Stem cell therapy in early post-traumatic talus osteonecrosis.

Abstract:

PURPOSE:Avascular necrosis of the talus is one of the most notable complications associated with talar neck fractures with frequent evolution of the osteonecrosis into a difficult arthrodesis. We tested whether the injection of bone marrow mesenchymal stem cells (MSCs) could improve the repair process of the osteonecrosis. MATERIAL AND METHODS:Forty-five early (without collapse) post-traumatic talus osteonecroses (group 1; study group) were treated between 1995 and 2012 with percutaneous injection of progenitor cells (autologous bone marrow concentrate from the iliac crest). The number of MSCs transplanted in each ankle of group 1 was 124 × 103 cells (range 101 × 103 to 164 × 103 cells). The evolution of these osteonecroses treated with autologous bone marrow implantation was compared with the evolution of a control group of 34 talar osteonecroses without collapse and treated with only core decompression (group 2; control group) between 1985 and 1995. The outcome was determined by progression in radiographic stages to collapse, by the need of arthrodesis, and by the time to successfully achieve fusion for patients who needed arthrodesis. RESULTS:For the 45 ankles with autologous concentrate bone marrow grafting, collapse frequency was lower (27%, 12 among 45 versus 71%, 24 among 34; odds ratio 0.1515, 95% CI 0.0563-0.4079; P = 0.0002) and follow-up showed longer duration of survival before collapse or arthrodesis, compared to 34 ankles of the control patients with core decompression alone. Furthermore, the time to successfully achieve fusion after arthrodesis was significantly shorter in patients treated with bone marrow progenitors as compared with the other ankles, which had core decompression alone. CONCLUSION:In our study the early conservative surgical treatment with autologous bone marrow grafting improved the natural course of the disease as compared with core decompression alone.

journal_name

Int Orthop

authors

Hernigou P,Dubory A,Flouzat Lachaniette CH,Khaled I,Chevallier N,Rouard H

doi

10.1007/s00264-017-3716-7

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

2949-2956

issue

12

eissn

0341-2695

issn

1432-5195

pii

10.1007/s00264-017-3716-7

journal_volume

42

pub_type

杂志文章
  • Reconstruction of the patella with an autogenous iliac graft: clinical and radiologic results in thirteen patients.

    abstract:PURPOSE:Extension lag, quadriceps weakness and subluxation of the extensor apparatus are known complications of patellectomy. In the case of total knee joint replacement with a nonconstrained system an instability may be encountered. Reconstruction of the patella allows restoration of the moment arm to improve quadrice...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-011-1281-z

    authors: Daentzer D,Rudert M,Wirth CJ,Stukenborg-Colsman C

    更新日期:2012-03-01 00:00:00

  • Composite reverse shoulder arthroplasty can provide good function and quality of life in cases of malignant tumour of the proximal humerus.

    abstract:PURPOSE:Management of proximal humeral tumours remains a surgical challenge. No study to date has assessed the quality of life scores following the composite reverse shoulder arthroplasty for this indication. We, therefore, evaluated function and quality of life following reconstruction with allograft for malignant tum...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-017-3538-7

    authors: Lazerges C,Dagneaux L,Degeorge B,Tardy N,Coulet B,Chammas M

    更新日期:2017-12-01 00:00:00

  • Measuring femoral neck torsion angle using femoral neck oblique axial computed tomography reconstruction.

    abstract:PURPOSE:To propose a novel method for measuring the femoral neck torsion angle (FNTA) with femoral neck oblique axial computed tomography (CT) reconstruction. METHODS:Fifty-five patients (24 females, 31 males; mean age 48.8 years [range, 20-91 years]) were included in the study. CT scans were performed on the left fem...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-015-2922-4

    authors: Yin Y,Zhang L,Hou Z,Yang Z,Zhang R,Chen W,Wang P

    更新日期:2016-02-01 00:00:00

  • The microbiology of the infected knee arthroplasty.

