The organomercurial 4-aminophenylmercuric acetate, independent of matrix metalloproteinases, induces dose-dependent activation/inhibition of platelet aggregation.

abstract：:We investigated the molecular basis of hypofibrinogenaemia in a woman with a history of recurrent, pregnancy-associated bleeding, and miscarriage. She had a Clauss fibrinogen of 0.9 mg/ml and SDS PAGE of purified fibrinogen showed a normal pattern of chains. However careful inspection of reverse phase chain separation...

journal_title：Thrombosis and haemostasis

authors： Wyatt J,Brennan SO,May S,George PM

更新日期：2000-09-01 00:00:00

abstract：:Membrane-permeable 8-(4-chlorophenylthio)-2'-O-methyl cyclic AMP (8-pCPT-2'-O-Me-cAMP) has been shown to specifically activate cAMP-regulated Epac proteins, without direct effects on protein kinase A and protein kinase G. During isometric tension measurements in thoracic aortic rings from Wistar rats, we observed that...

journal_title：Thrombosis and haemostasis

authors： Sand C,Grandoch M,Börgermann C,Oude Weernink PA,Mahlke Y,Schwindenhammer B,Weber AA,Fischer JW,Jakobs KH,Schmidt M

更新日期：2010-03-01 00:00:00

abstract：:Platelet aggregation and thromboxane A2 have been implicated in the pathogenesis of several forms of vascular disease. The aim of this study was to determine the effect of a wide range of adrenoceptor antagonists on platelet aggregation, and thromboxane A2 production, from normal human platelet rich plasma in vitro. L...

journal_title：Thrombosis and haemostasis

authors： Greer IA,Walker JJ,McLaren M,Calder AA,Forbes CD

更新日期：1985-08-30 00:00:00

abstract：:We performed a case-controlled study to investigate whether the FV Leiden mutation and the C > T677 polymorphism of the 5, 10 methylene tetrahydrofolate reductase (MTHFR) are associated with the occurrence of preeclampsia in 96 otherwise healthy preeclamptic women and 129 parous women as controls. FV Leiden carriers w...

journal_title：Thrombosis and haemostasis

authors： Grandone E,Margaglione M,Colaizzo D,Cappucci G,Paladini D,Martinelli P,Montanaro S,Pavone G,Di Minno G

更新日期：1997-06-01 00:00:00

abstract：:The gel-chromatography of the beta-alanine precipitate of human plasma and of purified fibrinogen shows the presence of different classes of fibrinogen complexes. A first class of complexes is detectable in correspondence with the ascending branch of the fibrinogen peak ("shoulder" complexes or high molecular weight f...

journal_title：Thrombosis and haemostasis

authors： Serneri GGE,Gensini GF,Abbate R,Favilla S

更新日期：1979-07-01 00:00:00

abstract：:Cellular adhesion molecules also known as selectins promote recruitment of inflammatory cells into the arterial wall where they interact with lipid particles leading subsequently to plaque formation. The intercellular adhesion molecule-1 (ICAM-1), the vascular cell adhesion molecule-1 (VCAM-1) and the endothelial-leuk...

journal_title：Thrombosis and haemostasis

authors： Hoke M,Winter MP,Wagner O,Exner M,Schillinger M,Arnold Z,Mlekusch W,Maurer G,Koppensteiner R,Minar E,Goliasch G

更新日期：2015-08-31 00:00:00

abstract：:In wound repair, fibrin has a multiplicity of activities, some of which are intrinsic to the protein itself and some attributable to other blood constituents associated with the fibrin clot. Fibrin sealants, which have been approved for hemostasis in the US and Europe, are occasionally used wounds to promote healing. ...

journal_title：Thrombosis and haemostasis

authors： Clark RA

更新日期：2003-12-01 00:00:00

abstract：:Microvascular thrombosis is considered an important pathogenetic factor in renal failure associated with obstructive jaundice but the mechanisms leading to fibrin deposition are still unknown. The plasma levels of plasminogen activator inhibitor (PAI) in 29 patients with obstructive jaundice were found significantly i...

journal_title：Thrombosis and haemostasis

authors： Colucci M,Altomare DF,Chetta G,Triggiani R,Cavallo LG,Semeraro N

更新日期：1988-08-30 00:00:00

abstract：:Neuroserpin is a member of the serine proteinase inhibitor (serpin) gene family that reacts preferentially with tissue-type plasminogen activator (tPA) and is primarily localized to neurons in regions of the brain where tPA is also found. Outside of the central nervous system (CNS) tPA is predominantly found in the bl...

journal_title：Thrombosis and haemostasis

authors： Yepes M,Lawrence DA

更新日期：2004-03-01 00:00:00

abstract：:Advanced electronic alerts (eAlerts) and computerised physician order entry (CPOE) increase adequate thromboprophylaxis orders among hospitalised medical patients. It remains unclear whether eAlerts maintain their efficacy over time, after withdrawal of continuing medical education (CME) on eAlerts and on thromboproph...

