Changes in platelet function, blood coagulation and fibrinolysis during insulin-induced hypoglycaemia in juvenile diabetics and normal subjects.

abstract：:Thromboembolism remains a serious problem in patients with prosthetic heart valves. Previous studies documented a number of platelet abnormalities in such patients and correlated the occurrence of thromboembolic complications with short platelet survival. We have studied platelet survival and platelet aggregation in e...

journal_title：Thrombosis and haemostasis

authors： Al-Mondhiry H,Pierce WS,Richenbacher W

更新日期：1984-10-31 00:00:00

abstract：:Abnormalities of Hageman factor dependent pathways have been described in a wide variety of human disease states. Congenital deficiencies of factor XII (Hageman trait) prekallikrein (Fletcher trait) and high molecular weight kininogen (Williams, Fitzgerald and Flaujeac traits) although resulting in profound in vitro c...

journal_title：Thrombosis and haemostasis

authors： Colman RW,Wong PY

更新日期：1977-12-15 00:00:00

abstract：:Compared with Caucasian patients, East Asian patients have the unique risk-benefit trade-off and different responsiveness to antithrombotic regimens. The aim of this study was to compare pharmacodynamic profile in East Asian patients with acute coronary syndromes (ACS) treated with prasugrel standard-dose vs. de-escal...

journal_title：Thrombosis and haemostasis

authors： Jeong YH,Oh JH,Yoon HJ,Park Y,Suh J,Lee SW,Lee K,Kim JS,Chun WJ,Park YH,Nam CW,Kim JH,Ahn JH,Hwang SJ,Hwang JY,Tantry US,Gurbel P,Shin ES

更新日期：2021-01-05 00:00:00

abstract：:The fibrinolytic system was studied in 96 patients with type I diabetes mellitus. Patients were grouped according to their degree of retinopathy; 38 patients with no evidence of retinopathy, 28 patients with background retinopathy and 30 patients with proliferative retinopathy. Thirty healthy individuals served as con...

journal_title：Thrombosis and haemostasis

authors： Ostermann H,Tschöpe D,Greber W,Meyer-Rüsenberg HW,van de Loo J

更新日期：1992-10-05 00:00:00

abstract：:Mouse C127 epithelioid cells were genetically engineered to produce biologically active gamma-carboxylated human protein S. A full length human protein S cDNA was cloned into a bovine papilloma virus (BPV) based shuttle vector under the transcriptional control of the Moloney murine sarcoma virus enhancer and the mouse...

journal_title：Thrombosis and haemostasis

authors： Chang GT,Ploos van Amstel HK,Hessing M,Reitsma PH,Bertina RM,Bouma BN

更新日期：1992-05-04 00:00:00

abstract：:Leukocytes recruitment to thrombi supports an intimate cellular interaction leading to the enhancement of pro-coagulant functions and pro-inflammatory responses at site of vascular injury. Recent observations of neutrophil extracellular traps (NETs) formation and its mutual reactions with platelet thrombi adds more cl...

journal_title：Thrombosis and haemostasis

authors： Ghasemzadeh M,Hosseini E

更新日期：2015-06-01 00:00:00

abstract：:Although intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) play a relevant role in atherosclerosis, little is known about the prognostic impact of their soluble forms (s) in patients with peripheral arterial disease (PAD). The aim of this prospective study was to verify whether ...

journal_title：Thrombosis and haemostasis

authors： Silvestro A,Brevetti G,Schiano V,Scopacasa F,Chiariello M

更新日期：2005-03-01 00:00:00

abstract：:Von Willebrand factor (vWF) plays an essential role in platelet adhesion and thrombus formation. Patients with atrial fibrillation (AF) exhibit higher plasma vWF and lower ADAMTS13 antigen levels compared to controls. Little is known about vWF and ADAMTS13 in AF patients treated with cardioversion (CV). Thus we invest...

journal_title：Thrombosis and haemostasis

authors： Freynhofer MK,Bruno V,Jarai R,Gruber S,Höchtl T,Brozovic I,Farhan S,Wojta J,Huber K

