated Ca(2+) have not been fully resolved. For example, it is still unclear whether the increase comes exclusively from membrane Ca(2+) influx o...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Arnaudeau S,Holzer N,König S,Bader CR,Bernheim L

    更新日期:2006-08-01 00:00:00

  • Effects of IGFBP3 gene silencing mediated inhibition of ERK/MAPK signaling pathway on proliferation, apoptosis, autophagy, and cell senescence in rats nucleus pulposus cells.

    abstract:OBJECTIVE:Disc degeneration is the common life-threatening disease characterized by flank pain. The gene expression of insulin-like growth factor binding protein 3 (IGFBP3) is increased in patients with disc degeneration, however, its mechanism is still unknown. This study aimed to investigate the influence of IGFBP3 g...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Chen G,Zhou X,Xu Z

    更新日期:2019-06-01 00:00:00

  • High expression of IMPACT protein promotes resistance to indoleamine 2,3-dioxygenase-induced cell death.

    abstract::Indoleamine 2,3-dioxygenase (IDO), a tryptophan degrading enzyme, is a potent immunomodulatory factor. IDO expression in fibroblasts selectively induces apoptosis in immune cells but not in primary skin cells. However, the mechanism(s) of this selective effect of IDO-induced low tryptophan environment is not elucidate...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Habibi D,Jalili RB,Forouzandeh F,Ong CJ,Ghahary A

    更新日期:2010-10-01 00:00:00

  • Mechanisms of cytosolic targeting of matrix metalloproteinase-2.

    abstract::Matrix metalloproteinase-2 (MMP-2) is best understood for its biological actions outside the cell. However, MMP-2 also localizes to intracellular compartments and the cytosol where it has several substrates, including troponin I (TnI). Despite a growing list of cytosolic substrates, we currently do not know the mechan...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Ali MA,Chow AK,Kandasamy AD,Fan X,West LJ,Crawford BD,Simmen T,Schulz R

    更新日期:2012-10-01 00:00:00

  • Dexamethasone interferes with osteoblasts formation during osteogenesis through altering IGF-1-mediated angiogenesis.

    abstract::Dexamethasone (Dex), a synthetic glucocorticoid (GC) with long-lasting treatment effects, has been proved to exert a modulatory effect on osteoblast proliferation and differentiation during embryonic osteogenesis. However, it is still controversial if Dex exposure influences endochondral ossification and the underlyin...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Xu S,Guo R,Li PZ,Li K,Yan Y,Chen J,Wang G,Brand-Saberi B,Yang X,Cheng X

    更新日期:2019-01-22 00:00:00

  • Stimulation of bone resorption and osteoclast clear zone formation by low pH: a time-course study.

    abstract::The significance of low pH-induced stimulation of osteoclastic bone resorption has recently been questioned following the finding that embryonic chick osteoclasts were only weakly stimulated by extremely low pH (6.5) and that the effect was transient, apparently due to cytotoxicity. Although low pH in the range 6.8-7....

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Murrills RJ,Stein LS,Dempster DW

    更新日期:1993-03-01 00:00:00

  • Irisin ameliorates angiotensin II-induced cardiomyocyte apoptosis through autophagy.

    abstract::Cardiac hypertrophy is the main cause of heart failure and sudden death in patients. But the pathogenesis is unclear. Angiotensin II may contribute to cardiac hypertrophy in response to pressure overload. In angiotensin II-treated cardiomyocytes, there is a larger cross-sectional area, more apoptosis cells, and a redu...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Li R,Wang X,Wu S,Wu Y,Chen H,Xin J,Li H,Lan J,Xue K,Li X,Zhuo C,He J,Tang CS,Jiang W

    更新日期:2019-08-01 00:00:00

  • Establishment of Four New Human Primary Cell Cultures from Chemo-Naïve Italian Osteosarcoma Patients.

    abstract::Osteosarcoma (OS) is a primary highly malignant tumor of bone, affecting predominately adolescents and young adults between 10 and 20 years of age. OS is characterized by an extremely aggressive clinical course, with a rapid development of metastasis to the lung and distant bones. ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Laschi M,Bernardini G,Geminiani M,Ghezzi L,Amato L,Braconi D,Millucci L,Frediani B,Spreafico A,Franchi A,Campanacci D,Capanna R,Santucci A

    更新日期:2015-11-01 00:00:00

  • Membrane bound and cellular cationic changes associated with insulin stimulation of cultured cells.