journal_title：Thrombosis and haemostasis

authors： Beeler PE,Kucher N,Blaser J

更新日期：2011-10-01 00:00:00

abstract：:Severe factor XI (FXI) deficiency is a bleeding disorder generally inherited as an autosomal recessive trait and characterized by haemorrhagic symptoms mainly associated with injury or surgery. So far, more than 150 causative molecular defects have been identified throughout the F11 gene. In the present study, we inve...

journal_title：Thrombosis and haemostasis

authors： Guella I,Soldà G,Spena S,Asselta R,Ghiotto R,Tenchini ML,Castaman G,Duga S

更新日期：2008-03-01 00:00:00

abstract：:The interaction of beta 2-glycoprotein-I (beta 2-G-I), a plasma constituent of unknown function, with blood platelets was studied. The following results were obtained: 1) beta 2-G-I binds to washed human platelets isolated by centrifugation (WP) at one kind of specific, saturable binding sites. The dissociation consta...

journal_title：Thrombosis and haemostasis

authors： Nimpf J,Wurm H,Kostner GM

更新日期：1985-08-30 00:00:00

abstract：:Catheter-directed thrombolysis has gained increasing acceptance for the treatment of patients who present with vascular occlusion; however, intravenous injection may be preferable in selected patients. Recombinant prourokinase (r-proUK) is a recently-developed fibrin-selective thrombolytic agent with specificity for c...

journal_title：Thrombosis and haemostasis

authors： Burke SE,Lubbers NL,Nelson RA,Wegner CD,Cox BF

更新日期：1999-02-01 00:00:00

abstract：:This study assessed the frequency and factors associated with failure to correct international normalised ratio (INR) in patients administered fresh frozen plasma (FFP) for warfarin-related major bleeding. This retrospective database analysis used electronic health records from an integrated health system. Patients wh...

journal_title：Thrombosis and haemostasis

authors： Menzin J,White LA,Friedman M,Nichols C,Menzin J,Hoesche J,Bergman GE,Jones C

更新日期：2012-04-01 00:00:00

abstract：:Emicizumab, a bispecific monoclonal antibody, bridges activated factor IX (FIXa) and FX, replacing the function of missing FVIIIa to restore effective hemostasis in persons with hemophilia A (PwHA). Here we assess pharmacokinetic (PK) and pharmacodynamic (PD) biomarkers in PwHA with FVIII inhibitors in the Phase III H...

journal_title：Thrombosis and haemostasis

authors： Schmitt C,Adamkewicz JI,Xu J,Petry C,Catalani O,Young G,Negrier C,Callaghan MU,Levy GG

更新日期：2020-10-21 00:00:00

abstract：BACKGROUND: There have been no prior nationwide reports on the prevalence of hypertrophic cardiomyopathy (HCM) among patients suffering from atrial fibrillation (AF). It is also unclear how much stroke risk is attributable to HCM compared with other stroke risks in patients with AF. This study assessed the prevalence o...

journal_title：Thrombosis and haemostasis

authors： Jung H,Yang PS,Sung JH,Jang E,Yu HT,Kim TH,Uhm JS,Kim JY,Pak HN,Lee MH,Lip GYH,Joung B

更新日期：2019-02-01 00:00:00

abstract：:Heparin is often used as an adjunct to thrombolytic therapy in order to prevent reocclusion of the patent vessels in patients with thrombotic disease. Controversy exists as to whether heparin is required for effective clot lysis with tissue-type plasminogen activator, while in vitro data and small scale clinical trial...

journal_title：Thrombosis and haemostasis

authors： Burke SE,Lubbers NL,Nelson RA,Henkin J

更新日期：1993-04-01 00:00:00

abstract：:Hemophilia B is a sex-linked recessive bleeding disorder characterized by the presence of either a decreased amount of normal factor IX (FIX) or the presence of a dysfunctional FIX. We have identified a unique mutation in a family with mild hemophilia B. DNA analysis of family members revealed a single base transition...

journal_title：Thrombosis and haemostasis

authors： Lefkowitz JB,Nuss R,Haver T,Jacobson L,Thompson AR,Manco-Johnson M

更新日期：2001-09-01 00:00:00

abstract：:Accumulating evidence indicates that accelerated formation of fibrin clots composed of compact, highly-branched networks with thin fibres which are relatively resistant to plasmin-mediated lysis can be commonly observed in patients with venous or arterial thrombosis. This review discusses characteristics of fibrin clo...

journal_title：Thrombosis and haemostasis

authors： Undas A

更新日期：2014-07-03 00:00:00

abstract：:Heparin and its derivatives have been shown to inhibit angiogenesis and metastasis formation. Accordingly, we investigated the effect of heparin fragments containing 4 to 22 monomers on human melanoma cell proliferation, migration and invasion in vitro as well as on the in vivo metastatic potential in a SCID mouse mod...

journal_title：Thrombosis and haemostasis

authors： Kenessey I,Simon E,Futosi K,Bereczky B,Kiss A,Erdödi F,Gallagher JT,Tímár J,Tóvári J

