Abstract：
:Correlations between pairs of spontaneous climbing fiber responses (CFRs) recorded from couples of nearby Purkinje cells (PCs) were studied in immature rats by using cross-correlograms between CFR pairs, and compaired to those in adult animals. Correlations were found as early as day 3. Some days later, on PN days 7--9, these correlations were higher than in the adult. In most cases, this was apparently not due to the multiple innervation of PC by climbing fibers (CFs) which normally occurs during this immature stage since: 1) temporal relationships between the paired CFRs varied by more than 30 ms and 2) thresholds for pairs of graded CFRs and additional components of the responses evoked in the 2 PCs by juxtafastigial or olivary stimulation were different. Synchronizing mechanisms were therefore likely to be already located at the olivary level. However, in 3 couples of multiply innervated PCs whose spontaneous CF activities were highly correlated, stimulation experiments revealed a common innervation of the 2 cells by branches of the same CF. In multiply innervated cells, spontaneous responses mediated through distinct CFs were also synchronized, suggesting that these fibers originate from neighboring neurons of the inferior olive. Finally, in 7 to 9-day-old rats, correlations among CFR pairs were much more restricted in the longitudinal axis of the folium than in the transverse one. On the whole, the present study indicates that correlations among CFRs of nearby PCs exist as soon as CF-PC synapses are established and the latter are already organized in sagittal strips at early stages of development.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Dupont JL,Crepel Fdoi
10.1007/BF00236821subject
Has Abstractpub_date
1979-01-01 00:00:00pages
525-35issue
3eissn
0014-4819issn
1432-1106journal_volume
37pub_type
杂志文章abstract：:Transient changes in extracellular potassium concentration ([K+]o) and field potentials were evoked by 4-aminopyridine (4-AP; 50-100 microM) and recorded with ion-selective microelectrodes in CA1b, CA3b and dentate sectors of adult rat hippocampal slices. Long-lasting field potentials recurred at a frequency of approx...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228628
更新日期：1996-04-01 00:00:00
abstract：:The current study examines the modulation of the motion-onset response based on the frequency-range of sound stimuli. Delayed motion-onset and stationary stimuli were presented in a free-field by sequentially activating loudspeakers on an azimuthal plane keeping the natural percept of externalized sound presentation. ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-018-5329-9
更新日期：2018-10-01 00:00:00
abstract：:During everyday life, healthy adults occasionally trip over an obstacle that they knew was there. These 'spontaneous' trips can provide insight into the circumstances leading to trips and falls. The goal of this study was to describe the errors in foot placement and/or foot elevation that resulted in a spontaneous con...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3253-y
更新日期：2012-11-01 00:00:00
abstract：:Optokinetic circular vection (CV) was investigated in 12 subjects using an optokinetic pattern rotating at 15 degrees /s, 30 degrees /s, or 60 degrees /s, and four viewing conditions: FOL, subjects attentively followed details of pattern; STA, subjects stared at the pattern; SUP, subjects suppressed their optokinetic ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1104-y
更新日期：2002-06-01 00:00:00
abstract：:Recently, Kounios J, Frymiare JL, Bowden EM, Fleck JI, Subramaniam K, Parrish TB et al. (2006) found that the mental preparation leading to insight involves heightened activity in medial frontal areas and temporal areas. In the present study, the electrophysiological correlates of successful and unsuccessful Chinese l...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1270-7
更新日期：2008-04-01 00:00:00
abstract：:We investigated the effect of spatial uncertainty on motor planning by using the cueing method in a reaching task (experiment 1). Discrete spatial cues indicated the different locations in which the target could be presented. The number of cues as well as their direction changed from trial to trial. We tested the adeq...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1453-1
更新日期：2003-06-01 00:00:00
abstract：:For 1 week, healthy human participants ( n=7) were devoid of normal vision by exposure to prism lenses that optically rotated their perceived world around the line of sight by 180 degrees. Adaptation to such prisms involved sustained and vigorous practice of the ability to redirect the unadapted efferent motor command...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1097-6
更新日期：2002-06-01 00:00:00
abstract：:Retinal and cortical afferents to the superior colliculus of the rabbit were labelled simultaneously by injecting 3H-leucine into the right eye and HRP into the left visual cortex. It could be shown that there is some convergence of retinal and cortical input onto common postsynaptic elements in the superficial grey, ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00243837
更新日期：1986-01-01 00:00:00
abstract：:Ageing affects many visual functions. Here, we investigated the effects of ageing on vernier acuity and backward masking using the shine-through paradigm. We divided healthy older adults (>60 years) into two groups depending on whether vernier duration was comparable to younger adults (Older Adults 1) or not (Older Ad...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4314-9
更新日期：2015-08-01 00:00:00
abstract：:A database of positron-emission-tomography studies published between January 1993 and November 1996 was created to address several questions regarding the function and connectivity of the human anterior cingulate cortex (ACC). Using this database, we have previously reported on the relationship between behavioural var...
