Abstract:
:The immunogenicity of a virus-induced rat osteosarcoma was studied utilizing the lymphocyte microcytoxicity test. Lymphocytes from "progressor" animals (in which the tumour progressed and metastasized) demonstrated an ability to kill osteosarcoma cells in vitro, while serum from these animals abrogated or blocked the cell-mediated cytotoxicity. Lymphocytes from "regressor" animals (in which tumours failed to develop or regressed spontaneously) also showed cytolytic activity against osteosarcoma cells in vitro, but their serum failed to block the lymphocyte-mediated cytolysis. Both progressor and regressor animals demonstrated the presence of humoral cytotoxic antibodies to tumour antigens on the basis of the ability of their serum to kill tumour cells in vitro. In an attempt to alter the fatal course of the disease in progressor animals, immunoprophylaxis and immunotherapy of the osteosarcoma in F1 hybrid rats war carried out by injecting them with parentalor, third party, allogeneic lymphoid cells. Injection of parental spleen lymphocytes into F1 hybrids produced a transient graft versus host reaction (GVHR), and prolonged the survival of the animals when lymphocytes were injected three days before, seven days after and on the day of tumour induction. Injection of allogeneic, third party lymphoid cells produced no detectable GVHR and prolonged the survival of F1 hybrids with osteosarcoma only when injected on the day of tumour induction. The prolonged survival of the groups treated with parental lymphoid cells was a result of stimulation of the host's immunological mechanisms during a transient GVHR, whereas the prolongation of survival in the group given allogeneic cells was most likely the result of a direct action of the donor lymphocytes on tumour cells, and not connected to a GVHR.
journal_name
Int Orthopjournal_title
International orthopaedicsauthors
Czitrom AA,Langer F,Gross AE,Urovitz EP,Pritzker KPdoi
10.1007/BF00268153subject
Has Abstractpub_date
1980-01-01 00:00:00pages
167-75issue
3eissn
0341-2695issn
1432-5195journal_volume
4pub_type
杂志文章abstract:PURPOSE:Adolescent idiopathic scoliosis (AIS) is reported to be associated with the two traditional estrogen receptor genes, ESR1 and ESR2. Yet, the novel estrogen receptor G protein-coupled estrogen receptor 1 (GPER) has not been studied. To investigate the association of GPER gene polymorphisms with the onset and det...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-011-1374-8
更新日期:2012-03-01 00:00:00
abstract::The purpose of this study was to investigate the effects of addition of antibiotics into cement powder on the shear properties of the cement-metal interface. The approach involved adding 800 mg of teicoplanin to 40 g bone cement powder in the t-800 group, 1,600 mg teicoplanin in the t-1,600 group, and no antibiotic in...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-007-0347-4
更新日期:2008-08-01 00:00:00
abstract:PURPOSE:Although there are various new scaffold-based techniques for cartilage regeneration it remains unclear up to which defect size they can be used. The present study reports of a cell-free collagen type I gel matrix for the treatment of large cartilage defects of the knee after a two-year follow-up. METHODS:Twent...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-015-2695-9
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:To compare the results of two groups of patients affected by osteochondritis dissecans (OCD) of the knee and treated with either osteochondral autologous transplantation (OAT) or bone-cartilage paste grafting (PG). METHODS:A total of 27 patients affected by OCD lesions of the femoral condyles were included: 15...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-020-04804-6
更新日期:2021-02-01 00:00:00
abstract:PURPOSE:Avascular necrosis of the talus is one of the most notable complications associated with talar neck fractures with frequent evolution of the osteonecrosis into a difficult arthrodesis. We tested whether the injection of bone marrow mesenchymal stem cells (MSCs) could improve the repair process of the osteonecro...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-017-3716-7
更新日期:2018-12-01 00:00:00
abstract::From 1996 to 2000, we reoperated nine patients totally dissatisfied after previous surgery for cubital tunnel syndrome. All patients had simple external neurolysis in situ of the transposed ulnar nerve. Only the anterior aspect of the ulnar nerve was dissected and released. Dense scarring around the ulnar nerve was fo...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-004-0589-3
更新日期:2004-12-01 00:00:00
abstract::We describe the results of a retrospective analysis of patients with microbiologically proven infection, who underwent revision TKA between 1994 and 2008. Of the 121 patients included in the study, 61 (50%) were male and 60 (50%) were female. The mean age was 71 (range 42-88) years. The most common organisms identifie...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-009-0797-y
更新日期:2010-04-01 00:00:00
abstract:INTRODUCTION:We hypothesised that the use of a polyaxial locking plate design offers the same clinical benefits as a monoaxial locking plate system following distal femoral osteoporotic/periprosthetic fracture fixation. METHOD:A multicentre prospective randomised pilot trial was conducted. Inclusion criteria were pati...
