Genomic polymorphisms of G-protein estrogen receptor 1 are associated with severity of adolescent idiopathic scoliosis.


PURPOSE:Adolescent idiopathic scoliosis (AIS) is reported to be associated with the two traditional estrogen receptor genes, ESR1 and ESR2. Yet, the novel estrogen receptor G protein-coupled estrogen receptor 1 (GPER) has not been studied. To investigate the association of GPER gene polymorphisms with the onset and deterioration of AIS, we performed a case-control study. METHODS:Clinical information was recorded, blood samples were taken and genomic DNA was extracted. After resequencing the gene in 45 cases and 45 controls who were randomly selected, 16 tag single nucleotide polymorphisms (SNPs) were selected. Then the association study was extended by an additional 344 patients and 293 controls with direct sequencing and a TaqMan-based genotyping assay. The chi-square test and logistic regression were used to analyse the genotypic and allelic association. One-way analysis of variance was used to compare the mean maximum Cobb angles and ages with different genotypes in the case-only data set. RESULTS:No association was observed between the polymorphisms of the GPER gene and susceptibility to AIS. However, heterozygotes in three SNPs of the gene (rs3808351, rs10269151 and rs426655s3) were related significantly with the curve severity in AIS patients (P = 0.004, 0.048 and 0.028, respectively). CONCLUSIONS:Our results demonstrate that GPER gene polymorphisms are associated with the severity of curvature in AIS; deficits of GPER may contribute to the deterioration of spine deformity.


Int Orthop


Peng Y,Liang G,Pei Y,Ye W,Liang A,Su P




Has Abstract


2012-03-01 00:00:00












  • Kirschner wire versus Herbert screw fixation for the treatment of unstable scaphoid waist fracture nonunion using corticocancellous iliac bone graft: randomized clinical trial.

    abstract:PURPOSE:The study compared the impact of the Kirschner wires versus Herbert screw fixation on the rate of union, time to union, correction of deformity, and clinical outcome in adults with unstable scaphoid waist fracture nonunions without avascular necrosis. METHODS:We prospectively randomized 122 patients to undergo...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Hegazy G,Alshal E,Abdelaal M,Abdelaziz M,Moawad M,Saqr YM,El-Sebaey I,Abdelazeem M,El-Barody M

    更新日期:2020-11-01 00:00:00

  • Stenosis of the lumbar spinal canal in Forestier's disease.

    abstract::Hyperostosis of the spine, Forestier's disease, is a rare, but well defined entity which results from silent, extensive paraspinal calcification. It has been regarded as an asymptomatic ankylosis requiring no medical or surgical treatment. Two patients with Forestier's disease are presented who show severe stenosis of...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Weisz GM

    更新日期:1983-01-01 00:00:00

  • Kinematic factors affecting postoperative knee flexion after cruciate-retaining total knee arthroplasty.

    abstract:PURPOSE:The purpose of this study was to investigate kinematic factors affecting postoperative knee flexion after cruciate-retaining (CR) total knee arthroplasty (TKA) by analysing pre- and postoperative knee kinematics. METHODS:We retrospectively analysed 58 patients with osteoarthritis who received the same implant ...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Matsuzaki T,Matsumoto T,Muratsu H,Kubo S,Matsushita T,Kawakami Y,Ishida K,Oka S,Kuroda R,Kurosaka M

    更新日期:2013-05-01 00:00:00

  • The Ponseti method of treatment for neuromuscular and syndromic (non-idiopathic) clubfeet: evaluation of a programme-based approach at a mean follow-up of 5.8 years.

    abstract:PURPOSE:To analyse the results of the Ponseti method in the treatment of non-idiopathic clubfeet and compare them with idiopathic clubfeet in a programme-based setting using a standardized protocol METHODS: We reviewed two groups of 782 children treated prospectively in our programme-based Clubfoot Clinic: group I comp...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Shah A,Aroojis A,Mehta R

    更新日期:2021-01-01 00:00:00

  • Comparison of transforaminal verse interlaminar epidural steroid injection in low back pain with lumbosacral radicular pain: a meta-analysis of the literature.

    abstract:OBJECTIVE:The object of the present meta-analysis is to compare the effectiveness of transforaminal epidural steroid injection (TFESI) and interlaminar epidural steroid injection (ILESI) for treating patients with low back pain (LBP) secondary to lumbosacral radicular pain. METHODS:A systematic search was performed in...

    journal_title:International orthopaedics

    pub_type: 杂志文章,meta分析


    authors: Wei G,Liang J,Chen B,Zhou C,Ru N,Chen J,Zhang F

    更新日期:2016-12-01 00:00:00

  • Pathogen-driven decision for implant retention in the management of infected total knee prostheses.

