Competitive inhibition of gamma-aminobutyric acid receptor binding by N-2-hydroxyethylpiperazine-N'-2-e-ethanesulfonic acid and related buffers.

abstract：:Amyloid beta (Aβ) peptide is the major constituent of the extracellular amyloid plaques deposited in the brains of Alzheimer's disease patients and is central to the pathogenic pathway causing this disease. The identity of the neurotoxic Aβ species remains elusive. We previously reported that Aβ toxicity correlates st...

journal_title：Journal of neurochemistry

authors： Jana MK,Cappai R,Pham CL,Ciccotosto GD

更新日期：2016-02-01 00:00:00

abstract：:The mesolimbic system of the brain has been shown to be involved in the reward properties of a number of agents. It is possible that release of monoamines by nicotine in this brain area could be related to the pleasurable aspects related to cigarette smoking. In this investigation, the effect of nicotine on the releas...

journal_title：Journal of neurochemistry

authors： Rowell PP,Carr LA,Garner AC

更新日期：1987-11-01 00:00:00

abstract：:The N141I missense mutation in presenilin (PS) 2 is tightly linked with a form of autosomal dominant familial Alzheimer's disease (AD) in the Volga German families. We have generated transgenic mouse lines overexpressing human wild-type or mutant PS2 under transcriptional control of the chicken beta-actin promoter. In...

journal_title：Journal of neurochemistry

authors： Oyama F,Sawamura N,Kobayashi K,Morishima-Kawashima M,Kuramochi T,Ito M,Tomita T,Maruyama K,Saido TC,Iwatsubo T,Capell A,Walter J,Grünberg J,Ueyama Y,Haass C,Ihara Y

更新日期：1998-07-01 00:00:00

abstract：:Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease and is estimated to affect approximately 1-4% of individuals aged over 60 years old. Although considerable efforts have been invested into developing disease-modifying therapies for Parkinson's disease, such efforts have...

journal_title：Journal of neurochemistry

authors： Fayyad M,Salim S,Majbour N,Erskine D,Stoops E,Mollenhauer B,El-Agnaf OMA

更新日期：2019-09-01 00:00:00

abstract：:Microglia, macrophage-like cells in the CNS, are multifunctional cells; they play an important role in removal of dead cells or their remnants by phagocytosis in the CNS degeneration and are one of important cells in the CNS cytokine network to produce and respond to a variety of cytokines. The functions of microglia ...

journal_title：Journal of neurochemistry

authors： Sawada M,Suzumura A,Hosoya H,Marunouchi T,Nagatsu T

更新日期：1999-04-01 00:00:00

abstract：:Cricket (Acheta domesticus) terminal abdominal ganglia (TG) contain high concentrations (approximately 2 pmol/mg protein) of muscarinic and nicotinic cholinergic binding sites, based on the capacity of TG to bind specifically the labelled ligands L-[3H]quinuclidinyl benzilate ([3H]QNB) and [125I]alpha-bungarotoxin ([1...

journal_title：Journal of neurochemistry

authors： Meyer MR,Reddy GR

更新日期：1985-10-01 00:00:00

abstract：:The role of asparagine as precursor for the neurotransmitter aspartate was investigated in rat striatum in vitro. 14C-asparagine incubated with striatal slices is converted to a great extent to 14C-aspartate which is released in a calcium-dependent manner by high KCl. Furthermore, a frontoparietal cortex ablation of t...

journal_title：Journal of neurochemistry

authors： Reubi JC,Toggenburger G,Cuénod M

更新日期：1980-10-01 00:00:00

abstract：:The [14C]deoxyglucose [Sokoloff et al., J. Neurochem. 28, 897-916 (1977)] and [6-14C]glucose [Hawkins et al., Am. J. Physiol. 248, C170-C176 (1985)] quantitative autoradiographic methods were used to measure regional brain glucose utilization in awake rats. The spatial resolution and qualitative appearance of the auto...

journal_title：Journal of neurochemistry

authors： Collins RC,McCandless DW,Wagman IL

更新日期：1987-11-01 00:00:00

abstract：:The loss of ATP, which is needed for ionic homeostasis, is an early event in the neurotoxicity of glutamate and beta-amyloid (A(beta)). We hypothesize that cells supplemented with the precursor creatine make more phosphocreatine (PCr) and create larger energy reserves with consequent neuroprotection against stressors....

journal_title：Journal of neurochemistry

authors： Brewer GJ,Wallimann TW

更新日期：2000-05-01 00:00:00

abstract：:Abstract The dualistic activities of the amyloid beta (Abeta) peptide as a pro-oxidant and ubiquitous constituent of amyloid deposits in Alzheimer's disease plaques and as an antioxidant of purported physiological function has been suggested but the mechanisms are far from being understood. In this report we measure s...

