Stimulation of [3H]dopamine release by nicotine in rat nucleus accumbens.

abstract：:Presynaptic receptors modulating the release of acetylcholine (ACh) were studied in fetal septal neurons cultured in a growth medium to which various drugs were added from day 3 in vitro (DIV 3) to DIV 14. The influence of these drugs on the function of the presynaptic muscarinic (M-) autoreceptor was determined at DI...

journal_title：Journal of neurochemistry

authors： Ehret A,Birthelmer A,Rutz S,Riegert C,Rothmaier AK,Jackisch R

更新日期：2007-08-01 00:00:00

abstract：:Neuronal nicotinic acetylcholine receptors labelled with tritiated agonists are reduced in the cerebral cortex in Alzheimer's disease (AD), but to date it has not been demonstrated which nicotinic receptor subunits contribute to this deficit. In the present study, autopsy tissue from the temporal cortex of 14 AD cases...

journal_title：Journal of neurochemistry

authors： Martin-Ruiz CM,Court JA,Molnar E,Lee M,Gotti C,Mamalaki A,Tsouloufis T,Tzartos S,Ballard C,Perry RH,Perry EK

更新日期：1999-10-01 00:00:00

abstract：:A procedure is described for the rapid preparation of nerve ending particles (synaptosomes) from 11 regions of one rat brain. The synaptosomal fractions have been characterized by electron microscopy and determination of four marker enzymes, i.e., glutamate decarboxylase (GAD), acetylcholinesterase, succinate dehydrog...

journal_title：Journal of neurochemistry

authors： Löscher W,Böhme G,Müller F,Pagliusi S

更新日期：1985-09-01 00:00:00

abstract：:The export of glutamine from astrocytes, and the uptake of glutamine by neurons, are integral steps in the glutamate-glutamine cycle, a major pathway for the replenishment of neuronal glutamate. We review here the functional and molecular identification of the transporters that mediate this transfer. The emerging pict...

journal_title：Journal of neurochemistry

authors： Bröer S,Brookes N

更新日期：2001-05-01 00:00:00

abstract：:The effects of acute and chronic administration of buspirone, a serotonin 5-HT1A agonist, on the 5-HT synthesis rates in various rat brain structures were investigated using alpha-[14C]methyl-L-tryptophan (alpha-[14C]MTrp) and an autoradiographic method. In the acute treatment study, buspirone (10 mg/kg) was injected ...

journal_title：Journal of neurochemistry

authors： Okazawa H,Yamane F,Blier P,Diksic M

更新日期：1999-05-01 00:00:00

abstract：:K-252b is a kinase inhibitor structurally related to K-252a, which is known to abolish selectively the effects of nerve growth factor (NGF) on PC12 cells and PNS neurons. We tested whether K-252b, K-252a, and staurosporine, another related compound, are effective and selective inhibitors of NGF actions on CNS neurons....

journal_title：Journal of neurochemistry

authors： Knüsel B,Hefti F

更新日期：1991-09-01 00:00:00

abstract：:Hyperphosphorylated tau, the major component of the paired helical filaments of Alzheimer's disease, was found to accumulate in the brains of mice in which the calcineurin A alpha gene was disrupted [calcineurin A alpha knockout (CNA alpha -/-)]. The hyperphosphorylation involved several sites on tau, especially the S...

journal_title：Journal of neurochemistry

authors： Kayyali US,Zhang W,Yee AG,Seidman JG,Potter H

更新日期：1997-04-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) gene expression was analyzed in PC12 cells. PC12 cells transfected with a PACAP promoter-luciferase reporter construct were utilized to investigate the effects of PACAP, either alone or in combination with nerve growth factor (NGF), on PACAP transcriptional re...

journal_title：Journal of neurochemistry

authors： Hashimoto H,Hagihara N,Koga K,Yamamoto K,Shintani N,Tomimoto S,Mori W,Koyama Y,Matsuda T,Baba A

更新日期：2000-02-01 00:00:00

abstract：:Mutations within the amyloid-beta (Abeta) domain of the amyloid precursor protein (APP) typically generate hemorrhagic strokes and vascular amyloid angiopathy. In contrast, the Arctic mutation (APP E693G) results in Alzheimer's disease. Little is known about the pathologic mechanisms that result from the Arctic mutati...

journal_title：Journal of neurochemistry

authors： Sahlin C,Lord A,Magnusson K,Englund H,Almeida CG,Greengard P,Nyberg F,Gouras GK,Lannfelt L,Nilsson LN

更新日期：2007-05-01 00:00:00

abstract：:Sprague-Dawley rats were fed one of three purified diets--10% corn oil, 10% hydrogenated coconut oil, or 10% linseed oil--through two generations. At 60-80 days of age the animals were sacrificed. The fatty acyl composition of phosphatidylcholine, phosphatidylethanolamine, plasmalogen phosphatidylethanolamine, and com...

