Abstract:
PURPOSE:Diagnosing periprosthetic infection remains a challenge. Multiplex-PCR and biomarkers such as alpha-defensin are potentially useful and fast methods for detecting periprosthetic infection. This study compared these new methods with clinical assessment, conventional microbiological methods and histo-pathological examination. METHODS:Twenty-eight consecutive patients with 30 joints and a mean age of 67.7 years (range 39 to 88) with removal of total hip arthroplasty (THA) or total knee replacement (TKR) were included in this study. Patients were classified according to the modified Musculoskeletal Infection Society score (MSIS) for infected joints. Punction fluid and tissue specimens were taken for conventional microbiological examination, alphadefensin test was performed, a synovial membrane specimen was used for multiplex-PCR and histopathological examination was carried out. RESULTS:The alpha-defensin test and multiplex-PCR showed a sensitivity of 76.9 vs. 30.8% and a specificity of 82.4 vs. 100%, respectively. We found a significant difference between the positive and negative results (p = 0.0023). The conventional microbiological methods were not significantly different from the alpha-defensin test (p = 0.244) with a sensitivity of 84.6% and a specificity of 100% but did differ significantly from the multiplex PCR (p = 0.0030). There was a significant difference between modified MSIS classification and multiplex PCR (p = 0.0007). CONCLUSIONS:Neither alpha-defensin test nor multiplex-PCR could detect periprosthetic infection immediately and reliably. Multiplex-PCR was suitable for detecting the non-infected but not the truly infected. Alpha-defensin test was helpful but showed no satisfactory results. Conventional microbiological methods remain the most reliable for periprosthetic infection diagnosis.
journal_name
Int Orthopjournal_title
International orthopaedicsauthors
Suda AJ,Tinelli M,Beisemann ND,Weil Y,Khoury A,Bischel OEdoi
10.1007/s00264-017-3412-7subject
Has Abstractpub_date
2017-07-01 00:00:00pages
1307-1313issue
7eissn
0341-2695issn
1432-5195pii
10.1007/s00264-017-3412-7journal_volume
41pub_type
杂志文章abstract::The purpose of this study was to review the association between compensation status and surgical outcome especially of the shoulder. Given the high prevalence of shoulder injuries in the workplace and the large proportion of workers compensation (WC) claims involving such injuries, it is worth examining the correlatio...
journal_title:International orthopaedics
pub_type: 杂志文章,评审
doi:10.1007/s00264-007-0493-8
更新日期:2009-04-01 00:00:00
abstract::During a 4-year period, 32 patients with type C unstable sacral fractures were treated in our university hospital. All patients had neurological deficits as a result of their sacral fracture. The average age was 31.2 (range 22-54) years and the average Hannover Polytrauma Score (PTS) was 24 (range 19-40) points. Twelv...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-007-0468-9
更新日期:2009-02-01 00:00:00
abstract::Short stem prostheses that preserve the femoral neck are becoming more and more popular. The CFP (collum femoris preserving) has been introduced especially for the treatment of younger patients. However, information about remodelling, complications and learning curve are thus far rare. We present a retrospective study...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-010-1020-x
更新日期:2011-05-01 00:00:00
abstract:PURPOSE:The most common long-term complication of joint arthroplasty is aseptic loosening. The proinflammatory cytokines secreted by macrophages are involved in aseptic loosening. Recently, a novel proinflammatory cytokine IL-17C was reported to participate in inflammatory diseases by synergising with proinflammatory c...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-013-1812-x
更新日期:2013-05-01 00:00:00
abstract::A clinical and radiological follow-up investigation with at least 20 years observation time was made of 255 persons with lumbar spondylolysis with or without spondylolisthesis. The main purposes were to study the relationship between clinical and radiological features and to look for radiological and other variables o...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00269912
更新日期:1984-01-01 00:00:00
abstract:STUDY DESIGN:This was a retrospective study to evaluate clinical characteristics of patients who developed symptomatic spinal epidural haematoma (SSEH) after spinal surgery. OBJECTIVE:The objective was to determine clinical parameters associated with the development of SSEH after spinal surgery, and to discuss clinica...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-017-3506-2
更新日期:2017-07-01 00:00:00
abstract::Twenty-five patients underwent scapulectomy for various tumours between 1989 and 2005. We describe 23 patients with scapular tumours who were followed-up for a minimum of 2 years after scapulectomy. The average age was 29 years, and two-thirds of the patients were male. Nineteen patients had malignant neoplasms, of wh...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-006-0261-1
更新日期:2007-12-01 00:00:00
abstract::In a randomised clinical trial in 50 patients with symptomatic osteoarthritis of the medial compartment of the knee, the clinical results of high tibial osteotomy (HTO) according to the open wedge osteotomy (OWO) and closed wedge osteotomy (CWO) were compared. In both groups locked plate fixation was used. Clinical an...
