Translocation of protein kinase C in anterior pituitary tumor cells.


:Previous studies have shown that phorbol esters and lithium each stimulate the secretion of adrenocorticotropic hormone (ACTH) by the anterior pituitary tumor cell line AtT20/D16-16. Pretreatment with either lithium or phorbol ester desensitizes the cells to subsequent stimulation by phorbol ester. An early consequence of phorbol ester action in other systems is the translocation of protein kinase C from cytosol to membranes. We have assayed protein kinase C activity in cytosol and membranes of AtT20 cells after treatment with phorbol dibutyrate, lithium, or other agents that stimulate secretion of ACTH in these cells. Phorbol dibutyrate clearly induced translocation of protein kinase C, but lithium treatment did not cause translocation itself, nor did pretreatment with lithium affect the translocation induced by phorbol dibutyrate. These results are consistent with a role for translocation of protein kinase C in the stimulatory and desensitizing effects of phorbol esters but fail to implicate translocation in the actions of lithium on AtT20 cells.


J Neurochem


Zatz M,Mahan LC,Reisine T




Has Abstract


1987-01-01 00:00:00












  • Promotion of microtubule assembly by neurofilament-associated microtubule-associated proteins.

    abstract::Intact neurofilaments (NF) purified from mammalian brain and spinal cord promote the assembly of microtubules in solutions of pure phosphocellulose (PC)-purified tubulin. This assembly is temperature-dependent and is inhibited by mitotic spindle inhibitors. The ability of NF to induce microtubule formation is 20% of t...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Leterrier JF,Wong J,Liem RK,Shelanski ML

    更新日期:1984-11-01 00:00:00

  • Murine cathepsin D deficiency is associated with dysmyelination/myelin disruption and accumulation of cholesteryl esters in the brain.

    abstract::Cathepsin D (CTSD) deficiencies are fatal neurological diseases that in human infants and in sheep are characterized by extreme loss of neurons and myelin. To date, similar morphological evidence for myelin disruption in CTSD knockout mice has not been reported. Here, we show that CTSD deficiency leads to pronounced m...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Mutka AL,Haapanen A,Käkelä R,Lindfors M,Wright AK,Inkinen T,Hermansson M,Rokka A,Corthals G,Jauhiainen M,Gillingwater TH,Ikonen E,Tyynelä J

    更新日期:2010-01-01 00:00:00

  • The turnover of the H3 deuterons from (2-13C) glutamate and (2-13C) glutamine reveals subcellular trafficking in the brain of partially deuterated rats.

    abstract::We investigated by 13C NMR the turnover of the H3 deuterons of (2-13C) glutamate and (2-13C) glutamine in the brain of partially deuterated rats. Adult animals (150-200 g) fed ad libitum received 50% 2H2O or tap water 9 days before infusing (1-13C) glucose or (2-13C) acetate for 5, 10, 15, 30, 60, or 90 min. The brain...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Cerdán S,Sierra A,Fonseca LL,Ballesteros P,Rodrigues TB

    更新日期:2009-05-01 00:00:00

  • Hierarchical recruitment by AMPA but not staurosporine of pro-apoptotic mitochondrial signaling in cultured cortical neurons: evidence for caspase-dependent/independent cross-talk.

    abstract::Excitotoxicity mediated via the (S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) subtype of receptor for l-glutamate contributes to various neuropathologies involving acute brain injury and chronic degenerative disorders. In this study, AMPA-induced neuronal injury and staurosporine (STS)-mediated apopt...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Beart PM,Lim ML,Chen B,Diwakarla S,Mercer LD,Cheung NS,Nagley P

    更新日期:2007-12-01 00:00:00

  • Separation of neuropeptides by HPLC: evaluation of different supports, with analytical and preparative applications to human and porcine neurophysins, beta-lipotropin, adrenocorticotropic hormone, and beta-endorphin.

    abstract::The separation of 38 hypophyseal or hypothalamic peptides and proteins by reversed-phase HPLC is described. The efficacy of several supports is discussed: large-pore reversed-phase silica supports turned out to be most effective in the separation of neuropeptides and proteins. The use of high sodium phosphate and phos...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Richter WO,Schwandt P

    更新日期:1985-06-01 00:00:00

  • Blockade of striatal 5-hydroxytryptamine2 receptors reduces the increase in extracellular concentrations of dopamine produced by the amphetamine analogue 3,4-methylenedioxymethamphetamine.

