Translocation of protein kinase C in anterior pituitary tumor cells.

Abstract:

:Previous studies have shown that phorbol esters and lithium each stimulate the secretion of adrenocorticotropic hormone (ACTH) by the anterior pituitary tumor cell line AtT20/D16-16. Pretreatment with either lithium or phorbol ester desensitizes the cells to subsequent stimulation by phorbol ester. An early consequence of phorbol ester action in other systems is the translocation of protein kinase C from cytosol to membranes. We have assayed protein kinase C activity in cytosol and membranes of AtT20 cells after treatment with phorbol dibutyrate, lithium, or other agents that stimulate secretion of ACTH in these cells. Phorbol dibutyrate clearly induced translocation of protein kinase C, but lithium treatment did not cause translocation itself, nor did pretreatment with lithium affect the translocation induced by phorbol dibutyrate. These results are consistent with a role for translocation of protein kinase C in the stimulatory and desensitizing effects of phorbol esters but fail to implicate translocation in the actions of lithium on AtT20 cells.

journal_name

J Neurochem

authors

Zatz M,Mahan LC,Reisine T

doi

10.1111/j.1471-4159.1987.tb13133.x

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

106-10

issue

1

eissn

0022-3042

issn

1471-4159

journal_volume

48

pub_type

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