Phytanoyl-CoA hydroxylase from rat liver. Protein purification and cDNA cloning with implications for the subcellular localization of phytanic acid alpha-oxidation.

abstract：:Bile acids are physiological detergents that generate bile flow and facilitate intestinal absorption and transport of lipids, nutrients, and vitamins. Bile acids also are signaling molecules and inflammatory agents that rapidly activate nuclear receptors and cell signaling pathways that regulate lipid, glucose, and en...

journal_title：Journal of lipid research

authors： Chiang JY

更新日期：2009-10-01 00:00:00

abstract：:The cellular content of total and individual phospholipids and gangliosides was measured in fibroblasts cultured from four normal subjects, three patients with lysosomal lipid storage diseases, and two subjects with homozygous familial hypercholesterolemia. Measurements were made on cells grown in medium containing fe...

journal_title：Journal of lipid research

authors： Fishman PH,Bradley RM,Brown MS,Faust JR,Goldstein JL

更新日期：1978-03-01 00:00:00

abstract：:Four hours after intraportal injection of retinoic acid-(14)C into bile duct-cannulated rats, less than 10% of the radioactivity was recovered in the liver, intestine, and kidneys. Within 6 hr, 40% of the radioactivity had appeared in bile. When suspensions of retinol-(14)C or retinal were similarly injected, 25-35% o...

journal_title：Journal of lipid research

authors： Zachman RD,Dunagin PE Jr,Olson JA

更新日期：1966-01-01 00:00:00

abstract：:The bioactive sphingolipid metabolite, ceramide, regulates physiological processes important for inflammation and elevated levels of ceramide have been implicated in IL-1-mediated events. Although much has been learned about ceramide generation by activation of sphingomyelinases in response to IL-1, the contribution o...

journal_title：Journal of lipid research

authors： Cai L,Oyeniran C,Biswas DD,Allegood J,Milstien S,Kordula T,Maceyka M,Spiegel S

更新日期：2016-08-01 00:00:00

abstract：:Ecdysteroids are potent developmental regulators that control molting, reproduction, and stress response in arthropods. In developing larvae, picogram quantities of individual ecdysteroids and their conjugated forms are present along with milligrams of structural and energy storage lipids. To enhance the specificity a...

journal_title：Journal of lipid research

authors： Lavrynenko O,Nedielkov R,Möller HM,Shevchenko A

更新日期：2013-08-01 00:00:00

abstract：:Mixed background SHP(-/-) mice are resistant to diet-induced obesity due to increased energy expenditure caused by enhanced PGC-1α expression in brown adipocytes. However, congenic SHP(-/-) mice on the C57BL/6 background showed normal expression of PGC-1α and other genes involved in brown adipose tissue thermogenesis....

journal_title：Journal of lipid research

authors： Park YJ,Kim SC,Kim J,Anakk S,Lee JM,Tseng HT,Yechoor V,Park J,Choi JS,Jang HC,Lee KU,Novak CM,Moore DD,Lee YK

更新日期：2011-12-01 00:00:00

abstract：:In the present study, the relative positions of 11 anti-apolipoprotein B monoclonal antibodies have been mapped onto the surface of human low density lipoproteins by electron microscopy. As the epitopes recognized by these antibodies have been previously located on the primary sequence of apoB, these data provide a ma...

journal_title：Journal of lipid research

authors： Chatterton JE,Phillips ML,Curtiss LK,Milne R,Fruchart JC,Schumaker VN

更新日期：1995-09-01 00:00:00

abstract：:Oxidized low density lipoprotein (Ox-LDL) has a plethora of components that are not present in native LDL. Their presence and quantity depends on the nature, type, and extent of oxidation. Lipids esterified to oxidized fatty acids are the major components formed during the early phase of oxidation and these show a num...

journal_title：Journal of lipid research

authors： Parthasarathy S,Santanam N,Ramachandran S,Meilhac O

更新日期：1999-12-01 00:00:00

abstract：:Conditions leading to oxidation of LDL in vivo are still unknown. While the occurrence of oxidized lipoproteins and catalytic free iron in advanced atherosclerotic lesions has been demonstrated, the origin of both is unclear. In vivo, iron metabolism is tightly regulated by iron-binding proteins that ensure that virtu...

journal_title：Journal of lipid research

authors： Balagopalakrishna C,Paka L,Pillarisetti S,Goldberg IJ

更新日期：1999-07-01 00:00:00

abstract：:Ursodeoxycholic acid (UDCA, ursodiol) is used to prevent damage to the liver in patients with primary biliary cirrhosis. The drug also prevents the progression of colorectal cancer and the recurrence of high-grade colonic dysplasia. However, the molecular mechanism by which UDCA elicits its beneficial effects is not e...