    abstract::We describe the results of a retrospective analysis of patients with microbiologically proven infection, who underwent revision TKA between 1994 and 2008. Of the 121 patients included in the study, 61 (50%) were male and 60 (50%) were female. The mean age was 71 (range 42-88) years. The most common organisms identifie...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-009-0797-y

    authors: Nickinson RS,Board TN,Gambhir AK,Porter ML,Kay PR

    更新日期:2010-04-01 00:00:00

  • Patellofemoral arthroplasty: a multi-centre study with minimum 2-year follow-up.

    abstract::Recently, patellofemoral arthroplasty has attracted increased interest as a salvage treatment for isolated patellofemoral arthritis. However, there are very few reports of the experience with modern generation patellofemoral arthroplasties. This investigation describes a collective experience of four centres reporting...

    journal_title:International orthopaedics

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00264-008-0692-y

    authors: Leadbetter WB,Kolisek FR,Levitt RL,Brooker AF,Zietz P,Marker DR,Bonutti PM,Mont MA

    更新日期:2009-12-01 00:00:00

  • The techniques of soft tissue release and true socket reconstruction in total hip arthroplasty for patients with severe developmental dysplasia of the hip.

    abstract:PURPOSE:Total hip arthroplasty (THA) is an effective procedure for developmental dysplasia of the hip (DDH); however, it is sometimes difficult to complete for severe cases because of femoral head dislocation, dysplasia of the acetabulum and the femur, disparity in limb length, soft tissue contraction, and muscular atr...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-012-1622-6

    authors: Wu X,Li SH,Lou LM,Cai ZD

    更新日期:2012-09-01 00:00:00

  • Kirschner wire versus Herbert screw fixation for the treatment of unstable scaphoid waist fracture nonunion using corticocancellous iliac bone graft: randomized clinical trial.

    abstract:PURPOSE:The study compared the impact of the Kirschner wires versus Herbert screw fixation on the rate of union, time to union, correction of deformity, and clinical outcome in adults with unstable scaphoid waist fracture nonunions without avascular necrosis. METHODS:We prospectively randomized 122 patients to undergo...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-020-04730-7

    authors: Hegazy G,Alshal E,Abdelaal M,Abdelaziz M,Moawad M,Saqr YM,El-Sebaey I,Abdelazeem M,El-Barody M

    更新日期:2020-11-01 00:00:00

  • Treatment of fracture sequelae of the proximal humerus: anatomical vs reverse shoulder prosthesis.

    abstract::The treatment of complex humeral fractures or fracture-dislocations presents several challenges. Late complications such as malunion, avascular necrosis, or nonunion are frequent and often lead to articular incongruence. Patients can be severely handicapped, presenting with considerable pain, stiffness, and important ...

    journal_title:International orthopaedics

    pub_type: 杂志文章,评审

    doi:10.1007/s00264-014-2651-0

    authors: Mansat P,Bonnevialle N

    更新日期:2015-02-01 00:00:00

  • Management of unstable thoracolumbar spinal injuries by posterior short segment spinal fixation.

    abstract::Fifty patients with thoracolumbar fractures were treated operatively between July 2000 and December 2001. The average age of the patients was 33.6 years (range: 20-50 years), 36 were males and 14 were females and the follow-up averaged 59 months (range: 49-68 months). A fall from a height, usually a tree, was the most...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-006-0161-4

    authors: Butt MF,Farooq M,Mir B,Dhar AS,Hussain A,Mumtaz M

    更新日期:2007-04-01 00:00:00

  • Functional implications of femoral offset following hemiarthroplasty for displaced femoral neck fracture.