journal_title:International orthopaedics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00264-018-4061-1
更新日期:2019-05-01 00:00:00
abstract::At an average follow-up of 3.7 years we assessed the results of non-operative treatment of 84 symptomatic shoulders in 59 patients with a diagnosis of multidirectional shoulder instability. Sixty-two shoulders had received no previous surgical treatment (group A) while 22 had failed to respond to surgical treatment be...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s002640000202
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Previous studies of soft tissue infiltration in hip arthroplasty present variable results. The purpose of this study is to identify whether injection of an analgesic mixture improves pain management during the immediate post-operative period. MATERIALS AND METHODS:This cohort study compared 129 patients tha...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-018-3788-z
更新日期:2018-08-01 00:00:00
abstract::We prospectively studied all patients admitted for total hip (THR) or knee (TKR) arthroplasty from July 2000 to February 2001. No pharmacological anticoagulation was given. All patients received a standardized postoperative rehabilitation regimen. Forty-six patients with known risk factors for deep vein thrombosis (DV...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-003-0427-z
更新日期:2003-01-01 00:00:00
abstract::A prospective study was carried out in order to evaluate the predictive value of MRI in the early postoperative course after cruciate ligament replacement. Twenty patients who had undergone anterior cruciate ligament reconstruction using autologous patellar tendon/bone grafts were examined clinically and with contrast...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s002640050262
更新日期:1998-01-01 00:00:00
abstract::Periprosthetic infections following total knee arthroplasty (TKA) are diagnostically challenging. We evaluated the sensitivity and specificity of ESR and CRP, false negative rates, whether false negative rates differed between early post-operative and late infections, and the predictive ability of ESR and CRP to diffe...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-010-1175-5
更新日期:2011-11-01 00:00:00
abstract:PURPOSE:To evaluate the safety and efficacy of a novel technique of preconditioning autologous blood with gold particles (GOLDIC®) and injection in patients with moderate to severe knee osteoarthritis (KOA). METHODS:During this phase 2a, proof-of-concept (PoC) open label study, 83 consecutive patients that 64 patients...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-020-04870-w
更新日期:2021-02-01 00:00:00
abstract::A case of bilateral habitual dislocation of the patella associated with cleft lip and palate, and short metatarsals, metacarpals and phalanges is reported. The possible cause of habitual dislocation is discussed in the light of 20 cases which have been seen by the author. ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00183358
更新日期:1990-01-01 00:00:00
abstract::The objective of this study was to confirm the presence and frequency of a bifurcation of the popliteus tendon. The popliteus tendon has received attention due to its important function as a knee stabiliser. Several anatomical variants have recently been reported, one of them being a bifurcated tendon. However, the ac...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-008-0685-x
更新日期:2009-12-01 00:00:00
abstract:PURPOSE:To review available approaches and fixation methods for posterolateral fracture fragment (PLF) in tibial plateau fracture, and to propose an algorithm to treat various types of plateau fractures which all involve the PLF. METHODS:This article reviews multiple surgical approaches for PLF and suggests an algorit...
journal_title:International orthopaedics
pub_type: 杂志文章,评审
doi:10.1007/s00264-017-3563-6
更新日期:2017-09-01 00:00:00
abstract::A new twisted plate has been designed for biplane fixation of diaphyseal fractures of long bones. Comparative mechanical testing of the new twisted plate and conventional flat plates showed that the twisted plate was 40% stronger when a bending moment was applied and 132% stronger to a twisting moment. The overall imp...
