Abstract：
OBJECTIVE:To determine if the endometrium of women exposed in utero to diethylstilbestrol (DES) demonstrates altered integrin expression compared with normal fertile controls. DESIGN:Case control study. Expression of eight integrins in 15 luteal phase endometrial biopsies from DES-exposed women were compared with 17 biopsies from age- and cycle day-matched controls. All patients were ovulatory. Endometrial biopsies were performed in the luteal phase, and all were histologically "in phase." SETTING:Infertility practice of an academic teaching hospital. PATIENTS:Women exposed in utero to DES and matched fertile controls. MAIN OUTCOME MEASURES:Intensity of endometrial integrin immunohistochemical staining by the semiquantitative HSCORE technique. RESULTS:Endometrial stroma of DES-exposed women demonstrated greater expression of the integrin subunits alpha 5 and alpha v. No differences were noted between DES-exposed women and fertile controls in the glandular epithelial expression of integrin subunits alpha 1, alpha 2, alpha 3, alpha 6, and alpha v nor the stromal staining of subunits of alpha 6 and beta 3. Epithelial expression of integrin subunits beta 3 and alpha 4, reliable luteal markers of uterine receptivity, were similar in DES and control patients. CONCLUSIONS:Markers of uterine receptivity are similar in the endometrium of women exposed in utero to DES compared with normal fertile controls. Interesting differences exist in stromal integrin expression between groups, though the significance of this finding is uncertain at present. It is unlikely that DES-exposed women have significantly altered endometrial function as a cause of infertility.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Castelbaum AJ,Sawin SW,Bellardo LJ,Lessey BAsubject
Has Abstractpub_date
1995-06-01 00:00:00pages
1217-21issue
6eissn
0015-0282issn
1556-5653pii
S0015-0282(16)57600-6journal_volume
63pub_type
杂志文章abstract：OBJECTIVE:To study birth outcomes among live born infants conceived by women who used infertility treatment. DESIGN:Population-based surveillance of women who recently delivered a live infant. SETTING:The birth outcomes among infants whose mothers used assisted reproductive technology (ART) or ovulation stimulation m...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2011.05.073
更新日期：2011-08-01 00:00:00
abstract：OBJECTIVE:To measure in vitro fertilization (IVF) outcomes following 24-chromosome single‒nucleotide-polymorphism (SNP)-based preimplantation genetic testing for aneuploidy (PGT-A) and euploid embryo transfer. DESIGN:Retrospective. SETTING:Fertility clinics and laboratory. PATIENT(S):Women 20-46 years of age undergo...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2018.03.026
更新日期：2018-07-01 00:00:00
abstract：:The role of the macromolecular constituents of human oviductal fluid (hOF) in reproductive physiology is poorly understood. Oviductal fluid contains proteins derived by transudation from serum and those synthesized and secreted by the tubal mucosa. In this communication, we describe purification of hOF-specific protei...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60433-8
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVE:To determine the influence of ejaculatory abstinence on within-subject semen parameters and DNA fragmentation. DESIGN:Prospective study. SETTING:Private infertility institute and university-based research laboratory. PATIENT(S):Sixteen consenting male volunteers undergoing infertility investigation. INTER...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.03.014
更新日期：2004-07-01 00:00:00
abstract：OBJECTIVE:To observe the ultrastructure of human oocytes at different maturity stages and morphologies before and after in vitro maturation. DESIGN:Case report. SETTING:University-based center for human reproduction. PATIENT(S):A 28-year-old patient with polycystic ovary syndrome undergoing IVM/IVF-ET treatment. IN...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.02.010
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVE:To review our experience with low-dose IM methotrexate for the medical management of ectopic pregnancy (EP). DESIGN:Retrospective chart review. SETTING:Magee-Womens Hospital, Pittsburgh, Pennsylvania. PATIENT(S):The first 50 women treated by the resident service in whom EP was diagnosed and treated with me...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)00284-7
更新日期：1997-10-01 00:00:00
abstract：:Appropriate endometrial maturation is of paramount importance to achieve reproductive success. Practical and ethical considerations require that in vitro methods be available to evaluate regulation of human endometrial function. Additionally, tissue complexity requires separation of individual cell populations. This r...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)53160-4
