Abstract:
:The phorbol esters phorbol 12-retinoate 13-acetate (RPA) and 12-O-tetradecanoyl phorbol 13-acetate (TPA) were used to investigate the role of tumor promoters in the control of hormone response in normal and leukemic myeloid cells. RPA and TPA inhibited the binding of [20-3H]phorbol 12,13-dibutyrate to the leukemic cells in a competitive manner with 50% inhibition values of 5.2 +/- 1.3 and 1.1 +/- 0.6 nM, respectively. RPA, like TPA, enhanced (1) prostaglandin E1-induced cyclic AMP synthesis, (2) the differentiation of leukemic cells induced by the normal myeloid differentiation-inducing protein, and (3) the formation of normal myeloid cells colonies induced by the normal myeloid growth-inducing protein. Both compounds can thus control endogenous cell regulators. Since RPA functions in the second stage of tumor promotion in mouse skin, it is suggested that the control of such endogenous regulators may involve biochemical pathways similar to those that are activated in the second stage of tumor promotion.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Simantov R,Marks F,Fürstenberger G,Sachs Ldoi
10.1002/ijc.2910310416subject
Has Abstractpub_date
1983-04-15 00:00:00pages
497-500issue
4eissn
0020-7136issn
1097-0215journal_volume
31pub_type
杂志文章abstract::Commercial cow milk contains considerable amounts of estrogens. Our study assessed the effect of commercial low-fat milk on the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats. Eighty 6-week-old female Sprague-Dawley rats received a single oral dose of 5 mg DMBA. Twenty-four hours l...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20172
更新日期:2004-07-01 00:00:00
abstract::Results of epidemiologic studies of physical activity and ovarian cancer risk are inconsistent. Few have attempted to measure physical activity over the lifetime or in specific age windows, which may better capture etiologically relevant exposures. We examined participation in moderate-to-vigorous recreational physica...
journal_title:International journal of cancer
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更新日期:2020-04-01 00:00:00
abstract::The insulin like growth factor (IGF) signaling pathway has been shown to contribute to melanoma progression, but little is known about the role of the IGF binding protein 3 (IGFBP-3) in melanoma biology. The aim of the present study was to characterize expression, function and regulation of IGFBP-3 in malignant melano...
journal_title:International journal of cancer
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更新日期:2010-01-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1038
更新日期:2001-12-20 00:00:00
abstract::Aberrant promoter methylation of normally unmethylated CpG-islands offers a promising tool for the development of molecular biomarkers. We investigated bronchial aspirates of patients admitted for suspected lung cancer with regard to the prevalence of aberrant methylation of potential marker genes. Applying quantitati...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21090
更新日期:2005-09-20 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/ijc.24472
更新日期:2009-10-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970502)71:3<429::aid-ijc
更新日期:1997-05-02 00:00:00
abstract::Second-line ipilimumab has been publicly funded in Ontario for metastatic melanoma (MM) since September 2012. We examined real-world toxicity of second-line ipilimumab compared to standard second-line treatments prior to funding. MM patients who received systemic treatment from April 2005 to March 2015 were included. ...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2020-10-26 00:00:00
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journal_title:International journal of cancer
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更新日期:2012-06-15 00:00:00
abstract::Polychlorinated biphenyls (PCBs) are widespread, chemically-stable environmental contaminants; some congeners are commonly found in human adipose tissue and breast milk. We investigated the effects of a single dose of one PCB mixture (Aroclor 1254) on tumors initiated by N-nitrosodimethylamine (NDMA), also a common en...
journal_title:International journal of cancer
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doi:10.1002/ijc.2910380118
更新日期:1986-07-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2010-11-15 00:00:00
abstract::The incidence of tonsillar cancer and the proportion of human papillomavirus (HPV) positive tonsillar cancer cases have increased in the last decades. In parallel, treatment for tonsillar cancer has been intensified e.g., by accelerated radiotherapy, and chemotherapy, resulting in more side effects. Patients with HPV-...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26490
更新日期:2012-09-01 00:00:00
abstract::Osteolytic bone diseases are a prominent feature of multiple myeloma (MM), resulting from aberrant osteoclastic bone resorption that is uncoupled from osteoblastic bone formation. Myeloma stimulates osteoclastogenesis, which is largely dependent on an increase in receptor activator of NF-κB ligand (RANKL) and a decrea...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28116
更新日期:2013-09-01 00:00:00
abstract::miRNAs have emerged as post-transcriptional regulators that are critically involved in the pathogenesis of a number of human cancers. Cdc42, one of the best characterized members of the Rho GTPase family, is found to be up-regulated in several types of human tumors and has been implicated in cancer initiation and prog...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25452
更新日期:2011-03-15 00:00:00
abstract::Hooded rats bearing a syngeneic methylcholanthrene-induced tumour were evaluated for extent of in vivo host immunity and this was correlated by in vitro techniques with the levels of circulating tumour antigen and specific antibody. Early tumour growth was associated with detectable immunity, as measured by the capaci...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910150619
更新日期:1975-06-15 00:00:00
