Abstract:
:Synchronous gastric carcinomas are found in 4% to 10% of all gastric carcinomas, and the tumor multiplicity is believed to be related to genetic predisposition. To investigate the role of mismatch repair error in synchronous gastric carcinomas, we analyzed the microsatellite instability (MSI) status of 101 cancers from 48 gastrectomy specimens and compared them with 149 solitary gastric carcinomas. Multiple synchronous gastric carcinomas are characterized by slightly older age, predominance in males, early stage and lower lymph node metastasis. Among the 48 cases, 8 (18 lesions) were associated with a gastric adenoma (type I) and 40 (83 lesions) were not associated with a gastric adenoma (type II). The MSI+ rate was 50% in the type I and 8.4% in the type II synchronous gastric carcinomas (p < 0.001), while that of solitary gastric carcinomas was 9.4%. In addition, the frameshift mutation rates of the TGF-betaRII, BAX and hMSH3 genes in the type I synchronous carcinomas were higher than those in the type II synchronous carcinomas. These findings indicate that a defect in the mismatch repair system might play a role in the carcinogenesis of a minor subset of multiple gastric carcinomas associated with adenomas.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Lee HS,Lee BL,Kim SH,Woo DK,Kim HS,Kim WHdoi
10.1002/1097-0215(200002)9999:9999<::aid-ijc1105>3keywords:
subject
Has Abstractpub_date
2001-03-01 00:00:00pages
619-24issue
5eissn
0020-7136issn
1097-0215pii
10.1002/1097-0215(200002)9999:9999<::AID-IJC1105>3journal_volume
91pub_type
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