Abstract:
:The plasma concentration of soluble P-selectin (GMP-140/CD62P/PADGEM), a selectin produced by activated platelets and endothelial cells, was quantitated in a group of adults and East African negro children presenting with either non-severe or severe (cerebral) malaria caused by Plasmodium falciparum. Sixty percent of adults with non-severe malaria had immunoreactive levels of P-selectin above 200 ng/ml (the maximum recorded for any normal healthy adult in the assay) and 86% of all African children with malaria had concentrations above normal irrespective of their clinical categorization, and most exceeded the maximum limits of the assay (> 640 ng/ml). There was no correlation between P-selectin levels and parasitemia. These results raise the possibility that elevated soluble P-selectin in malaria may have an important beneficial anti-inflammatory function.
journal_name
Microbiol Immunoljournal_title
Microbiology and immunologyauthors
Facer CA,Theodoridou Adoi
10.1111/j.1348-0421.1994.tb01848.xsubject
Has Abstractpub_date
1994-01-01 00:00:00pages
727-31issue
9eissn
0385-5600issn
1348-0421journal_volume
38pub_type
杂志文章abstract::Cattle enterotoxemia caused by Clostridium perfringens toxins is a noncontagious, sporadic, and fatal disease characterized by sudden death. Strategies for controlling and preventing cattle enterotoxemia are based on systematic vaccination of herds with toxoids. Because the process of producing conventional clostridia...
journal_title:Microbiology and immunology
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doi:10.1111/1348-0421.12198
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journal_title:Microbiology and immunology
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Microbiology and immunology
pub_type: 杂志文章
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journal_title:Microbiology and immunology
pub_type: 杂志文章
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journal_title:Microbiology and immunology
pub_type: 杂志文章
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journal_title:Microbiology and immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2011-12-01 00:00:00
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journal_title:Microbiology and immunology
pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:Microbiology and immunology
pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:Microbiology and immunology
pub_type: 杂志文章
doi:10.1111/j.1348-0421.1994.tb01791.x
更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00