MAL6 of Saccharomyces: a complex genetic locus containing three genes required for maltose fermentation.

abstract：:Cadherin/catenin-based adhesions coordinate cellular growth, survival, migration, and differentiation within a tissue by mechanically anchoring cells to their neighbors. They also intersect with diverse signaling pathways in development and cancer. Although the adhesive functions of adherens junction proteins are well...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Livshits G,Kobielak A,Fuchs E

更新日期：2012-03-27 00:00:00

abstract：:Glands of the uterus are essential for pregnancy establishment. Forkhead box A2 (FOXA2) is expressed specifically in the glands of the uterus and a critical regulator of glandular epithelium (GE) differentiation, development, and function. Mice with a conditional deletion of FOXA2 in the adult uterus, created using th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dhakal P,Kelleher AM,Behura SK,Spencer TE

更新日期：2020-09-22 00:00:00

abstract：:Humans shift their gaze to a new location several times per second. It is still unclear what determines where they look next. Fixation behavior is influenced by the low-level salience of the visual stimulus, such as luminance, contrast, and color, but also by high-level task demands and prior knowledge. Under natural ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schütz AC,Trommershäuser J,Gegenfurtner KR

更新日期：2012-05-08 00:00:00

abstract：:Recently the definition of the metazoan RNA polymerase II and archaeal core promoters has been expanded to include a region immediately upstream of the TATA box called the B recognition element (BRE), so named because eukaryal transcription factor TFIIB and its archaeal orthologue TFB interact with the element in a se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Littlefield O,Korkhin Y,Sigler PB

更新日期：1999-11-23 00:00:00

abstract：:Salt and water secretion from intestinal epithelia requires enhancement of anion permeability across the apical membrane of Cl- secreting cells lining the crypt, the secretory gland of the intestine. Paneth cells located at the base of the small intestinal crypt release enteric defensins (cryptdins) apically into the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lencer WI,Cheung G,Strohmeier GR,Currie MG,Ouellette AJ,Selsted ME,Madara JL

更新日期：1997-08-05 00:00:00

abstract：:Mutations in copper/zinc superoxide dismutase (SOD1) are causative for dominantly inherited amyotrophic lateral sclerosis (ALS). Despite high variability in biochemical properties among the disease-causing mutants, a proportion of both dismutase-active and -inactive mutants are stably bound to spinal cord mitochondria...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vande Velde C,Miller TM,Cashman NR,Cleveland DW

更新日期：2008-03-11 00:00:00

abstract：:During the periimplantation period of pregnancy, pig blastocysts undergo morphological changes and differentiation requiring secretion and transport of nutrients (histotroph) into the uterine lumen. Of these nutrients, glucose is converted to fructose, an isomer of glucose, by conceptus trophectoderm. Although glucose...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim J,Song G,Wu G,Bazer FW

更新日期：2012-06-19 00:00:00

abstract：:The [A] allele of SNP rs965513 in 9q22 has been consistently shown to be highly associated with increased papillary thyroid cancer (PTC) risk with an odds ratio of ∼1.8 as determined by genome-wide association studies, yet the molecular mechanisms remain poorly understood. Previously, we noted that the expression of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He H,Li W,Liyanarachchi S,Srinivas M,Wang Y,Akagi K,Wang Y,Wu D,Wang Q,Jin V,Symer DE,Shen R,Phay J,Nagy R,de la Chapelle A

更新日期：2015-05-12 00:00:00

abstract：:The nuclear envelope is a unique topological structure formed by lipid membranes in eukaryotic cells. Unlike other membrane structures, the nuclear envelope comprises two concentric membrane shells fused at numerous sites with toroid-shaped pores that impart a "geometric" genus on the order of thousands. Despite the i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torbati M,Lele TP,Agrawal A

更新日期：2016-10-04 00:00:00

abstract：:Mice with a targeted mutation of the gastric inhibitory polypeptide (GIP) receptor gene (GIPR) were generated to determine the role of GIP as a mediator of signals from the gut to pancreatic beta cells. GIPR-/- mice have higher blood glucose levels with impaired initial insulin response after oral glucose load. Althou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyawaki K,Yamada Y,Yano H,Niwa H,Ban N,Ihara Y,Kubota A,Fujimoto S,Kajikawa M,Kuroe A,Tsuda K,Hashimoto H,Yamashita T,Jomori T,Tashiro F,Miyazaki J,Seino Y