更新日期：2009-12-01 00:00:00

abstract：:Novel strategies for a tailored risk prediction in chronic heart failure (CHF) are crucial to identify patients at very high risk for an improved patient management and to specify treatment regimens. Endothelial progenitor cells (EPCs) are an important endogenous repair mechanism with the ability to counteract endothe...

journal_title：Thrombosis and haemostasis

authors： Koller L,Hohensinner P,Sulzgruber P,Blum S,Maurer G,Wojta J,Hülsmann M,Niessner A

更新日期：2016-08-01 00:00:00

abstract：:Magnesium deficiency is associated with a high frequency of cardiac arrhythmia, hypertension and sudden ischemic death. We investigated the if vivo effects of intravenous magnesium administration in a rat model of chemically induced (FeCl3) carotid thrombosis. The infusion of magnesium sulfate (MgSO4) before the topic...

journal_title：Thrombosis and haemostasis

authors： Mussoni L,Sironi L,Tedeschi L,Calvio AM,Colli S,Tremoli E

更新日期：2001-11-01 00:00:00

abstract：:Direct oral factor inhibitors (DOFIs) are an attractive alternative to vitamin K antagonists (VKA) for the treatment of patients with antiphospholipid syndrome (APS). In the absence of prospective, randomised trial data, reports of therapeutic failures in clinical practice alert clinicians to potential limitations of ...

journal_title：Thrombosis and haemostasis

authors： Schaefer JK,McBane RD,Black DF,Williams LN,Moder KG,Wysokinski WE

更新日期：2014-11-01 00:00:00

abstract：:Thrombocytopenia occurred in 11.6% of 43 patients prospectively randomized to receive either bovine lung or porcine mucosal heparin. Four patients received bovine heparin and developed mild to moderate thrombocytopenia after eight to twelve days which resolved when therapy was stopped in one to six days. One patient r...

journal_title：Thrombosis and haemostasis

authors： Ansell J,Slepchuk N Jr,Kumar R,Lopez A,Southard L,Deykin D

更新日期：1980-02-29 00:00:00

abstract：:Anisoylated Lys-plasminogen streptokinase activator complex (APSAC) was purified from Eminase by chromatography on Superose-12. Purified APSAC did not significantly deacylate within 4 h at 4 degrees C in solution as determined by hydrolysis of D-Val-L-leu-L-lys-p-nitroanilide HCl (S-2251). At 37 degrees C, maximum ami...

journal_title：Thrombosis and haemostasis

authors： Vasudevan J,Humphries JE,Gonias SL

更新日期：1993-04-01 00:00:00

abstract：:Seven mouse monoclonal antibodies have been produced against human melanoma tissue plasminogen activator (t-PA). They were specifically bound to 125I t-PA but not 125I urokinase (u-PA) and inhibited t-PA, but not u-PA, activity in plasminogen-rich 125I fibrin wells. Three of the antibodies directly inhibited the amido...

journal_title：Thrombosis and haemostasis

authors： MacGregor IR,Micklem LR,James K,Pepper DS

更新日期：1985-02-18 00:00:00

abstract：:The haematopoietic hormone erythropoietin (EPO) has neuroprotective properties and is currently being explored for treatment of stroke and other neurological disorders. Short-term, high-dose treatment with EPO seems to improve neurological function of stroke patients but may be associated with increased thrombotic ris...

journal_title：Thrombosis and haemostasis

authors： Kirkeby A,Torup L,Bochsen L,Kjalke M,Abel K,Theilgaard-Monch K,Johansson PI,Bjørn SE,Gerwien J,Leist M

更新日期：2008-04-01 00:00:00

abstract：:Circulating microparticles play a pro-inflammatory and procoagulant detrimental role in the vascular dysfunction of septic shock. It was the objective of this study to investigate mechanisms by which a pharmacological modulation of microparticles could affect vascular dysfunction in a rat model of septic shock. Septic...

journal_title：Thrombosis and haemostasis

authors： Boisramé-Helms J,Delabranche X,Degirmenci SE,Zobairi F,Berger A,Meyer G,Burban M,Mostefai HA,Levy B,Toti F,Meziani F

更新日期：2014-01-01 00:00:00

abstract：:Protein C is an important inhibitor of blood coagulation. We investigated the effect of two polymorphisms within the promoter region of the protein C gene (C/T at position 2405 and A/G at position 2418) on risk of venous thrombosis and on plasma protein C levels. In addition the combined effect of the two polymorphism...

journal_title：Thrombosis and haemostasis

authors： Pomp ER,Doggen CJ,Vos HL,Reitsma PH,Rosendaal FR

更新日期：2009-01-01 00:00:00

abstract：:The structural and functional properties of plasma and platelet vWF were studied in 8 patients (5 unrelated families) with vWD demonstrating a mutation at position 611 (R611C or R611H). Following reduction, electrophoresis and immunoblotting with a polyclonal anti-reduced vWF antibody, abnormal proteolysis of vWF was ...

journal_title：Thrombosis and haemostasis

authors： Nishikubo T,Christophe O,Lavergne JM,Obert B,Nonami K,Takahashi Y,Yoshioka A,Meyer D,Girma JP

更新日期：1997-01-01 00:00:00