journal_title：Experimental brain research
pub_type： 杂志文章,meta分析
doi：10.1007/s002210000400
更新日期：2000-07-01 00:00:00
abstract：:The spatial frequency tuning and the contrast-response function of striate neurons in Siamese cats were investigated with drifting sinusoidal gratings of high contrast, and the results were compared to the data obtained in normally pigmented cats. The optimal spatial frequency of the tuning curves obtained from Siames...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236278
更新日期：1984-01-01 00:00:00
abstract：:The cerebral representation of space depends on the integration of many different sensory inputs. The vestibular system provides one such input and its dysfunction can cause profound spatial disorientation. Using positron emission tomography (PET), we measured regional cerebral perfusion with various vestibular stimul...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/BF00241421
更新日期：1994-01-01 00:00:00
abstract：:Feedback about error or reward is regarded essential for aiding learners to acquire a perceptual-motor skill. Yet, when a task has redundancy and the mapping between execution and performance outcome is unknown, simple error feedback does not suffice in guiding the learner toward the optimal solutions. The present stu...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4251-7
更新日期：2015-06-01 00:00:00
abstract：:The present study assessed changes in perceived heaviness of weights lifted by the thumb, index, ring and little fingers during anaesthesia of the "lifting" digit. Subjects (n = 19) lifted weights solely by flexion of the distal joint of the digit, using a bilateral weight-matching paradigm. Changes in perceived heavi...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050247
更新日期：1997-12-01 00:00:00
abstract：:Horizontal DC-electrooculograms were recorded in subjects rotating on a horizontal turntable sinusoidally at 0.1 Hz and 35 to 40 degrees amplitude. The subjects either fixated a stroboscopically illuminated vertically striped pattern (1.15 to 3.45 degrees period) rotating with the turntable or initiated Sigma-OKN befo...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235311
更新日期：1985-01-01 00:00:00
abstract：:We conducted a series of experiments to determine whether negative priming is used in the process of target selection for a saccadic eye movement. The key questions addressed the circumstances in which the negative priming of an object takes place, and the distinction between spatial and object-based effects. Experime...