journal_title：Journal of neurochemistry

authors： Kuperstein F,Brand A,Yavin E

更新日期：2004-11-01 00:00:00

abstract：:We have examined the binding of the adenosine agonist radioligands [3N]N6-cyclohexyladenosine ([3H]CHA) and [3H]5'-N-ethylcarboxamidoadenosine ([3H]NECA) to membranes prepared from postmortem human pineal glands. The results showed that the A-1-specific ligand CHA did not bind to membranes. By contrast, [3H]NECA, a no...

journal_title：Journal of neurochemistry

authors： Reynaud D,Gharib A,Lagarde M,Sarda N

更新日期：1990-10-01 00:00:00

abstract：:It is well established that inflammatory changes contribute to brain ageing, and an increased concentration of proinflammatory cytokine, interleukin-1beta (IL-1beta), has been reported in the aged brain associated with a deficit in long-term potentiation (LTP) in rat hippocampus. The precise age at which changes are i...

journal_title：Journal of neurochemistry

authors： Griffin R,Nally R,Nolan Y,McCartney Y,Linden J,Lynch MA

更新日期：2006-11-01 00:00:00

abstract：:We recently reported that prostaglandin E2 (PGE2) stimulated phosphoinositide metabolism in cultured bovine adrenal chromaffin cells and that PGE2 and ouabain, an inhibitor of Na+,K+-ATPase, synergistically induced a gradual secretion of catecholamines from the cells. The effect on catecholamine release was specific f...

journal_title：Journal of neurochemistry

authors： Tanaka T,Yokohama H,Negishi M,Hayashi H,Ito S,Hayaishi O

更新日期：1990-01-01 00:00:00

abstract：:Cyclin-dependent kinase 5 (Cdk5) is emerging as a neuronal protein kinase involved in multiple aspects of neurotransmission in both post- and presynaptic compartments. Within the reward/motor circuitry of the basal ganglia, Cdk5 regulates dopamine neurotransmission via phosphorylation of the postsynaptic signal transd...

journal_title：Journal of neurochemistry

authors： Kansy JW,Daubner SC,Nishi A,Sotogaku N,Lloyd MD,Nguyen C,Lu L,Haycock JW,Hope BT,Fitzpatrick PF,Bibb JA

更新日期：2004-10-01 00:00:00

abstract：:Mechanical transection of the nigrostriatal dopamine pathway at the medial forebrain bundle (MFB) results in the delayed degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). We have previously demonstrated that c-Jun activation is an obligate component of neuronal death in this model. Her...

journal_title：Journal of neurochemistry

authors： Crocker SJ,Hayley SP,Smith PD,Mount MP,Lamba WR,Callaghan SM,Slack RS,Park DS

更新日期：2006-01-01 00:00:00

abstract：:Leucine and beta-(+/-)-2-aminobicyclo[2.2.1]heptane-2-carboxylic acid (BCH) stimulated, in a dose-dependent manner, reductive amination of 2-oxoglutarate in rat brain synaptosomes treated with Triton X-100. The concentration dependence curves were sigmoid, with 10-15-fold stimulations at 15 mM leucine (or BCH); oxidat...

journal_title：Journal of neurochemistry

authors： Erecińska M,Nelson D

更新日期：1990-04-01 00:00:00

abstract：:Hippocampus mossy fibre terminals activate CA3 pyramidal neurons via two distinct mechanisms, both quantal and glutamatergic: (i) rapid excitatory transmission in response to afferent action potentials and (ii) delayed and prolonged release following nicotinic receptor activation. These processes were analysed here us...

journal_title：Journal of neurochemistry

authors： Bancila V,Cordeiro JM,Bloc A,Dunant Y

更新日期：2009-07-01 00:00:00

abstract：:The presence of the biologically uncommon D-aspartic acid (D-aspartate) in human brain white matter has been previously reported. The earlier study has now been expanded to include D/L-aspartate ratios from 67 normal brains. The data show that the D-aspartate content increases rapidly from 1 year to approximately 35 y...

journal_title：Journal of neurochemistry

authors： Man EH,Fisher GH,Payan IL,Cadilla-Perezrios R,Garcia NM,Chemburkar R,Arends G,Frey WH 2nd

更新日期：1987-02-01 00:00:00

abstract：:Regulation of prostaglandin (PG) E2 receptors was investigated in a 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate-solubilized fraction from the synaptic membrane of porcine temporal cortex. The fraction was preincubated with exogenous protein kinases, and then the binding of PGE2 was measured. PGE2 binding...

journal_title：Journal of neurochemistry

authors： Morii H,Tanemura M,Watanabe Y

更新日期：1991-10-01 00:00:00

abstract：:The export of glutamine from astrocytes, and the uptake of glutamine by neurons, are integral steps in the glutamate-glutamine cycle, a major pathway for the replenishment of neuronal glutamate. We review here the functional and molecular identification of the transporters that mediate this transfer. The emerging pict...

