RU486 inhibits ovulation, fertilization and early embryonic development in rabbits: in vivo and in vitro studies.

Abstract:

OBJECTIVE:To clarify the role of P in ovulation, fertilization, and early embryonic development using RU486, a potent P receptor blocker. DESIGN:Ovulatory efficiency, IVF, and early embryonic development were evaluated after RU486 administration in vivo and in vitro. SETTING:Research laboratory of a university hospital. PARTICIPANTS:Mature male and female New Zealand white rabbits. INTERVENTIONS:Animals were treated with RU486 or vehicle for 3 days before hCG-induced ovulation. Ovaries treated with hCG to induce ovulation were perfused for 6 hours in vitro with RU486 or vehicle. In vitro fertilization was performed in the presence or absence of RU486. MAIN OUTCOME MEASURES:The percentage of mature follicles ovulating (ovulatory efficiency) was determined after in vivo and in vitro treatment. Fertilization, morula, and blastocyst development were evaluated every 24 hours for 120 hours. RESULTS:RU486 significantly inhibited ovulation, fertilization, and early embryonic development. CONCLUSIONS:Progesterone plays a significant role in ovulation, fertilization, and preimplantation embryonic development.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Chen SH,Dharmarajan AM,Wallach EE,Mastroyannis C

doi

10.1016/s0015-0282(16)57803-0

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

627-33

issue

3

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)57803-0

journal_volume

64

pub_type

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