abstract::The numbers of new cancer cases in 16 common sites occurring in 1980 have been estimated for 24 areas of the world for which the United Nations produces population estimates. For the world as a whole, the total number of new cases was 6.35 million, almost exactly evenly divided between the developed and developing cou...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410205
更新日期:1988-02-15 00:00:00
abstract::We examined pp60c-src protein kinase activity in human gastric carcinoma cell lines and gastric carcinoma tissues as well as normal mucosa. pp60c-src kinase activity was detected in all 5 carcinoma cell lines at various levels. Of 16 gastric carcinoma tissues, 8 showed higher pp60c-src kinase activity in tumor tissues...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450510
更新日期:1990-05-15 00:00:00
abstract::Transforming growth factor-beta (TGFbeta1) enhances human MDA-MB-231 breast tumour cell invasion of reconstituted basement membrane in vitro but does not inhibit proliferation of this cell line. In contrast to basal invasion, which is plasmin-, urokinase (uPA)-, tissue-type plasminogen activator (t-PA)-, matrix metall...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980302)75:5<721::aid-ijc
更新日期:1998-03-02 00:00:00
abstract::An important feature of cytochrome P450 (CYP) 2B1 is its high ability to convert the prodrug cyclophosphamide (CPA) to therapeutically cytotoxic metabolites, resulting in interstrand DNA-cross-linking and cell death. We have examined whether and how the phosphorylation of CYP2B1 influences CPA metabolic activation in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1517
更新日期:2001-12-01 00:00:00
abstract::Data on the incidence of childhood cancer in Queensland during the 10-year period 1979-88 are presented. During this period, 786 cases were registered. The average annual crude and age-standardized (to the world population) incidence rates for both sexes were 12.63 and 13.30 per 100,000 respectively. The incidence of ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450603
更新日期:1990-06-15 00:00:00
abstract::Fibronectin in human solid tumors was studied by indirect immunofluorescence staining of biopsy material. Altogether 73 tumors were examined, comprising 12 sarcomas, 3 melanomas 1 reticulum cell sarcoma, 39 carcinomas, 6 benign soft-tissue tumors and 12 benign epithelial tumors. In all sarcomas the individual tumor ce...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270403
更新日期:1981-01-01 00:00:00
abstract::Colorectal cancer is among the commonest cancers worldwide. Dietary factors have been linked to colorectal cancer risk, however, few studies have evaluated the relationship between a priori dietary patterns and colorectal cancer risk. We evaluated the effect of adherence to a Mediterranean dietary pattern, as measured...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27740
更新日期:2013-03-15 00:00:00
abstract::Oncolytic adenoviruses are being developed as novel anticancer therapeutics and currently undergoing clinical trials. We previously demonstrated that telomerase-specific replication-competent adenovirus (Telomelysin: OBP-301), in which the human telomerase reverse transcriptase (hTERT) promoter regulates viral replica...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21846
更新日期:2006-07-15 00:00:00
abstract::Six oncogenic cell lines were established from primary sarcomas that had been induced in thymectomized, aged, BALB/cSt mice by the injection of 3-methylcholanthrene. Of these lines, three produced B-tropic murine leukemia virus (MuLV), i.e. MuLV that would patently infect fibroblasts of BALB/c origin but not those fro...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210216
更新日期:1978-02-15 00:00:00
abstract::We evaluated whether regular mammographic screening of women aged 65 years or older affected breast cancer mortality. In Nijmegen, a population-based screening program for breast cancer was started in 1975, with biennial mammography for women aged 35-64 years. Since 1977, elderly women have also been participating. Fo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960611)66:6<727::AID-IJC
更新日期:1996-06-11 00:00:00
abstract::Previously, the induction of pancreatic carcinogenesis in the rat using azaserine has involved a multiple-dose treatment protocol. The objective of the present study was to determine the effect of multiple azaserine treatments on pancreatic DNA synthesis and to develop a protocol for a single-dose initiation of pancre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280511
更新日期:1981-11-15 00:00:00
abstract::Leukocyte-transforming agents were isolated in baboon leukocytes inoculated with oral excretions from immunosuppressed chimpanzees. The transformed lymphoblasts had B cell surface markers and harbored herpes-type virus particles; 5-10% of the cells contained cytoplasmic antigens reactive with Epstein-Barr virus (EBV)-...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910200318
更新日期:1977-09-15 00:00:00
abstract::The lck gene encodes a lymphocyte-specific tyrosine protein kinase, p56lck, the expression of which is almost exclusive in T-cells. The expression of lck in human T-cell leukemia virus type I (HTLV-I)-transformed T-cell lines is closely associated with interleukin-2 (IL-2) dependence for their growth. That is, IL-2-de...
journal_title:International journal of cancer
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doi:10.1002/ijc.2910480526
更新日期:1991-07-09 00:00:00
abstract::Gliomas are aggressive tumors of the central nervous system originating from proliferating neural cells. Regulators of neural stem or progenitor cells biology may thus influence aspects of brain tumorigenesis, such as the maintenance of tumor-propagating potential. We investigated the role of Pax6, a neurogenic transc...
journal_title:International journal of cancer
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doi:10.1002/ijc.27606
更新日期:2012-10-01 00:00:00
abstract::Following exposure to feline leukemia virus (FeLV), cats that resist leukemia produce complement dependent antibodies (CDA) which lyse leukemia cells in the presence of cat complement. The CDA activity has been shown to be directed to feline oncornavirus-associated cell membrane antigen (FOCMA) found on the surface of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280215
更新日期:1981-08-15 00:00:00