更新日期：1999-12-21 00:00:00

abstract：:Recombinant plasmids containing mutant or wild-type adenovirus serotype 2 EIa genes that produce the 12S mRNA alone, the 13S mRNA alone, or both mRNAs were cotransfected into HeLa cells with plasmids containing the viral EIIa or EIII transcription units. The amount of RNA produced from the EIIa and EIII promoters was ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leff T,Elkaim R,Goding CR,Jalinot P,Sassone-Corsi P,Perricaudet M,Kédinger C,Chambon P

更新日期：1984-07-01 00:00:00

abstract：:Deletion of 5 residues (Delta5) from the central cytoplasmic loop of the lactose permease of Escherichia coli has no significant effect on expression or activity, whereas Delta12 leads to increased rates of permease turnover after membrane insertion and decreased transport activity, and Delta20 abolishes insertion and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weinglass AB,Kaback HR

更新日期：2000-08-01 00:00:00

abstract：:Auditory speech perception enables listeners to access phonological categories from speech sounds. During speech production and speech motor learning, speakers' experience matched auditory and somatosensory input. Accordingly, access to phonetic units might also be provided by somatosensory information. The present st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patri JF,Ostry DJ,Diard J,Schwartz JL,Trudeau-Fisette P,Savariaux C,Perrier P

更新日期：2020-03-17 00:00:00

abstract：:APOBEC3 (A3) genes are members of the AID/APOBEC gene family that are found exclusively in mammals. A3 genes encode antiviral proteins that restrict the replication of retroviruses by inducing G-to-A mutations in their genomes and have undergone extensive amplification and diversification during mammalian evolution. E...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ito J,Gifford RJ,Sato K

更新日期：2020-01-07 00:00:00

abstract：:We report here that component members of the keratin intermediate filament (IF) type I and type II gene families of sheep are closely linked but apparently the two families are not. Nine genes, accounting for up to half of the keratin IF gene repertoire, were mapped in four cosmid clones and the linkage between the ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Powell BC,Cam GR,Fietz MJ,Rogers GE

更新日期：1986-07-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small, 18-22 nt long, noncoding RNAs that act as potent negative gene regulators in a variety of physiological and pathological processes. To repress gene expression, miRNAs are packaged into RNA-induced silencing complexes (RISCs) that target mRNAs for degradation and/or translational repressio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen AK,Sengupta P,Waki K,Van Engelenburg SB,Ochiya T,Ablan SD,Freed EO,Lippincott-Schwartz J

更新日期：2014-07-01 00:00:00

abstract：:T cells must respond differently to antigens of varying affinity presented at different doses. Previous attempts to map peptide MHC (pMHC) affinity onto T-cell responses have produced inconsistent patterns of responses, preventing formulations of canonical models of T-cell signaling. Here, a systematic analysis of T-c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lever M,Lim HS,Kruger P,Nguyen J,Trendel N,Abu-Shah E,Maini PK,van der Merwe PA,Dushek O

更新日期：2016-10-25 00:00:00

abstract：:We recently reported that CD3- natural killer (NK) cells express the zeta chain of the T-cell receptor complex (zeta NK) in association with higher molecular weight structures whose expression differs between individual NK cell clones. Because NK cell cytolytic activity is known to be triggered by perturbation of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson P,Caligiuri M,O'Brien C,Manley T,Ritz J,Schlossman SF

更新日期：1990-03-01 00:00:00

abstract：:CDK7 is a cyclin-dependent kinase proposed to function in two essential cellular processes: transcription and cell cycle regulation. CDK7 is the kinase subunit of the general transcription factor TFIIH that phosphorylates the C-terminal domain (CTD) of RNA polymerase II, and has been shown to be broadly required for t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wallenfang MR,Seydoux G

更新日期：2002-04-16 00:00:00

abstract：:Multiple independent mutations in neuroligin genes were identified in patients with familial autism, including the R451C substitution in neuroligin-3 (NL3). Previous studies showed that NL3(R451C) knock-in mice exhibited modestly impaired social behaviors, enhanced water maze learning abilities, and increased synaptic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Etherton M,Földy C,Sharma M,Tabuchi K,Liu X,Shamloo M,Malenka RC,Südhof TC

