Three forms of rat basic fibroblast growth factor are made from a single mRNA and localize to the nucleus.

abstract：:Studies on a normal human diploid cell strain revealed that the specific activity of the cell protein, for each of the three enzymes of the Leloir pathway, changed significantly as the cells grew. The kinetics of change in specific activity varied according to the enzyme being studied, and the kinetics for each enzyme...

journal_title：Journal of cellular physiology

authors： Stern ES,Krooth RS

更新日期：1975-08-01 00:00:00

abstract：:Autophagy is considered as an important mechanism for maintaining homeostasis and responsible for the degradation of superfluous or potentially toxic components and organelles. Autophagy impairment is associated with a number of pathological conditions, such as aging, neurological disorders, cancer, and infection. Aut...

journal_title：Journal of cellular physiology

authors： Ashrafizadeh M,Ahmadi Z,Farkhondeh T,Samarghandian S

更新日期：2020-04-01 00:00:00

abstract：:We have studied the transcriptional activity, steady-state mRNA levels, and steady-state protein levels of the c-myc and transferrin receptor (TfR) genes in murine M1 myeloid leukemia cells arrested in G1 phase of the cell cycle by different methods. When cells are growth-arrested by density inhibition, a technique th...

journal_title：Journal of cellular physiology

authors： Neckers LM,Tsuda H,Weiss E,Pluznik DH

更新日期：1988-05-01 00:00:00

abstract：:Adult bone marrow mesenchymal stromal cells (BMSCs) can easily be differentiated into a variety of cells. In vivo transplantation of BMSCs-differentiated cells has had limited success, suggesting that these cells may not be fully compatible with the cells they are intended to replace in vivo. We investigated the struc...

journal_title：Journal of cellular physiology

authors： Gruia AT,Suciu M,Barbu-Tudoran L,Azghadi SM,Cristea MI,Nica DV,Vaduva A,Muntean D,Mic AA,Mic FA

更新日期：2016-04-01 00:00:00

abstract：:Increasing evidence has demonstrated that abnormal expression of lncRNA is correlated with various malignant tumors, including hepatocellular carcinoma (HCC). Our current study was aimed to investigate the role of LINC00707 in HCC development. We observed that LINC00707 was upregulated in HCC cell lines compared with ...

journal_title：Journal of cellular physiology

authors： Wang J,Luo Z,Yao T,Li W,Pu J

更新日期：2019-05-01 00:00:00

abstract：:The development of acute pancreatitis (AP) is triggered by acinar events, but the subsequent extra-acinar events, particularly a distinct immune response, appear to determine its severity. Cytokines modulate this immune response and are derived not only from immunocytes but also from pancreatic acinar cells. We studie...

journal_title：Journal of cellular physiology

authors： Gallmeier E,Schäfer C,Moubarak P,Tietz A,Plössl I,Huss R,Göke B,Wagner AC

更新日期：2005-04-01 00:00:00

abstract：:Differentiation of 3T3-L1 adipocytes, monitored by accumulation of neutral lipid and by increase in alpha-glycerophosphate dehydrogenase activity, is accelerated by incubation of confluent 3T3-L1 fibroblasts in media containing insulin, dexamethasone and isobutylmethylxantine (IBMX). IBMX inhibits cyclic nucleotide ph...

journal_title：Journal of cellular physiology

authors： Elks ML,Manganiello VC

更新日期：1985-08-01 00:00:00

abstract：:Differentiated embryo chondrocyte 1 (DEC1), a member of basic-helix-loop-helix transcription factor Bhlhe40, also called stimulated by retinoic acid 13, STRA13, plays an important role in the regulation of adipogenesis, tumorigenesis, peripheral circadian output, response to hypoxia, and development of metabolic syndr...

journal_title：Journal of cellular physiology

authors： Huang Y,Lai X,Hu L,Lei C,Lan X,Zhang C,Ma Y,Zheng L,Bai YY,Lin F,Chen H

更新日期：2018-12-01 00:00:00

abstract：:In the present study, we have employed a unique breast cancer cell line (Met-1, which was derived from a high metastatic potential tumor in transgenic mice expressing polyomavirus middle T oncogene) to study the role of CD44 variant isoform(s) in the regulation of metastatic breast tumor cell behavior. The results of ...

journal_title：Journal of cellular physiology

authors： Bourguignon LY,Gunja-Smith Z,Iida N,Zhu HB,Young LJ,Muller WJ,Cardiff RD

更新日期：1998-07-01 00:00:00

abstract：:Rb2/p130 tumor suppressor protein regulates cell cycle progression primarily through interactions with members of the E2F family of transcription factors and repression of the transactivation of E2F target genes. In ATRA sensitive ovarian carcinoma CA-OV3 cells, a dramatic increase in Rb2/p130 protein mediates growth ...