更新日期：2011-03-01 00:00:00

abstract：:Severe factor XI (FXI) deficiency is a bleeding disorder generally inherited as an autosomal recessive trait and characterized by haemorrhagic symptoms mainly associated with injury or surgery. So far, more than 150 causative molecular defects have been identified throughout the F11 gene. In the present study, we inve...

journal_title：Thrombosis and haemostasis

authors： Guella I,Soldà G,Spena S,Asselta R,Ghiotto R,Tenchini ML,Castaman G,Duga S

更新日期：2008-03-01 00:00:00

abstract：:Increased fibrinogen concentration is a well known phenomenon following acute ischemic stroke. However, the natural course of this hyperfibrinogenemia is uncertain. We aimed to clarify whether it is of a transient or more persistent nature in patients who harbor an underlying morbid biology of atherothrombo-inflammati...

journal_title：Thrombosis and haemostasis

authors： Shenhar-Tsarfaty S,Ben Assayag E,Bova I,Shopin L,Cohen M,Berliner S,Shapira I,Bornstein NM

更新日期：2008-01-01 00:00:00

abstract：:Induction of procoagulant factors in malignant cells is considered to be the major cause of coagulation disorders in cancer. Thrombomodulin (TM), a negative regulator of coagulation was also found to be expressed in cancer cells. We report here evidence for another anticoagulant, the endothelial cell protein C recepto...

journal_title：Thrombosis and haemostasis

authors： Tsuneyoshi N,Fukudome K,Horiguchi S,Ye X,Matsuzaki M,Toi M,Suzuki K,Kimoto M

更新日期：2001-02-01 00:00:00

abstract：:ADAMTS13 dysfunction has been involved in the pathogenesis of Thrombotic Thrombocytopenic Purpura. This disorder occurs more frequently in women and, in 13% of them, is associated with pregnancy. However, there is little information on the protease behaviour in normal pregnancy. We studied von Willebrand factor and AD...

journal_title：Thrombosis and haemostasis

authors： Sánchez-Luceros A,Farías CE,Amaral MM,Kempfer AC,Votta R,Marchese C,Salviú MJ,Woods AI,Meschengieser SS,Lazzari MA

更新日期：2004-12-01 00:00:00

abstract：:Epidemiological studies suggest that hormone replacement therapy (HRT) decreases the risk of cardiovascular disease in postmenopausal women via several mechanisms, including modifications in the fibrinolytic system and lipoprotein(a) [Lp(a)] levels. The aim of this study was to examine the influence of the levels and ...

journal_title：Thrombosis and haemostasis

authors： Estellés A,Cano A,Falcó C,España F,Gilabert J,Grancha S,Aznar J

更新日期：1999-01-01 00:00:00

abstract：:Major orthopedic surgery is known to be associated with potentially serious arterial and venous vascular complications, although uncertainty exists about current event rates. Using electronic databases and investigator contact, we identified randomized and cohort studies reporting overall mortality and fatal vascular ...

journal_title：Thrombosis and haemostasis

authors： Dahl OE,Caprini JA,Colwell CW Jr,Frostick SP,Haas S,Hull RD,Laporte S,Stein PD

更新日期：2005-05-01 00:00:00

abstract：:Patients with intermediate-risk pulmonary embolism (PE) may, depending on the method and cut-off values used for definition, account for up to 60% of all patients with PE and have an 8% or higher risk of short-term adverse outcome. Although four non-vitamin K-dependent direct oral anticoagulants (NOACs) have been appr...

journal_title：Thrombosis and haemostasis

authors： Klok FA,Ageno W,Barco S,Binder H,Brenner B,Duerschmied D,Empen K,Faggiano P,Ficker JH,Galiè N,Ghuysen A,Held M,Heydenreich N,Huisman MV,Jiménez D,Kozak M,Lang IM,Lankeit M,Münzel T,Petris A,Pruszczyk P,Quitzau K

