Spot applicator for thin-layer plates.

abstract：:Chronic inflammation contributes to cardiovascular disease. Increased levels of the inflammatory cytokine, TNF-α, are often present in conditions associated with cardiovascular disease risk, and TNF-α induces a number of pro-atherogenic effects in macrovascular endothelial cells, including expression of adhesion molec...

journal_title：Journal of lipid research

authors： Jung HS,Shimizu-Albergine M,Shen X,Kramer F,Shao D,Vivekanandan-Giri A,Pennathur S,Tian R,Kanter JE,Bornfeldt KE

更新日期：2020-01-01 00:00:00

abstract：:Inflammatory lipid mediators derived from arachidonic acid (AA) and docosahexaenoic acid (DHA) modify the pathophysiology of brain ischemia. The goal of this work was to investigate the formation of eicosanoids and docosanoids generated from AA and DHA, respectively, during no-flow cerebral ischemia. Rats were subject...

journal_title：Journal of lipid research

authors： Farias SE,Basselin M,Chang L,Heidenreich KA,Rapoport SI,Murphy RC

更新日期：2008-09-01 00:00:00

abstract：:Three glycosides of 13-hydroxydocosanoic acid isolated from Candida bogoriensis were characterized by quantitating the amount of carbohydrate, acetate, and hydroxy acid in each, and by gas-liquid chromatography and mass spectrometry of their methyl ester, trimethylsilyl ether derivatives. One of the glycosides was the...

journal_title：Journal of lipid research

authors： Esders TW,Light RJ

更新日期：1972-09-01 00:00:00

abstract：:The differentiation of macrophages into lipid-filled foam cells is a hallmark of the lung granuloma that forms in patients with active tuberculosis (TB). Mycolic acids (MAs), the abundant lipid virulence factors in the cell wall of Mycobacterium tuberculosis (Mtb), can induce this foam phenotype possibly as a way to p...

journal_title：Journal of lipid research

authors： Vermeulen I,Baird M,Al-Dulayymi J,Smet M,Verschoor J,Grooten J

更新日期：2017-04-01 00:00:00

abstract：:To investigate the relative turnover of esterified polyunsaturated fatty acids in diacylglycerophospholipids and plasmalogens in isolated cardiac myocytes, we characterized the phospholipid composition and distribution of radiolabel in different phospholipid classes and in individual molecular species of diradyl choli...

journal_title：Journal of lipid research

authors： DaTorre SD,Creer MH

更新日期：1991-07-01 00:00:00

abstract：:A synthetic analog of glucocerebroside, N-hexyl-O-glucosyl sphingosine, was found to inhibit the glucosidase in rat spleen that hydrolyzes glucocerebroside. At a concentration of 1 micro m, the analog inhibited the enzyme by 48%. The mode of action appeared to be competitive, probably aided by tight binding of the ami...

journal_title：Journal of lipid research

authors： Erickson JS,Radin NS

更新日期：1973-03-01 00:00:00

abstract：:Ketone bodies (KBs), acetoacetate and β-hydroxybutyrate (βHB), were considered harmful metabolic by-products when discovered in the mid-19th century in the urine of patients with diabetic ketoacidosis. It took physicians many years to realize that KBs are normal metabolites synthesized by the liver and exported into t...

journal_title：Journal of lipid research

authors： Hashim SA,VanItallie TB

更新日期：2014-09-01 00:00:00

abstract：:Elaborate control mechanisms of intracellular triacylglycerol (TAG) breakdown are critically involved in the maintenance of energy homeostasis. Hypoxia-inducible lipid droplet-associated protein (HILPDA)/hypoxia-inducible gene-2 (Hig-2) has been shown to affect intracellular TAG levels, yet, the underlying molecular m...

journal_title：Journal of lipid research

authors： Padmanabha Das KM,Wechselberger L,Liziczai M,De la Rosa Rodriguez M,Grabner GF,Heier C,Viertlmayr R,Radler C,Lichtenegger J,Zimmermann R,Borst JW,Zechner R,Kersten S,Oberer M

更新日期：2018-03-01 00:00:00

abstract：:The inverse relationship between plasma levels of high density lipoprotein (HDL) and coronary heart disease rates has suggested that HDL might influence body stores of cholesterol. Therefore, we have investigated potential relationships between the parameters of body cholesterol metabolism and the plasma levels of HDL...

journal_title：Journal of lipid research

authors： Blum CB,Dell RB,Palmer RH,Ramakrishnan R,Seplowitz AH,Goodman DS

更新日期：1985-09-01 00:00:00

abstract：:Oxidized LDL (oxLDL) is a known risk factor for atherogenesis. This study aimed to reveal structural features of oxLDL present in human circulation related to atherosclerosis. When LDL was fractionated on an anion-exchange column, in vivo-oxLDL, detected by the anti-oxidized PC (oxPC) mAb, was recovered in flow-throug...

journal_title：Journal of lipid research

authors： Sawada N,Obama T,Koba S,Takaki T,Iwamoto S,Aiuchi T,Kato R,Kikuchi M,Hamazaki Y,Itabe H