    abstract:PURPOSE:In prosthetic joint infections (PJIs) of the knee, debridement with implant retention is associated with a high risk of recurrence. METHODS:A single-centre cohort study was performed with extensive analysis of the literature covering 1980-2012. RESULTS:In 21 patients (mean age 80.4 years, 19 immunosuppressed)...

    journal_title:International orthopaedics

    pub_type: 杂志文章,评审


    authors: Zürcher-Pfund L,Uçkay I,Legout L,Gamulin A,Vaudaux P,Peter R

    更新日期:2013-08-01 00:00:00

  • Evaluation of biomarkers of joint damage in patients subjected to arthroscopy.

    abstract:AIMS:Recently, the determination of biochemical markers has been intensely explored to better understand the mechanisms underlying knee OA. In this study, we aimed to explore the expression pattern of five biochemical markers in patients with knee OA. METHODS:After IRB approval and signed informed consent, 26 patients...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Izaguirre A,González-Gutiérrez G,Galindo-López SE,Arenas-Serna G,Rodríguez A,Flores-Torrero E,Franco Y Bourland RE,Ballinas-Verdugo MA,Sánchez-Muñoz F

    更新日期:2020-10-01 00:00:00

  • The incidence of vertebral body metastases.

    abstract::Over 10 years, 842 consecutive autopsies on patients dying from a malignant neoplasm were evaluated microscopically to determine the incidence of spinal and skeletal metastases. Vertebral wedging, sclerosis and areas of osteolysis were defined as features of spinal metastases. The incidence was 30.6%, 65% of which aro...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Ortiz Gómez JA

    更新日期:1995-01-01 00:00:00

  • Limb lengthening in achondroplasia by Ilizarov's method.

    abstract::In achondroplasts limb lengthening can restore the normal proportion of the body. The Ilizarov method of limb lengthening has been used in 37 patients, 23 of whom have had an adequate follow-up after operation. In this technique the cortex of the bone is partially cut, leaving the medulla intact; the two bone segments...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Cattaneo R,Villa A,Catagni M,Tentori L

    更新日期:1988-01-01 00:00:00

  • Modified sacrospinalis muscle pedicle bone graft for fusion of isthmic spondylolisthesis.

    abstract::We treated 20 patients with symptomatic L4-5 isthmic spondylolisthesis (ten grade I, nine grade II and one grade III) surgically. All patients complained of low back pain and nine had additional radicular pain. Bilateral posterolateral fusion using the sacrospinalis muscle as a muscle pedicle bone graft was carried ou...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Adam FF

    更新日期:2001-01-01 00:00:00

  • The use of postoperative suction drainage in total knee arthroplasty: a systematic review.

    abstract:PURPOSE:The purpose of this systematic review and meta-analysis of randomised controlled trials is to assess the effectiveness of no drainage when compared to drainage in total knee arthroplasty, in terms of recovery of knee flexion, reduction in swelling, length of hospital stay and haemoglobin levels following TKA. ...

    journal_title:International orthopaedics

    pub_type: 杂志文章,meta分析,评审


    authors: Quinn M,Bowe A,Galvin R,Dawson P,O'Byrne J

    更新日期:2015-04-01 00:00:00

  • Validation of a self-reported Beighton score to assess hypermobility in patients with femoroacetabular impingement.

    abstract:PURPOSE:The prevalence of joint hypermobility (JH) in patients with femoroacetabular impingement (FAI) and its association with outcomes is yet widely unknown. This study aimed to validate a self-reported version of the Beighton score for FAI patients, and to determine possible associations between JH and clinical and ...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Naal FD,Hatzung G,Müller A,Impellizzeri F,Leunig M

    更新日期:2014-11-01 00:00:00

  • Kuntscher nailing of femoral shaft fractures in children and adolescents.

    abstract::We have reviewed 29 cases of very unstable diaphyseal fractures of the femur in children and adolescents treated by Kuntscher nailing. Follow up was for at least 5 years, and in most cases until after the end of growth. There were no postoperative complications, and the mean overgrowth of the femur was 7.06 mm. There ...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Maruenda-Paulino JI,Sanchis-Alfonso V,Gomar-Sancho F,Darder-Prats A,Gasco-Gomez de Membrillera J

    更新日期:1993-01-01 00:00:00

  • Paediatric lateral humeral condylar fracture outcomes at twelve years follow-up as compared with age and sex matched paired controls.