    abstract::5-Hydroxytryptamine2 (5-HT2) receptor antagonists have been shown to interfere with the stimulation of striatal dopamine synthesis and release produced by the amphetamine analogue 3,4-methylenedioxymethamphetamine (MDMA). To localize the receptors responsible for the attenuation of MDMA-induced release, 5-HT2 receptor...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Schmidt CJ,Sullivan CK,Fadayel GM

    更新日期:1994-04-01 00:00:00

  • Inhibitory effects of aripiprazole on interferon-gamma-induced microglial activation via intracellular Ca2+ regulation in vitro.

    abstract::The activation of the inflammatory/immunological response system is suggested to be related to the pathophysiology of schizophrenia. Aripiprazole is a novel atypical antipsychotic, which is a high-affinity dopamine D(2) receptor partial agonist. Atypical antipsychotics, all of which have dopamine D(2) receptor antagon...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Kato T,Mizoguchi Y,Monji A,Horikawa H,Suzuki SO,Seki Y,Iwaki T,Hashioka S,Kanba S

    更新日期:2008-07-01 00:00:00

  • The dipeptidyl peptidase IV inhibitor vildagliptin suppresses development of neuropathy in diabetic rodents: effects on peripheral sensory nerve function, structure and molecular changes.

    abstract::Incretin-related therapy was found to be beneficial for experimental diabetic neuropathy, but its mechanism is obscure. The purpose of this study is to explore the mechanism through which dipeptidyl peptidase IV inhibitor, vildagliptin (VG), influences neuropathy in diabetic rodents. To this end, non-obese type 2 diab...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Tsuboi K,Mizukami H,Inaba W,Baba M,Yagihashi S

    更新日期:2016-02-01 00:00:00

  • Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism.

    abstract::The importance of the nuclear receptor nurr1 for the appropriate development of mesencephalic dopamine-synthesizing neurons has been clearly demonstrated through the targeted disruption of the nurr1 gene. The persistence of nurr1 expression in adult tissue suggests a possible role for this transcription factor in the ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Sacchetti P,Mitchell TR,Granneman JG,Bannon MJ

    更新日期:2001-03-01 00:00:00

  • Characterization of the Ca2+- and Mg2+-dependent ATPases in Electrophorus electroplax microsomes.

    abstract::Electrophorus electroplax microsomes were examined for Ca2+- and Mg2+-dependent ATPase activity. In addition to the previously reported low-affinity ATPase, a high-affinity (Ca2+,Mg2+)-ATPase was found. At low ATP and Mg2+ concentrations (200 microM or less), the high-affinity (Ca2+,Mg2+)-ATPase exhibits an activity o...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Amende LM,Chock SP,Albers RW

    更新日期:1983-04-01 00:00:00

  • Circadian rhythm in pineal methionine S-adenosyltransferase.

    abstract::The circadian rhythm of methionine S-adenosyltransferase, which catalyzes the formation of S-adenosylmethionine, a cosubstrate for melatonin in the pineal gland, follows the pattern of hydroxyindole-O-methyltransferase. Around the middle of the dark period, methionine S-adenosyltransferase and hydroxyindole-O-methyltr...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Guchhait RB,Monjan AA

    更新日期:1981-06-01 00:00:00

  • Cerebrospinal fluid total tau concentration predicts clinical phenotype in Huntington's disease.

    abstract::Huntington's disease (HD) is a hereditary neurodegenerative condition with no therapeutic intervention known to alter disease progression, but several trials are ongoing and biomarkers of disease progression are needed. Tau is an axonal protein, often altered in neurodegeneration, and recent studies pointed out its ro...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章,多中心研究


    authors: Rodrigues FB,Byrne L,McColgan P,Robertson N,Tabrizi SJ,Leavitt BR,Zetterberg H,Wild EJ

    更新日期:2016-10-01 00:00:00

  • Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels.

    abstract::Previous studies showed that prolonged access to cocaine or heroin self-administration (long access, or LgA) produces an escalation in drug intake not observed with limited access to the drug (short access, or ShA). The present experiment employed in vivo microdialysis to test the role of alterations in drug pharmacok...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Ahmed SH,Lin D,Koob GF,Parsons LH

    更新日期:2003-07-01 00:00:00

  • Distribution and localization of pro-brain-derived neurotrophic factor-like immunoreactivity in the peripheral and central nervous system of the adult rat.

    abstract::The precursors for neurotrophins are proteolytically cleaved to form biologically active mature molecules which activate their receptors p75NTR and trks. A recent study showed that the precursor for nerve growth factor (NGF) can bind to p75NTR with a high affinity and induces apoptosis of neurons in vitro. Mutation in...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Zhou XF,Song XY,Zhong JH,Barati S,Zhou FH,Johnson SM