更新日期：2017-12-01 00:00:00

abstract：:Accumulating evidence indicates that accelerated formation of fibrin clots composed of compact, highly-branched networks with thin fibres which are relatively resistant to plasmin-mediated lysis can be commonly observed in patients with venous or arterial thrombosis. This review discusses characteristics of fibrin clo...

journal_title：Thrombosis and haemostasis

authors： Undas A

更新日期：2014-07-03 00:00:00

abstract：:The multimeric plasma glycoprotein von Willebrand factor (VWF) is best known for recruiting platelets to sites of injury during primary hemostasis. Generally, mutations in the VWF gene lead to loss of hemostatic activity and thus the bleeding disorder von Willebrand Disease. By employing cone and platelet aggregometry...

journal_title：Thrombosis and haemostasis

authors： Huck V,Chen PC,Xu ER,Tischer A,Klemm U,Aponte-Santamaría C,Mess C,Obser T,Kutzki F,König G,Denis C,Gräter F,Wilmanns M,Auton M,Schneider SW,Schneppenheim R,Hennig J,Brehm MA

更新日期：2020-12-31 00:00:00

abstract：:The spleen is a crucial organ in humans. However, little is known about the association of venous thromboembolism (VTE) with splenic injury and splenectomy in trauma patients. The aim of this study was to determine the subsequent risk of VTE following splenic injury and splenectomy. A nationwide retrospective cohort s...

journal_title：Thrombosis and haemostasis

authors： Lin JN,Chen HJ,Lin MC,Lai CH,Lin HH,Yang CH,Kao CH

更新日期：2016-01-01 00:00:00

abstract：:The demographic and clinical characteristics of adults and children with lower extremity deep-vein thrombosis and/or pulmonary embolism (LE DVT/PE) may differ from those with abdominal vein thrombosis (abdominal VT). Abdominal VT can be a presenting sign of an underlying prothrombotic state, and its presence in the se...

journal_title：Thrombosis and haemostasis

authors： Landi D,Beckman MG,Shah NR,Bockenstedt P,Grant AM,Heit JA,Key NS,Kulkarni R,Manco-Johnson M,Moll S,Philipp CS,Andersen JC,Ortel TL

更新日期：2013-04-01 00:00:00

abstract：:Plaque rupture underlies most myocardial infarctions. Plaques vulnerable to rupture have thin fibrous caps, an excess of macrophages over vascular smooth muscle cells, large lipid cores, and depletion of collagen and other matrix proteins form the cap and lipid core. Production of matrix metalloproteinases from macrop...

journal_title：Thrombosis and haemostasis

authors： Newby AC,George SJ,Ismail Y,Johnson JL,Sala-Newby GB,Thomas AC

更新日期：2009-06-01 00:00:00

abstract：:Acid-treated human plasma is a competitive inhibitor of the hydrolysis of D-Val-Leu-Lys-Nan (S-2251) by plasmin. The rate of hydrolysis is decreased to 50% by 750 fold diluted acidified normal plasma and by 60 fold diluted acidified alpha 2-antiplasmin depleted plasma (alpha 2-antiplasmin concentration less than 2%). ...

journal_title：Thrombosis and haemostasis

authors： Lijnen HR,Maes M,Castel M,Samama M,Collen D

更新日期：1982-12-27 00:00:00

abstract：:The prevalence of coagulation disorders in patients with upper extremity deep-vein thrombosis (UE-DVT) is unknown due to only a few observational studies of limited size reporting varying results. Therefore, we aimed to evaluate the prevalence of thrombophilia in patients with UE-DVT compared to patients with lower ex...

journal_title：Thrombosis and haemostasis

authors： Linnemann B,Meister F,Schwonberg J,Schindewolf M,Zgouras D,Lindhoff-Last E,MAISTHRO registry.

