Abstract:
:Human cytomegalovirus (HCMV) infection alters the expression of many cellular genes, including IFN-stimulated genes (ISGs) [Zhu, H., Cong, J.-P., Mamtora, G., Gingeras, T. & Shenk, T. (1998) Proc. Natl. Acad. Sci. USA 95, 14470-14475]. By using high-density cDNA microarrays, we show that the HCMV-regulated gene expression profile in fibroblasts does not differ substantially from the response generated by IFN. Furthermore, we identified the specific viral component triggering this response as the envelope glycoprotein B (gB). Cells treated with gB, but not other herpesviral glycoproteins, exhibited the same transcriptional profile as HCMV-infected cells. Thus, the interaction of gB with its as yet unidentified cellular receptor is the principal mechanism by which HCMV alters cellular gene expression early during infection. These findings highlight a pioneering paradigm for the consequences of virus-receptor interactions.
journal_name
Proc Natl Acad Sci U S Aauthors
Simmen KA,Singh J,Luukkonen BG,Lopper M,Bittner A,Miller NE,Jackson MR,Compton T,Früh Kdoi
10.1073/pnas.121177598keywords:
subject
Has Abstractpub_date
2001-06-19 00:00:00pages
7140-5issue
13eissn
0027-8424issn
1091-6490pii
121177598journal_volume
98pub_type
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