    abstract::Insulin was employed as a stimulant in our continuing investigations of the molecular mechanisms involved in the coordinate control of cellular metabolism and growth. Incubation of chicken embryo fibroblasts for 16 hours in media containing 0-0.1 U insulin/ml resulted in a 17-fold increase in the rate of 3H-thymidine ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Sanui H,Rubin AH

    更新日期:1978-09-01 00:00:00

  • Transmembrane potential responses during HL-60 promyelocyte differentiation.

    abstract::Myeloid cells, including granulocytes and monocyte/macrophages, are important in disease-associated inflammatory reactions. These cells come from a common progenitor, the promyelocyte. The human promyelocytic cell line, HL-60, can be induced to terminally differentiate into granulocytes or monocyte/ macrophages in a c...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Brent LH,Rubenstein B,Gong QH,Wieland SJ

    更新日期:1996-07-01 00:00:00

  • Innate-immune responses of tilapia (Oreochromis mossambicus) exposure to acute cold stress.

    abstract::In this present study, Oreochromis mossambicus tilapia were transferred to cold water at 12°C for various time intervals (1, 4, 8, 24, and 48 hr) and its innate immune response was analyzed by studying cellular and humoral parameters. In vivo, alternative complement pathway activity in blood plasma was rapidly increas...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Velmurugan BK,Chan CR,Weng CF

    更新日期:2019-02-11 00:00:00

  • Fibronectin Fiber Extension Decreases Cell Spreading and Migration.

    abstract::The extracellular matrix (ECM) is present in a range of molecular conformations and intermolecular arrangements. Fibronectin (Fn) molecules that constitute fibers within the ECM can exist in a variety of conformations that result from both mechanical stress and chemical factors such as allosteric binding partners. The...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Hubbard B,Buczek-Thomas JA,Nugent MA,Smith ML

    更新日期:2016-08-01 00:00:00

  • C-C motif chemokine ligand 2 regulates lps-induced inflammation and ER stress to enhance proliferation of bovine endometrial epithelial cells.

    abstract::Chemokines play an important role in regulating the complex immune system at the maternal-fetal interface during pregnancy. Among various chemokines, CC motif chemokine ligand 2 (CCL2) plays a role in the recruitment of immune regulatory cells to implantation sites within the endometrium. In cattle, CCL2 is abundantl...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Lim W,Bae H,Bazer FW,Kim SM,Song G

    更新日期:2018-04-01 00:00:00

  • Cellular control of ornithine decarboxylase activity by its antizyme.

    abstract::Conditions have been established under which the antizyme of ornithine decarboxylase (E.C., L-ornithine carboxy-lyase, ODC) a non-competitive protein inhibitor of ODC, can be detected in cells in response to as little as 10(-7) M putrescine. The maintenance of intracellular antizyme activity depends upon the ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Heller JS,Canellakis ES

    更新日期:1981-05-01 00:00:00

  • Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity.

    abstract::Cancer cells in poorly vascularized solid tumors are constantly or intermittently exposed to stressful microenvironments, including glucose deprivation, hypoxia, and other forms of nutrient starvation. These tumor-specific conditions, especially glucose deprivation, activate a signaling pathway called the unfolded pro...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Kim JY,Hwang JH,Cha MR,Yoon MY,Son ES,Tomida A,Ko B,Song SW,Shin-ya K,Hwang YI,Park HR

    更新日期:2010-07-01 00:00:00

  • Corneal endothelium tissue engineering: An evolution of signaling molecules, cells, and scaffolds toward 3D bioprinting and cell sheets.

    abstract::Cornea is an avascular and transparent tissue that focuses light on retina. Cornea is supported by the corneal-endothelial layer through regulation of hydration homeostasis. Restoring vision in patients afflicted with corneal endothelium dysfunction-mediated blindness most often requires corneal transplantation (CT), ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Khalili M,Asadi M,Kahroba H,Soleyman MR,Andre H,Alizadeh E

    更新日期:2020-10-08 00:00:00

  • Cell-cycle-dependent turnover of P-glycoprotein in multidrug-resistant cells.

    abstract::Regulation of P-glycoprotein (Pgp) expression occurs not only at the DNA and mRNA level but also at the protein level. We showed previously that Pgp was stabilized when multidrug-resistant CH(R)C5 and SKVCR 2.0 ovarian cell lines were subjected to serum-starved or high-cell-density growth conditions, whereas Pgp turno...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Zhang W,Ling V

    更新日期:2000-07-01 00:00:00

  • Fibronectin promotes the elongation of microvessels during angiogenesis in vitro.