journal_title:International orthopaedics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00264-009-0861-7
更新日期:2010-02-01 00:00:00
abstract:PURPOSE:The purpose of this study was to investigate kinematic factors affecting postoperative knee flexion after cruciate-retaining (CR) total knee arthroplasty (TKA) by analysing pre- and postoperative knee kinematics. METHODS:We retrospectively analysed 58 patients with osteoarthritis who received the same implant ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-013-1803-y
更新日期:2013-05-01 00:00:00
abstract::Forty patients with unilateral osteoarthritis of the hip were studied with dual energy X-ray absorptiometry to quantify disuse osteopenia in their affected leg by examining the proximal femur and tibia. Bone loss was assessed as a percentage of the contralateral value which compares bone mineral density of the affecte...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00188325
更新日期:1994-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to assess the anatomical results, functional results and the incidence of arthritis of a mixed intra- and extra-articular hamstring tendon based reconstruction for anterior instability of the knee. METHODS:This retrospective study consists of 100 knees in 99 patients (22 female and 77...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-013-1957-7
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:Degenerative disc disease involves sequential events that lead to the loss of cells, a decrease in disc matrix production, disc dehydration, and alteration of its biomechanical properties. The aim of this study was to determine whether cryoinjury of the nucleus pulposus performed through endplate perforation co...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-018-3971-2
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:Leg-length changes at total hip arthroplasty (THA) may result from too proximal position of the femoral component, i.e. not being sunk deep enough into the femoral canal due to the size and shape of both medullary canal and implant. Some femoral implants are designed to achieve such fixation in the mediolateral...
journal_title:International orthopaedics
pub_type: 杂志文章,评审
doi:10.1007/s00264-020-04671-1
更新日期:2020-06-22 00:00:00
abstract:PURPOSE:Despite bilateral knee replacement being frequently performed, little data is available to inform on the relative outcomes of each knee for individual patients. The purpose of this study was to compare these outcomes in a series of bilateral total knee replacements (TKRs) performed either simultaneously or at a...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-016-3122-6
更新日期:2016-10-01 00:00:00
abstract::We have reviewed 20 cases of synovial sarcoma. The main clinical and pathological features of these cases are outlined. Typically these tumours arise in the leg in young adults with a long history before presentation and diagnosis. Clinical and radiological findings are unhelpful in making an early diagnosis. The five...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00192303
更新日期:1991-01-01 00:00:00
abstract:PURPOSE:Different target areas within the concept of combined cup and stem anteversion have been published for total hip arthroplasty (THA). We asked whether component positioning according to eight standard combined anteversion rules is associated with (1) more physiological gait patterns, (2) higher improvement of ga...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-015-2777-8
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:The purpose of this study was to compare the load-to-failure of different common suturing techniques with a new technique for the medial meniscus posterior root tear (MMPRT). METHODS:Thirty porcine medial menisci were randomly assigned to three suturing techniques used for transtibial pullout repair of the MMP...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-017-3561-8
更新日期:2017-10-01 00:00:00
abstract::We reviewed a series of consecutive total hip replacements with cemented femoral components. Modern cementing techniques were followed in all cases, but two different medullary plugs were used-one was polyethylene and the other bioabsorbable gelatin. Cement mantle quality and plug migration were assessed by three diff...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-003-0506-1
更新日期:2004-02-01 00:00:00
abstract:PURPOSE:Residual feeling of leg length discrepancy (LLD) is a common cause of patient dissatisfaction following total hip arthroplasty (THA). The purpose of this study is to propose a method for determining an optimal leg length correction goal in THA. METHODS:We conducted a retrospective study of 132 patients to exam...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-019-04411-0
