Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice.

abstract：:Methanogenic archaea are major contributors to the global carbon cycle and were long thought to belong exclusively to the euryarchaeal phylum. Discovery of the methanogenesis gene cluster methyl-coenzyme M reductase (Mcr) in the Bathyarchaeota, and thereafter the Verstraetearchaeota, led to a paradigm shift, pushing b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berghuis BA,Yu FB,Schulz F,Blainey PC,Woyke T,Quake SR

更新日期：2019-03-12 00:00:00

abstract：:The kinetics of electrogenic events associated with the different steps of the light-induced proton pump of bacteriorhodopsin is well studied in a wide range of time scales by direct electric methods. However, the investigation of the fundamental primary charge translocation phenomena taking place in the functional en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Groma GI,Hebling J,Kozma IZ,Váró G,Hauer J,Kuhl J,Riedle E

更新日期：2008-05-13 00:00:00

abstract：:Mixed-metal oxides play a very important role in many areas of chemistry, physics, materials science, and geochemistry. Recently, there has been a strong interest in understanding phenomena associated with the deposition of oxide nanoparticles on the surface of a second (host) oxide. Here, scanning tunneling microscop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park JB,Graciani J,Evans J,Stacchiola D,Ma S,Liu P,Nambu A,Sanz JF,Hrbek J,Rodriguez JA

更新日期：2009-03-31 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection alters the expression of many cellular genes, including IFN-stimulated genes (ISGs) [Zhu, H., Cong, J.-P., Mamtora, G., Gingeras, T. & Shenk, T. (1998) Proc. Natl. Acad. Sci. USA 95, 14470-14475]. By using high-density cDNA microarrays, we show that the HCMV-regulated gene expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simmen KA,Singh J,Luukkonen BG,Lopper M,Bittner A,Miller NE,Jackson MR,Compton T,Früh K

更新日期：2001-06-19 00:00:00

abstract：:Extragalactic X-ray surveys over the past decade have dramatically improved understanding of the majority populations of active galactic nuclei (AGNs) over most of the history of the universe. Here we briefly highlight some of the exciting discoveries about AGN demography, physics, and ecology, with a focus on results...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brandt WN,Alexander DM

更新日期：2010-04-20 00:00:00

abstract：:Human nociceptive voltage-gated sodium channel (Na(v)1.7), a target of significant interest for the development of antinociceptive agents, is blocked by low nanomolar concentrations of (-)-tetrodotoxin(TTX) but not (+)-saxitoxin (STX) and (+)-gonyautoxin-III (GTX-III). These findings question the long-accepted view th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walker JR,Novick PA,Parsons WH,McGregor M,Zablocki J,Pande VS,Du Bois J

更新日期：2012-10-30 00:00:00

abstract：:High-grade neuroendocrine lung malignancies (large-cell neuroendocrine cell carcinoma, LCNEC, and small-cell lung carcinoma, SCLC) are among the most deadly lung cancer conditions with no optimal clinical management. The biological relationships between SCLC and LCNEC are still largely unknown and a current matter of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lázaro S,Pérez-Crespo M,Lorz C,Bernardini A,Oteo M,Enguita AB,Romero E,Hernández P,Tomás L,Morcillo MÁ,Paramio JM,Santos M

更新日期：2019-10-29 00:00:00

abstract：:The spatial organization of complex natural microbiomes is critical to understanding the interactions of the individual taxa that comprise a community. Although the revolution in DNA sequencing has provided an abundance of genomic-level information, the biogeography of microbiomes is almost entirely uncharted at the m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mark Welch JL,Rossetti BJ,Rieken CW,Dewhirst FE,Borisy GG

更新日期：2016-02-09 00:00:00

abstract：:The role of the renin-angiotensin system in blood pressure control and in the development of hypertension was investigated by generating transgenic mice carrying the rat renin or angiotensinogen gene or both genes under the control of the mouse metallothionein I promoter. The systolic blood pressure was significantly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohkubo H,Kawakami H,Kakehi Y,Takumi T,Arai H,Yokota Y,Iwai M,Tanabe Y,Masu M,Hata J

更新日期：1990-07-01 00:00:00

abstract：:It was shown in an earlier paper how to connect, in principle, the biochemical states of a cross-bridge with the mechanics of muscular contraction, by the methods of statistical mechanics. The treatment applies to cross-bridges that are able to interact with only one actin site at a time. The present paper shows that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hill TL