    abstract:PURPOSE:Inadequate reconstruction of femoral offset after total hip arthroplasty (THA) is associated with unfavourable outcomes, but its importance following hemiarthroplasty for displaced femoral neck fracture is unknown. METHODS:Our study examined the correlation between reconstructed femoral offset and functional o...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-015-2828-1

    authors: Buecking B,Boese CK,Bergmeister VA,Frink M,Ruchholtz S,Lechler P

    更新日期:2016-07-01 00:00:00

  • Distraction osteogenesis with conventional external fixator for tibial bone loss.

    abstract::Between 1991 and 2002, we treated 21 patients with tibial bone loss using a conventional external fixator. Nine patients had an infected open fracture and 12 patients an infected nonunion. After corticotomy, the bone was distracted at the rate of 1 mm (1 mm/step) on alternate days or every 48 h. The mean follow-up per...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-004-0553-2

    authors: Sangkaew C

    更新日期:2004-06-01 00:00:00

  • Orthopaedic publications from Egypt in the last five years: a bibliometric report.

    abstract:INTRODUCTION:This review was done to find the trend for orthopaedic publications from Egypt in the last 5 years, detailing the specialties that are most published and comparing this with the surrounding Middle East region. METHODS:The search included orthopaedic-related articles published in journals that are listed i...

    journal_title:International orthopaedics

    pub_type: 杂志文章,评审

    doi:10.1007/s00264-018-4152-z

    authors: Said HG,El-Radi MA,Hassanein MY,Said GZ

    更新日期:2018-11-01 00:00:00

  • Cartilage labelling for mechanical testing in T-peel configuration.

    abstract:PURPOSE:The purpose of this study was to find a suitable method of labelling cartilage samples for the measurement of distraction distances in biomechanical testing. METHODS:Samples of bovine cartilage were labelled using five different methods: hydroquinone and silver nitrate (AgNO3), potassium permanganate (KMnO4) w...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-011-1468-3

    authors: Pfeifer C,Müller M,Prantl L,Berner A,Dendorfer S,Englert C

    更新日期:2012-07-01 00:00:00

  • Polygonal triple (Kotz) osteotomy (over 10 years experience).

    abstract::We evaluated the results of polygonal triple (Kotz) osteotomy for the treatment of acetabular dysplasia over 10 years. This study included 31 hips of 27 patients who had the Kotz osteotomy for acetabular dysplasia. The mean age was 21.5 years. We performed the original Kotz osteotomy for the first 22 hips (group I), w...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-006-0203-y

    authors: Sen C,Gunes T,Erdem M,Ozger H,Tozun IR

    更新日期:2007-06-01 00:00:00

  • Outcome of open massive rotator cuff repairs with double-row suture knotless anchors: case series.

    abstract:PURPOSE:The aim of the present study was to evaluate functional and quality of life outcomes after transosseous equivalent (TOE) double row suture technique for massive rotator cuff (RTC) tear repair using validated subjective and objective measures. This technique has shown promising preliminary results in RTC repair;...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-015-2720-z

    authors: Connelly TM,Shaw A,O'Grady P

    更新日期:2015-06-01 00:00:00

  • The impact of standard combined anteversion definitions on gait and clinical outcome within one year after total hip arthroplasty.

    abstract:PURPOSE:Different target areas within the concept of combined cup and stem anteversion have been published for total hip arthroplasty (THA). We asked whether component positioning according to eight standard combined anteversion rules is associated with (1) more physiological gait patterns, (2) higher improvement of ga...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-015-2777-8

    authors: Weber M,Weber T,Woerner M,Craiovan B,Worlicek M,Winkler S,Grifka J,Renkawitz T

    更新日期:2015-12-01 00:00:00

  • Predictive factors for thirty day mortality in geriatric patients with hip fractures: a prospective study.

    abstract:PURPOSE:The study aims to analyze the incidence of 30-day mortality in elderly patients who underwent surgery for hip fractures and its associated factors. METHODS:A prospective multicentric study was performed. All patients aged ≥ 65 years, with fragility hip fractures, consecutively admitted in two Italian hospitals...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-018-4057-x

    authors: Forni C,Gazineo D,D'Alessandro F,Fiorani A,Morri M,Sabattini T,Ambrosi E,Chiari P