    更新日期:2004-11-01 00:00:00

  • Differential vulnerability of neurons in Huntington's disease: the role of cell type-specific features.

    abstract::Abnormal expansion of a polyglutamine tract in huntingtin (Htt) protein results in Huntington's disease (HD), an autosomal dominant neurodegenerative disorder involving progressive loss of motor and cognitive function. Contrasting with the ubiquitous tissue expression of polyglutamine-expanded Htt, HD pathology is cha...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章,评审


    authors: Han I,You Y,Kordower JH,Brady ST,Morfini GA

    更新日期:2010-06-01 00:00:00

  • Acute selective serotonin reuptake inhibitors regulate the dorsal raphe nucleus causing amplification of terminal serotonin release.

    abstract::Selective serotonin reuptake inhibitors (SSRIs) were designed to treat depression by increasing serotonin levels throughout the brain via inhibition of clearance from the extracellular space. Although increases in serotonin levels are observed after acute SSRI exposure, 3-6 weeks of continuous use is required for reli...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Dankoski EC,Carroll S,Wightman RM

    更新日期:2016-03-01 00:00:00

  • Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.

    abstract::The N141I missense mutation in presenilin (PS) 2 is tightly linked with a form of autosomal dominant familial Alzheimer's disease (AD) in the Volga German families. We have generated transgenic mouse lines overexpressing human wild-type or mutant PS2 under transcriptional control of the chicken beta-actin promoter. In...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Oyama F,Sawamura N,Kobayashi K,Morishima-Kawashima M,Kuramochi T,Ito M,Tomita T,Maruyama K,Saido TC,Iwatsubo T,Capell A,Walter J,Grünberg J,Ueyama Y,Haass C,Ihara Y

    更新日期:1998-07-01 00:00:00

  • Further characterization of an enkephalin-generating enzyme from adrenal medullary chromaffin granules.

    abstract::An adrenomedullary protease capable of generating Met5-enkephalin from endogenous precursor(s) has been purified 1,000-fold using affinity chromatography in combination with gel filtration. This trypsin-like enzyme has an apparent molecular weight of 20,000 daltons by gel filtration. The reactivity of the enzyme towar...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Lindberg I,Yang HY,Costa E

    更新日期:1984-05-01 00:00:00

  • Role of protein kinase A in GABAA receptor dysfunction in CA1 pyramidal cells following chronic benzodiazepine treatment.

    abstract::One-week treatment with the benzodiazepine (BZ) flurazepam (FZP), results in anticonvulsant tolerance, associated with reduced GABAA receptor (GABAR) subunit protein and miniature inhibitory post-synaptic current (mIPSC) amplitude in CA1 neurons of rat hippocampus. Because protein kinase A (PKA) has been shown to modu...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Lilly SM,Zeng XJ,Tietz EI

    更新日期:2003-05-01 00:00:00

  • Reggie/flotillin and the targeted delivery of cargo.

    abstract::The two proteins reggie-1/flotillin-2 and reggie-2/flotillin-1 form microdomains at the plasma membrane and at intracellular compartments where src tyrosine kinases associate with them. Specific GPI-anchored proteins, in particular prion protein and Thy-1, co-cluster with reggie microdomains at the plasma membrane and...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章,评审


    authors: Stuermer CA

    更新日期:2011-03-01 00:00:00

  • Synaptic scaffolding molecule (S-SCAM) membrane-associated guanylate kinase with inverted organization (MAGI)-2 is associated with cell adhesion molecules at inhibitory synapses in rat hippocampal neurons.

    abstract::Synaptic scaffolding molecule (S-SCAM) is a synaptic protein, which harbors five or six PSD-95/Discs large/ZO-1 (PDZ), a guanylate kinase and two WW domains. It interacts with NMDA receptor subunits, neuroligin and beta-catenin, and is involved in the accumulation of neuroligin at excitatory synapses. In this study, w...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Sumita K,Sato Y,Iida J,Kawata A,Hamano M,Hirabayashi S,Ohno K,Peles E,Hata Y

    更新日期:2007-01-01 00:00:00

  • Selective destruction of cultured dopaminergic neurons from fetal rat mesencephalon by 1-methyl-4-phenylpyridinium: cytochemical and morphological evidence.

    abstract::Dopaminergic neurons in cultures of dissociated cells from fetal rat mesencephalon were exposed to the principal metabolite of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 1-methyl-4-phenyl-pyridinium ion (MPP+), and several of its structural analogues. At concentrations between 0.01 and 0.1 mic...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Sanchez-Ramos JR,Michel P,Weiner WJ,Hefti F

