Abstract:
:Peptidoglycans of organisms belonging to the strictly anaerobic family Bacteroidaceae were investigated for the presence of lanthionine. Different procedures for the quantitation of lanthionine were compared. Performic acid and peroxide oxidation procedures on 35S-labeled peptidoglycan from Fusobacterium nucleatum Fev1 resulted in low yields of cysteic acid (42 and 60%, respectively) and many other additional unidentified oxidation products. Lanthionine was, however, recovered in high yield (89% or more) from acid hydrolysates of unoxidized peptidoglycans. Lanthionine was found exclusively in some species of Fusobacterium, in particular F. nucleatum, F. necrophorum, F. russi, and F. gonidiaformans, for which lanthionine may be ascribed a function as a taxonomic marker. Peptidoglycans of these bacteria are thus proposed to belong to a new chemotype, assigned A1 delta. One strain of Fusobacterium, F. mortiferum VPI 0473 contained both lanthionine and diaminopimelic acid in about equal proportions. Species of F.plauti had a composition atypic of gram-negative cells. Chemotypic differences were also indicated among the species of Bacteroides investigated. Thus, some species contained lysine and not diaminopimelic acid as the major dibasic amino acid (e.g., F. asaccharolyticus). It is concluded that peptidoglycans of gram-negative organisms constitute a somewhat more heterogeneous group than hitherto assumed.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Vasstrand EN,Jensen HB,Miron T,Hofstad Tdoi
10.1128/IAI.36.1.114-122.1982subject
Has Abstractpub_date
1982-04-01 00:00:00pages
114-22issue
1eissn
0019-9567issn
1098-5522journal_volume
36pub_type
杂志文章abstract::Human defensins play a fundamental role in the initiation of innate immune responses to some microbial pathogens. Here we show that colonic epithelial model HCT116 cells respond to Trypanosoma cruzi infection by secreting defensin α-1, which reduces infection. We also report the early effects of defensin α-1 on invasi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01459-12
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00074-16
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journal_title:Infection and immunity
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pub_type: 杂志文章
doi:10.1128/IAI.6.5.877-879.1972
更新日期:1972-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.4.1593-1595.1993
更新日期:1993-04-01 00:00:00
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
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doi:10.1128/IAI.74.4.2115-2120.2006
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.6.1381-1386.1987
更新日期:1987-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.7.1760-1765.1988
更新日期:1988-07-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.6.3422-3430.2005
更新日期:2005-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1986-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.10.4856-4866.1998
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1994-08-01 00:00:00
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2017-03-23 00:00:00
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journal_title:Infection and immunity
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更新日期:2000-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.7.4698-4701.2001
更新日期:2001-07-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.12.3272-3279.1988
更新日期:1988-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.2.490-495.1999
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00819-19
更新日期:2020-03-23 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.9.3678-3687.1993
更新日期:1993-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02005-14
更新日期:2014-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00356-18
更新日期:2018-08-22 00:00:00