journal_title：Journal of neurochemistry

authors： Brown ML,Marshall LA,Johnston PV

更新日期：1984-11-01 00:00:00

abstract：:SH-SY5Y neural cells expressing mu- and delta-opioid receptors were maintained viable in isotonic, sodium-free buffer in vitro. Intracellular sodium levels were manipulated by various methods, and ligand binding to intact cells was studied. In physiological buffer containing 118 mM sodium, [3H]Tyr-D-Ala-Gly-(Me)Phe-Gl...

journal_title：Journal of neurochemistry

authors： Yabaluri N,Medzihradsky F

更新日期：1997-03-01 00:00:00

abstract：:Bone fracture at the acute stage of stroke exacerbates stroke injury by increasing neuroinflammation. We hypothesize that activation of α-7 nicotinic acetylcholine receptor (α-7 nAchR) attenuates neuroinflammation and oxidative stress, and reduces brain injury in mice with bone fracture and stroke. Permanent middle ce...

journal_title：Journal of neurochemistry

authors： Han Z,Li L,Wang L,Degos V,Maze M,Su H

更新日期：2014-11-01 00:00:00

abstract：:Post-traumatic immune suppression renders individuals with spinal cord injury (SCI) susceptible to infection. Normally, proper immune function is regulated by collaboration between the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis and involves the controlled release of glucocorticoids ...

journal_title：Journal of neurochemistry

authors： Lucin KM,Sanders VM,Popovich PG

更新日期：2009-09-01 00:00:00

abstract：:Peptidyl-glycine alpha-amidation enzyme activity has been measured in 36 nuclei or areas in the rat CNS and pituitary using D-Tyr-Phe-Gly as the substrate. The distribution of this enzyme is highly uneven, with highest activity levels (greater than 30 pmol/mg of protein/h) in hypothalamic nuclei, substantia grisea cen...

journal_title：Journal of neurochemistry

authors： Meng F,Tsou K

更新日期：1988-05-01 00:00:00

abstract：:Primary rat fibroblasts genetically modified to express Drosophila choline acetyltransferase (dChAT) synthesize and release acetylcholine (ACh) in vitro. The ACh produced from the transduced fibroblasts was found to be enhanced by increasing amounts of choline chloride in the culture media. These dChAT-expressing cell...

journal_title：Journal of neurochemistry

authors： Fisher LJ,Schinstine M,Salvaterra P,Dekker AJ,Thal L,Gage FH

更新日期：1993-10-01 00:00:00

abstract：:The effect of compounds that activate sodium channels on the number of muscarinic acetylcholine receptors in neuroblastoma NIE 115 cells has been investigated. The cells were used in electrically unexcitable ("control" cells) and excitable ("differentiated" cells) states. Although receptor assays using a single concen...

journal_title：Journal of neurochemistry

authors： Milligan G,Strange PG

更新日期：1984-07-01 00:00:00

abstract：:Interleukin-1β (IL-1β) is released from activated microglia and involved in the neurodegeneration of acute and chronic brain disorders, such as stroke and Alzheimer's disease, in which extracellular acidification has been shown to occur. Here, we examined the extracellular acidic pH regulation of IL-1β production, esp...

journal_title：Journal of neurochemistry

authors： Jin Y,Sato K,Tobo A,Mogi C,Tobo M,Murata N,Ishii S,Im DS,Okajima F

更新日期：2014-05-01 00:00:00

abstract：:Serotonin-1A (5-HT(1A) receptors in the dorsal raphe nucleus (DRN) function as somatodendritic autoreceptors, and therefore play a critical role in controlling serotonergic cell firing and serotonergic neurotransmission. We hypothesized that a decrease in the capacity of 5-HT(1A) receptors to activate G proteins was a...

journal_title：Journal of neurochemistry

authors： Rossi DV,Burke TF,McCasland M,Hensler JG

更新日期：2008-05-01 00:00:00

abstract：:Previous studies have shown that phorbol esters and lithium each stimulate the secretion of adrenocorticotropic hormone (ACTH) by the anterior pituitary tumor cell line AtT20/D16-16. Pretreatment with either lithium or phorbol ester desensitizes the cells to subsequent stimulation by phorbol ester. An early consequenc...

journal_title：Journal of neurochemistry

authors： Zatz M,Mahan LC,Reisine T

更新日期：1987-01-01 00:00:00

abstract：:Chondroitin sulphate proteoglycans (CSPGs) are axon growth inhibitory molecules present in the glial scar that play a part in regeneration failure after damage to the CNS and which restrict CNS plasticity. Removal of chondroitin sulphate glycosaminoglycan (GAG) chains with chondroitinase-ABC (chABC) in models of CNS i...