更新日期：1973-10-01 00:00:00

abstract：:We investigated the effects of beta-estradiol on the locomotor behavior of female mice in a radial maze. Data comprising the total distance traveled during each arm entry were obtained from video records of six consecutive daily recording sessions. Distributions of these data were bimodal for both ovariectomized contr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coop AD,Stavarache MA,Pfaff DW,Reeke GN

更新日期：2006-10-17 00:00:00

abstract：:The accumulation of misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and triggers the unfolded protein response (UPR). Failure to resolve ER stress leads to apoptotic cell death via a yet unclear mechanism. Here, we show that RNF183, a membrane-spanning RING finger protein, localizes to the ER and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu Y,Li X,Jia J,Zhang Y,Li J,Zhu Z,Wang H,Tang J,Hu J

更新日期：2018-03-20 00:00:00

abstract：:Unlike other predators that use vision as their primary sensory system, bats compute the three-dimensional (3D) position of flying insects from discrete echo snapshots, which raises questions about the strategies they employ to track and intercept erratically moving prey from interrupted sensory information. Here, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salles A,Diebold CA,Moss CF

更新日期：2020-11-17 00:00:00

abstract：:The dendritic building blocks with a focal pyrene unit self-organize into vesicles in aqueous phase. The in situ inclusion of the focal pyrene units into the cavity of beta- or gamma-cyclodextrin (CD) induces self-assembled organic nanotubes with an average outer diameter of approximately 45 nm and inner diameter of 2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park C,Lee IH,Lee S,Song Y,Rhue M,Kim C

更新日期：2006-01-31 00:00:00

abstract：:Climate change and resource exploitation have been shown to modify the importance of bottom-up and top-down forces in ecosystems. However, the resulting pattern of trophic control in complex food webs is an emergent property of the system and thus unintuitive. We develop a statistical nondeterministic model, capable o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lynam CP,Llope M,Möllmann C,Helaouët P,Bayliss-Brown GA,Stenseth NC

更新日期：2017-02-21 00:00:00

abstract：:Mitochondrial DNA from several mammalian species has been digested with a site-specific restriction endonuclease (HaeIII) from Haemophilus aegyptius. A quantitative analysis of the resulting specific fragments indicates that the mtDNA of any individual mammal is predominantly a single molecular clone. Gel analysis of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Potter SS,Newbold JE,Hutchison CA 3rd,Edgell MH

更新日期：1975-11-01 00:00:00

abstract：:Cellular communities in living tissues act in concert to establish intricate microenvironments, with complexity difficult to recapitulate in vitro. We report a method for docking numerous cellularized hydrogel shapes (100-1,000 µm in size) into hydrogel templates to construct 3D cellular microenvironments. Each shape ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eng G,Lee BW,Parsa H,Chin CD,Schneider J,Linkov G,Sia SK,Vunjak-Novakovic G

更新日期：2013-03-19 00:00:00

abstract：:Relatively low concentrations of methylxanthines increase spontaneous twitching in cultured muscle fibers; they also cause a second activity, escalation, which is the initiation and undiminished propagation of visible waves. The effect on twitching is abolished by depolarizing concentrations of K(+) or by tetrodotoxin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coleman AW,Coleman JR,Griffin JD,Weltman JK,Chapman KM

更新日期：1972-03-01 00:00:00

abstract：:The nature of integrated viral DNA in normal and leukemic chicken cells has been studied by sequential nucleic acid hybridization procedures that localize the viral specific DNA in cellular DNA regions differing in reiteration frequency. First, DNA.DNA reassociation was employed to fractionate cellular DNA sequences a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Evans RM,Baluda MA,Shoyab M

更新日期：1974-08-01 00:00:00

abstract：:The spleen from a patient with adult Gaucher's disease was shown to be deficient in a beta-glucosidase (EC 3.2.1.21) isoenzyme that has optimal activity at pH 4.0-4.3, and is stimulated by 0.02% Triton X-100. A mixture of spleen homogenates from a control and from the patient contained beta-glucosidase activity equiva...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho MW,O'Brien JS

更新日期：1971-11-01 00:00:00

abstract：:The long-lived ethylene, cyclohexene, and norbornenemercurinium ions prepared in superacidic, low-nucleophilic media have been studied by (13)C and (199)Hg NMR spectroscopy. The norbornenemercurinium ion shows temperature-dependent (13)C and (199)Hg NMR spectra, consistent with equilibration via rapid hydride and Wagn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olah GA,Garcia-Luna A