    abstract:INTRODUCTION:Lateral humeral condylar fractures are the second most common elbow fractures in children. We present the long-term clinical and radiographic results. MATERIAL AND METHODS:All children (<16 years) in the geographic catchment area with lateral condylar fracture were asked to participate and 32 (76.2%) pati...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Sinikumpu JJ,Pokka T,Victorzon S,Lindholm EL,Serlo W

    更新日期:2017-07-01 00:00:00

  • Occult intra-operative periprosthetic fractures of the acetabulum may affect implant survival.

    abstract:PURPOSE:Occult intra-operative periprosthetic acetabular fracture is a seldom-reported complication of primary total hip arthroplasty (THA). It may potentially be associated with cup instability and implant loosening. The present study aimed to investigate clinical consequences of this complication. METHODS:Between 20...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Dammerer D,Putzer D,Glodny B,Petersen J,Arrich F,Krismer M,Biedermann R

    更新日期:2019-07-01 00:00:00

  • Outcomes of combined hip procedure with dual mobility cup versus osteosynthesis for acetabular fractures in elderly patients: a retrospective observational cohort study of fifty one patients.

    abstract:PURPOSES:Acetabular fractures are more and more common in the elderly. Open reduction and internal fixation (ORIF) may lead to poor outcomes and high revision rates. Primary total hip arthroplasty (THA) combined with internal fixation, also known as the combined hip procedure (CHP), associated with dual mobility cup (D...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Lannes X,Moerenhout K,Duong HP,Borens O,Steinmetz S

    更新日期:2020-10-01 00:00:00

  • Post-operative pain control following arthroscopic rotator cuff repair: peri-articular injection versus interscalene brachial plexus block.

    abstract:PURPOSE:To compare post-operative pain relief with peri-articular injection (PI) versus interscalene brachial plexus block (IBPB) after arthroscopic rotator cuff repair (ARCR) surgery. METHODS:We retrospectively reviewed 121 consecutive patients undergoing ARCR surgery divided into two groups: the PI group and the IBP...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Saito M,Tsukada S,Fujita N,Rahman M,Morita W,Kitamura N,Tasaki A

    更新日期:2019-06-01 00:00:00

  • Tensile strength of the pullout repair technique for the medial meniscus posterior root tear: a porcine study.

    abstract:PURPOSE:The purpose of this study was to compare the load-to-failure of different common suturing techniques with a new technique for the medial meniscus posterior root tear (MMPRT). METHODS:Thirty porcine medial menisci were randomly assigned to three suturing techniques used for transtibial pullout repair of the MMP...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Fujii M,Furumatsu T,Xue H,Miyazawa S,Kodama Y,Hino T,Kamatsuki Y,Ozaki T

    更新日期:2017-10-01 00:00:00

  • Variables influencing the pelvic radiological evaluation in children with developmental dysplasia of the hip managed by closed reduction: a multicentre investigation.

    abstract:PURPOSE:This study aims to evaluate (1) the probability to achieve normal pelvic radiographs in children with developmental dysplasia of the hip (DDH) treated by closed reduction and (2) the amount of time needed to achieve normal pelvic radiographs and to assess what factors influence both probability and time to achi...

    journal_title:International orthopaedics

    pub_type: 杂志文章,多中心研究


    authors: Li Y,Liu H,Guo Y,Xu H,Xun F,Liu Y,Yuan Z,Li J,Pereira B,Canavese F,Chinese Multicenter Pediatric Orthopaedic Study Group (CMPOS).

    更新日期:2020-03-01 00:00:00

  • Density and strength distribution in the human subchondral bone plate of the patella.

    abstract:PURPOSE:The aim of this study was to map the strength distribution of the human patella and correlate it to the subchondral bone plate density obtained by means of computed tomographyosteoabsorptiometry (CT-OAM). METHODS:Measurements were performed at 34 standardized points on each patella. The mineralization patterns...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Hoechel S,Wirz D,Müller-Gerbl M

    更新日期:2012-09-01 00:00:00

  • Magnetic resonance evaluation of tubercular lesion in spine.

    abstract:PURPOSE:Information on Magnetic Resonance (MR) features of active and healed lesions in tuberculosis (TB) spine are lacking. We evaluated MRI findings in active and healed proven TB spine to establish the diagnostic features. MATERIALS AND METHOD:Forty-nine consecutive spinal TB patients (20 male; 29 female) diagnosed...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Jain AK,Sreenivasan R,Saini NS,Kumar S,Jain S,Dhammi IK

    更新日期:2012-02-01 00:00:00

  • Fixation of periprosthetic or osteoporotic distal femoral fractures with locking plates: a pilot randomised controlled trial.