    更新日期:2019-02-01 00:00:00

  • High tibial osteotomy for valgus and varus deformities of the knee.

    abstract::In 53 patients with a mean age of 38 (17-73) years, 71 high tibial osteotomies were performed. Twenty-three patients had no radiological signs of osteoarthrosis (Ahlbäck grade 0), whereas 26 patients had primary and 22 patients secondary osteoarthritis. Follow-up was 10.5 (5.8-16.6) years. The patients without radiolo...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s002640100244

    authors: Leutloff D,Tobian F,Perka C

    更新日期:2001-01-01 00:00:00

  • Three-dimensional computed tomography analysis and functional results of calcaneal fractures treated by an intramedullary nail.

    abstract:BACKGROUND:Intramedullary calcaneal nailing is used to treat displaced intra-articular calcaneal fractures. The main goal of the study was to assess the reduction of tomography and secondary goals were patient functional scores and complication rates. METHODS:The functional outcome and restoration of the radiographic ...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-019-04381-3

    authors: Fourgeaux A,Estens J,Fabre T,Laffenetre O,Lucas Y Hernandez J

    更新日期:2019-12-01 00:00:00

  • Limb salvage in aggressive and malignant tumours of the fibula.

    abstract::We treated 25 patients with aggressive and malignant fibular tumours between April 1989 and May 2001. There were 11 osteosarcomas, seven Ewing's sarcoma and five chondrosarcomas. The tumours predominantly involved the upper one third; 16 were of Stage IIB. Neo-adjuvant and adjuvant chemotherapy were given to all patie...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-004-0566-x

    authors: Natarajan M,Paraskumar M,Rajkumar G,Sivaseelam A,Natarajan S

    更新日期:2004-10-01 00:00:00

  • Femoral metastatic fractures treated with intramedullary nailing.

    abstract::Between 1993 and 1998, 49 consecutive patients with impending or complete pathological fractures of the femur due to metastatic bone disease were treated with intramedullary nailing. Twenty-four were treated with a long Gamma nail and 32 with an AO nail with a cephalomedullary spiral blade. Both implants gave a good f...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s002640000114

    authors: Gibbons CE,Pope SJ,Murphy JP,Hall AJ

    更新日期:2000-01-01 00:00:00

  • A method of treatment for nonunion after fractures using mesenchymal stromal cells loaded on collagen microspheres and incorporated into platelet-rich plasma clots.

    abstract:PURPOSE:There is evidence showing that mesenchymal stromal cells (MSC) may constitute a potential therapeutic strategy to induce bone regeneration. In this work, we investigate the capacity of autologous bone marrow (BM) MSC loaded on collagen microspheres (CM) and included into autologous platelet-rich plasma (PRP) cl...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-016-3130-6

    authors: Wittig O,Romano E,González C,Diaz-Solano D,Marquez ME,Tovar P,Aoun R,Cardier JE

    更新日期:2016-05-01 00:00:00

  • Pre-operative virtual simulation and three-dimensional printing techniques for the surgical management of acetabular fractures.

    abstract:PURPOSE:Surgical treatment of acetabular fractures with plate fixation is challenging for orthopaedic surgeons because of variations of the surface curvature and complex fracture patterns of the acetabulum. We present our experience with pre-operative computer-assisted virtual simulation and three-dimensional (3D) prin...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-018-4111-8

    authors: Hsu CL,Chou YC,Li YT,Chen JE,Hung CC,Wu CC,Shen HC,Yeh TT

    更新日期:2019-08-01 00:00:00

  • Surgical therapy of hip-joint empyema. Is the Girdlestone arthroplasty still up to date?