更新日期：1989-12-01 00:00:00
abstract：OBJECTIVE:To determine the prevalence of compound genetic abnormalities in patients who are carriers of cystic fibrosis mutations. DESIGN:Case report. SETTING:Tertiary referral center for male infertility. PATIENT(S):Between 2000 and 2005, 65 patients were identified to be carriers of cystic fibrosis transmembrane r...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.07.1537
更新日期：2007-06-01 00:00:00
abstract：:Standardized bilateral ovarian-adrenal vein catheterization was utilized to assess directly glandular steroid release in 60 androgenized women without evidence of a functional neoplasm. Testosterone (T), dihydrotestosterone (DHT), androstenedione (delta 4 A), dehydroepiandrosterone (DHEA), DHEA sulfate (DHEA-S), 17-hy...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)47960-4
更新日期：1984-07-01 00:00:00
abstract：OBJECTIVE:To compare basal gonadotropin and estradiol levels between women using acetaminophen versus those using no or other types of analgesics. DESIGN:Observational study. SETTING:Three IVF clinics in greater Boston. PATIENT(S):Three hundred eighty-six women accepted for their first IVF treatment who completed qu...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(98)00153-8
更新日期：1998-08-01 00:00:00
abstract：OBJECTIVE:To examine the results of 7 years of thawed ET during natural or controlled cycles using exogenous steroids. DESIGN:Retrospective evaluation to compare implantation and pregnancy rates with two protocols for transfer of cryopreserved-thawed pre-embryos. SETTING:Tertiary care academic center. PATIENTS:From ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)56943-x
更新日期：1994-09-01 00:00:00
abstract：OBJECTIVE:To examine the literature systematically in order to identify prospective comparative trials answering the following question: Is vitrification of human embryos associated with a higher postthawing survival rate as compared with slow freezing? DESIGN:Systematic review and meta-analysis. SETTING:University-b...
journal_title：Fertility and sterility
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.fertnstert.2007.06.010
更新日期：2008-07-01 00:00:00
abstract：OBJECTIVE:To describe a case of superior mesenteric vein thrombosis associated with IVF. DESIGN:Case report. SETTING:University teaching hospital. PATIENT(S):A 33-year-old female developed progressive abdominal pain several days after ET in her first IVF cycle. A computed tomography scan 12 days after ET showed a su...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.06.081
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:To further understand the association between semen quality and cancer risk by means of well defined semen parameters. DESIGN:Retrospective cohort study. SETTING:Not applicable. PATIENT(S):A total of 20,433 men who underwent semen analysis (SA) and a sample of 20,433 fertile control subjects matched by age...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2015.10.027
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVE:To evaluate the role of the environmental estrogens polychlorinated biphenyls (PCBs) and phthalate esters (PEs) as potential environmental hazards in the deterioration of semen parameters in infertile men without an obvious etiology. DESIGN:Randomized controlled study. SETTING:Tertiary care referral inferti...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(02)04389-3
更新日期：2002-12-01 00:00:00
abstract：OBJECTIVE:To investigate whether interleukin-1beta (IL-1beta) and interleukin-1alpha (IL-1alpha) affect the implantation rate of patients undergoing IVF-ET. DESIGN:Follicular fluid and serum were obtained on the day of hCG administration, the day of oocyte retrieval, and the day of embryo transfer. SETTING:Cellular i...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(98)00243-x
更新日期：1998-09-01 00:00:00
abstract：:To explore possible relationships between genital tract infections, sperm antibodies, and infertility, seminal fluid from 100 men was analyzed. Sperm antibodies, measured by an enzyme-linked immunosorbent assay, were detected in 14 of 29 men (48%) with culture-positive asymptomatic infections, 8 of 17 men (47%) with a...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)47484-4
更新日期：1983-12-01 00:00:00
abstract：:Semen analysis results obtained by a recently developed semi-automated Autosperm system (Amsaten N.V.S.A. Corp., De Pinte, Belgium) were compared with those obtained by the conventional, time-exposure photomicrographic, and automated CellSoft system (Cryo Resources Inc., New York, NY) analyses. The Autosperm system ei...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVE:To evaluate binding characteristics of a specific zona pellucida (ZP) protein 3 (ZP3) antiserum to human oocytes in order to determine its usefulness as a clinical marker for human ZP integrity and function and its correlation with IVF outcome. DESIGN:Prospectively designed, blinded, internally controlled st...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)58041-8