    abstract:INTRODUCTION:We hypothesised that the use of a polyaxial locking plate design offers the same clinical benefits as a monoaxial locking plate system following distal femoral osteoporotic/periprosthetic fracture fixation. METHOD:A multicentre prospective randomised pilot trial was conducted. Inclusion criteria were pati...

    journal_title:International orthopaedics

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kanakaris NK,Obakponovwe O,Krkovic M,Costa ML,Shaw D,Mohanty KR,West RM,Giannoudis PV

    更新日期:2019-05-01 00:00:00

  • Inter-observer reliability in the assessment of heterotopic ossification: proposal of a combined classification.

    abstract::We applied four published classifications for assessment of heterotopic ossification after total hip arthroplasty (Arcq, Brooker, DeLee and Della Valle [1, 2, 5, 6]. The average incidence of heterotopic ossification varied from 19.8% to 27.7%. The inter-observer reliability of the various classifications was determine...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Toom A,Fischer K,Märtson A,Rips L,Haviko T

    更新日期:2005-06-01 00:00:00

  • Bone morphogenetic protein-7 enhances bone-tendon integration in a murine in vitro co-culture model.

    abstract:PURPOSE:Bone-tendon healing following anterior cruciate ligament reconstruction is reportedly enhanced by bone morphogenetic protein (BMP)-7. To improve our understanding of the underlying biologic processes, we examined the effects of BMP-7 on region-specific gene expression in vitro. METHODS:A murine in vitro co-cul...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Schwarting T,Benölken M,Ruchholtz S,Frink M,Lechler P

    更新日期:2015-04-01 00:00:00

  • [Multiple perforation in cryogenically preserved bone allografts. Comparative histological and microradiographic study of perforated and non-perforated allograft in sheep].

    abstract::Incorporation of massive cortical bone allografts in the human is slow and remains incomplete. Late biopsies of implanted allografts or histological studies of explanted allografts always show the partial substitution of necrotic bone by new bone from the host. The aim of the present study was to evaluate the value of...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Simon P,Babin SR,Delloye C,Schmitt D

    更新日期:1993-01-01 00:00:00

  • Experience of a seating clinic.

    abstract::Patients who cannot walk, particularly those with orthopaedic deformities, need more than a simple wheelchair; they require a special seating system. Since the early 1970's many different systems have been introduced to the field of orthotics and prescribed through "Seating Clinics" in many centres in North America an...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Medhat MA,Redford JB

    更新日期:1985-01-01 00:00:00

  • Cementless cup fixation in total hip arthroplasty after 5-8 years.

    abstract::A series of 199 total hip arthroplasties was performed using a porous-coated, hemispherical press-fit acetabular cup. At a mean follow-up of 91.5 months 158 cups were available for clinical and radiological review. The mean age of the patients at the time of the index arthroplasty was 62.5 years. The mean Harris Hip s...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Spicer DD,Schaper LA,Pomeroy DL,Badenhausen WE Jr,Curry JI,Suthers KE,Smith MW

    更新日期:2001-01-01 00:00:00

  • Computed axial tomography and Disulphine Blue in the evaluation of osteonecrosis of the femoral head.

    abstract::Precise evaluation of bone loss and bone viability is necessary in order to select the most appropriate operation for patients with osteonecrosis of the femoral head. Bone destruction, and its exact location, can be assessed by computed axial tomography. The viability of remaining bone can be observed at operation by ...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Casteleyn PP,De Boeck H,Handelberg F,Opdecam P

    更新日期:1983-01-01 00:00:00

  • Atraumatic tendon handling during tendon repair.

    abstract::Two techniques are presented for atraumatic handling of tendon ends during repair of flexor and extensor tendons. If the tendon is cleanly transected, the suture is carried out by holding the tendon in nerve holding forceps. If debridement is needed, a slice is partly cut and used to handle the tendon; the slice is th...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Lanzetta M,Chollet A

    更新日期:1996-01-01 00:00:00

  • Relationship between skin and urine colonization and surgical site infection in the proximal femur fracture: a prospective study.

    abstract:PURPOSE:Antibiotic prophylaxis is routinely used in the surgical management of proximal femur fractures. The role of bacterial colonization of the skin and urine in the development of deep surgical site infections (SSI) is yet to be elucidated. This study aimed to evaluate the role of previous skin and urine colonizati...

    journal_title:International orthopaedics

    pub_type: 杂志文章


    authors: Cuchí E,García LG,Jiménez E,Haro D,Castillón P,Puertas L,Matamala A,Anglès F,Pérez J

    更新日期:2020-06-01 00:00:00