Regulation of axotomy-induced dopaminergic neuron death and c-Jun phosphorylation by targeted inhibition of cdc42 or mixed lineage kinase.

abstract：:The glial glutamate transporter EAAT2 (excitatory amino acid transporter 2) is the major mediator of glutamate clearance that terminates glutamate-mediated neurotransmission. Loss of EAAT2 and associated glutamate uptake function has been reported in the brains of patients with Alzheimer's disease (AD). We previously ...

journal_title：Journal of neurochemistry

authors： Tian G,Kong Q,Lai L,Ray-Chaudhury A,Lin CL

更新日期：2010-05-01 00:00:00

abstract：:Leptin regulates energy balance by suppressing appetite and increasing energy expenditure through actions in the hypothalamus. Recently we demonstrated that the effects of leptin are, at least in part, mediated by the release of interleukin (IL)-1beta in the brain. Microglia constitute the major source of IL-1beta in ...

journal_title：Journal of neurochemistry

authors： Pinteaux E,Inoue W,Schmidt L,Molina-Holgado F,Rothwell NJ,Luheshi GN

更新日期：2007-08-01 00:00:00

abstract：:The activity-dependent fusion, retrieval and recycling of synaptic vesicles is essential for the maintenance of neurotransmission. Until relatively recently it was believed that most mutations in genes that were essential for this process would be incompatible with life, because of this fundamental role. However, an e...

journal_title：Journal of neurochemistry

authors： Bonnycastle K,Davenport EC,Cousin MA

更新日期：2020-05-07 00:00:00

abstract：:Several mechanisms are thought to be involved in the progressive decline in neurons of the substantia nigra pars compacta (SNpc) that leads to Parkinson's disease (PD). Neurotoxin 6-hydroxydopamine (6-OHDA), which induces parkinsonian symptoms in experimental animals, is thought to be formed endogenously in patients w...

journal_title：Journal of neurochemistry

authors： Barkats M,Millecamps S,Bilang-Bleuel A,Mallet J

更新日期：2002-07-01 00:00:00

abstract：:The role of gamma-aminobutyric acid (GABA) modulation of septohippocampal cholinergic neurons in kindling was investigated. Hippocampal acetylcholine release was evaluated with the microdialysis technique in freely moving rats either after acute administration of isoniazid (an inhibitor of GABA synthesis) or pentylene...

journal_title：Journal of neurochemistry

authors： Serra M,Dazzi L,Cagetti E,Chessa MF,Pisu MG,Sanna A,Biggio G

更新日期：1997-01-01 00:00:00

abstract：:Rarefaction of the dendritic tree leading to neuronal dysfunction is a hallmark of many neurodegenerative diseases and we have shown previously that heat shock protein B5 (HspB5)/αB-crystallin is able to increase dendritic complexity in vitro. The aim of this study was to investigate if this effect is also present in ...

journal_title：Journal of neurochemistry

authors： Bartelt-Kirbach B,Wiegreffe C,Birk S,Baur T,Moron M,Britsch S,Golenhofen N

更新日期：2020-11-21 00:00:00

abstract：:Dendritic trafficking and translation of brain-derived neurotrophic factor (BDNF) transcripts play a key role in mediating synaptic plasticity. Recently, we demonstrated that siRNA-mediated knockdown of translin, an RNA-binding protein, impairs KCl-induced dendritic trafficking of BDNF mRNA in cultured hippocampal neu...

journal_title：Journal of neurochemistry

authors： Wu YC,Williamson R,Li Z,Vicario A,Xu J,Kasai M,Chern Y,Tongiorgi E,Baraban JM

更新日期：2011-03-01 00:00:00

abstract：:Intraperitoneal injection of the cyclic imine 1-piperideine in mice resulted in measurable quantities of 5-aminopentanoic acid in brain. 5-Aminopentanoic acid is a methylene homologue of gamma-aminobutyric acid (GABA) that is a weak GABA agonist. 5-Aminopentanoic acid formed in the periphery was ruled out as the sourc...

journal_title：Journal of neurochemistry

authors： Callery PS,Geelhaar LA

更新日期：1985-09-01 00:00:00

abstract：:Dystrobrevin binding protein-1 (dysbindin-1), a candidate gene for schizophrenia, modulates cognition, synaptic plasticity and frontocortical circuitry and interacts with glutamatergic and dopaminergic transmission. Loss of dysbindin-1 modifies cellular trafficking of dopamine (DA) D2 receptors to increase cell surfac...

journal_title：Journal of neurochemistry

authors： Schmieg N,Rocchi C,Romeo S,Maggio R,Millan MJ,Mannoury la Cour C

更新日期：2016-03-01 00:00:00

abstract：:Transient exposure to ethanol (EtOH) results in a massive neurodegeneration in the developing brain leading to behavioral and cognitive deficits observed in fetal alcohol syndrome. There is now compelling evidence that K+ channels play an important role in the control of programmed cell death. The aim of the present w...