更新日期：1996-01-01 00:00:00
abstract：OBJECTIVE:To report on experience in the United States with a monophasic oral contraceptive (OC) containing 150 micrograms desogestrel and 30 micrograms ethinyl E2 (EE). The results of a multicenter evaluation of efficacy, cycle control, and safety over 6 months of exposure using a "Sunday start" regimen is evaluated. ...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/s0015-0282(16)57720-6
更新日期：1995-08-01 00:00:00
abstract：:Hormone patterns during 113 nonconceptual gonadotropin-induced cycles of 65 infertile anovulatory women were analyzed. All but one women ovulated, i.e., the ovulation rate was 98%. Signs of defective corpus luteum function were observed during 8 cycles, and anovulation occurred in 11 treatment cycles. The duration of ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)47115-3
更新日期：1983-06-01 00:00:00
abstract：OBJECTIVE:To introduce a combined laparovaginal metroplasty approach to the treatment of bicornuate uterus. DESIGN:Case report. SETTING:Private community hospital. PATIENT:A nulliparous patient with three recurrent spontaneous midtrimester abortions and a double uterus on hysterosalpingogram was evaluated laparoscop...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)58235-1
更新日期：1996-04-01 00:00:00
abstract：OBJECTIVE:To analyze the endometrium sonographically in patients undergoing controlled ovarian stimulation with clomiphene citrate (CC) in addition to menotropins to determine the significance of endometrial pattern and thickness on pregnancy rate (PR). DESIGN:A prospective study analyzing patients receiving sequentia...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)81509-9
更新日期：1997-08-01 00:00:00
abstract：:Human testes, removed in treating patients for prostatic carcinoma, were used. Tissues were homogenized and incubated in vitro with labeled progesterone and 2 different antiovulatories, lynestrenol (17alpha-ethin yl-17beta-hydroxy-estr-4-one) and MK 665 (17alpha-chloroethinyl-19-nor-4 ,9(10)-androstadiene-17beta-ol-...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)36309-9
更新日期：1967-05-01 00:00:00
abstract：OBJECTIVE:To provide a quantitative assessment of patient knowledge about fertility and fertility preservation treatment options before the initial fertility preservation consultation at a university-based fertility preservation center. DESIGN:Prospective pilot survey containing 13 items assessing patient knowledge ab...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.02.016
更新日期：2011-05-01 00:00:00
abstract：OBJECTIVES:To investigate the presence of Poly (ADP-ribose) polymerase (PARP) and evaluate its function in ejaculated spermatozoa. DESIGN:Experimental study. SETTING:Reproductive Research Center. PATIENT(S):Semen specimens from 18 healthy donors and 12 infertile males. INTERVENTION(S):Ejaculated spermatozoa were su...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.12.079
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVE:To quantify nerve fibers and mast cells in human ovaries at different functional stages. DESIGN:Retrospective study. SETTING:Research laboratory of the university. SPECIMEN(S): 8 human ovaries in the follicular (cyclic) phase, 7 polycystic ovaries, and postmenopausal ovaries with (n=5) or without (n=7) hype...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(01)01805-2
更新日期：2001-06-01 00:00:00
abstract：:A laparotomy was performed in 40 rats and the cecum was subjected to a standardized trauma. Half the rats were treated with oxyphenbutazone in a dose of 40 mg/kg body weight daily for 14 days. The remaining 20 rats served as controls. All of the rats were killed 2 weeks after the laparotomy, and the number of intraper...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)42731-7
更新日期：1977-08-01 00:00:00
abstract：:Menopausal hormone therapy (HT) has complex biologic effects but continues to have an important clinical role in the management of vasomotor and other menopausal symptoms. The rational use of menopausal HT requires balancing the potential benefits and risks of treatment. Findings from the Women's Health Initiative (WH...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2014.02.043
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVE:To assess the impact on women's reproductive outcomes of barbed sutures to repair uterine breaches during laparoscopic myomectomy compared with traditional smooth sutures. DESIGN:Retrospective, monocentric cohort study, with information on subsequent pregnancies prospectively acquired for some women. SETTIN...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2020.07.036
更新日期：2021-01-01 00:00:00