journal_title：Experimental brain research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00221-012-3234-1
更新日期：2012-10-01 00:00:00
abstract：:In the present study, we examined the effects of explicit knowledge, obtained through instruction or spontaneous detection, on the transfer of visuomotor sequence learning. In the learning session, participants learned a visuomotor sequence, via trial and error. In the transfer session, the order of the sequence was r...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-017-4933-4
更新日期：2017-06-01 00:00:00
abstract：:Supervised learning of different postural tasks in patients with lesions of the motor cortex or pyramidal system (poststroke hemiparesis: 20 patients), nigro-striatal system (Parkinson's disease: 33 patients) and cerebellum (spinocerebellar ataxia: 37 patients) was studied. A control group consisted of 13 healthy subj...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-0096-9
更新日期：2006-01-01 00:00:00
abstract：:Although maintenance of steady contractions is required for many daily tasks, there is little understanding of brain areas that modulate lower limb force accuracy. Functional magnetic resonance imaging was used to determine brain areas associated with steadiness and force during static (isometric) lower limb target-ma...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-3976-z
更新日期：2014-10-01 00:00:00
abstract：:Brain-damaged patients may extinguish contralesional stimuli when ipsilesional stimuli are presented simultaneously. Most theories of extinction postulate that stimuli compete for pathologically limited attentional resources with a bias to process ipsilesional over contralesional stimuli. Implicit in this view is the ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1823-8
更新日期：2004-07-01 00:00:00
abstract：:Extracellular single-neuron recordings were obtained from electrophysiologically identified nigrostriatal neurons in chloral hydrate anesthetized rats, in order to test the hypothesis that excitatory amino acid receptors are involved in responses of these neurons to electrical stimulation of the pontine region where t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229003
更新日期：1992-01-01 00:00:00
abstract：:It is a common experience, immediately after the removal of a cast or a splint, to feel motor awkwardness, which is usually attributed to muscular and joint immobilization. However, the same feeling may also be perceived after a brief period of immobilization. We provide evidence that this last effect stems from chang...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3115-7
更新日期：2012-07-01 00:00:00
abstract：:Young children rely heavily on vision for postural control during the transition to walking. Although by 10 years of age, children have automatic postural responses similar to adults, it is not clear when the integration of sensory inputs becomes fully developed. The purpose of this study was to examine this transitio...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-0109-8
更新日期：2006-01-01 00:00:00
abstract：:In this study, we investigated the effects of ginkgolides (Gins A, B, C and J), the main constituent of the non-flavone fraction of EGb 761, on hypoxic injury induced by potassium cyanide (KCN) in primary cortical neurons. The neurons were pretreated with or without ginkgolides for 24 h before incubation with KCN for ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0823-x
更新日期：2007-06-01 00:00:00
abstract：:The European Resuscitation Guidelines recommend that survivors of cardiac arrest (CA) be resuscitated with 100% O2 and undergo subsequent-post-return of spontaneous circulation (ROSC)-reduction of O2 supply to prevent hyperoxia. Hyperoxia produces a "second neurotoxic hit," which, together with the initial ischemic in...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-020-05746-6
更新日期：2020-04-01 00:00:00
abstract：:Morphometric changes have been studied at the mouse neuromuscular junction (NMJ) as a function of the frequency of stimulation. In vivo stimulation was made at either 10, 25, 50 or 100 Hz. No significant change in the area of NMJ profiles is observed after stimulation. This indicates that stimulation does not change t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237590
更新日期：1986-01-01 00:00:00
abstract：:We investigated how neurons in the different motor areas of the frontal lobe reflect the movement dynamics, and how their neuronal activity undergoes plastic changes when monkeys adapt to perturbing forces (they learn new dynamics). Here we describe the results obtained in the dorsal premotor area (PMd) and ventral pr...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-0074-2
更新日期：2006-01-01 00:00:00
abstract：:In two experiments, we examined the effect of selective attention at encoding on repetition priming in normal aging and Alzheimer's disease (AD) patients for objects presented visually (experiment 1) or haptically (experiment 2). We used a repetition priming paradigm combined with a selective attention procedure at en...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1441-6
更新日期：2008-08-01 00:00:00
abstract：:The contribution of different cortical regions to visuospatial attention can be probed with the help of perturbation techniques, such as transcranial magnetic stimulation (TMS). Repetitive TMS (rTMS) has also been suggested as a tool for the therapy of brain injuries, by adjusting the neural excitability of injured or...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1449-y
更新日期：2008-07-01 00:00:00
abstract：:We studied the effects of morphine injected either systemically or into the dorsal periaqueductal gray (DPAG) or nucleus accumbens (NA) using conventional and ethological analyses of behavior of rats submitted to the elevated plus-maze test with transparent walls. Intraperitoneal morphine (0.1 mg/kg and 0.3 mg/kg) inc...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050896
更新日期：1999-11-01 00:00:00