journal_title：Journal of neurochemistry

authors： Lefebvre T,Gonzalez BJ,Vaudry D,Desrues L,Falluel-Morel A,Aubert N,Fournier A,Tonon MC,Vaudry H,Castel H

更新日期：2009-08-01 00:00:00

abstract：:Our interest in investigating the presynaptic modulation of acetylcholine release led to the development of a synaptosomal preparation from the guinea pig ileum myenteric plexus-longitudinal muscle. A crude synaptosomal fraction (P2) was obtained by homogenization and differential centrifugation. The preparation exhib...

journal_title：Journal of neurochemistry

authors： Briggs CA,Cooper JR

更新日期：1981-03-01 00:00:00

abstract：:Ras-related GTPases of the Rho family, such as RhoA and RhoB, are well-characterised mediators of morphological change in peripheral tissues via their effects on the actin cytoskeleton. We tested the hypothesis that Rho family GTPases are involved in synaptic transmission in the CA1 region of the hippocampus. We show ...

journal_title：Journal of neurochemistry

authors： O'Kane EM,Stone TW,Morris BJ

更新日期：2003-12-01 00:00:00

abstract：:The effect of phorbol esters was investigated on the down-regulation of protein kinase C (PKC) and on the release of [3H]norepinephrine (NE) in synaptosomes from the rat cerebrum. Treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) promoted the translocation of PKC activity in a P2 fraction from the cytosol to t...

journal_title：Journal of neurochemistry

authors： Oda T,Shearman MS,Nishizuka Y

更新日期：1991-04-01 00:00:00

abstract：:The uptake of amino acids by microvessels isolated from brains of rats was studied. Previous studies have demonstrated alterations in blood-brain amino acid transport after portacaval shunt in rats. In order to elucidate whether such changes in the blood-brain barrier were located in the microvessels, brain microvesse...

journal_title：Journal of neurochemistry

authors： Cardelli-Cangiano P,Cangiano C,James JH,Jeppsson B,Brenner W,Fischer JE

更新日期：1981-02-01 00:00:00

abstract：:Lactoferrin (Lf) is an iron-binding protein involved in host defense against infection and severe inflammation, which accumulates in the brain during neurodegenerative disorders. Prior to determining Lf function in pathological brain tissues, we investigated its transport through the blood-brain barrier (BBB) in infla...

journal_title：Journal of neurochemistry

authors： Fillebeen C,Dehouck B,Benaïssa M,Dhennin-Duthille I,Cecchelli R,Pierce A

更新日期：1999-12-01 00:00:00

abstract：:Spinocerebellar ataxia 1 (SCA1) is a dominantly inherited neurodegenerative disease associated with progressive ataxia resulting from the loss of cerebellar Purkinje cells (PCs) and neurons in the brainstem. In PCs of SCA1 transgenic mice, the disease causing ataxin-1 protein mediates the formation of S100B containing...

journal_title：Journal of neurochemistry

authors： Hearst SM,Lopez ME,Shao Q,Liu Y,Vig PJ

更新日期：2010-08-01 00:00:00

abstract：:Integrin-mediated interactions of cells with components of the extracellular matrix (ECM) regulate cell survival, cell proliferation, cell differentiation and cell migration through activation of multiple intracellular signal transduction pathways. In this study, we have demonstrated that integrin-matrix interactions ...

journal_title：Journal of neurochemistry

authors： Li BS,Daniels MP,Pant HC

更新日期：2001-02-01 00:00:00

abstract：:Perhaps the most reproducible early event induced by the interaction of amyloid beta peptide (A beta) with the cell is the inhibition of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction. We recently demonstrated that cytotoxic amyloid peptides such as A beta and human amylin inhibi...

journal_title：Journal of neurochemistry

authors： Liu Y,Schubert D

更新日期：1998-12-01 00:00:00

abstract：:Previous studies point to quaternary assembly of dopamine transporters (DATs) in oligomers. However, it is not clear whether the protomers function independently in the oligomer. Is each protomer an entirely separate unit that takes up dopamine and is inhibited by drugs known to block DAT function? In this work, human...

journal_title：Journal of neurochemistry

authors： Zhen J,Antonio T,Cheng SY,Ali S,Jones KT,Reith ME

更新日期：2015-04-01 00:00:00

abstract：:The dose-dependent effects of two putative gamma-aminobutyric acid (GABA)-ergic agonists, muscimol and 4,5,6,7-tetrahydroisoxazolo(4,5-e)-pyridin-3-ol (THIP), upon local cerebral glucose utilisation in 60 discrete regions of the CNS have been examined in conscious rats using the [14C]2-deoxyglucose quantitative autora...