journal_title：Journal of cellular physiology

authors： Fields AL,Soprano DR,Soprano KJ

更新日期：2008-10-01 00:00:00

abstract：:Retinopathy has become one of the major factors that lead to blindness worldwide. Although many clinical therapies are concerned about such disease, most of them focus on symptoms alleviation. In this study, we aim to investigate whether coculture retinal stem cells (RSCs) with bone marrow mesenchymal stem cells trans...

journal_title：Journal of cellular physiology

authors： Ma QQ,Liu FY,Shi M,Sun CH,Tan Z,Chang XD,Li QP,Feng ZC

更新日期：2019-11-01 00:00:00

abstract：:Earlier studies in multiple epithelia have shown that cell-cell actin-based adherens junction (AJ) dynamics are regulated, at least in part, by the interplay of kinases and phosphatases that determines the intracellular phosphoprotein content. Yet it is virtually unknown regarding the role of protein kinases in Sertol...

journal_title：Journal of cellular physiology

authors： Lee NP,Cheng CY

更新日期：2005-02-01 00:00:00

abstract：:Recent studies have indicated that endoplasmic reticulum stress, the unfolded protein response activation and altered GRP78 expression can play an important role in a variety of tumors development and progression. Very recently we reported for the first time that GRP78 is increased in endometrial tumors. However, whet...

journal_title：Journal of cellular physiology

authors： Calì G,Insabato L,Conza D,Bifulco G,Parrillo L,Mirra P,Fiory F,Miele C,Raciti GA,Di Jeso B,Terrazzano G,Beguinot F,Ulianich L

更新日期：2014-10-01 00:00:00

abstract：:Butyrate and acetate are bacterial metabolites present in the large intestine lumen. Although butyrate is well known to inhibit the in vitro proliferation of human colon carcinoma cells in a process involving the hyperacetylation of specific nuclear histones, little is known about the possible link between butyrate me...

journal_title：Journal of cellular physiology

authors： Andriamihaja M,Chaumontet C,Tome D,Blachier F

更新日期：2009-01-01 00:00:00

abstract：:Hyperinsulinemia is a likely cause of the increased cancer incidence and mortality in diabetic patients, but its role is difficult to define in vivo. Previous in vitro studies testing the mitogenic potential of insulin and its analogs provided incomplete and sometimes contradictory results. To better evaluate cancer c...

journal_title：Journal of cellular physiology

authors： Sciacca L,Cassarino MF,Genua M,Vigneri P,Giovanna Pennisi M,Malandrino P,Squatrito S,Pezzino V,Vigneri R

更新日期：2014-11-01 00:00:00

abstract：:NGF appears to be involved in spermatogenesis. However, mice lacking NGF or TrkA genes do not survive more than a few days whereas p75(NTR) knockout mice are viable and fertile. Therefore, we addressed the effect of betaNGF on spermatogenesis by using the systems of rat germ cell culture we established previously. bet...

journal_title：Journal of cellular physiology

authors： Perrard MH,Vigier M,Damestoy A,Chapat C,Silandre D,Rudkin BB,Durand P

更新日期：2007-01-01 00:00:00

abstract：:Osteoclasts are responsible for bone resorption during the process of bone remodeling. Increased osteoclast numbers and bone resorption activity are the main factors contributing to bone loss-related diseases such as osteoporosis. Therefore, modulating the formation and function of osteoclasts is critical for the effe...

journal_title：Journal of cellular physiology

authors： Guo Q,Cao Z,Wu B,Chen F,Tickner J,Wang Z,Qiu H,Wang C,Chen K,Tan R,Gao Q,Xu J

更新日期：2018-01-01 00:00:00

abstract：:The transient nuclear localization of metallothionein during cell growth and differentiation may be related to the increased requirement of zinc for DNA synthesis, activation of metalloenzymes, and transcription factors. Treatment of 3T3-L1 fibroblasts with aphidicolin, an inhibitor of nuclear DNA synthesis, caused a ...

journal_title：Journal of cellular physiology

authors： Apostolova MD,Cherian MG

更新日期：2000-05-01 00:00:00

abstract：:Glucose deprivation, a pathophysiological cell condition, causes up-regulation of GRP78 and induction of etoposide resistance in human cancer cells. The induction of drug resistance can be partly explained by the fact that GRP78 can block activation of caspase-7 induced by treatment with etoposide. Therefore, downregu...

journal_title：Journal of cellular physiology

authors： Hwang JH,Kim JY,Cha MR,Ryoo IJ,Choo SJ,Cho SM,Tsukumo Y,Tomida A,Shin-Ya K,Hwang YI,Yoo ID,Park HR

更新日期：2008-04-01 00:00:00

abstract：:miR-142a-5p plays critical roles in multiple biological processes and diseases, such as inflammation and tumorigenesis. However, it remains to be explored if and how miR-142a-5p contributes to osteoblast differentiation. In this study, our results showed that miR-142a-5p was highly expressed in bone tissue of mice and...