更新日期：2020-06-01 00:00:00

abstract：:The factors involved in shuttling cholesterol among cellular membranes have not been defined. Using amphotericin B selection, we previously isolated Chinese hamster ovary cell mutants expressing defects in intracellular cholesterol transport. Complementation analysis among seven mutants identified one cell line, mutan...

journal_title：Journal of lipid research

authors： Jacobs NL,Andemariam B,Underwood KW,Panchalingam K,Sternberg D,Kielian M,Liscum L

更新日期：1997-10-01 00:00:00

abstract：:Unesterified cholesterol is an essential structural component of the plasma membrane of every cell. During evolution, this membrane came to play an additional, highly specialized role in the central nervous system (CNS) as the major architectural component of compact myelin. As a consequence, in the human the mean con...

journal_title：Journal of lipid research

authors： Dietschy JM,Turley SD

更新日期：2004-08-01 00:00:00

abstract：:Using [13C]-tracers and direct fetal doses, we show for the first time that the fetal primate converts alpha-linolenic acid (18:3) to docosahexaenoic acid (22:6) in vivo, and we estimate the relative bioefficacy of the two substrates for brain 22:6 accretion. Pregnant female baboons consumed a diet free of long chain ...

journal_title：Journal of lipid research

authors： Su HM,Huang MC,Saad NM,Nathanielsz PW,Brenna JT

更新日期：2001-04-01 00:00:00

abstract：:ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty acids. There are two known genes encoding the two ACAT enzymes, ACAT1 and ACAT2 (also known as Soat1 and Soat2). In adult humans, ACAT1 is present in most tissues, whereas ACAT2 is localized to enterocytes and hepatocytes. In this...

journal_title：Journal of lipid research

authors： Pramfalk C,Davis MA,Eriksson M,Rudel LL,Parini P

更新日期：2005-09-01 00:00:00

abstract：:Phytanic acid (3,7,11,15-tetramethylhexadecanoic acid) is a branched-chain fatty acid derived from dietary sources and broken down in the peroxisome to pristanic acid (2,6,10,14-tetramethylpentadecanoic acid) via alpha-oxidation. Pristanic acid then undergoes beta-oxidation in peroxisomes. Phytanic acid naturally occu...

journal_title：Journal of lipid research

authors： Ferdinandusse S,Rusch H,van Lint AE,Dacremont G,Wanders RJ,Vreken P

更新日期：2002-03-01 00:00:00

abstract：:Previously, we have shown that lipid-free apoA-I, when incubated with fibroblasts, will produce lipoproteins of pre-alpha mobility (Asztalos, B. F., et al. 1997. Arterioscler. Thromb. Vasc. Biol. 17: 1630-1636). In order to understand the nature of these pre-alpha particles, we further characterized their lipid conten...

journal_title：Journal of lipid research

authors： Zhang W,Asztalos B,Roheim PS,Wong L

更新日期：1998-08-01 00:00:00

abstract：:Subcellular localization of nonesterified cholesterol has been determined in normal human fibroblasts from cultures incubated with human low density lipoprotein (LDL). Nonesterified and esterified cholesterol content of fibroblasts, grown initially in the absence of cholesterol, increased significantly after a 1-hour ...

journal_title：Journal of lipid research

authors： Kruth HS,Blanchette-Mackie J,Avigan J,Gamble W,Vaughan M

更新日期：1982-11-01 00:00:00

abstract：:PPARs regulate the expression of genes for energy metabolism in a ligand-dependent manner. PPARs can influence fatty acid oxidation, the level of circulating triglycerides, glucose uptake and insulin sensitivity. Here, we demonstrate that 5-hydroxyeicosapentaenoic acid (HEPE), 8-HEPE, 9-HEPE, 12-HEPE and 18-HEPE (hydr...

journal_title：Journal of lipid research

authors： Yamada H,Oshiro E,Kikuchi S,Hakozaki M,Takahashi H,Kimura K

更新日期：2014-05-01 00:00:00

abstract：:Endothelial dysfunction is a key step in atherosclerosis development. Our recent studies suggested that oxLDL-induced increase in endothelial stiffness plays a major role in dyslipidemia-induced endothelial dysfunction. In this study, we identify oxysterols, as the major component of oxLDL, responsible for the increas...

journal_title：Journal of lipid research

authors： Shentu TP,Singh DK,Oh MJ,Sun S,Sadaat L,Makino A,Mazzone T,Subbaiah PV,Cho M,Levitan I

更新日期：2012-07-01 00:00:00

abstract：:Phytanoyl-CoA hydroxylase (PhyH) catalyzes the conversion of phytanoyl-CoA to 2-hydroxyphytanoyl-CoA, which is the first step in the phytanic acid alpha-oxidation pathway. Recently, several studies have shown that in humans, phytanic acid alpha-oxidation is localized in peroxisomes. In rat, however, the alpha-oxidatio...

