当前位置： SCI文献检索 > INTERNATIONAL ORTHOPAEDICS期刊下所有文献 > Short-term follow up after implantation of a cell-free collagen type I matrix for the treatment of large cartilage defects of the knee.

Short-term follow up after implantation of a cell-free collagen type I matrix for the treatment of large cartilage defects of the knee.

Abstract：

PURPOSE:Although there are various new scaffold-based techniques for cartilage regeneration it remains unclear up to which defect size they can be used. The present study reports of a cell-free collagen type I gel matrix for the treatment of large cartilage defects of the knee after a two-year follow-up. METHODS:Twenty-eight patients with a mean cartilage defect size of 3.71 ± 1.93 cm² were treated with a cell-free collagen type I gel matrix (CaReS-1S®, Arthro Kinetics AG, Krems/Donau, Austria) via a mini-arthrotomy. Clinical outcome was assessed preoperatively and six weeks as well as six, 12 and 24 months after surgery using various clinical outcome scores (IKDC, Tegner, KOOS, VAS). Cartilage regeneration was evaluated via MRI using the MOCART score. RESULTS:Seventeen male and 11 female patients with a mean age of 34.6 years were included in this study. Significant pain reduction (VAS) could be noted after six weeks already. Patient activity (IKDC, Tegner) could be significantly improved from 12 months on and nearly reached reported pre-operative values. All subject categories of the KOOS except for symptom (swelling) showed significant improvements throughout the study. Constant significant improvements of the mean MOCART score were observed from 12 months on. MR images did not yield any signs of infection or synovitis. After 24 months a complete defect filling could be noted in 24 out of 28 cases with a mainly smooth surface, complete integration of the border zone and homogenous structure of the repaired tissue. CONCLUSION:Cell-free collagen type I matrices appear to be a safe and suitable treatment option even for large cartilage defects of the knee. Results of this study were comparable to the better-established findings for small cartilage defects. Mid- and long-term results will be needed to see if clinical and MR-tomographic outcome can be maintained beyond 24 months.

journal_name

Int Orthop

journal_title

International orthopaedics

authors

Roessler PP,Pfister B,Gesslein M,Figiel J,Heyse TJ,Colcuc C,Lorbach O,Efe T,Schüttler KF

doi

10.1007/s00264-015-2695-9

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

2473-9

issue

eissn

0341-2695

issn

1432-5195

pii

10.1007/s00264-015-2695-9

journal_volume

pub_type

杂志文章

在线工具

Short-term follow up after implantation of a cell-free collagen type I matrix for the treatment of large cartilage defects of the knee.