    更新日期:1988-06-01 00:00:00

  • Molecular and pharmacological characterization of muscarinic receptors in retinal pigment epithelium: role in light-adaptive pigment movements.

    abstract::Muscarinic receptors are the predominant cholinergic receptors in the central and peripheral nervous systems. Recently, activation of muscarinic receptors was found to elicit pigment granule dispersion in retinal pigment epithelium isolated from bluegill fish. Pigment granule movement in retinal pigment epithelium is ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Phatarpekar PV,Durdan SF,Copeland CM,Crittenden EL,Neece JD,García DM

    更新日期:2005-12-01 00:00:00

  • A subtype of kappa-opioid receptor mediates inhibition of high-affinity GTPase inherent in Gi1 in guinea pig cerebellar membranes.

    abstract::The kappa-opioid receptor agonists including U-50,488H and dynorphin A (1-17) in ranges of 0.1-100 nM inhibited the hydrolysis of GTP to GDP (P(i) release) inherent in GTP-binding proteins (G proteins) in guinea pig cerebellar membranes. U-50,488H inhibited only high-affinity GTPase activity, not low-affinity activity...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Ueda H,Misawa H,Fukushima N,Katada T,Ui M,Satoh M

    更新日期:1996-02-01 00:00:00

  • Dimercaprol is an acrolein scavenger that mitigates acrolein-mediated PC-12 cells toxicity and reduces acrolein in rat following spinal cord injury.

    abstract::Acrolein is one of the most toxic byproducts of lipid peroxidation, and it has been shown to be associated with multiple pathological processes in trauma and diseases, including spinal cord injury, multiple sclerosis, and Alzheimer's disease. Therefore, suppressing acrolein using acrolein scavengers has been suggested...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Tian R,Shi R

    更新日期:2017-06-01 00:00:00

  • Assembly and cell surface expression of KA-2 subunit-containing kainate receptors.

    abstract::Kainate receptors (KARs) modulate synaptic transmission at both pre-synaptic and post-synaptic sites. The overlap in the distribution of KA-2 and GluR6/7 subunits in several brain regions suggests the co-assembly of these subunits in native KARs. The molecular mechanisms that control the assembly and surface expressio...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Gallyas F Jr,Ball SM,Molnar E

    更新日期:2003-09-01 00:00:00

  • Brain microvessels produce 12-hydroxyeicosatetraenoic acid.

    abstract::Cerebral microvessels isolated from perfused, adult murine brain produce a compound with the chromatographic properties of a monohydroxyeicosatetraenoic acid when incubated with arachidonic acid or stimulated with calcium ionophore A23187. The formation of this arachidonic acid metabolite is not reduced in the presenc...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Moore SA,Figard PH,Spector AA,Hart MN

    更新日期:1989-08-01 00:00:00

  • Modulation of receptors for thyrotropin-releasing hormone by benzodiazepines: brain regional differences.

    abstract::The benzodiazepines (BZDs) chlordiazepoxide (CDE), diazepam (DZM), and flurazepam (FLM) inhibited receptor binding for thyrotropin-releasing hormone (TRH) with low micromolar potency. In contrast, numerous other categories of drugs were previously shown to be inactive. Scatchard analysis of competition data suggested ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Sharif NA,Burt DR

    更新日期:1984-09-01 00:00:00

  • 4-Aminopyridine stimulates B-50 (GAP43) phosphorylation and [3H]noradrenaline release in rat hippocampal slices.

    abstract::In situ phosphorylation of the presynaptic protein kinase C substrate B-50 was investigated in rat hippocampal slices incubated with the convulsant drug 4-aminopyridine (4-AP). Phosphorylation of B-50 was significantly enhanced 1 min after the addition of 4-AP (100 microM). This increase by 4-AP was concentration depe...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Heemskerk FM,Schrama LH,Gianotti C,Spierenburg H,Versteeg DH,De Graan PN,Gispen WH

    更新日期:1990-03-01 00:00:00

  • Regulated secretion of pro-opiomelanocortin converting enzyme and an aminopeptidase B-like enzyme from dispersed bovine intermediate lobe pituitary cells.

    abstract::Coordinate secretion of two prohormone/proneuropeptide processing enzymes [pro-opiomelanocortin converting enzyme (PCE) and an aminopeptidase B-like enzyme (APBE)] and alpha-melanotropin (alpha-MSH) from bovine intermediate lobe pituitary cells was studied. Stimulation of secretion with 8-bromo-cyclic AMP produced sig...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Castro MG,Birch NP,Loh YP

    更新日期:1989-05-01 00:00:00