    abstract::Fibronectin is a component of the extracellular matrix of developing microvessels whose role in angiogenesis is poorly understood. This study evaluated the effect of plasma fibronectin on angiogenesis in serum-free collagen gel culture of rat aorta. Aortic explants embedded in collagen gels generated microvascular out...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Nicosia RF,Bonanno E,Smith M

    更新日期:1993-03-01 00:00:00

  • Is unconventional secretion inhibited during cell division by Cdk1 activity?

    abstract::A process of unconventional secretion that is dependent on the Golgi stacking protein GRASP and multiple components of the autophagy machinery has recently been documented for several cytoplasmic and membrane protein. Classical secretion via the exocytic pathway is inhibited during cell division in animal cells, as ke...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Tang BL

    更新日期:2013-05-01 00:00:00

  • Diminished calcium influx in lectin-stimulated T cells from old mice.

    abstract::T lymphocytes from aged donors function poorly, but the biochemical basis for the defect remains uncertain. We tested the hypothesis that T cells from old mice had a diminished ability to transmit extracellular signals into the cytoplasm, by measuring intracellular free calcium concentrations (Cai) in T cells stimulat...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Miller RA,Jacobson B,Weil G,Simons ER

    更新日期:1987-08-01 00:00:00

  • Regulation of platelet heparanase during inflammation: role of pH and proteinases.

    abstract::Heparan sulfate is rapidly degraded by an endoglycosidase (heparanase) secreted by activated platelets. Since the cleavage and release of heparan sulfate would profoundly alter the local physiology of the endothelium, platelet heparanase activity should be tightly regulated. Consistent with this hypothesis, platelet h...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Ihrcke NS,Parker W,Reissner KJ,Platt JL

    更新日期:1998-06-01 00:00:00

  • Transcriptome analysis reveals GPNMB as a potential therapeutic target for gastric cancer.

    abstract::Gastric cancer has the fifth highest incidence of disease and is the third leading cause of cancer-associated mortality in the world. The etiology of gastric cancer is complex and needs to be fully elucidated. Thus, it is necessary to explore potential pathogenic genes and pathways that contribute to gastric cancer. G...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Ren F,Zhao Q,Liu B,Sun X,Tang Y,Huang H,Mei L,Yu Y,Mo H,Dong H,Zheng P,Mi Y

    更新日期:2020-03-01 00:00:00

  • Melatonin-induced increase of lipid droplets accumulation and in vitro maturation in porcine oocytes is mediated by mitochondrial quiescence.

    abstract::Melatonin, the major pineal secretory product, has a significant impact on the female reproductive system. Recently, the beneficial effects of melatonin on mammalian oocyte maturation and embryonic development have drawn increased attention. However, the exact underlying mechanisms remain to be fully elucidated. This ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: He B,Yin C,Gong Y,Liu J,Guo H,Zhao R

    更新日期:2018-01-01 00:00:00

  • C6 ceramide motivates the anticancer sensibility induced by PKC412 in preclinical head and neck squamous cell carcinoma models.

    abstract::The purpose of this study was to evaluate the anti-head and neck squamous cell carcinoma (anti-HNSCC) cell activity by C6 ceramide and multikinase inhibitor PKC412. Experiments were performed on HNSCC cell lines (SQ20B and SCC-9) and primary human oral carcinoma cells. Results showed that PKC412 inhibited HNSCC cell p...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Zhu Y,Wang C,Zhou Y,Ma N,Zhou J

    更新日期:2018-12-01 00:00:00

  • The ultrastructure of MCF-10A acini.

    abstract::MCF-10A human mammary epithelial cells cultured inside reconstituted basement membrane form acini that resemble the acinar structures of mammary lobules. This three-dimensional culture system has been used for identifying and characterizing the signal transduction pathways controlling cell proliferation and death, and...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Underwood JM,Imbalzano KM,Weaver VM,Fischer AH,Imbalzano AN,Nickerson JA

    更新日期:2006-07-01 00:00:00

  • Studies on the regulation of the three enzymes of the Leloir pathway in cultured mammalian cells. II. A search for quantitative interrelationships between the three enzyme activities.

    abstract::Studies on a normal human diploid cell strain revealed that the specific activity of the cell protein, for each of the three enzymes of the Leloir pathway, changed significantly as the cells grew. The kinetics of change in specific activity varied according to the enzyme being studied, and the kinetics for each enzyme...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Stern ES,Krooth RS

    更新日期:1975-08-01 00:00:00