更新日期:2020-03-01 00:00:00
abstract::Trauma, infection, local injections and even acupuncture may cause fibrosis of the muscles of the first web space of the hand, leading to severe malposition and loss of function of the thumb and index finger. The authors present the anatomical basis for the deformity and the results of surgical treatment by tenotomy o...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00266837
更新日期:1984-01-01 00:00:00
abstract::Following manipulation of frozen shoulders under general anaesthesia, we reviewed 74 shoulders at an average of 3 weeks and again at an average of 33 months following the manipulation. We used an adjusted Constant score by excluding the abduction strength measurement. The maximum score was therefore 75 points. The ave...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-002-0348-2
更新日期:2002-01-01 00:00:00
abstract::A distinction must be drawn between the older constrained prostheses, in which load was transferred via metal-coated hinges, and later models using the low-friction principle, where the axle is not load bearing. The latter show good long-term results. The greater stability of constrained prosthesis allows earlier and ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
abstract::In achondroplasts limb lengthening can restore the normal proportion of the body. The Ilizarov method of limb lengthening has been used in 37 patients, 23 of whom have had an adequate follow-up after operation. In this technique the cortex of the bone is partially cut, leaving the medulla intact; the two bone segments...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00547160
更新日期:1988-01-01 00:00:00
abstract::In this study the authors present the results of 44 patients with 49 interfascicular nerve grafting procedures necessitated by gunshot wounds. The aim was to establish the effectiveness of microsurgical interfascicular nerve grafting for war injuries. The 49 interfascicular nerve grafting procedures were performed bet...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s002640050036
更新日期:1996-01-01 00:00:00
abstract:INTRODUCTION:The restoration of acetabular bone stock during revision hip arthroplasty remains a challenge. There have been no clinical series reporting the efficacy of bone morphogenic protein-2 (rhBMP-2) in the revision hip setting. METHODS:We retrospectively reviewed the radiographs and records of 15 patients who r...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-017-3671-3
更新日期:2018-04-01 00:00:00
abstract::Two cases of septic loosening due to a tuberculosis infection occurred 18 months and 14 years after total hip arthroplasties. The primary source was pulmonary tuberculosis. Treatment was by removal of the prosthesis and radical debridement with the local implantation of gentamicin PMMA beads, followed by antituberculo...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00184916
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:Computed tomography (CT) is widely used to assess component rotation in patients with poor results after total knee arthroplasty (TKA). The purpose of this study was to simultaneously determine the accuracy and reliability of CT in measuring TKA component rotation. METHODS:TKA components were implanted in dry-...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-015-2917-1
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Insufficient levels of serum 25-hydroxyvitamin D (25-OHD) influence the knee joint cartilage and lead to development and progression of knee osteoarthritis (OA). The purpose of this study was to determine the status of serum 25-OHD levels in patients with knee OA compared with controls. METHODS:A total of 1...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-010-1186-2
更新日期:2011-11-01 00:00:00
abstract:INTRODUCTION:This review was done to find the trend for orthopaedic publications from Egypt in the last 5 years, detailing the specialties that are most published and comparing this with the surrounding Middle East region. METHODS:The search included orthopaedic-related articles published in journals that are listed i...
journal_title:International orthopaedics
pub_type: 杂志文章,评审
doi:10.1007/s00264-018-4152-z
更新日期:2018-11-01 00:00:00
abstract::We conducted a prospective, randomised study on primary total knee replacements to evaluate the effects of tourniquet use on total calculated blood loss using Gross formula, post-operative measured blood loss, operating time, need for blood transfusion, post-operative pain, analgesia requirement and knee flexion. Fort...
journal_title:International orthopaedics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00264-002-0360-6
更新日期:2002-01-01 00:00:00