更新日期：1980-09-01 00:00:00

abstract：:In this study, we defined the role of peroxisome proliferator-activated receptor beta/delta (PPARdelta) in metabolic homeostasis by using subtype selective agonists. Analysis of rat L6 myotubes treated with the PPARdelta subtype-selective agonist, GW501516, by the Affymetrix oligonucleotide microarrays revealed that P...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tanaka T,Yamamoto J,Iwasaki S,Asaba H,Hamura H,Ikeda Y,Watanabe M,Magoori K,Ioka RX,Tachibana K,Watanabe Y,Uchiyama Y,Sumi K,Iguchi H,Ito S,Doi T,Hamakubo T,Naito M,Auwerx J,Yanagisawa M,Kodama T,Sakai J

更新日期：2003-12-23 00:00:00

abstract：:The main consequence of the Chernobyl accident has been an increase in papillary thyroid carcinomas (PTCs) in those exposed to radioactive fallout as young children. Our aim was to identify genomic alterations that are associated with exposure to radiation. We used array comparative genomic hybridization to analyze a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hess J,Thomas G,Braselmann H,Bauer V,Bogdanova T,Wienberg J,Zitzelsberger H,Unger K

更新日期：2011-06-07 00:00:00

abstract：:Secreted parasitism proteins encoded by parasitism genes expressed in esophageal gland cells mediate infection and parasitism of plants by root-knot nematodes (RKN). Parasitism gene 16D10 encodes a conserved RKN secretory peptide that stimulates root growth and functions as a ligand for a putative plant transcription ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang G,Allen R,Davis EL,Baum TJ,Hussey RS

更新日期：2006-09-26 00:00:00

abstract：:The roots and stems of dicotyledonous plants thicken by the cell proliferation in the cambium. Cambial proliferation changes in response to environmental factors; however, the molecular mechanisms that regulate cambial activity are largely unknown. The quadruple Arabidopsis thaliana mutant atipt1;3;5;7, in which 4 gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsumoto-Kitano M,Kusumoto T,Tarkowski P,Kinoshita-Tsujimura K,Václavíková K,Miyawaki K,Kakimoto T

更新日期：2008-12-16 00:00:00

abstract：:To visualize histone acetylation in living cells, we developed a genetically encoded fluorescent resonance energy transfer (FRET)-based indicator. Response of the indicator reflects changes in the acetylation state of both K5 and K8 in histone H4. Using this acetylation indicator, we were able to monitor the dynamic f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sasaki K,Ito T,Nishino N,Khochbin S,Yoshida M

更新日期：2009-09-22 00:00:00

abstract：:A crucial step in recent theories of human origins is the emergence of strong pair-bonding between males and females accompanied by a dramatic reduction in the male-to-male conflict over mating and an increased investment in offspring. How such a transition from promiscuity to pair-bonding could be achieved is puzzlin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gavrilets S

更新日期：2012-06-19 00:00:00

abstract：:Keratins 14 and 5 are the structural hallmarks of the basal keratinocytes of the epidermis and outer root sheath (ORS) of the hair follicle. Their genes are controlled in a tissue-specific manner and thus serve as useful tools to elucidate the regulatory mechanisms involved in keratinocyte-specific transcription. Prev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sinha S,Fuchs E

更新日期：2001-02-27 00:00:00

abstract：:In rod photoreceptors, several phototransduction components display light-dependent translocation between cellular compartments. Notably, the G protein transducin translocates from rod outer segments to inner segments/spherules in bright light, but the functional consequences of translocation remain unclear. We genera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Majumder A,Pahlberg J,Boyd KK,Kerov V,Kolandaivelu S,Ramamurthy V,Sampath AP,Artemyev NO

更新日期：2013-07-23 00:00:00

abstract：:The pore domain of voltage-gated potassium (Kv) channels consists of transmembrane helices S5 and S6, the turret, the pore helix, the selectivity filter, and the loop preceding S6, with a tertiary reentrant structure between S5 and S6. Using biogenic intermediates, mass tagging (pegylation), and a molecular tape measu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gajewski C,Dagcan A,Roux B,Deutsch C

更新日期：2011-02-22 00:00:00