Abstract:
:The maximum rate of expression of the lac operon is severely reduced in lac promoter mutants. Revertants of these mutations which produce higher levels of enzyme were isolated. Some of these revertants had lost sensitivity to catabolite repression and transient repression. The mutations responsible for these losses took place at sites very close to the original promoter mutations. From these results we conclude that the promoter itself is the target site for both catabolite and transient repression of the lac operon.
journal_name
Proc Natl Acad Sci U S Aauthors
Silverstone AE,Arditti RR,Magasanik Bdoi
10.1073/pnas.66.3.773subject
Has Abstractpub_date
1970-07-01 00:00:00pages
773-9issue
3eissn
0027-8424issn
1091-6490journal_volume
66pub_type
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