Abstract：
:This review emphasizes some of the differences between the fate of allogeneic H2-incompatible T-cells, when injected into immunodeficient, T-depleted mice, or as parental cells injected into F1 hybrids. In both conditions, allogeneic cells are eliminated, a rejection which cannot be predicted from the fate of a skin graft. While in both situations a phase of GVHR is observed, it is of short duration in allogeneic T-B reactions, and it is obvious that the production of allo-antibodies by the host, which is enhanced by the GVHR, is the major mechanism of allogeneic T-cell elimination, resulting in a rapid self-cure of the GVHR. In T-vs-B GVHR, the enhancement of the humoral response is strikingly restricted to the allo-antigens of the T-cells, and correspond therefore to a peculiar form of "allogeneic effect", in fact an "allogeneic suicide" which implies a linked T-B collaboration, while in P-F1 combinations, there is a enhancement of the humoral response to unrelated antigens (i.e. unlinked T-B collaboration or the classical allogeneic effect) and a polyclonal B-cell activation, which can result from the much more protracted course of the GVHR. The parental cells surviving in the spleen of an F1 semi-allogeneic host, undergoing a lethal GVHR were characterized at the clonal level: they were exclusively of the Lyt 2- MLR responder and polyvalent helper variety. This indicates that the Lyt-2- and polyvalent helper subset is selected during an allo-reaction in vivo (either because it is more rapidly replicating and/or less negatively selected by the host resistance) and that it is capable of inflicting a lethal GVHR.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Piguet PF,Vassalli Pdoi
10.1111/j.1600-065x.1983.tb01079.xsubject
Has Abstractpub_date
1983-01-01 00:00:00pages
71-86eissn
0105-2896issn
1600-065Xjournal_volume
73pub_type
杂志文章,评审abstract：:X-linked lymphoproliferative disease (XLP) is an inherited immune defect caused by mutations in the Src homology 2 domain-containing gene 1A, which encodes the adapter protein, signaling lymphocytic activation molecule (SLAM)-associated protein (SAP). SAP is expressed in T cells, natural killer (NK) cells, and NKT cel...
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journal_title：Immunological reviews
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更新日期：1992-08-01 00:00:00
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更新日期：2015-11-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2012-05-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2008-12-01 00:00:00
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更新日期：2010-05-01 00:00:00
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journal_title：Immunological reviews
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更新日期：1990-08-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2007-06-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2001-12-01 00:00:00
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journal_title：Immunological reviews
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更新日期：1999-12-01 00:00:00
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journal_title：Immunological reviews
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更新日期：1989-12-01 00:00:00
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journal_title：Immunological reviews
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更新日期：1995-12-01 00:00:00
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更新日期：2017-09-01 00:00:00