journal_title：Journal of cellular physiology

authors： Yuan H,Li M,Feng X,Zhu E,Wang B

更新日期：2021-03-01 00:00:00

abstract：:Myeloid cells, including granulocytes and monocyte/macrophages, are important in disease-associated inflammatory reactions. These cells come from a common progenitor, the promyelocyte. The human promyelocytic cell line, HL-60, can be induced to terminally differentiate into granulocytes or monocyte/ macrophages in a c...

journal_title：Journal of cellular physiology

authors： Brent LH,Rubenstein B,Gong QH,Wieland SJ

更新日期：1996-07-01 00:00:00

abstract：:Several organic cations are actively transported by proximal renal tubules by mediated processes across both the apical and basolateral cell membranes. In order to evaluate this transport system in a cultured renal epithelium, uptake of 3H-tetraethylammonium (TEA) across the apical membrane was measured in LLCPK1 cell...

journal_title：Journal of cellular physiology

authors： McKinney TD,DeLeon C,Speeg KV Jr

更新日期：1988-12-01 00:00:00

abstract：:Recently, after the identification of ferritin light chain (L-ferritin) gene and protein over-expression in human metastatic melanoma cells, we engineered, starting from the LM metastatic melanoma cell line, clones in which L-ferritin gene expression was down-regulated by the stable expression of a specific antisense ...

journal_title：Journal of cellular physiology

authors： Maresca V,Flori E,Cardinali G,Briganti S,Lombardi D,Mileo AM,Paggi MG,Picardo M

更新日期：2006-03-01 00:00:00

abstract：:The stroma-vascular fraction (SVF) of human adipose tissue has recently been described to be composed of endothelial cells identified as CD34+/CD31+ cells, infiltrated/resident macrophages defined as CD14+/CD31+ cells, and a new cell population characterized as CD34+/CD31- cells. To elucidate the cell identity of the ...

journal_title：Journal of cellular physiology

authors： Sengenès C,Lolmède K,Zakaroff-Girard A,Busse R,Bouloumié A

更新日期：2005-10-01 00:00:00

abstract：:Sterol regulatory element binding protein 1 (SREBP-1) is well-known as the master regulator of lipogenesis in rodents. Acyl-CoA synthetase short-chain family member 2 (ACSS2) plays a key role in lipogenesis by synthesizing acetyl-CoA from acetate for lipogenesis. ATP citrate lyase (ACLY) catalyzes the conversion of ci...

journal_title：Journal of cellular physiology

authors： Xu H,Luo J,Ma G,Zhang X,Yao D,Li M,Loor JJ

更新日期：2018-02-01 00:00:00

abstract：:The differentiation of human keratinocytes in most culture systems is incomplete; e.g., lamellar bodies, the characteristic lipid-delivery organelles of epidermis, are not present. Moreover, their lipid profile does not reflect the distinctive composition found in cornifying epidermis. In contrast, keratinocytes that ...

journal_title：Journal of cellular physiology

authors： Williams ML,Brown BE,Monger DJ,Grayson S,Elias PM

更新日期：1988-07-01 00:00:00

abstract：:Lung squamous cell carcinoma (LSCC) is a common cancer worldwide, and this study aimed to investigate the key regulatory networks and prognostic indicators of LSCC. MicroRNA (miRNA)/messenger RNA (mRNA) sequencing and DNA methylation data were obtained from the Cancer Genome Atlas. Differentially expressed miRNAs (DEm...

journal_title：Journal of cellular physiology

authors： Shen Y,Pan X,Yang J

更新日期：2019-12-01 00:00:00

abstract：:A linear pathway of morphologically intermediate cells has been identified between the cuboidal epithelial stem cells and the doming alveolar-like cultures of the cell line Rat Mammary (Rama) 25 in the order: cuboidal----grey----dark----dark droplet cell----doming cultures. The overall process can be accelerated by di...

journal_title：Journal of cellular physiology

authors： Paterson FC,Rudland PS

更新日期：1985-09-01 00:00:00

abstract：:Restitution is a crucial event during the healing of superficial injury of the gastric mucosa involving epithelial cell sheet movement into the damaged area. We demonstrated that growth factors promote the restitution of human gastric epithelial cells. However, the intracellular signaling pathways that transmit extrac...

journal_title：Journal of cellular physiology

authors： Tétreault MP,Chailler P,Beaulieu JF,Rivard N,Ménard D

更新日期：2008-02-01 00:00:00

abstract：:The non-POU-domain-containing octamer binding protein (NONO; also known as p54nrb) has various nuclear functions ranging from transcription, RNA splicing, DNA synthesis and repair. Although tyrosine phosphorylation has been proposed to account for the multi-functional properties of p54nrb, direct evidence on p54nrb as...

journal_title：Journal of cellular physiology

authors： Lee AR,Hung W,Xie N,Liu L,He L,Dong X

更新日期：2017-04-01 00:00:00