journal_title：Journal of lipid research

authors： Fang C,Filipp FV,Smith JW

更新日期：2012-04-01 00:00:00

abstract：:The effects of eicosapentaenoic acid and oleic acid on lipid synthesis and secretion by HepG2 cells were examined to identify fatty acid specific changes in lipid metabolism that might indicate a basis for the hypolipidemic effect attributed to eicosapentaenoic acid and related n-3 fatty acids. Cellular glycerolipid s...

journal_title：Journal of lipid research

authors： Homan R,Grossman JE,Pownall HJ

更新日期：1991-02-01 00:00:00

abstract：:The origin of the cholesterol needed by the cornea for growth and cell turnover was addressed by comparing absolute rates of sterol synthesis with rates of sterol accumulation during early development of the rabbit. Linearity of incorporation of 3H2O and [14C]mevalonate into digitonin-precipitable sterols with time of...

journal_title：Journal of lipid research

authors： Cenedella RJ,Fleschner CR

更新日期：1989-07-01 00:00:00

abstract：:Significant amounts of ursodeoxycholic acid (UDCA) used for the treatment of patients with primary biliary cirrhosis (PBC) become epimerized at C-3 to isoUDCA. We investigated the metabolism of isoUDCA and a possible pharmacologic effect in five patients (51.4 +/- 5.8 years old; 3 females, 2 males) with PBC and persis...

journal_title：Journal of lipid research

authors： Marschall HU,Broomé U,Einarsson C,Alvelius G,Thomas HG,Matern S

更新日期：2001-05-01 00:00:00

abstract：:Over the past several years, considerable progress has been made in the development of gene therapy as a therapeutic strategy for a variety of inherited metabolic diseases, including neuropathic lysosomal storage disorders (LSDs). The premise of gene therapy for this group of diseases is borne of findings that genetic...

journal_title：Journal of lipid research

authors： Cheng SH

更新日期：2014-09-01 00:00:00

abstract：:Groups of gerbils were fed purified diets containing either 10 or 20% of safflower, olive, or coconut oil. Each diet was fed without cholesterol and with 0.1 and 0.2% of added cholesterol. The animals were bled after 2, 4, and 8 wk for the determination of the level of serum cholesterol. The major factors affecting th...

journal_title：Journal of lipid research

authors： Hegsted DM,Gallagher A

更新日期：1967-05-01 00:00:00

abstract：:LPL is an enzyme involved in the breakdown and uptake of lipoprotein triglycerides. In the present study, we examined how the transgenic (Tg) overexpression of human LPL in mouse skeletal muscle affected tolerance to cold temperatures, cold-induced thermogenesis, and fuel utilization during this response. Tg mice and ...

journal_title：Journal of lipid research

authors： Jensen DR,Knaub LA,Konhilas JP,Leinwand LA,MacLean PS,Eckel RH

更新日期：2008-04-01 00:00:00

abstract：:The rate-limiting step in the transit of dietary fat across the intestinal absorptive cell is its exit from the endoplasmic reticulum (ER) in a specialized ER-to-Golgi transport vesicle, the prechylomicron transport vesicle (PCTV). PCTV bud off from the ER membranes and have unique features; they are the largest ER-de...

journal_title：Journal of lipid research

authors： Siddiqi S,Siddiqi SA,Mansbach CM 2nd

更新日期：2010-05-01 00:00:00

abstract：:apoE is a multi-functional protein expressed in several cell types and in several organs. It is highly expressed in adipose tissue, where it is important for modulating adipocyte lipid flux and gene expression in isolated adipocytes. In order to investigate a potential systemic role for apoE that is produced in adipos...

journal_title：Journal of lipid research

authors： Huang ZH,Reardon CA,Getz GS,Maeda N,Mazzone T

更新日期：2015-02-01 00:00:00

abstract：:Lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes represent a group of rare genetic disorders of HDL metabolism that have been the subject of a large number of clinical, biochemical, and genetic studies. Of special interest are patients with LCAT-related disorders with severe HDL deficiency and the appa...

journal_title：Journal of lipid research

authors： Kuivenhoven JA,Pritchard H,Hill J,Frohlich J,Assmann G,Kastelein J

更新日期：1997-02-01 00:00:00

abstract：:The role of nuclear membrane phospholipids as targets of phospholipases resulting in the generation of nuclear signaling messengers has received attention. In the present study, we have exploited the utility of electrospray ionization mass spectrometry to determine the phospholipid content of nuclei isolated from perf...

journal_title：Journal of lipid research

authors： Williams SD,Hsu FF,Ford DA

更新日期：2000-10-01 00:00:00

abstract：:A lipid transfer particle (LTP) was isolated and purified from the hemolymph of the adult male American cockroach, Periplaneta americana, essentially according to the method previously developed for the purification of LTP from locust hemolymph. Fast protein liquid chromatography (FPLC) on a Mono Q column was used as ...