    abstract:PURPOSE:Hip-joint empyema is a severe local infection that can cause general illness and, in the worst-case scenario, death by septic complications. For severe hip-joint infections, the Girdlestone arthroplasty has been an established treatment option for many decades. We describe functional midterm results after treat...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-011-1351-2

    authors: Oheim R,Gille J,Schoop R,Mägerlein S,Grimme CH,Jürgens C,Gerlach UJ

    更新日期:2012-05-01 00:00:00

  • Para-articular chondroma and osteochondroma of the infrapatellar fat pad: a report of three cases.

    abstract::We report three cases of para-articular chondroma and osteochondroma in the region of infrapatellar fat pad. All three lesions were resected and examined histologically. Two of them were primarily cartilaginous with a lobular pattern internally, and one uniformly osseous with peripheral cartilage. We conclude that the...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s002640050322

    authors: Sakai H,Tamai K,Iwamoto A,Saotome K

    更新日期:1999-01-01 00:00:00

  • Prevalence of radiographic primary hip and knee osteoarthritis in a representative Central European population.

    abstract::The aim of our study was to determine the radiographic prevalence of hip and knee osteoarthritis and compare our results with prevalence data reported by other studies, as no similar study had been performed in Hungary previously. Our aim was also to investigate the usefulness of the different radiological scoring met...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-010-1069-6

    authors: Horváth G,Koroknai G,Ács B,Than P,Bellyei Á,Illés T

    更新日期:2011-07-01 00:00:00

  • Single-bundle versus double-bundle anterior cruciate ligament reconstruction: an up-to-date meta-analysis.

    abstract:PURPOSE:The aim of this meta-analysis was to compare the results of arthroscopic single-bundle and double-bundle anterior cruciate ligament (ACL) reconstruction. METHODS:We systematically searched electronic databases to identify randomised controlled trials (RCTs) in which arthroscopic single-bundle was compared with...

    journal_title:International orthopaedics

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00264-012-1651-1

    authors: Li X,Xu CP,Song JQ,Jiang N,Yu B

    更新日期:2013-02-01 00:00:00

  • Decompressive surgery for degenerative lumbar spinal stenosis: long-term results.

    abstract::We report the outcome of 50 patients with degenerative lumbar spinal stenosis who were treated surgically by spinal decompression between 1984 and 1995. Their mean age at the time of surgery was 59.9 (45-77) years and the mean follow-up was 11.6 (6.1-17.2) years. Five patients had a concomitant spinal fusion. The preo...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-005-0030-6

    authors: Gelalis ID,Stafilas KS,Korompilias AV,Zacharis KC,Beris AE,Xenakis TA

    更新日期:2006-02-01 00:00:00

  • Evidence showing the relationship between sagittal balance and clinical outcomes in surgical treatment of degenerative spinal diseases: a literature review.

    abstract::The measure of radiographic pelvic and spinal parameters for sagittal balance analysis has gained importance in reconstructive surgery of the spine and particularly in degenerative spinal diseases (DSD). Fusion in the lumbar spine may result in loss of lumbar lordosis (LL), with possible compensatory mechanisms: decre...

    journal_title:International orthopaedics

    pub_type: 杂志文章,评审

    doi:10.1007/s00264-014-2516-6

    authors: Le Huec JC,Faundez A,Dominguez D,Hoffmeyer P,Aunoble S

    更新日期:2015-01-01 00:00:00

  • Nationwide study on the risk of unprovoked venous thromboembolism in non-traumatic osteonecrosis of femoral head.

    abstract:PURPOSE:Endothelial dysfunction is a risk factor for osteonecrosis of femoral head (ONFH) and venous thromboembolism (VTE) [defined as deep venous thrombosis (DVT) or pulmonary embolism (PE)]. However, the risk of unprovoked VTE in non-traumatic ONFH patients remains unclear. METHODS:We investigated the relationship b...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-018-3866-2

    authors: Sung PH,Chiang HJ,Yang YH,Chiang JY,Chen CJ,Yip HK,Lee MS

    更新日期:2018-07-01 00:00:00