journal_title：Journal of neurochemistry

authors： Kelly PA,McCulloch J

更新日期：1982-09-01 00:00:00

abstract：:Activation of integrin receptors in neurons can promote cell survival and synaptic plasticity, but the underlying signal transduction pathway(s) is unknown. We report that integrin signaling prevents apoptosis of embryonic hippocampal neurons by a mechanism involving integrin-linked kinase (ILK) that activates Akt kin...

journal_title：Journal of neurochemistry

authors： Gary DS,Milhavet O,Camandola S,Mattson MP

更新日期：2003-02-01 00:00:00

abstract：:Early malnutrition is a risk factor for depression and schizophrenia. Since the offspring of malnourished dams exhibit increased brain levels of serotonin (5-HT), a tryptophan-derived neurotransmitter involved in the pathophysiology of these mental disorders, it is believed that the deleterious effects of early malnut...

journal_title：Journal of neurochemistry

authors： Honório de Melo Martimiano P,de Sa Braga Oliveira A,Ferchaud-Roucher V,Croyal M,Aguesse A,Grit I,Ouguerram K,Lopes de Souza S,Kaeffer B,Bolaños-Jiménez F

更新日期：2017-01-01 00:00:00

abstract：:Huntington's disease is a progressive neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the huntingtin gene. This expansion produces a mutant form of the huntingtin protein, which contains an elongated polyglutamine stretch at its amino-terminus. Mutant huntingtin may adopt an aberrant, aggr...

journal_title：Journal of neurochemistry

authors： Roscic A,Baldo B,Crochemore C,Marcellin D,Paganetti P

更新日期：2011-10-01 00:00:00

abstract：:Chandipura virus (CHPV; genus Vesiculovirus, family Rhabdoviridae) induces neuronal death through the Fas-mediated extrinsic apoptosis pathway. What propels this apoptosis remains unclear, although oxysterols have been reported to be key players in neurodegeneration. In our study of CHPV-infected brain samples, we obs...

journal_title：Journal of neurochemistry

authors： Ghosh S,Mukherjee S,Basu A

更新日期：2015-10-01 00:00:00

abstract：:In cerebellum, 13 different GABA(A) receptor subunits are expressed. The number of different receptor subtypes formed in this tissue, their subunit composition and their quantitative importance so far has not been determined. In the present study, immunodepletion by immunoaffinity chromatography, as well as immunoprec...

journal_title：Journal of neurochemistry

authors： Pöltl A,Hauer B,Fuchs K,Tretter V,Sieghart W

更新日期：2003-12-01 00:00:00

abstract：:To determine whether prolonged nicotine exposure persistently inactivates rat alpha4beta2 nicotinic receptors expressed in Xenopus oocytes, we measured the voltage-clamped alpha4beta2 response to acetylcholine (ACh) before and 24 h after, 1-h or 12-h incubations in 10 microm nicotine. A 12-h incubation in 10 microm ni...

journal_title：Journal of neurochemistry

authors： Jia L,Flotildes K,Li M,Cohen BN

更新日期：2003-02-01 00:00:00

abstract：:Research on stem cells has developed as one of the most promising areas of neurobiology. In the beginning of the 1990s, neurogenesis in the adult brain was indisputably accepted, eliciting great research efforts. Neural stem cells in the adult mammalian brain are located in the 'neurogenic' areas of the subventricular...

journal_title：Journal of neurochemistry

authors： Bellenchi GC,Volpicelli F,Piscopo V,Perrone-Capano C,di Porzio U

更新日期：2013-01-01 00:00:00

abstract：:In developing CNS D1 dopamine receptor-imaging agents with improved specificity and longer brain retention, an iodinated D1 ligand was synthesized. In vitro and in vivo radiolabeling studies of a new iodinated benzazepine, TISCH [7-chloro-8-hydroxy-1-(3'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3- benzazepine], an a...

journal_title：Journal of neurochemistry

authors： Billings JJ,Kung MP,Chumpradit S,Mozley D,Alavi A,Kung HF

更新日期：1992-01-01 00:00:00

abstract：:Purines are a class of small organic molecules that are essential for all cells. They play critical roles in neuronal differentiation and function. Their importance is highlighted by several inherited disorders of purine metabolism, such as Lesch-Nyhan disease, which is caused by a deficiency of the purine salvage enz...

journal_title：Journal of neurochemistry

authors： Göttle M,Burhenne H,Sutcliffe D,Jinnah HA

更新日期：2013-12-01 00:00:00

abstract：:Despite considerable efforts to unravel the role of cellular prion protein (PrP(C)) in neuronal functions, the mechanisms by which PrP(C) takes part in the homeostasis of a defined neuronal phenotype remain poorly characterized. By taking advantage of a neuroectodermal cell line (1C11) endowed with the capacity to dif...

journal_title：Journal of neurochemistry

authors： Pradines E,Loubet D,Mouillet-Richard S,Manivet P,Launay JM,Kellermann O,Schneider B

更新日期：2009-08-01 00:00:00