journal_title：Journal of neurochemistry

authors： Lin R,Kwok JC,Crespo D,Fawcett JW

更新日期：2008-01-01 00:00:00

abstract：:Studies performed over the past several years have provided evidence that phosphorylation of proteins is important in the regulation of neurotransmitter release. In this study, it is shown that rabphilin-3A is present in cerebellar granule cells as a phosphoprotein, by using 32P-labeling of cerebellar granule cells, i...

journal_title：Journal of neurochemistry

authors： Fykse EM

更新日期：1998-10-01 00:00:00

abstract：:The present experiments show that N-[3H]-methylcarbamylcholine ([3H]MCC) binds specifically and with high affinity to rat hippocampus, frontal cortex, and striatum. The highest maximal density of binding sites was apparent in frontal cortex and the lowest in hippocampus. [3H]MCC binding was potently inhibited by nicot...

journal_title：Journal of neurochemistry

authors： Araujo DM,Lapchak PA,Collier B,Quirion R

更新日期：1988-07-01 00:00:00

abstract：:Cerebral endothelial cells form the selective permeability barrier between brain and blood by virtue of their impermeable tight junctions and the presence of specific carrier systems. These specialized properties of brain capillaries are reflected in the presence of proteins that are not found in other capillaries of ...

journal_title：Journal of neurochemistry

authors： Risau W,Dingler A,Albrecht U,Dehouck MP,Cecchelli R

更新日期：1992-02-01 00:00:00

abstract：:Recent evidence suggests that neuronal apoptosis is the consequence of an inappropriate reentry into the cell cycle. Expression of the cell cycle gene cyclin D1, a G1-phase cell cycle regulator, was examined in primary cultures of murine cerebellar granule cells (CGCs) during kainate (KA)-mediated apoptosis. Using cul...

journal_title：Journal of neurochemistry

authors： Giardina SF,Cheung NS,Reid MT,Beart PM

更新日期：1998-09-01 00:00:00

abstract：:The (R) and (S) forms of 5-amino-2-hydroxyvaleric acid (2-OH-DAVA) and 5-amino-4-hydroxyvaleric acid (4-OH-DAVA) were designed as structural hybrids of the 4-aminobutyric acidB (GABAB) agonist (R)-(-)-4-amino-3-hydroxybutyric acid [(R)-(-)-3-OH-GABA] and the GABAB antagonist 5-aminovaleric acid (DAVA). (S)-(-)-2-OH-DA...

journal_title：Journal of neurochemistry

authors： Kristiansen U,Hedegaard A,Herdeis C,Lund TM,Nielsen B,Hansen JJ,Falch E,Hjeds H,Krogsgaard-Larsen P

更新日期：1992-03-01 00:00:00

abstract：:The brain adapts to dynamic environmental conditions by altering its epigenetic state, thereby influencing neuronal transcriptional programs. An example of an epigenetic modification is protein methylation, catalyzed by protein arginine methyltransferases (PRMT). One member, Prmt8, is selectively expressed in the cent...

journal_title：Journal of neurochemistry

authors： Lee PK,Goh WW,Sng JC

更新日期：2017-02-01 00:00:00

abstract：:2,4,5-Trihydroxyphenylalanine (6-OH-DOPA) destroys central and peripheral noradrenergic neurons, while sparing dopaminergic neurons. Previous studies indicate that 6-OH-DOPA toxicity is mediated by the formation of 6-hydroxydopamine. However, levels of 6-hydroxydopamine in brain following peripheral administration of ...

journal_title：Journal of neurochemistry

authors： Evans JM,Cohen G

更新日期：1989-05-01 00:00:00

abstract：:The objective of this study was to examine the role of dopamine (DA) receptors in the nucleus accumbens (ACB) in controlling feedback regulation of mesolimbic somatodendritic DA release in the ventral tegmental area (VTA) of Wistar rats using ipsilateral dual-probe in vivo microdialysis. Perfusion of the ACB for 60 mi...

journal_title：Journal of neurochemistry

authors： Rahman S,McBride WJ

更新日期：2000-02-01 00:00:00

abstract：:This study investigated possible D1/D2 interactions in rat and bovine striatal tissue by examining the effects of D2 antagonists on the action of dopamine at D1 dopamine receptors. In addition, the extent to which D2 antagonists may induce an agonist low-affinity state of the D1 receptor was evaluated in comparison wi...

journal_title：Journal of neurochemistry

authors： Farrell CB,Lawlor M,Dunne A,O'Boyle KM

更新日期：1995-09-01 00:00:00

abstract：:For a long time, prolyl endopeptidase (PEP) was believed to inactivate neuropeptides in the extracellular space. However, reports on the intracellular activity of PEP suggest additional, as yet unidentified, physiological functions for this enzyme. Here, we demonstrate using biochemical methods of subcellular fraction...

journal_title：Journal of neurochemistry

authors： Schulz I,Zeitschel U,Rudolph T,Ruiz-Carrillo D,Rahfeld JU,Gerhartz B,Bigl V,Demuth HU,Rossner S

更新日期：2005-08-01 00:00:00