Mode of action of zorbamycin.

Abstract:

:Zorbamycin (U-30,604E) induces rapid degradation of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) in Bacillus subtilis cells. DNA degradation is initiated first and is closely followed by the degradation of RNA. No interaction between isolated DNA and zorbamycin is observed. Nucleic acid and protein syntheses are not inhibited by zorbamycin in cell-free systems. Since the initial effect of the antibiotic is expressed at the level of the cellular DNA fraction, we assume that zorbamycin somehow induces a change in the structure or function of the cellular DNA fraction which results in rapid breakdown of this fraction.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Reusser F

doi

10.1128/JB.108.1.30-37.1971

subject

Has Abstract

pub_date

1971-10-01 00:00:00

pages

30-7

issue

1

eissn

0021-9193

issn

1098-5530

journal_volume

108

pub_type

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