journal_title：Journal of neurochemistry

authors： Bröer S,Brookes N

更新日期：2001-05-01 00:00:00

abstract：:Preincubation of D384 cells, derived from the human astrocytoma cell line G-CCM, with dopamine resulted in a time-dependent attenuation of cyclic AMP responsiveness to subsequent dopamine stimulation. This effect was agonist specific because the prostaglandin E1 (PGE1) stimulation of cyclic AMP of similarly treated ce...

journal_title：Journal of neurochemistry

authors： Balmforth AJ,Warburton P,Ball SG

更新日期：1990-12-01 00:00:00

abstract：:The RGS proteins are a recently discovered family of G protein regulators that have been shown to act as GTPase-activating proteins (GAPs) on the G(alpha i) and G(alpha q) subfamilies of the heterotrimeric G proteins. Here, we demonstrate that RGS7 is a potent GAP in vitro on G(alpha i1), and G(alpha o) heterotrimeric...

journal_title：Journal of neurochemistry

authors： Shuey DJ,Betty M,Jones PG,Khawaja XZ,Cockett MI

更新日期：1998-05-01 00:00:00

abstract：:Modulation of [3H]muscimol binding by picrotoxin, pentobarbitone, and etomidate was investigated in rat cerebellar and cerebral cortical membranes. In cerebellum, at 37 degrees C in the presence of chloride ions (150 mM), picrotoxin and picrotoxinin decreased specific [3H]muscimol binding to 43 +/- 3% of control, with...

journal_title：Journal of neurochemistry

authors： Quast U,Brenner O

更新日期：1983-08-01 00:00:00

abstract：:Obesity is a worldwide health problem that urgently needs to be solved. Leptin is an anti-obesity hormone that activates satiety signals to the brain. Evidence to suggest that leptin resistance is involved in the development of obesity is increasing; however, the molecular mechanisms involved remain unclear. We herein...

journal_title：Journal of neurochemistry

authors： Hosoi T,Matsuzaki S,Miyahara T,Shimizu K,Hasegawa Y,Ozawa K

更新日期：2015-05-01 00:00:00

abstract：:Calcium influx into SH-SY5Y human neuroblastoma cells after ionophore treatment or transient permeabilization in calcium-containing medium increased ALZ-50 immunoreactivity markedly. This increase was prevented by inhibitors active against calpain or against protein kinase C (PKC), suggesting that both of these enzyme...

journal_title：Journal of neurochemistry

authors： Shea TB,Spencer MJ,Beermann ML,Cressman CM,Nixon RA

更新日期：1996-04-01 00:00:00

abstract：:Perinatal hypoxic-ischaemic encephalopathy (HIE) occurs in 1-2 in every 1000 term infants and the devastating consequences range from cerebral palsy, epilepsy and neurological deficit to death. Cellular damage post insult occurs after a delay and is mediated by a secondary neural energy failure. AMP-activated protein ...

journal_title：Journal of neurochemistry

authors： Rousset CI,Leiper FC,Kichev A,Gressens P,Carling D,Hagberg H,Thornton C

更新日期：2015-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder that represents the most common type of dementia among elderly people. Amyloid beta (Aβ) peptides in extracellular Aβ plaques, produced from the amyloid precursor protein (APP) via sequential processing by β- and γ-secretases, impair hippocampal synaptic plastic...

journal_title：Journal of neurochemistry

authors： Kuwabara Y,Ishizeki M,Watamura N,Toba J,Yoshii A,Inoue T,Ohshima T

更新日期：2014-08-01 00:00:00

abstract：:The photic regulation of heme oxygenase (HO) activity was examined in the golden hamster retina. This enzymatic activity was significantly higher at midday than at midnight. When the hamsters were placed under constant darkness for 48 h and killed at subjective day or at subjective night, the differences in HO activit...

journal_title：Journal of neurochemistry

authors： Sacca GB,Sáenz DA,Jaliffa CO,Minces L,Keller Sarmiento MI,Rosenstein RE

更新日期：2003-04-01 00:00:00

abstract：:Developmental profiles were determined for the activities of eight enzymes involved in fatty acid beta-oxidation in rat brain. The enzymes studied were the palmitoyl-CoA, octanoyl-CoA, butyryl-CoA, glutaryl-CoA, and 3-hydroxyacyl-CoA dehydrogenases, the enoyl-CoA hydratase (crotonase), and the C4- and C10-thiolases. W...

journal_title：Journal of neurochemistry

authors： Reichmann H,Maltese WA,DeVivo DC

更新日期：1988-08-01 00:00:00

abstract：:Regional distribution of endogenous gamma-aminobutyric acid (GABA), its synthesizing enzyme, glutamic acid decarboxylase (GAD), and metabolic enzyme, GABA transaminase (GABA-T), were determined in the intestinal tract of guinea pigs and cats and the findings compared with the number of ganglion cells in Auerbach's ple...

journal_title：Journal of neurochemistry

authors： Miki Y,Taniyama K,Tanaka C,Tobe T

更新日期：1983-03-01 00:00:00