更新日期：2011-08-16 00:00:00

abstract：:Phospholamban (PLN) is an effective inhibitor of the sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA). Here, we examined PLN stability and degradation in primary cultured mouse neonatal cardiomyocytes (CMNCs) and mouse hearts using immunoblotting, molecular imaging, and [(35)S]methionine pulse-chase experiments, tog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teng AC,Miyake T,Yokoe S,Zhang L,Rezende LM Jr,Sharma P,MacLennan DH,Liu PP,Gramolini AO

更新日期：2015-06-09 00:00:00

abstract：:Active immunization using tumor antigen-loaded dendritic cells holds promise for the adjuvant treatment of cancer to eradicate or control residual disease, but so far, most dendritic cell trials have been performed in end-stage cancer patients with high tumor loads. Here, in a phase I/II trial, we investigated the eff...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Tendeloo VF,Van de Velde A,Van Driessche A,Cools N,Anguille S,Ladell K,Gostick E,Vermeulen K,Pieters K,Nijs G,Stein B,Smits EL,Schroyens WA,Gadisseur AP,Vrelust I,Jorens PG,Goossens H,de Vries IJ,Price DA,Oji Y

更新日期：2010-08-03 00:00:00

abstract：:Studies of the fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene in membranes of normal, transformed, and revertant 3T3 cells allowed estimation of microviscosities (eta) of the lipid bilayers of these cells. Fluorescence polarization values observed with normal cells were significantly lower than those obser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fuchs P,Parola A,Robbins PW,Blout ER

更新日期：1975-09-01 00:00:00

abstract：:Kss1, a yeast mitogen-activated protein kinase (MAPK), in its unphosphorylated (unactivated) state binds directly to and represses Ste12, a transcription factor necessary for expression of genes whose promoters contain filamentous response elements (FREs) and genes whose promoters contain pheromone response elements (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bardwell L,Cook JG,Zhu-Shimoni JX,Voora D,Thorner J

更新日期：1998-12-22 00:00:00

abstract：:The detrimental effects of elevated intensities of mid-UV radiation (UVB), a result of stratospheric ozone depletion during the austral spring, on the primary producers of the Antarctic marine ecosystem have been well documented. Here we report that natural populations of Antarctic zooplankton also sustain significant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malloy KD,Holman MA,Mitchell D,Detrich HW 3rd

更新日期：1997-02-18 00:00:00

abstract：:The RuvC protein of Escherichia coli catalyzes the resolution of recombination intermediates during genetic recombination and the recombinational repair of damaged DNA. Resolution involves specific recognition of the Holliday structure to form a complex that exhibits twofold symmetry with the DNA in an open configurat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennett RJ,West SC

更新日期：1996-10-29 00:00:00

abstract：:Intron removal from tRNA precursors involves cleavage by a tRNA splicing endonuclease to yield tRNA 3'-halves beginning with a 5'-hydroxyl, and 5'-halves ending in a 2',3'-cyclic phosphate. A tRNA ligase then incorporates this phosphate into the internucleotide bond that joins the two halves. Although this 3'-P RNA sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Englert M,Sheppard K,Aslanian A,Yates JR 3rd,Söll D

更新日期：2011-01-25 00:00:00

abstract：:Purine nucleoside analogs modified by replacement of the nitrogen atom at the 3 position by a CH group give a characteristic circular dichroism curve that is not substantially modified by chemical substitution at the 8 position. Since it is rather well established that 8-substituted purine nucleosides are predominantl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles DW,Townsend LB,Redington P,Eyring H

更新日期：1976-07-01 00:00:00

abstract：:The androgen receptor (AR) binds to androgen response elements and regulates target genes via a mechanism involving coregulators. Here we demonstrate that the AR can interact with the testicular orphan receptor-4 (TR4) and function as a repressor to down-regulate the TR4 target genes by preventing the TR4 binding to i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee YF,Shyr CR,Thin TH,Lin WJ,Chang C

更新日期：1999-12-21 00:00:00

abstract：:The 4D organization of the interphase nucleus, or the 4D Nucleome (4DN), reflects a dynamical interaction between 3D genome structure and function and its relationship to phenotype. We present initial analyses of the human 4DN, capturing genome-wide structure using chromosome conformation capture and 3D imaging, and f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen H,Chen J,Muir LA,Ronquist S,Meixner W,Ljungman M,Ried T,Smale S,Rajapakse I

更新日期：2015-06-30 00:00:00