Abstract:
PURPOSE:Adolescent idiopathic scoliosis (AIS) is reported to be associated with the two traditional estrogen receptor genes, ESR1 and ESR2. Yet, the novel estrogen receptor G protein-coupled estrogen receptor 1 (GPER) has not been studied. To investigate the association of GPER gene polymorphisms with the onset and deterioration of AIS, we performed a case-control study. METHODS:Clinical information was recorded, blood samples were taken and genomic DNA was extracted. After resequencing the gene in 45 cases and 45 controls who were randomly selected, 16 tag single nucleotide polymorphisms (SNPs) were selected. Then the association study was extended by an additional 344 patients and 293 controls with direct sequencing and a TaqMan-based genotyping assay. The chi-square test and logistic regression were used to analyse the genotypic and allelic association. One-way analysis of variance was used to compare the mean maximum Cobb angles and ages with different genotypes in the case-only data set. RESULTS:No association was observed between the polymorphisms of the GPER gene and susceptibility to AIS. However, heterozygotes in three SNPs of the gene (rs3808351, rs10269151 and rs426655s3) were related significantly with the curve severity in AIS patients (P = 0.004, 0.048 and 0.028, respectively). CONCLUSIONS:Our results demonstrate that GPER gene polymorphisms are associated with the severity of curvature in AIS; deficits of GPER may contribute to the deterioration of spine deformity.
journal_name
Int Orthopjournal_title
International orthopaedicsauthors
Peng Y,Liang G,Pei Y,Ye W,Liang A,Su Pdoi
10.1007/s00264-011-1374-8subject
Has Abstractpub_date
2012-03-01 00:00:00pages
671-7issue
3eissn
0341-2695issn
1432-5195journal_volume
36pub_type
杂志文章abstract::The purpose of this study was to evaluate the relationship between body mass index and early complications following total hip replacements. Five hundred and fifty patients who underwent primary total hip replacement were recruited. All these patients were subjected to a pre-operative assessment and follow-up at 6 wee...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-006-0222-8
更新日期:2007-08-01 00:00:00
abstract:INTRODUCTION:There is no evidence that anatomically correct anterior cruciate ligament reconstruction (ACLR) offers lower rate of degenerative changes development or that it would lead to a better outcome. The significance and understanding of the abnormal anterior tibial translation (ATT) in ACLR patients is yet to be...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-016-3386-x
更新日期:2017-04-01 00:00:00
abstract::Five hundred and fifteen children with single segment non-physeal extremity fractures were retrospectively reviewed. The male to female ratio was 2.7:1. The average age of study group was 9.9+/-4.7 years; 273 fractures (53%) were on the left, 242 (47%) were on the right. A fall was the main cause of the injury in most...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s002640050388
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:Patient-specific instrumentation (PSI) was usually applied in total knee arthroplasty (TKA) to acquire a favourable alignment. We hypothesized that using PSI had a potential risk of notching in the anterior femoral cortex, because the femoral component may be placed in an overextension position due to the dista...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-020-04779-4
更新日期:2020-12-01 00:00:00
abstract::We describe a case of rheumatoid arthritis (RA) with collapse of the L3 lumbar vertebra for which surgery was performed. The pathogenesis of lumbar lesions affected by RA is discussed and the literature reviewed. ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s002640050286
更新日期:1998-01-01 00:00:00
abstract::A description is given of an unusual case of a 13 year old girl who showed complete regression of neurogenically induced heterotopic ossification following recovery from her head injury. The case report indicates that heterotopic ossification is not necessarily permanent following neurological disturbance, but may be ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00267736
更新日期:1984-01-01 00:00:00
abstract::The purpose of this study was to evaluate the effects of partial and full weightbearing after cementless total hip arthroplasty over a two year follow-up period. Fifty-nine women and 41 men (average age 61 years) received an uncemented Spotorno stem and were randomised into a full and a partial weightbearing group. No...
journal_title:International orthopaedics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00264-010-1089-2
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:Weight-bearing sports might influence the alignment of the lower extremities during growth. The relationship between participation in weight-bearing sports and the alignment of the lower extremities in adolescents has not been adequately studied yet. The aim of the study was to investigate whether sports partic...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-018-4015-7
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:Unreamed nails have revolutionised the treatment of tibial shaft fractures. Many authors, however, have reported increasing bone healing complications with these implants. Unfortunately, few studies have addressed the factors affecting bone healing after unreamed tibial nailing. METHODS:One-hundred and sixty t...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-012-1505-x
更新日期:2012-07-01 00:00:00
abstract::Periprosthetic fractures of the acetabulum represent a rare incident in primary and revision total hip arthroplasty. The management of these fractures can be challenging. At present, there are no reliable guidelines for the treatment of periprosthetic acetabular fractures. Periprosthetic acetabular fractures can occur...
journal_title:International orthopaedics
pub_type: 杂志文章,评审
doi:10.1007/s00264-015-2968-3
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:The rotator cuff concept refers to the four scapulohumeral muscles that stabilize and rotate the humerus relative to the scapula. To date, the first description of the rotator cuff remained unidentified. METHOD:In light of the 500th birthday of Andreas Vesalius (1515-1564) we searched his 1543 masterwork "Fabr...