journal_title:International orthopaedics
pub_type: 临床试验,杂志文章
doi:10.1007/BF00182708
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Various types of dressing materials are available for wound care following hip and knee arthroplasty. However, it is unclear if one material is more beneficial than the others in terms of wound complications and fluid handling capacity. RESEARCH QUESTIONS:We performed a meta-analysis of randomized controlle...
journal_title:International orthopaedics
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00264-017-3484-4
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:Total hip arthroplasty with a dual mobility cup (DMC) is a proposed alternative to the widely performed bipolar hemiarthroplasty (BHA) for treating displaced intracapsular femoral neck fractures (DFNF) in the elderly. However, the comparison between the two modalities has not been extensively conducted thus far...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-018-3767-4
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:The aim of the study was to investigate risk factors for metastasis at diagnosis. METHODS:We collected patients diagnosed with conventional chondrosarcoma between 1983 and 2014 from the Surveillance, Epidemiology, and End Results (SEER) database. Each patient was classified as having metastatic or localized di...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-018-3942-7
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:Our aim was to evaluate quality of life (QoL) and functional outcome of patients with tibial nonunions after completion of surgical treatment with an average follow-up of five years. METHODS:The following data of 64 patients were retrospectively evaluated: fracture type, type and duration of surgical therapy, ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-014-2629-y
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:We have developed iodine-supported titanium implants that suppress microbial activities and conducted in vivo and in vitro studies to determine their antimicrobial properties. METHODS:The implants were Ti-6Al-4 V titanium implants either untreated (Ti), treated with oxide film on the Ti surface by anodization ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-017-3477-3
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Severe glenoid bone loss remains a surgical challenge. This condition is known to be associated with high rates of glenoid component failure. PURPOSE:The objective of this study was to evaluate clinical and radiological outcomes of a lateralized metal-backed 15.2-mm keeled baseplate prolonged by a thin 24.8...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-018-4249-4
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:Anatomically correct graft positioning at the femoral insertion site is a key factor in surgical reconstruction of the medial patello-femoral ligament (MPFL). Basically there are two techniques to define this point in fluoroscopy during surgery. The role of the anatomical femoral torsion on the accuracy and rep...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-014-2523-7
更新日期:2015-03-01 00:00:00
abstract::A computerised instrumentation system which measures the distribution of vertical load under the foot has been used to measure and record the loading under 148 normal feet during walking. The correlations and variations with load, contact time, sex, age and angle of the toe out are discussed. ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00266887
更新日期:1979-01-01 00:00:00
abstract:PURPOSE:This review explores the scientific evidence for clinical, functional and imaging outcomes after surgical management of Femoroacetabular Impingement (FAI) syndrome, and assesses the methodological quality of the published literature reporting this issue. METHODS:The medical literature databases of Pubmed, Medl...
journal_title:International orthopaedics
pub_type: 杂志文章,评审
doi:10.1007/s00264-011-1443-z
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:We will test the hypothesis that ultrasound supported by polymerase chain reaction (PCR) could improve bacterial identification in non-infected prosthetic joint loosening. The aim was to detect bacterial species in non-infected prosthetic joint loosening using ultrasound and 16S rRNA gene sequencing. METHODS:A...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-013-1955-9
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:The reporting of gait analysis data on operated fractures of the tibial plateau, while extensive for studies of knee osteoarthritis of mostly undisclosed aetiology and ACL deficient knees, is rather limited in literature. METHODS:In the present study we investigated 25 tibial plateau fractures classified as Sc...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-015-2691-0
更新日期:2015-07-01 00:00:00
abstract::The objective of this study was to determine whether BMP-2 and -14, noggin, and chordin could be detected in human fractures and to assess their regional and cellular distribution. The expression of these proteins was detected by immunohistochemistry in an archive of human fractures. BMP-2 and BMP-14 expression was st...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-008-0691-z
更新日期:2009-02-01 00:00:00