更新日期：2008-09-01 00:00:00

abstract：:Thrombocytopenia occurred in 11.6% of 43 patients prospectively randomized to receive either bovine lung or porcine mucosal heparin. Four patients received bovine heparin and developed mild to moderate thrombocytopenia after eight to twelve days which resolved when therapy was stopped in one to six days. One patient r...

journal_title：Thrombosis and haemostasis

authors： Ansell J,Slepchuk N Jr,Kumar R,Lopez A,Southard L,Deykin D

更新日期：1980-02-29 00:00:00

abstract：:Matrix metalloproteinases (MMPs) play an important role in many biological and pathological processes including tissue remodeling, wound healing, inflammation, atherosclerosis, and cancer. Numerous publications have supported the concept that activated MMP-2 enhances agonist-induced platelet aggregation and activated ...

journal_title：Thrombosis and haemostasis

authors： Rosenfeldt MT,Valentino M,Labruzzo S,Scudder L,Pavlaki M,Cao J,Vacirca J,Bahou WF,Zucker S

更新日期：2005-02-01 00:00:00

abstract：:The aim of this study was to evaluate the existence of an additive effect between standard heparin and dDAVP in the enhancement of endogenous fibrinolysis. Eight healthy volunteers were studied in a randomized double blind placebo controlled cross-over trial. The volunteers were treated i.v. with dDAVP, 0.4 micrograms...

journal_title：Thrombosis and haemostasis

authors： Agnelli G,Levi M,Cosmi B,ten Cate JW,Nenci GG

更新日期：1989-06-30 00:00:00

abstract：:The prevention and treatment of venous thromboembolism (VTE) remains a clinical challenge, primarily owing to drawbacks associated with the use of heparins and vitamin K antagonists (VKAs). These and other factors, including a growing elderly population, mean that VTE presents a continuing burden to patients and physi...

journal_title：Thrombosis and haemostasis

authors： Beyer-Westendorf J,Ageno W

更新日期：2015-02-01 00:00:00

abstract：:Abdominal aortic aneurysm (AAA) evolution is unpredictable, and there is no therapy except surgery for patients with an aortic size> 5 cm (large AAA). We aimed to identify new potential biomarkers that could facilitate prognosis and treatment of patients with AAA. A differential quantitative proteomic analysis of plas...

journal_title：Thrombosis and haemostasis

authors： Burillo E,Lindholt JS,Molina-Sánchez P,Jorge I,Martinez-Pinna R,Blanco-Colio LM,Tarin C,Torres-Fonseca MM,Esteban M,Laustsen J,Ramos-Mozo P,Calvo E,Lopez JA,Vega de Ceniga M,Michel JB,Egido J,Andrés V,Vazquéz J,Meilha

更新日期：2015-06-01 00:00:00

abstract：:The strong effect of protein adsorption on blood and tissue compatibility is well known. Little is presently known about the mechanisms which control the composition of the adsorbed protein layer which forms upon exposure of surfaces to mixtures of proteins. Reexamination of the ability of hemoglobin to inhibit the ad...

journal_title：Thrombosis and haemostasis

authors： Horbett TA

更新日期：1984-04-30 00:00:00

abstract：:In haemophilia B (HB) (factor IX [FIX] deficiency), F9 genotype largely determines clinical phenotype. Aimed to characterise Argentinian families with HB, this study presents F9 genotype frequencies and their specific FIX inhibitor risk and 10 novel F9 mutations. Ninety-one DNA samples from HB patients and relat...

journal_title：Thrombosis and haemostasis

authors： Radic CP,Rossetti LC,Abelleyro MM,Candela M,Pérez Bianco R,de Tezanos Pinto M,Larripa IB,Goodeve A,De Brasi C

更新日期：2013-01-01 00:00:00

abstract：:Fibrin sealant use in the United States has been limited because of the lack of a commercially available, government approved product. However, the significant need and usefulness of this material at the time of surgical operations has stimulated alternative sources of production. At the University of Virginia, the Bl...

journal_title：Thrombosis and haemostasis

authors： Spotnitz WD

更新日期：1995-07-01 00:00:00