Abstract:
:A series of experiments was conducted to determine the efficacy of 15 synthetic retinoic acid amides (retinamides) as inhibitors of chemical carcinogenesis of the urinary bladder in C57BL/6 x DBA/2F1 mice. Eight of the retinamides tested had significant protective activity when administered at nontoxic levels in the diet. Minor structural alterations, such as the addition of a methyl or hydroxyl group to the terminal amide moiety had a major influence on the anticarcinogenic activity of the retinamides. Although 13-cis retinamides generally were less toxic on a molar basis than were their all-trans isomers, no consistent pattern of differential anticarcinogenic activity was noted among the six pairs of all-trans and 13-cis isomers tested. All-trans-4-hydroxyphenyl retinamide was among the most active and least toxic of the retinoids tested, and appears to be the compound of choice for further study.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Moon RC,McCormick DL,Becci PJ,Shealy YF,Frickel F,Paust J,Sporn MBdoi
10.1093/carcin/3.12.1469subject
Has Abstractpub_date
1982-01-01 00:00:00pages
1469-72issue
12eissn
0143-3334issn
1460-2180journal_volume
3pub_type
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