journal_title:International orthopaedics
pub_type: 古典文章,历史文章,杂志文章
doi:10.1007/s00264-015-2823-6
更新日期:2015-12-01 00:00:00
abstract::This experimental study was undertaken in mice to investigate the procedures for storage of allogenic cancellous bone. Cancellous grafts were were stored at -80 degrees C, -196 degrees C or freeze dried. Grafts were implanted into a defect in the recipient's femur and after one week the cellular kinetic activity was a...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00178753
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:To assess functional outcomes in patients undergoing total knee arthroplasty (TKA) without previous corrective osteotomy for treatment of knee osteoarthritis associated with extra-articular deformity. METHODS:From January to December 2016, patients with knee osteoarthritis with extra-articular deformities who ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-018-4147-9
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:The aim of this study was to analyse the clinical outcome of a modified Sever-L'Episcopo technique for release of contracted muscles and tendon transfer to restore function of the shoulder joint in patients with Erb's palsy. METHODS:A case series was conducted from March 1988 to November 2009 for 19 patients. ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-014-2592-7
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:The mortality rate in patients with haemodynamically unstable pelvic fractures is as high as 40-60%. Despite the new advances in trauma care which are in phase in trauma centres in Hong Kong, the management of haemodynamically unstable pelvic fracture is still heterogeneous. The aim of this study is to review t...
journal_title:International orthopaedics
pub_type: 杂志文章,多中心研究
doi:10.1007/s00264-018-3842-x
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:Diagnosing periprosthetic infection remains a challenge. Multiplex-PCR and biomarkers such as alpha-defensin are potentially useful and fast methods for detecting periprosthetic infection. This study compared these new methods with clinical assessment, conventional microbiological methods and histo-pathological...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-017-3412-7
更新日期:2017-07-01 00:00:00
abstract::Myeloscopy has been undertaken in a series of 208 patients without any serious complications. Observations have been made of changes in blood flow in the vessels accompanying the cauda equina during Lasègue's test and in some pathological states. Direct observation of the nucleus pulposus has been achieved and the pos...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00266074
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:To identify potential risk factors and micro-organisms associated with prosthetic joint infection following primary total knee replacement surgery. HYPOTHESIS OF STUDY:Our hypothesis is that body mass index (BMI), operative time, type of surgery, and order of surgery especially in bilateral simultaneous cases ...
journal_title:International orthopaedics
pub_type: 杂志文章,多中心研究
doi:10.1007/s00264-019-04472-1
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Synovial haemangioma is a rare type of tumour for which only around 200 cases have been reported worldwide. It usually occurs in the female population during the second decade of life and most commonly affects the knee joint. Patients can complain of pain, recurrent knee swelling and limitation of motion. Si...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-015-2930-4
更新日期:2015-10-01 00:00:00
abstract:INTRODUCTION:Literature on the potential release of trace elements following implantation of Zirconia-platelet toughened alumina (ZPTA) ceramic components is scant. The present study therefore analysed the in vitro and in vivo potential release of ions from ZPTA bearings. MATERIAL AND METHODS:An in vitro and in vivo s...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-017-3568-1
更新日期:2018-01-01 00:00:00
abstract::Ten patients with clinical and radiological evidence of herniated discs at lower lumbar levels were treated with partial discectomy by a lateral percutaneous approach. Eight patients had complete relief from radicular pain and were discharged within four days. They returned to normal daily activity within one month. ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00271309
更新日期:1987-01-01 00:00:00
abstract::Incorporation of massive cortical bone allografts in the human is slow and remains incomplete. Late biopsies of implanted allografts or histological studies of explanted allografts always show the partial substitution of necrotic bone by new bone from the host. The aim of the present study was to evaluate the value of...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00183550
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:To evaluate the influence of stem offset and neck shaft angles on the range of motion before component impingement (ROMCI) and bony impingement (ROMBI), and the types of impingement in total hip arthroplasty (THA). METHODS:Using the computed tomography data of 101 patients who underwent THA, three-dimensional ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-015-2826-3
更新日期:2016-02-01 00:00:00
abstract::The aim of this study was to determine the diagnostic value of systemic biochemical markers of bone turnover in aseptic loosening in hip arthroplasty, namely the urine levels of three bone resorption peptides - crosslinked n-telopeptides (NTX), c-telopeptides (CTX I) and deoxypyridinoline (DPD). We compared 52 patient...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-007-0477-8
更新日期:2009-02-01 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章,评审
doi:10.1007/s00264-011-1443-z
更新日期:2012-05-01 00:00:00
abstract:INTRODUCTION:Fracture neck of femur (hip fracture) is a very common problem among old age group. Such elderly patients usually have some comorbidities for which they may use anti-platelet therapy (such as clopidogrel, aspirin, or others) for long duration (chronic use). These anti-platelet medications might make the bl...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-020-04633-7
更新日期:2020-09-01 00:00:00
abstract::Manipulation under anaesthesia (MUA) has been used to speed up recovery. However, the outcome of frozen shoulder after MUA in patients with diabetes has not been well documented in the past. A higher prevalence of frozen shoulder has been reported in diabetes mellitus (DM) patients. In this study, we revealed the shor...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-010-0968-x
更新日期:2010-12-01 00:00:00
abstract::This study included 15 patients with humeral shaft fractures who had no clinical, radiological or bone scan signs of healing after eight months. The patients were followed for a mean of 35.8 months. No patient was lost to follow-up. Anterior plating of humeral shaft nonunion via an anterior approach was performed usin...
journal_title:International orthopaedics
pub_type: 临床试验,杂志文章
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更新日期:2010-10-01 00:00:00
abstract::Subluxation of the patella may produce pain and instability in young people. However its classification, diagnosis and treatment are controversial. We have used computerized tomography (CT) to measure the amount of lateral shift of the patella and the angle of tilt to the femur in patients with subluxation. The mean l...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::Reverse total shoulder arthroplasty (RTSA) has been reported to be associated with a complication rate that is four times that of conventional total shoulder arthroplasty. It is the purpose of this article to identify and understand the most common and most serious complications of RTSA and to review current methods o...
journal_title:International orthopaedics
pub_type: 杂志文章,评审
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更新日期:2010-12-01 00:00:00