journal_title：Journal of lipid research

authors： Jansen GA,Ofman R,Denis S,Ferdinandusse S,Hogenhout EM,Jakobs C,Wanders RJ

更新日期：1999-12-01 00:00:00

abstract：:The enzymic incorporation of choline-1,2-(14)C from CDP-choline-1,2-(14)C into phosphatidylcholine by spinach leaf preparations was characterized. The enzyme catalyzing the incorporation, choline phosphotransferase, had a pH optimum of about 8.0 and required either Mn(2+) or Mg(2+) as cofactor. The saturation concentr...

journal_title：Journal of lipid research

authors： Devor KA,Mudd JB

更新日期：1971-07-01 00:00:00

abstract：:The phase behavior and temperature-dependent molecular motions of three cholesteryl ethers (caproyl, myristyl, oleyl) and a cholesteryl carbonate (oleyl) were characterized. The properties of each ether were qualitatively similar to, but quantitatively different from, those of the corresponding cholesteryl ester. For ...

journal_title：Journal of lipid research

authors： Croll DH,Sripada PK,Hamilton JA

更新日期：1987-12-01 00:00:00

abstract：:We determined the effect of storage at -70 degrees C on the determination of plasma high density lipoprotein (HDL)-cholesterol. Plasma from 106 subjects was stored for 1, 6, and 12 months, then treated with heparin and MnCl2 to remove other lipoproteins, and HDL-cholesterol was measured. The mean HDL-cholesterol level...

journal_title：Journal of lipid research

authors： Bachorik PS,Walker RE,Kwiterovich PO Jr

更新日期：1982-11-01 00:00:00

abstract：:The metabolism of chenodeoxycholic acid by Pseudomonas sp. NCIB 10590 under strict anaerobic conditions was studied. A range of unsaturated acidic and neutral metabolites were isolated and identified. The major acidic product was chola-4,6-dien-3-one-24-oic acid whilst the major neutral product was androsta-4,6-dien-3...

journal_title：Journal of lipid research

authors： Owen RW,Hill MJ,Bilton RF

更新日期：1983-09-01 00:00:00

abstract：:Rod outer segments (ROSs) are specialized light-sensitive organelles in vertebrate photoreceptor cells. Lipids in ROS are of considerable importance, not only in providing an adequate environment for efficient phototransduction, but also in originating the second messengers involved in signal transduction. ROSs have t...

journal_title：Journal of lipid research

authors： Giusto NM,Pasquaré SJ,Salvador GA,Ilincheta de Boschero MG

更新日期：2010-04-01 00:00:00

abstract：:Taurocholate, a relatively hydrophobic bile salt, is a potent down-regulator of HMG-CoA reductase and cholesterol 7 alpha-hydroxylase (C7 alpha H), the rate-determining enzymes of the cholesterol and bile acid biosynthetic pathways, respectively. Inhibition of cholesterol synthesis with a bolus dose of mevinolin (lova...

journal_title：Journal of lipid research

authors： Pandak WM,Vlahcevic ZR,Chiang JY,Heuman DM,Hylemon PB

更新日期：1992-05-01 00:00:00

abstract：:Rhizobium chitolipooligosaccharides (CLOSs) are heterogeneous fatty acylated N-acetyl glucosamine oligomers with variations in both the polar (hydrophilic) oligosaccharide head group and the non-polar (hydrophobic) fatty acyl chain. They trigger root hair deformation and cortical cell divisions in legume roots during ...

journal_title：Journal of lipid research

authors： Philip-Hollingsworth S,Dazzo FB,Hollingsworth RI

更新日期：1997-06-01 00:00:00

abstract：:This review focuses on adipose tissue biology and introduces the concept of adipose tissue plasticity and expandability as key determinants of obesity-associated metabolic dysregulation. This concept is fundamental to our understanding of adipose tissue as a dynamic organ at the center of nutritional adaptation. Here,...

journal_title：Journal of lipid research

authors： Sethi JK,Vidal-Puig AJ

更新日期：2007-06-01 00:00:00

abstract：:A gas-liquid chromatography-flame ionization detection method is described for measuring plasma levels of eicosatetraynoic acid using eicosatriynoic acid as an internal standard. The technique is simple, rapid, and reproducible. Eicosatetraynoic acid and eicosatriynoic acid behave similarly in the extraction system ch...

journal_title：Journal of lipid research

authors： Goodman RP,Brash AR

更新日期：1981-03-01 00:00:00

abstract：:Fatty acid binding protein 4 (FABP4), also known as adipocyte FABP or aP2, is secreted from adipocytes in association with lipolysis as a novel adipokine, and elevated serum FABP4 level is associated with obesity, insulin resistance, and atherosclerosis. However, little is known about the modulation of serum FABP4 lev...

journal_title：Journal of lipid research

authors： Furuhashi M,Hiramitsu S,Mita T,Fuseya T,Ishimura S,Omori A,Matsumoto M,Watanabe Y,Hoshina K,Tanaka M,Moniwa N,Yoshida H,Ishii J,Miura T

更新日期：2015-12-01 00:00:00