journal_title：Journal of lipid research

authors： Takeuchi N,Chino H

更新日期：1993-04-01 00:00:00

abstract：:Essential fatty acids (EFA) are important structural and functional components of cell membranes. Their deficiency has been associated with several clinical and biochemical abnormalities. In the present study, the lipid profile as well as the concentration, composition, and metabolism of lipoproteins were examined in ...

journal_title：Journal of lipid research

authors： Levy E,Thibault L,Garofalo C,Messier M,Lepage G,Ronco N,Roy CC

更新日期：1990-11-01 00:00:00

abstract：:Polyunsaturated fatty acids, including docosahexaenoic acid (DHA, 22:6n-3), modulate immune responses and exert beneficial immunosuppressive effects, but the molecular mechanisms inhibiting T-cell activation are not yet elucidated. Lipid rafts have been shown to play an important role in the compartmentalization and m...

journal_title：Journal of lipid research

authors： Li Q,Wang M,Tan L,Wang C,Ma J,Li N,Li Y,Xu G,Li J

更新日期：2005-09-01 00:00:00

abstract：:Seven Z-octadecenoic acids having the double bond located in positions 6Z to 13Z were photooxidized. The resulting hydroperoxy-E-octadecenoic acids [HpOME(E)] were resolved by chiral phase-HPLC-MS, and the absolute configurations of the enantiomers were determined by gas chromatographic analysis of diastereoisomeric d...

journal_title：Journal of lipid research

authors： Oliw EH,Wennman A,Hoffmann I,Garscha U,Hamberg M,Jernerén F

更新日期：2011-11-01 00:00:00

abstract：:The ATP binding cassette (ABC) half-transporters ABCG5 and ABCG8 facilitate biliary and intestinal removal of neutral sterols. Here, we identify a binding site for the orphan nuclear receptor liver receptor homolog-1 (LRH-1) at nt 134-142 of the ABCG5/ABCG8 intergenic region necessary for the activity of both the ABCG...

journal_title：Journal of lipid research

authors： Freeman LA,Kennedy A,Wu J,Bark S,Remaley AT,Santamarina-Fojo S,Brewer HB Jr

更新日期：2004-07-01 00:00:00

abstract：:Glycosylphosphatidylinositol (GPI) enriches GPI-anchored proteins (GPI-AP) in lipid rafts by intimate interaction of its lipid moiety with sphingolipids and cholesterol. In addition to such lipid-lipid interactions, it has been reported that GPI may interact with protein moiety linked to GPI and affect protein conform...

journal_title：Journal of lipid research

authors： Seong J,Wang Y,Kinoshita T,Maeda Y

更新日期：2013-04-01 00:00:00

abstract：:The Smith-Lemli-Opitz syndrome (SLOS) is a congenital birth defect syndrome caused by a deficiency of 3beta-hydroxysterol Delta(7)-reductase, the final enzyme in the cholesterol biosynthetic pathway. The patients have reduced plasma and tissue cholesterol concentrations with the accumulation of 7-dehydrocholesterol an...

journal_title：Journal of lipid research

authors： Honda A,Salen G,Shefer S,Batta AK,Honda M,Xu G,Tint GS,Matsuzaki Y,Shoda J,Tanaka N

更新日期：1999-08-01 00:00:00

abstract：:The metabolism of chenodeoxycholic acid by Pseudomonas sp. NCIB 10590 under strict anaerobic conditions was studied. A range of unsaturated acidic and neutral metabolites were isolated and identified. The major acidic product was chola-4,6-dien-3-one-24-oic acid whilst the major neutral product was androsta-4,6-dien-3...

journal_title：Journal of lipid research

authors： Owen RW,Hill MJ,Bilton RF

更新日期：1983-09-01 00:00:00

abstract：:Inflammation has been proposed to impair HDL function and reverse cholesterol transport (RCT). We investigated the effects of inflammation mediated by zymosan, a yeast glucan, on multiple steps along the RCT pathway in vivo and ex vivo. Acute inflammation with 70 mg/kg zymosan impaired RCT to plasma, liver, and feces ...

journal_title：Journal of lipid research

authors： Malik P,Berisha SZ,Santore J,Agatisa-Boyle C,Brubaker G,Smith JD

更新日期：2011-05-01 00:00:00

abstract：:After stereospecific oxidation, trimethylsilylated methyl esters of mono- and diunsaturated fatty acids were analyzed by combined gas-liquid chromatography-chemical ionization mass spectrometry. The positions of original double bonds were deduced from the fragment ions produced by the cleavage of the carbon-carbon bon...

journal_title：Journal of lipid research

authors： Murata T,Ariga T,Araki E

更新日期：1978-02-01 00:00:00