Abstract:
:The phorbol esters phorbol 12-retinoate 13-acetate (RPA) and 12-O-tetradecanoyl phorbol 13-acetate (TPA) were used to investigate the role of tumor promoters in the control of hormone response in normal and leukemic myeloid cells. RPA and TPA inhibited the binding of [20-3H]phorbol 12,13-dibutyrate to the leukemic cells in a competitive manner with 50% inhibition values of 5.2 +/- 1.3 and 1.1 +/- 0.6 nM, respectively. RPA, like TPA, enhanced (1) prostaglandin E1-induced cyclic AMP synthesis, (2) the differentiation of leukemic cells induced by the normal myeloid differentiation-inducing protein, and (3) the formation of normal myeloid cells colonies induced by the normal myeloid growth-inducing protein. Both compounds can thus control endogenous cell regulators. Since RPA functions in the second stage of tumor promotion in mouse skin, it is suggested that the control of such endogenous regulators may involve biochemical pathways similar to those that are activated in the second stage of tumor promotion.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Simantov R,Marks F,Fürstenberger G,Sachs Ldoi
10.1002/ijc.2910310416subject
Has Abstractpub_date
1983-04-15 00:00:00pages
497-500issue
4eissn
0020-7136issn
1097-0215journal_volume
31pub_type
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:1989-11-15 00:00:00
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journal_title:International journal of cancer
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更新日期:1998-11-23 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-11-15 00:00:00
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更新日期:2006-05-01 00:00:00
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journal_title:International journal of cancer
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更新日期:1996-08-07 00:00:00
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journal_title:International journal of cancer
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更新日期:2000-10-01 00:00:00
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